Homologous to animal CDC50 family phospholipid flippase (ATPase) proteins.. This family has expanded in kinetoplastids
Source | Evidence on protein | Close homologs |
---|---|---|
Cuervo et al. | no | yes: 0 |
Hassani et al. | no | yes: 0 |
Forrest at al. (metacyclic) | no | yes: 0 |
Forrest at al. (procyclic) | no | yes: 0 |
Silverman et al. | no | yes: 0 |
Pissara et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Pires et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Silverman et al. | no | yes: 0 |
Source | Evidence on protein | Close homologs |
---|---|---|
Jamdhade et al. | no | yes: 9 |
Source | Evidence on protein | Close homologs |
---|---|---|
DeepLoc | ||
SignalP6 | no | yes: 0, no: 26 |
NetGPI | no | yes: 0, no: 26 |
Term | Name | Level | Count |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | 5 | 3 |
GO:0005794 | Golgi apparatus | 5 | 3 |
GO:0005886 | plasma membrane | 3 | 3 |
GO:0016020 | membrane | 2 | 27 |
GO:0043226 | organelle | 2 | 3 |
GO:0043227 | membrane-bounded organelle | 3 | 3 |
GO:0043229 | intracellular organelle | 3 | 3 |
GO:0043231 | intracellular membrane-bounded organelle | 4 | 3 |
GO:0110165 | cellular anatomical entity | 1 | 27 |
GO:0005737 | cytoplasm | 2 | 1 |
GO:0031974 | membrane-enclosed lumen | 2 | 1 |
GO:0031981 | nuclear lumen | 5 | 1 |
GO:0032838 | plasma membrane bounded cell projection cytoplasm | 4 | 1 |
GO:0043233 | organelle lumen | 3 | 1 |
GO:0070013 | intracellular organelle lumen | 4 | 1 |
GO:0097014 | ciliary plasm | 5 | 1 |
GO:0099568 | cytoplasmic region | 3 | 1 |
Related structures:
AlphaFold database: E9AFG4
Term | Name | Level | Count |
---|---|---|---|
GO:0033036 | macromolecule localization | 2 | 27 |
GO:0051179 | localization | 1 | 27 |
Leishmania | From | To | Domain/Motif | Score |
---|---|---|---|---|
CLV_C14_Caspase3-7 | 132 | 136 | PF00656 | 0.253 |
CLV_C14_Caspase3-7 | 277 | 281 | PF00656 | 0.305 |
CLV_NRD_NRD_1 | 127 | 129 | PF00675 | 0.430 |
CLV_NRD_NRD_1 | 331 | 333 | PF00675 | 0.443 |
CLV_PCSK_KEX2_1 | 127 | 129 | PF00082 | 0.430 |
CLV_PCSK_SKI1_1 | 107 | 111 | PF00082 | 0.470 |
DEG_SCF_FBW7_1 | 28 | 35 | PF00400 | 0.596 |
DOC_CKS1_1 | 29 | 34 | PF01111 | 0.498 |
DOC_CYCLIN_yCln2_LP_2 | 109 | 115 | PF00134 | 0.201 |
DOC_MAPK_gen_1 | 107 | 115 | PF00069 | 0.247 |
DOC_MAPK_gen_1 | 409 | 418 | PF00069 | 0.509 |
DOC_PP1_RVXF_1 | 240 | 247 | PF00149 | 0.231 |
DOC_PP2B_LxvP_1 | 109 | 112 | PF13499 | 0.237 |
DOC_PP4_FxxP_1 | 259 | 262 | PF00568 | 0.268 |
DOC_USP7_MATH_1 | 147 | 151 | PF00917 | 0.312 |
DOC_USP7_MATH_1 | 245 | 249 | PF00917 | 0.270 |
DOC_USP7_MATH_1 | 32 | 36 | PF00917 | 0.476 |
DOC_USP7_MATH_1 | 56 | 60 | PF00917 | 0.299 |
