LeishMANIAdb
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ATP-dependent RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ATP-dependent RNA helicase
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFG1_LEIMA
TriTrypDb:
LmjF.35.3370 , LMJLV39_350041100 * , LMJSD75_350040600
Length:
1084

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AFG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFG1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 2
GO:0003723 RNA binding 4 2
GO:0005488 binding 1 2
GO:0097159 organic cyclic compound binding 2 2
GO:1901363 heterocyclic compound binding 2 2
GO:0003824 catalytic activity 1 2
GO:0004386 helicase activity 2 2
GO:0140640 catalytic activity, acting on a nucleic acid 2 2
GO:0140657 ATP-dependent activity 1 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 443 447 PF00656 0.563
CLV_C14_Caspase3-7 995 999 PF00656 0.599
CLV_NRD_NRD_1 1005 1007 PF00675 0.466
CLV_NRD_NRD_1 405 407 PF00675 0.588
CLV_NRD_NRD_1 505 507 PF00675 0.491
CLV_NRD_NRD_1 533 535 PF00675 0.518
CLV_NRD_NRD_1 63 65 PF00675 0.797
CLV_NRD_NRD_1 786 788 PF00675 0.378
CLV_NRD_NRD_1 8 10 PF00675 0.692
CLV_PCSK_KEX2_1 505 507 PF00082 0.487
CLV_PCSK_KEX2_1 533 535 PF00082 0.538
CLV_PCSK_KEX2_1 62 64 PF00082 0.815
CLV_PCSK_KEX2_1 786 788 PF00082 0.394
CLV_PCSK_KEX2_1 896 898 PF00082 0.402
CLV_PCSK_PC1ET2_1 62 64 PF00082 0.815
CLV_PCSK_PC1ET2_1 896 898 PF00082 0.402
CLV_PCSK_SKI1_1 786 790 PF00082 0.401
CLV_PCSK_SKI1_1 893 897 PF00082 0.448
CLV_PCSK_SKI1_1 926 930 PF00082 0.563
DEG_MDM2_SWIB_1 911 919 PF02201 0.489
DEG_SCF_FBW7_1 363 369 PF00400 0.406
DOC_CKS1_1 124 129 PF01111 0.804
DOC_CKS1_1 363 368 PF01111 0.625
DOC_CYCLIN_RxL_1 783 793 PF00134 0.518
DOC_CYCLIN_yCln2_LP_2 1048 1054 PF00134 0.698
DOC_CYCLIN_yCln2_LP_2 215 221 PF00134 0.585
DOC_MAPK_gen_1 231 240 PF00069 0.556
DOC_MAPK_gen_1 800 809 PF00069 0.445
DOC_MAPK_gen_1 893 902 PF00069 0.423
DOC_MAPK_HePTP_8 214 226 PF00069 0.501
DOC_MAPK_HePTP_8 228 240 PF00069 0.499
DOC_MAPK_MEF2A_6 217 226 PF00069 0.501
DOC_MAPK_MEF2A_6 231 240 PF00069 0.489
DOC_MAPK_MEF2A_6 630 637 PF00069 0.411
DOC_PP1_RVXF_1 784 791 PF00149 0.501
DOC_PP1_RVXF_1 881 888 PF00149 0.490
DOC_PP2B_LxvP_1 303 306 PF13499 0.530
DOC_PP2B_LxvP_1 548 551 PF13499 0.541
DOC_SPAK_OSR1_1 897 901 PF12202 0.424
DOC_USP7_MATH_1 103 107 PF00917 0.785
DOC_USP7_MATH_1 1030 1034 PF00917 0.802
DOC_USP7_MATH_1 1043 1047 PF00917 0.747
DOC_USP7_MATH_1 120 124 PF00917 0.597
DOC_USP7_MATH_1 19 23 PF00917 0.780
DOC_USP7_MATH_1 313 317 PF00917 0.532
