TP_methylase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetrapyrrole (Corrin/Porphyrin) Methylases, putative

Species:

Leishmania major

UniProt:

E9AFF9_LEIMA

TriTrypDb:

LmjF.35.3350 , LMJLV39_350040900 , LMJSD75_350040300 , LMJSD75_350040400

Length:

461

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AFF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006364	rRNA processing	8	12
GO:0006396	RNA processing	6	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016072	rRNA metabolic process	7	12
GO:0032259	methylation	2	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	364	366	PF00675	0.440
CLV_NRD_NRD_1	367	369	PF00675	0.446
CLV_NRD_NRD_1	413	415	PF00675	0.527
CLV_NRD_NRD_1	416	418	PF00675	0.499
CLV_NRD_NRD_1	424	426	PF00675	0.469
CLV_NRD_NRD_1	428	430	PF00675	0.464
CLV_NRD_NRD_1	58	60	PF00675	0.679
CLV_NRD_NRD_1	66	68	PF00675	0.572
CLV_PCSK_FUR_1	365	369	PF00082	0.422
CLV_PCSK_FUR_1	414	418	PF00082	0.502
CLV_PCSK_FUR_1	429	433	PF00082	0.456
CLV_PCSK_KEX2_1	225	227	PF00082	0.703
CLV_PCSK_KEX2_1	362	364	PF00082	0.420
CLV_PCSK_KEX2_1	367	369	PF00082	0.454
CLV_PCSK_KEX2_1	413	415	PF00082	0.517
CLV_PCSK_KEX2_1	416	418	PF00082	0.477
CLV_PCSK_KEX2_1	424	426	PF00082	0.409
CLV_PCSK_KEX2_1	431	433	PF00082	0.339
CLV_PCSK_KEX2_1	58	60	PF00082	0.591
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.703
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.416
CLV_PCSK_PC1ET2_1	431	433	PF00082	0.443
CLV_PCSK_PC7_1	363	369	PF00082	0.425
CLV_PCSK_PC7_1	420	426	PF00082	0.507
CLV_PCSK_PC7_1	427	433	PF00082	0.442
CLV_PCSK_SKI1_1	123	127	PF00082	0.230
CLV_PCSK_SKI1_1	447	451	PF00082	0.636
CLV_PCSK_SKI1_1	88	92	PF00082	0.430
DEG_APCC_DBOX_1	152	160	PF00400	0.532
DEG_APCC_DBOX_1	419	427	PF00400	0.515
DEG_Nend_Nbox_1	1	3	PF02207	0.652
DEG_SPOP_SBC_1	36	40	PF00917	0.561
DEG_SPOP_SBC_1	397	401	PF00917	0.627
DOC_CYCLIN_RxL_1	123	131	PF00134	0.428
DOC_MAPK_gen_1	336	344	PF00069	0.345
DOC_MAPK_gen_1	445	452	PF00069	0.465
DOC_MAPK_MEF2A_6	336	344	PF00069	0.331
DOC_MAPK_MEF2A_6	445	452	PF00069	0.585
DOC_MAPK_NFAT4_5	337	345	PF00069	0.339
DOC_PP1_RVXF_1	319	326	PF00149	0.346
DOC_USP7_MATH_1	199	203	PF00917	0.489
DOC_USP7_MATH_1	217	221	PF00917	0.361
DOC_USP7_MATH_1	26	30	PF00917	0.683
DOC_USP7_MATH_1	36	40	PF00917	0.716
DOC_USP7_MATH_1	379	383	PF00917	0.721
DOC_USP7_MATH_1	396	400	PF00917	0.740
DOC_USP7_MATH_1	438	442	PF00917	0.482
DOC_USP7_UBL2_3	358	362	PF12436	0.543
DOC_WW_Pin1_4	17	22	PF00397	0.667
DOC_WW_Pin1_4	171	176	PF00397	0.428