DOC_WW_Pin1_4 | 150 | 155 | PF00397 | 0.252 |
DOC_WW_Pin1_4 | 261 | 266 | PF00397 | 0.327 |
DOC_WW_Pin1_4 | 28 | 33 | PF00397 | 0.517 |
DOC_WW_Pin1_4 | 85 | 90 | PF00397 | 0.350 |
LIG_14-3-3_CanoR_1 | 142 | 148 | PF00244 | 0.354 |
LIG_14-3-3_CanoR_1 | 162 | 169 | PF00244 | 0.113 |
LIG_14-3-3_CanoR_1 | 266 | 272 | PF00244 | 0.280 |
LIG_14-3-3_CanoR_1 | 310 | 320 | PF00244 | 0.277 |
LIG_14-3-3_CanoR_1 | 324 | 329 | PF00244 | 0.255 |
LIG_14-3-3_CanoR_1 | 377 | 381 | PF00244 | 0.324 |
LIG_14-3-3_CanoR_1 | 55 | 65 | PF00244 | 0.251 |
LIG_AP2alpha_1 | 194 | 198 | PF02296 | 0.232 |
LIG_CtBP_PxDLS_1 | 48 | 52 | PF00389 | 0.409 |
LIG_eIF4E_1 | 183 | 189 | PF01652 | 0.207 |
LIG_FHA_1 | 150 | 156 | PF00498 | 0.286 |
LIG_FHA_1 | 195 | 201 | PF00498 | 0.247 |
LIG_FHA_1 | 245 | 251 | PF00498 | 0.338 |
LIG_FHA_1 | 93 | 99 | PF00498 | 0.256 |
LIG_FHA_2 | 202 | 208 | PF00498 | 0.314 |
LIG_FHA_2 | 312 | 318 | PF00498 | 0.241 |
LIG_LIR_Apic_2 | 251 | 257 | PF02991 | 0.217 |
LIG_LIR_Gen_1 | 13 | 23 | PF02991 | 0.562 |
LIG_LIR_Gen_1 | 179 | 189 | PF02991 | 0.254 |
LIG_LIR_Gen_1 | 223 | 233 | PF02991 | 0.299 |
LIG_LIR_Gen_1 | 398 | 406 | PF02991 | 0.379 |
LIG_LIR_Nem_3 | 13 | 18 | PF02991 | 0.527 |
LIG_LIR_Nem_3 | 174 | 178 | PF02991 | 0.233 |
LIG_LIR_Nem_3 | 179 | 184 | PF02991 | 0.223 |
LIG_LIR_Nem_3 | 196 | 201 | PF02991 | 0.238 |
LIG_LIR_Nem_3 | 223 | 228 | PF02991 | 0.278 |
LIG_LIR_Nem_3 | 398 | 402 | PF02991 | 0.397 |
LIG_MYND_1 | 28 | 32 | PF01753 | 0.514 |
LIG_OCRL_FandH_1 | 398 | 410 | PF00620 | 0.204 |
LIG_Pex14_2 | 194 | 198 | PF04695 | 0.232 |
LIG_Pex14_2 | 298 | 302 | PF04695 | 0.243 |
LIG_PTB_Apo_2 | 192 | 199 | PF02174 | 0.196 |
LIG_SH2_CRK | 254 | 258 | PF00017 | 0.257 |
LIG_SH2_GRB2like | 123 | 126 | PF00017 | 0.225 |
LIG_SH2_GRB2like | 297 | 300 | PF00017 | 0.256 |
LIG_SH2_NCK_1 | 276 | 280 | PF00017 | 0.178 |
LIG_SH2_SRC | 123 | 126 | PF00017 | 0.247 |
LIG_SH2_SRC | 183 | 186 | PF00017 | 0.299 |
LIG_SH2_STAP1 | 178 | 182 | PF00017 | 0.324 |
LIG_SH2_STAT3 | 67 | 70 | PF00017 | 0.198 |
LIG_SH2_STAT5 | 114 | 117 | PF00017 | 0.194 |
LIG_SH2_STAT5 | 183 | 186 | PF00017 | 0.273 |
LIG_SH2_STAT5 | 297 | 300 | PF00017 | 0.273 |
LIG_SH2_STAT5 | 347 | 350 | PF00017 | 0.237 |
LIG_SH2_STAT5 | 385 | 388 | PF00017 | 0.292 |
LIG_SH3_1 | 254 | 260 | PF00018 | 0.297 |
LIG_SH3_2 | 285 | 290 | PF14604 | 0.183 |
LIG_SH3_3 | 179 | 185 | PF00018 | 0.281 |
LIG_SH3_3 | 208 | 214 | PF00018 | 0.282 |
LIG_SH3_3 | 254 | 260 | PF00018 | 0.276 |
LIG_SH3_3 | 282 | 288 | PF00018 | 0.333 |
LIG_SH3_3 | 42 | 48 | PF00018 | 0.338 |
LIG_SH3_3 | 6 | 12 | PF00018 | 0.545 |
LIG_SUMO_SIM_par_1 | 47 | 52 | PF11976 | 0.311 |
LIG_WRC_WIRS_1 | 172 | 177 | PF05994 | 0.198 |