DOC_USP7_MATH_1 35 39 PF00917 0.660
DOC_USP7_MATH_1 471 475 PF00917 0.698
DOC_USP7_MATH_1 57 61 PF00917 0.767
DOC_USP7_MATH_1 694 698 PF00917 0.438
DOC_USP7_MATH_1 75 79 PF00917 0.787
DOC_USP7_MATH_1 80 84 PF00917 0.785
DOC_USP7_MATH_1 820 824 PF00917 0.565
DOC_USP7_MATH_1 848 852 PF00917 0.511
DOC_USP7_MATH_2 594 600 PF00917 0.624
DOC_USP7_MATH_2 874 880 PF00917 0.636
DOC_USP7_UBL2_3 725 729 PF12436 0.562
DOC_WW_Pin1_4 1021 1026 PF00397 0.679
DOC_WW_Pin1_4 123 128 PF00397 0.775
DOC_WW_Pin1_4 14 19 PF00397 0.695
DOC_WW_Pin1_4 22 27 PF00397 0.698
DOC_WW_Pin1_4 254 259 PF00397 0.640
DOC_WW_Pin1_4 362 367 PF00397 0.597
DOC_WW_Pin1_4 469 474 PF00397 0.726
DOC_WW_Pin1_4 62 67 PF00397 0.761
DOC_WW_Pin1_4 818 823 PF00397 0.594
LIG_14-3-3_CanoR_1 422 431 PF00244 0.546
LIG_14-3-3_CanoR_1 715 723 PF00244 0.486
LIG_14-3-3_CanoR_1 737 743 PF00244 0.496
LIG_14-3-3_CanoR_1 744 753 PF00244 0.452
LIG_14-3-3_CanoR_1 849 857 PF00244 0.525
LIG_Actin_WH2_2 208 225 PF00022 0.544
LIG_APCC_ABBA_1 703 708 PF00400 0.491
LIG_BRCT_BRCA1_1 1004 1008 PF00533 0.510
LIG_BRCT_BRCA1_1 131 135 PF00533 0.711
LIG_BRCT_BRCA1_1 32 36 PF00533 0.594
LIG_BRCT_BRCA1_1 512 516 PF00533 0.481
LIG_BRCT_BRCA1_1 619 623 PF00533 0.514
LIG_Clathr_ClatBox_1 704 708 PF01394 0.406
LIG_Clathr_ClatBox_1 833 837 PF01394 0.505
LIG_deltaCOP1_diTrp_1 1012 1018 PF00928 0.603
LIG_EH1_1 52 60 PF00400 0.764
LIG_eIF4E_1 857 863 PF01652 0.399
LIG_FHA_1 284 290 PF00498 0.486
LIG_FHA_1 299 305 PF00498 0.331
LIG_FHA_1 494 500 PF00498 0.433
LIG_FHA_1 502 508 PF00498 0.464
LIG_FHA_1 622 628 PF00498 0.456
LIG_FHA_1 84 90 PF00498 0.775
LIG_FHA_1 977 983 PF00498 0.577
LIG_FHA_2 280 286 PF00498 0.415
LIG_FHA_2 392 398 PF00498 0.689
LIG_FHA_2 564 570 PF00498 0.586
LIG_FHA_2 683 689 PF00498 0.572
LIG_FHA_2 775 781 PF00498 0.494
LIG_FHA_2 964 970 PF00498 0.549
LIG_LIR_Apic_2 398 404 PF02991 0.545
LIG_LIR_Apic_2 870 874 PF02991 0.423
LIG_LIR_Gen_1 741 750 PF02991 0.445
LIG_LIR_Gen_1 774 784 PF02991 0.440
LIG_LIR_Gen_1 856 867 PF02991 0.508
LIG_LIR_LC3C_4 234 239 PF02991 0.516
LIG_LIR_Nem_3 486 490 PF02991 0.578
LIG_LIR_Nem_3 708 712 PF02991 0.406
LIG_LIR_Nem_3 741 745 PF02991 0.436
LIG_LIR_Nem_3 748 753 PF02991 0.426
LIG_LIR_Nem_3 774 779 PF02991 0.506
LIG_LIR_Nem_3 856 862 PF02991 0.484
LIG_LYPXL_S_1 865 869 PF13949 0.397
LIG_LYPXL_yS_3 866 869 PF13949 0.399
LIG_MAD2 814 822 PF02301 0.529
LIG_NBox_RRM_1 778 788 PF00076 0.522
LIG_PCNA_PIPBox_1 311 320 PF02747 0.510
LIG_PCNA_yPIPBox_3 52 64 PF02747 0.773