DOC_WW_Pin1_4	236	241	PF00397	0.600
DOC_WW_Pin1_4	69	74	PF00397	0.522
LIG_14-3-3_CanoR_1	146	156	PF00244	0.438
LIG_14-3-3_CanoR_1	35	44	PF00244	0.481
LIG_14-3-3_CanoR_1	365	371	PF00244	0.554
LIG_Actin_WH2_1	432	449	PF00022	0.455
LIG_BIR_III_2	376	380	PF00653	0.509
LIG_BRCT_BRCA1_1	246	250	PF00533	0.418
LIG_BRCT_BRCA1_1	39	43	PF00533	0.690
LIG_BRCT_BRCA1_1	60	64	PF00533	0.599
LIG_FHA_1	124	130	PF00498	0.438
LIG_FHA_1	172	178	PF00498	0.429
LIG_FHA_1	302	308	PF00498	0.396
LIG_FHA_2	126	132	PF00498	0.438
LIG_FHA_2	149	155	PF00498	0.521
LIG_FHA_2	240	246	PF00498	0.597
LIG_FHA_2	367	373	PF00498	0.608
LIG_FHA_2	406	412	PF00498	0.488
LIG_FHA_2	70	76	PF00498	0.478
LIG_FHA_2	82	88	PF00498	0.428
LIG_IRF3_LxIS_1	204	211	PF10401	0.445
LIG_LIR_Gen_1	40	50	PF02991	0.423
LIG_LIR_Nem_3	247	253	PF02991	0.483
LIG_LIR_Nem_3	273	277	PF02991	0.441
LIG_LIR_Nem_3	280	286	PF02991	0.442
LIG_LIR_Nem_3	40	46	PF02991	0.424
LIG_LIR_Nem_3	63	69	PF02991	0.503
LIG_MAD2	263	271	PF02301	0.381
LIG_MLH1_MIPbox_1	246	250	PF16413	0.380
LIG_NRBOX	155	161	PF00104	0.438
LIG_Pex14_2	274	278	PF04695	0.428
LIG_Pex14_2	43	47	PF04695	0.427
LIG_Pex14_2	60	64	PF04695	0.538
LIG_RPA_C_Fungi	46	58	PF08784	0.433
LIG_SH2_CRK	283	287	PF00017	0.235
LIG_SH2_CRK	66	70	PF00017	0.500
LIG_SH2_NCK_1	279	283	PF00017	0.237
LIG_SH2_STAT3	326	329	PF00017	0.391
LIG_SH2_STAT5	117	120	PF00017	0.262
LIG_SH2_STAT5	302	305	PF00017	0.437
LIG_SH2_STAT5	326	329	PF00017	0.506
LIG_SH3_3	130	136	PF00018	0.407
LIG_SH3_3	15	21	PF00018	0.700
LIG_SH3_3	91	97	PF00018	0.262
LIG_SUMO_SIM_anti_2	128	134	PF11976	0.276
LIG_TRAF2_1	409	412	PF00917	0.649
LIG_TRAF2_1	441	444	PF00917	0.576
LIG_TYR_ITIM	281	286	PF00017	0.229
MOD_CDK_SPK_2	17	22	PF00069	0.456
MOD_CK1_1	17	23	PF00069	0.654
MOD_CK1_1	211	217	PF00069	0.410
MOD_CK1_1	239	245	PF00069	0.599
MOD_CK1_1	38	44	PF00069	0.549
MOD_CK1_1	401	407	PF00069	0.667
MOD_CK2_1	148	154	PF00069	0.407
MOD_CK2_1	213	219	PF00069	0.405
MOD_CK2_1	380	386	PF00069	0.636
MOD_CK2_1	397	403	PF00069	0.792
MOD_CK2_1	405	411	PF00069	0.648
MOD_CK2_1	438	444	PF00069	0.584
MOD_GlcNHglycan	171	174	PF01048	0.262
MOD_GlcNHglycan	190	193	PF01048	0.262
MOD_GlcNHglycan	201	204	PF01048	0.272
MOD_GlcNHglycan	205	208	PF01048	0.255
MOD_GlcNHglycan	210	213	PF01048	0.255
MOD_GlcNHglycan	215	218	PF01048	0.501
MOD_GlcNHglycan	219	222	PF01048	0.468
MOD_GlcNHglycan	22	25	PF01048	0.683
MOD_GlcNHglycan	386	389	PF01048	0.752
MOD_GlcNHglycan	4	7	PF01048	0.664
MOD_GlcNHglycan	48	51	PF01048	0.620