MOD_CDK_SPK_2 | 261 | 266 | PF00069 | 0.148 |
MOD_CK1_1 | 150 | 156 | PF00069 | 0.248 |
MOD_CK1_1 | 223 | 229 | PF00069 | 0.249 |
MOD_CK1_1 | 367 | 373 | PF00069 | 0.245 |
MOD_CK1_1 | 392 | 398 | PF00069 | 0.421 |
MOD_CK2_1 | 201 | 207 | PF00069 | 0.310 |
MOD_CK2_1 | 245 | 251 | PF00069 | 0.325 |
MOD_CK2_1 | 311 | 317 | PF00069 | 0.240 |
MOD_GlcNHglycan | 143 | 146 | PF01048 | 0.443 |
MOD_GlcNHglycan | 149 | 152 | PF01048 | 0.431 |
MOD_GlcNHglycan | 222 | 225 | PF01048 | 0.510 |
MOD_GlcNHglycan | 269 | 272 | PF01048 | 0.450 |
MOD_GlcNHglycan | 34 | 37 | PF01048 | 0.349 |
MOD_GlcNHglycan | 391 | 394 | PF01048 | 0.356 |
MOD_GlcNHglycan | 58 | 61 | PF01048 | 0.524 |
MOD_GSK3_1 | 127 | 134 | PF00069 | 0.216 |
MOD_GSK3_1 | 149 | 156 | PF00069 | 0.229 |
MOD_GSK3_1 | 28 | 35 | PF00069 | 0.569 |
MOD_GSK3_1 | 286 | 293 | PF00069 | 0.284 |
MOD_GSK3_1 | 356 | 363 | PF00069 | 0.206 |
MOD_GSK3_1 | 92 | 99 | PF00069 | 0.230 |
MOD_N-GLC_1 | 194 | 199 | PF02516 | 0.414 |
MOD_N-GLC_1 | 220 | 225 | PF02516 | 0.450 |
MOD_N-GLC_1 | 56 | 61 | PF02516 | 0.524 |
MOD_N-GLC_1 | 77 | 82 | PF02516 | 0.515 |
MOD_NEK2_1 | 129 | 134 | PF00069 | 0.264 |
MOD_NEK2_1 | 171 | 176 | PF00069 | 0.276 |
MOD_NEK2_1 | 194 | 199 | PF00069 | 0.218 |
MOD_NEK2_1 | 384 | 389 | PF00069 | 0.285 |
MOD_NEK2_1 | 49 | 54 | PF00069 | 0.326 |
MOD_PKA_1 | 127 | 133 | PF00069 | 0.268 |
MOD_PKA_2 | 10 | 16 | PF00069 | 0.593 |
MOD_PKA_2 | 127 | 133 | PF00069 | 0.263 |
MOD_PKA_2 | 141 | 147 | PF00069 | 0.275 |
MOD_PKA_2 | 161 | 167 | PF00069 | 0.113 |
MOD_PKA_2 | 201 | 207 | PF00069 | 0.270 |
MOD_PKA_2 | 226 | 232 | PF00069 | 0.298 |
MOD_PKA_2 | 376 | 382 | PF00069 | 0.329 |
MOD_Plk_1 | 194 | 200 | PF00069 | 0.214 |
MOD_Plk_1 | 56 | 62 | PF00069 | 0.273 |
MOD_Plk_4 | 10 | 16 | PF00069 | 0.603 |
MOD_Plk_4 | 171 | 177 | PF00069 | 0.315 |
MOD_Plk_4 | 343 | 349 | PF00069 | 0.338 |
MOD_Plk_4 | 369 | 375 | PF00069 | 0.231 |
MOD_Plk_4 | 376 | 382 | PF00069 | 0.235 |
MOD_Plk_4 | 395 | 401 | PF00069 | 0.344 |
MOD_Plk_4 | 49 | 55 | PF00069 | 0.338 |
MOD_ProDKin_1 | 150 | 156 | PF00069 | 0.252 |
MOD_ProDKin_1 | 261 | 267 | PF00069 | 0.327 |
MOD_ProDKin_1 | 28 | 34 | PF00069 | 0.515 |
MOD_ProDKin_1 | 85 | 91 | PF00069 | 0.350 |
TRG_DiLeu_BaLyEn_6 | 214 | 219 | PF01217 | 0.257 |
TRG_ENDOCYTIC_2 | 116 | 119 | PF00928 | 0.229 |
TRG_ENDOCYTIC_2 | 178 | 181 | PF00928 | 0.225 |
TRG_ENDOCYTIC_2 | 335 | 338 | PF00928 | 0.238 |
TRG_ENDOCYTIC_2 | 385 | 388 | PF00928 | 0.318 |
TRG_ER_diArg_1 | 127 | 129 | PF00400 | 0.227 |
TRG_Pf-PMV_PEXEL_1 | 336 | 340 | PF00026 | 0.524 |
Protein | Taxonomy | Sequence identity | Coverage |
---|---|---|---|
A0A0N1I0U8 | Leptomonas seymouri | 34% | 67% |