LIG_PCNA_yPIPBox_3 770 779 PF02747 0.516
LIG_PCNA_yPIPBox_3 954 965 PF02747 0.553
LIG_Pex14_1 1014 1018 PF04695 0.704
LIG_Pex14_2 619 623 PF04695 0.526
LIG_Pex14_2 706 710 PF04695 0.486
LIG_Pex14_2 911 915 PF04695 0.485
LIG_REV1ctd_RIR_1 355 364 PF16727 0.591
LIG_REV1ctd_RIR_1 787 796 PF16727 0.564
LIG_SH2_CRK 172 176 PF00017 0.573
LIG_SH2_CRK 219 223 PF00017 0.558
LIG_SH2_CRK 664 668 PF00017 0.544
LIG_SH2_CRK 871 875 PF00017 0.432
LIG_SH2_NCK_1 243 247 PF00017 0.554
LIG_SH2_NCK_1 379 383 PF00017 0.525
LIG_SH2_PTP2 545 548 PF00017 0.479
LIG_SH2_SRC 379 382 PF00017 0.529
LIG_SH2_STAT5 1072 1075 PF00017 0.610
LIG_SH2_STAT5 185 188 PF00017 0.598
LIG_SH2_STAT5 290 293 PF00017 0.466
LIG_SH2_STAT5 317 320 PF00017 0.493
LIG_SH2_STAT5 435 438 PF00017 0.527
LIG_SH2_STAT5 545 548 PF00017 0.381
LIG_SH2_STAT5 742 745 PF00017 0.443
LIG_SH2_STAT5 857 860 PF00017 0.410
LIG_SH2_STAT5 886 889 PF00017 0.423
LIG_SH2_STAT5 921 924 PF00017 0.548
LIG_SH3_3 122 128 PF00018 0.723
LIG_SH3_3 235 241 PF00018 0.422
LIG_SH3_3 360 366 PF00018 0.615
LIG_SH3_3 367 373 PF00018 0.622
LIG_SH3_3 41 47 PF00018 0.738
LIG_SH3_3 552 558 PF00018 0.569
LIG_SH3_3 872 878 PF00018 0.577
LIG_SUMO_SIM_anti_2 1062 1070 PF11976 0.654
LIG_SUMO_SIM_anti_2 234 240 PF11976 0.476
LIG_SUMO_SIM_par_1 342 347 PF11976 0.563
LIG_SUMO_SIM_par_1 389 394 PF11976 0.610
LIG_SUMO_SIM_par_1 631 636 PF11976 0.419
LIG_SUMO_SIM_par_1 832 837 PF11976 0.504
LIG_SUMO_SIM_par_1 872 879 PF11976 0.586
LIG_TRAF2_1 587 590 PF00917 0.543
LIG_TRAF2_1 685 688 PF00917 0.517
LIG_TYR_ITIM 170 175 PF00017 0.369
LIG_TYR_ITIM 740 745 PF00017 0.511
LIG_TYR_ITIM 864 869 PF00017 0.381
LIG_TYR_ITIM 884 889 PF00017 0.211
LIG_TYR_ITIM 919 924 PF00017 0.575
LIG_UBA3_1 444 450 PF00899 0.579
LIG_WRC_WIRS_1 484 489 PF05994 0.613
LIG_WRC_WIRS_1 775 780 PF05994 0.494
MOD_CDC14_SPxK_1 257 260 PF00782 0.560
MOD_CDC14_SPxK_1 65 68 PF00782 0.801
MOD_CDK_SPxK_1 254 260 PF00069 0.637
MOD_CDK_SPxK_1 469 475 PF00069 0.712
MOD_CDK_SPxK_1 62 68 PF00069 0.800
MOD_CK1_1 1017 1023 PF00069 0.702
MOD_CK1_1 104 110 PF00069 0.766
MOD_CK1_1 1046 1052 PF00069 0.711
MOD_CK1_1 123 129 PF00069 0.677
MOD_CK1_1 22 28 PF00069 0.708
MOD_CK1_1 229 235 PF00069 0.551
MOD_CK1_1 244 250 PF00069 0.525
MOD_CK1_1 267 273 PF00069 0.497
MOD_CK1_1 30 36 PF00069 0.647
MOD_CK1_1 425 431 PF00069 0.519
MOD_CK1_1 483 489 PF00069 0.635
MOD_CK1_1 519 525 PF00069 0.555
MOD_CK1_1 617 623 PF00069 0.464
MOD_CK1_1 768 774 PF00069 0.512
MOD_CK1_1 78 84 PF00069 0.786
MOD_CK1_1 821 827 PF00069 0.534
MOD_CK1_1 843 849 PF00069 0.503