MOD_GlcNHglycan	53	56	PF01048	0.586
MOD_GlcNHglycan	60	63	PF01048	0.547
MOD_GSK3_1	167	174	PF00069	0.407
MOD_GSK3_1	199	206	PF00069	0.317
MOD_GSK3_1	208	215	PF00069	0.248
MOD_GSK3_1	301	308	PF00069	0.394
MOD_GSK3_1	35	42	PF00069	0.563
MOD_GSK3_1	380	387	PF00069	0.721
MOD_GSK3_1	388	395	PF00069	0.593
MOD_GSK3_1	397	404	PF00069	0.648
MOD_N-GLC_1	147	152	PF02516	0.276
MOD_N-GLC_1	310	315	PF02516	0.385
MOD_NEK2_1	168	173	PF00069	0.276
MOD_NEK2_1	188	193	PF00069	0.145
MOD_NEK2_1	2	7	PF00069	0.566
MOD_NEK2_1	208	213	PF00069	0.232
MOD_NEK2_1	310	315	PF00069	0.404
MOD_NEK2_1	366	371	PF00069	0.481
MOD_NEK2_1	37	42	PF00069	0.476
MOD_NEK2_1	46	51	PF00069	0.529
MOD_NEK2_1	53	58	PF00069	0.515
MOD_NEK2_1	60	65	PF00069	0.458
MOD_PK_1	402	408	PF00069	0.461
MOD_PKA_1	58	64	PF00069	0.512
MOD_PKA_2	148	154	PF00069	0.392
MOD_PKA_2	193	199	PF00069	0.295
MOD_PKA_2	366	372	PF00069	0.518
MOD_PKA_2	401	407	PF00069	0.585
MOD_PKA_2	58	64	PF00069	0.533
MOD_Plk_1	102	108	PF00069	0.262
MOD_Plk_1	310	316	PF00069	0.383
MOD_Plk_1	402	408	PF00069	0.554
MOD_Plk_1	455	461	PF00069	0.576
MOD_Plk_4	125	131	PF00069	0.276
MOD_Plk_4	244	250	PF00069	0.387
MOD_Plk_4	291	297	PF00069	0.435
MOD_Plk_4	39	45	PF00069	0.590
MOD_ProDKin_1	17	23	PF00069	0.669
MOD_ProDKin_1	171	177	PF00069	0.262
MOD_ProDKin_1	236	242	PF00069	0.587
MOD_ProDKin_1	69	75	PF00069	0.515
MOD_SUMO_for_1	409	412	PF00179	0.524
TRG_DiLeu_BaEn_1	330	335	PF01217	0.398
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.276
TRG_DiLeu_BaLyEn_6	431	436	PF01217	0.487
TRG_ENDOCYTIC_2	283	286	PF00928	0.330
TRG_ENDOCYTIC_2	66	69	PF00928	0.498
TRG_ER_diArg_1	261	264	PF00400	0.337
TRG_ER_diArg_1	363	365	PF00400	0.431
TRG_ER_diArg_1	366	368	PF00400	0.451
TRG_ER_diArg_1	413	416	PF00400	0.517
TRG_ER_diArg_1	423	425	PF00400	0.456
TRG_ER_diArg_1	426	429	PF00400	0.421
TRG_ER_diArg_1	445	448	PF00400	0.339
TRG_ER_diArg_1	58	60	PF00400	0.531
TRG_NLS_MonoCore_2	361	366	PF00514	0.462
TRG_NLS_MonoExtC_3	416	422	PF00514	0.619
TRG_NLS_MonoExtN_4	414	421	PF00514	0.565
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4G3	Leptomonas seymouri	71%	100%
A0A0S4IXW1	Bodo saltans	43%	100%
A0A1X0P5K8	Trypanosomatidae	56%	100%
A0A3R7N6Y9	Trypanosoma rangeli	55%	100%
A0A3S7X9K0	Leishmania donovani	96%	100%
A4HN02	Leishmania braziliensis	84%	100%
A4IBM5	Leishmania infantum	96%	100%
C9ZZ09	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B6L4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BY28	Trypanosoma cruzi	55%	100%