A0A0N1PBG2 | Leptomonas seymouri | 70% | 100% |
A0A0N1PDQ9 | Leptomonas seymouri | 33% | 100% |
A0A0S4IMK4 | Bodo saltans | 43% | 100% |
A0A0S4J4T1 | Bodo saltans | 33% | 100% |
A0A0S4JB98 | Bodo saltans | 34% | 100% |
A0A0S4JJY0 | Bodo saltans | 34% | 100% |
A0A0S4JQR9 | Bodo saltans | 31% | 80% |
A0A1X0NHQ5 | Trypanosomatidae | 32% | 88% |
A0A1X0NV71 | Trypanosomatidae | 29% | 100% |
A0A1X0P5L3 | Trypanosomatidae | 50% | 100% |
A0A3Q8IBY5 | Leishmania donovani | 35% | 71% |
A0A3R7LIN7 | Trypanosoma rangeli | 34% | 98% |
A0A3R7MGX3 | Trypanosoma rangeli | 33% | 100% |
A0A3S7X551 | Leishmania donovani | 31% | 100% |
A0A3S7X9N4 | Leishmania donovani | 97% | 100% |
A0A422NR22 | Trypanosoma rangeli | 49% | 100% |
A4H5T1 | Leishmania braziliensis | 33% | 69% |
A4HK31 | Leishmania braziliensis | 29% | 100% |
A4HN07 | Leishmania braziliensis | 86% | 100% |
A4HU24 | Leishmania infantum | 35% | 71% |
A4I7N1 | Leishmania infantum | 31% | 100% |
A4IBN0 | Leishmania infantum | 96% | 100% |
C9ZZ02 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 40% | 100% |
D0A9K3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 34% | 90% |
D0A9R9 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 29% | 100% |
E9AMV4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 33% | 71% |
E9B2H4 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 30% | 100% |
E9B6L9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
H2L0H3 | Caenorhabditis elegans | 27% | 100% |
P25656 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 27% | 100% |
P42838 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 26% | 100% |
P53740 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 27% | 100% |
Q17QL5 | Bos taurus | 30% | 100% |
Q1MTQ5 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 29% | 100% |
Q2T9P5 | Bos taurus | 25% | 100% |
Q3MIR4 | Homo sapiens | 26% | 100% |
Q4Q5N2 | Leishmania major | 31% | 100% |
Q4QHS2 | Leishmania major | 35% | 71% |
Q5F362 | Gallus gallus | 29% | 100% |
Q5R6C0 | Pongo abelii | 29% | 100% |
Q67YS6 | Arabidopsis thaliana | 30% | 100% |
Q6AY41 | Rattus norvegicus | 30% | 100% |
Q8BHG3 | Mus musculus | 28% | 100% |
Q8L8W0 | Arabidopsis thaliana | 32% | 100% |
Q8VEK0 | Mus musculus | 29% | 100% |
Q95JK4 | Macaca fascicularis | 25% | 100% |
Q96WW4 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 27% | 100% |
Q9D4D7 | Mus musculus | 25% | 100% |
Q9LTW0 | Arabidopsis thaliana | 30% | 100% |
Q9NV96 | Homo sapiens | 29% | 100% |
Q9SA35 | Arabidopsis thaliana | 31% | 100% |
Q9SLK2 | Arabidopsis thaliana | 32% | 100% |
V5AY40 | Trypanosoma cruzi | 35% | 100% |
V5B6A6 | Trypanosoma cruzi | 33% | 100% |
V5BY23 | Trypanosoma cruzi | 49% | 100% |