MOD_CK1_1 976 982 PF00069 0.494
MOD_CK2_1 375 381 PF00069 0.451
MOD_CK2_1 391 397 PF00069 0.556
MOD_CK2_1 517 523 PF00069 0.475
MOD_CK2_1 563 569 PF00069 0.603
MOD_CK2_1 603 609 PF00069 0.502
MOD_CK2_1 682 688 PF00069 0.517
MOD_CK2_1 774 780 PF00069 0.461
MOD_CK2_1 81 87 PF00069 0.822
MOD_CK2_1 898 904 PF00069 0.504
MOD_CK2_1 963 969 PF00069 0.552
MOD_Cter_Amidation 7 10 PF01082 0.694
MOD_DYRK1A_RPxSP_1 254 258 PF00069 0.635
MOD_GlcNHglycan 103 106 PF01048 0.759
MOD_GlcNHglycan 1045 1048 PF01048 0.727
MOD_GlcNHglycan 109 112 PF01048 0.648
MOD_GlcNHglycan 265 269 PF01048 0.523
MOD_GlcNHglycan 329 332 PF01048 0.586
MOD_GlcNHglycan 346 349 PF01048 0.519
MOD_GlcNHglycan 37 40 PF01048 0.711
MOD_GlcNHglycan 396 400 PF01048 0.619
MOD_GlcNHglycan 519 522 PF01048 0.577
MOD_GlcNHglycan 670 673 PF01048 0.614
MOD_GlcNHglycan 762 765 PF01048 0.495
MOD_GlcNHglycan 77 81 PF01048 0.785
MOD_GlcNHglycan 828 831 PF01048 0.520
MOD_GlcNHglycan 83 86 PF01048 0.812
MOD_GlcNHglycan 850 853 PF01048 0.496
MOD_GlcNHglycan 870 874 PF01048 0.238
MOD_GlcNHglycan 92 95 PF01048 0.748
MOD_GSK3_1 1013 1020 PF00069 0.570
MOD_GSK3_1 1038 1045 PF00069 0.776
MOD_GSK3_1 20 27 PF00069 0.763
MOD_GSK3_1 279 286 PF00069 0.457
MOD_GSK3_1 344 351 PF00069 0.478
MOD_GSK3_1 362 369 PF00069 0.515
MOD_GSK3_1 391 398 PF00069 0.660
MOD_GSK3_1 42 49 PF00069 0.656
MOD_GSK3_1 519 526 PF00069 0.507
MOD_GSK3_1 617 624 PF00069 0.433
MOD_GSK3_1 76 83 PF00069 0.743
MOD_GSK3_1 816 823 PF00069 0.475
MOD_GSK3_1 97 104 PF00069 0.759
MOD_N-GLC_1 153 158 PF02516 0.733
MOD_N-GLC_1 306 311 PF02516 0.507
MOD_N-GLC_1 47 52 PF02516 0.709
MOD_N-GLC_1 510 515 PF02516 0.605
MOD_N-GLC_1 614 619 PF02516 0.571
MOD_N-GLC_1 694 699 PF02516 0.546
MOD_N-GLC_1 75 80 PF02516 0.744
MOD_N-GLC_1 771 776 PF02516 0.443
MOD_N-GLC_1 843 848 PF02516 0.457
MOD_N-GLC_1 853 858 PF02516 0.517
MOD_N-GLC_2 643 645 PF02516 0.525
MOD_NEK2_1 1013 1018 PF00069 0.639
MOD_NEK2_1 415 420 PF00069 0.497
MOD_NEK2_1 424 429 PF00069 0.600
MOD_NEK2_1 453 458 PF00069 0.628
MOD_NEK2_1 501 506 PF00069 0.520
MOD_NEK2_1 516 521 PF00069 0.383
MOD_NEK2_1 575 580 PF00069 0.447
MOD_NEK2_1 619 624 PF00069 0.419
MOD_NEK2_1 808 813 PF00069 0.439
MOD_NEK2_1 887 892 PF00069 0.429
MOD_NEK2_1 898 903 PF00069 0.457
MOD_NEK2_2 153 158 PF00069 0.733
MOD_PIKK_1 178 184 PF00454 0.503
MOD_PIKK_1 226 232 PF00454 0.500
MOD_PIKK_1 290 296 PF00454 0.476
MOD_PKA_2 327 333 PF00069 0.634
MOD_PKA_2 809 815 PF00069 0.461
MOD_PKA_2 848 854 PF00069 0.508
MOD_PKA_2 898 904 PF00069 0.508
