Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFG3_LEIMA

TriTrypDb:

LmjF.35.3390 , LMJLV39_350041300 , LMJSD75_350040800

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.666
CLV_C14_Caspase3-7	205	209	PF00656	0.555
CLV_NRD_NRD_1	228	230	PF00675	0.592
CLV_PCSK_KEX2_1	228	230	PF00082	0.592
CLV_PCSK_SKI1_1	183	187	PF00082	0.598
CLV_PCSK_SKI1_1	28	32	PF00082	0.576
CLV_Separin_Metazoa	15	19	PF03568	0.643
DEG_SCF_FBW7_1	172	179	PF00400	0.726
DEG_SPOP_SBC_1	176	180	PF00917	0.674
DOC_CKS1_1	173	178	PF01111	0.739
DOC_PP4_FxxP_1	146	149	PF00568	0.555
DOC_PP4_FxxP_1	93	96	PF00568	0.765
DOC_PP4_MxPP_1	235	238	PF00568	0.529
DOC_USP7_MATH_1	117	121	PF00917	0.513
DOC_USP7_MATH_1	122	126	PF00917	0.550
DOC_USP7_MATH_1	160	164	PF00917	0.703
DOC_USP7_MATH_1	176	180	PF00917	0.674
DOC_WW_Pin1_4	127	132	PF00397	0.485
DOC_WW_Pin1_4	172	177	PF00397	0.750
DOC_WW_Pin1_4	83	88	PF00397	0.733
DOC_WW_Pin1_4	92	97	PF00397	0.623
LIG_14-3-3_CanoR_1	121	127	PF00244	0.479
LIG_14-3-3_CanoR_1	189	193	PF00244	0.512
LIG_14-3-3_CanoR_1	28	37	PF00244	0.512
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_FHA_2	10	16	PF00498	0.643
LIG_FHA_2	51	57	PF00498	0.574
LIG_LIR_Apic_2	90	96	PF02991	0.763
LIG_LIR_Gen_1	120	131	PF02991	0.524
LIG_LIR_Gen_1	31	38	PF02991	0.541
LIG_LIR_LC3C_4	218	221	PF02991	0.437
LIG_LIR_Nem_3	12	16	PF02991	0.594
LIG_LIR_Nem_3	120	126	PF02991	0.506
LIG_LIR_Nem_3	31	37	PF02991	0.498
LIG_LIR_Nem_3	42	47	PF02991	0.507
LIG_SH2_PTP2	123	126	PF00017	0.485
LIG_SH2_STAT5	123	126	PF00017	0.491
LIG_SH2_STAT5	127	130	PF00017	0.524
LIG_SH2_STAT5	184	187	PF00017	0.463
LIG_SH3_3	141	147	PF00018	0.524
LIG_SH3_3	170	176	PF00018	0.688
LIG_SH3_3	227	233	PF00018	0.521
LIG_SH3_3	79	85	PF00018	0.722
LIG_SH3_3	8	14	PF00018	0.661
MOD_CK2_1	207	213	PF00069	0.449
MOD_CK2_1	255	261	PF00069	0.532
MOD_CK2_1	50	56	PF00069	0.589
MOD_CK2_1	75	81	PF00069	0.544
MOD_CK2_1	9	15	PF00069	0.579
MOD_Cter_Amidation	226	229	PF01082	0.578
MOD_DYRK1A_RPxSP_1	83	87	PF00069	0.640
MOD_GlcNHglycan	160	163	PF01048	0.686
MOD_GSK3_1	122	129	PF00069	0.444
MOD_GSK3_1	172	179	PF00069	0.672
MOD_GSK3_1	83	90	PF00069	0.659
MOD_N-GLC_1	256	261	PF02516	0.549
MOD_NEK2_1	126	131	PF00069	0.472
MOD_NEK2_2	122	127	PF00069	0.442
MOD_OFUCOSY	128	135	PF10250	0.523
MOD_PKA_2	188	194	PF00069	0.510
MOD_PKA_2	231	237	PF00069	0.553
MOD_Plk_1	256	262	PF00069	0.552
MOD_Plk_2-3	9	15	PF00069	0.597
MOD_Plk_4	122	128	PF00069	0.451
MOD_Plk_4	231	237	PF00069	0.551
MOD_Plk_4	39	45	PF00069	0.624
MOD_ProDKin_1	127	133	PF00069	0.476
MOD_ProDKin_1	172	178	PF00069	0.735
MOD_ProDKin_1	83	89	PF00069	0.735
MOD_ProDKin_1	92	98	PF00069	0.623
MOD_SUMO_rev_2	208	216	PF00179	0.518
TRG_DiLeu_BaEn_4	111	117	PF01217	0.474
TRG_ENDOCYTIC_2	123	126	PF00928	0.534
TRG_ER_diArg_1	228	230	PF00400	0.592
TRG_NES_CRM1_1	66	81	PF08389	0.613
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.406

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X1	Leptomonas seymouri	42%	97%
A0A3Q8II73	Leishmania donovani	90%	100%
A4HN06	Leishmania braziliensis	74%	100%
A4IBM9	Leishmania infantum	89%	100%
E9B6L8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BYA4	Trypanosoma cruzi	25%	100%