MOD_Plk_1 153 159 PF00069 0.721
MOD_Plk_1 306 312 PF00069 0.527
MOD_Plk_1 375 381 PF00069 0.434
MOD_Plk_1 391 397 PF00069 0.470
MOD_Plk_1 409 415 PF00069 0.314
MOD_Plk_1 454 460 PF00069 0.571
MOD_Plk_1 47 53 PF00069 0.696
MOD_Plk_1 493 499 PF00069 0.449
MOD_Plk_1 617 623 PF00069 0.501
MOD_Plk_1 758 764 PF00069 0.482
MOD_Plk_1 771 777 PF00069 0.369
MOD_Plk_1 853 859 PF00069 0.507
MOD_Plk_2-3 195 201 PF00069 0.697
MOD_Plk_2-3 596 602 PF00069 0.592
MOD_Plk_4 120 126 PF00069 0.823
MOD_Plk_4 267 273 PF00069 0.572
MOD_Plk_4 313 319 PF00069 0.469
MOD_Plk_4 415 421 PF00069 0.500
MOD_Plk_4 454 460 PF00069 0.571
MOD_Plk_4 480 486 PF00069 0.521
MOD_Plk_4 493 499 PF00069 0.387
MOD_Plk_4 563 569 PF00069 0.568
MOD_Plk_4 771 777 PF00069 0.419
MOD_Plk_4 821 827 PF00069 0.499
MOD_Plk_4 853 859 PF00069 0.475
MOD_ProDKin_1 1021 1027 PF00069 0.682
MOD_ProDKin_1 123 129 PF00069 0.770
MOD_ProDKin_1 14 20 PF00069 0.696
MOD_ProDKin_1 22 28 PF00069 0.699
MOD_ProDKin_1 254 260 PF00069 0.649
MOD_ProDKin_1 362 368 PF00069 0.602
MOD_ProDKin_1 469 475 PF00069 0.712
MOD_ProDKin_1 62 68 PF00069 0.764
MOD_ProDKin_1 818 824 PF00069 0.590
MOD_SUMO_for_1 941 944 PF00179 0.620
TRG_DiLeu_BaEn_1 960 965 PF01217 0.559
TRG_DiLeu_BaEn_2 492 498 PF01217 0.578
TRG_DiLeu_BaEn_4 531 537 PF01217 0.542
TRG_DiLeu_BaLyEn_6 449 454 PF01217 0.647
TRG_ENDOCYTIC_2 1072 1075 PF00928 0.639
TRG_ENDOCYTIC_2 172 175 PF00928 0.364
TRG_ENDOCYTIC_2 219 222 PF00928 0.551
TRG_ENDOCYTIC_2 243 246 PF00928 0.417
TRG_ENDOCYTIC_2 545 548 PF00928 0.395
TRG_ENDOCYTIC_2 742 745 PF00928 0.426
TRG_ENDOCYTIC_2 750 753 PF00928 0.361
TRG_ENDOCYTIC_2 866 869 PF00928 0.386
TRG_ENDOCYTIC_2 886 889 PF00928 0.207
TRG_ENDOCYTIC_2 921 924 PF00928 0.552
TRG_ER_diArg_1 505 507 PF00400 0.495
TRG_ER_diArg_1 786 788 PF00400 0.498
TRG_NLS_MonoCore_2 60 65 PF00514 0.789
TRG_NLS_MonoExtC_3 61 66 PF00514 0.820
TRG_NLS_MonoExtN_4 61 66 PF00514 0.820
TRG_NLS_MonoExtN_4 893 900 PF00514 0.533
TRG_Pf-PMV_PEXEL_1 406 410 PF00026 0.518
TRG_Pf-PMV_PEXEL_1 505 510 PF00026 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HWI4 Leptomonas seymouri 74% 99%
A0A0S4JM26 Bodo saltans 27% 100%
A0A1X0P5G8 Trypanosomatidae 40% 100%
A0A3S5IQN1 Trypanosoma rangeli 36% 100%
A0A3S7X9K2 Leishmania donovani 96% 100%
A4HN04 Leishmania braziliensis 87% 100%
A4IBM7 Leishmania infantum 96% 100%
C9ZZ06 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
E9B6L6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
V5BCW9 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS