LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania major

UniProt:

E9AFF5_LEIMA

TriTrypDb:

LmjF.35.3310 , LMJLV39_350040500 , LMJSD75_350039900

Length:

303

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	15
GO:0042995	cell projection	2	15
GO:0043226	organelle	2	15
GO:0043227	membrane-bounded organelle	3	15
GO:0110165	cellular anatomical entity	1	15
GO:0120025	plasma membrane bounded cell projection	3	15

Expansion

Sequence features

E9AFF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	129	133	PF00656	0.531
CLV_C14_Caspase3-7	288	292	PF00656	0.372
CLV_NRD_NRD_1	108	110	PF00675	0.252
CLV_NRD_NRD_1	194	196	PF00675	0.712
CLV_NRD_NRD_1	20	22	PF00675	0.407
CLV_NRD_NRD_1	294	296	PF00675	0.439
CLV_NRD_NRD_1	64	66	PF00675	0.237
CLV_NRD_NRD_1	71	73	PF00675	0.221
CLV_PCSK_KEX2_1	108	110	PF00082	0.263
CLV_PCSK_KEX2_1	20	22	PF00082	0.500
CLV_PCSK_KEX2_1	294	296	PF00082	0.454
CLV_PCSK_KEX2_1	64	66	PF00082	0.267
CLV_PCSK_SKI1_1	124	128	PF00082	0.333
CLV_PCSK_SKI1_1	195	199	PF00082	0.611
DOC_CDC14_PxL_1	85	93	PF14671	0.447
DOC_MAPK_gen_1	20	27	PF00069	0.516
DOC_MAPK_gen_1	64	71	PF00069	0.478
DOC_MAPK_MEF2A_6	39	46	PF00069	0.493
DOC_PP4_FxxP_1	144	147	PF00568	0.625
DOC_SPAK_OSR1_1	109	113	PF12202	0.463
DOC_USP7_MATH_1	114	118	PF00917	0.459
DOC_USP7_MATH_1	182	186	PF00917	0.738
DOC_USP7_MATH_1	197	201	PF00917	0.601
DOC_USP7_MATH_1	244	248	PF00917	0.720
DOC_WW_Pin1_4	156	161	PF00397	0.601
DOC_WW_Pin1_4	224	229	PF00397	0.602
DOC_WW_Pin1_4	245	250	PF00397	0.712
DOC_WW_Pin1_4	283	288	PF00397	0.623
LIG_14-3-3_CanoR_1	13	22	PF00244	0.416
LIG_14-3-3_CanoR_1	195	204	PF00244	0.604
LIG_BIR_II_1	1	5	PF00653	0.403
LIG_FHA_1	14	20	PF00498	0.381
LIG_FHA_1	196	202	PF00498	0.565
LIG_FHA_1	4	10	PF00498	0.356
LIG_FHA_2	125	131	PF00498	0.498
LIG_FHA_2	160	166	PF00498	0.601
LIG_FHA_2	181	187	PF00498	0.776
LIG_Integrin_isoDGR_2	211	213	PF01839	0.646
LIG_LIR_Apic_2	143	147	PF02991	0.536
LIG_LIR_Apic_2	149	154	PF02991	0.537
LIG_LIR_Gen_1	258	266	PF02991	0.591
LIG_LIR_Nem_3	104	110	PF02991	0.461
LIG_LIR_Nem_3	258	262	PF02991	0.643
LIG_LRP6_Inhibitor_1	71	77	PF00058	0.345
LIG_MAD2	279	287	PF02301	0.510
LIG_MYND_3	88	92	PF01753	0.447
LIG_Rb_LxCxE_1	86	104	PF01857	0.447
LIG_SH2_CRK	151	155	PF00017	0.685
LIG_SH2_CRK	259	263	PF00017	0.744
LIG_SH2_SRC	233	236	PF00017	0.616
LIG_SH2_STAT5	70	73	PF00017	0.372
LIG_SH3_3	225	231	PF00018	0.741
LIG_SH3_3	260	266	PF00018	0.701
LIG_SH3_3	94	100	PF00018	0.430
LIG_TRAF2_1	127	130	PF00917	0.516
LIG_TRAF2_1	162	165	PF00917	0.665
LIG_TRAF2_1	269	272	PF00917	0.617
LIG_WRC_WIRS_1	141	146	PF05994	0.625
MOD_CDK_SPxxK_3	245	252	PF00069	0.642
MOD_CK1_1	180	186	PF00069	0.778
MOD_CK1_1	199	205	PF00069	0.487
MOD_CK1_1	216	222	PF00069	0.625
MOD_CK1_1	261	267	PF00069	0.668
MOD_CK1_1	283	289	PF00069	0.495
MOD_CK2_1	124	130	PF00069	0.339
MOD_CK2_1	159	165	PF00069	0.631
MOD_CK2_1	180	186	PF00069	0.621
MOD_CK2_1	296	302	PF00069	0.374
MOD_GlcNHglycan	179	182	PF01048	0.744
MOD_GlcNHglycan	201	204	PF01048	0.680
MOD_GlcNHglycan	215	218	PF01048	0.635
MOD_GlcNHglycan	266	269	PF01048	0.655
MOD_GSK3_1	171	178	PF00069	0.600
MOD_GSK3_1	195	202	PF00069	0.657
MOD_GSK3_1	216	223	PF00069	0.634
MOD_LATS_1	193	199	PF00433	0.607
MOD_N-GLC_1	172	177	PF02516	0.640
MOD_N-GLC_2	26	28	PF02516	0.364
MOD_NEK2_1	11	16	PF00069	0.357
MOD_NEK2_1	296	301	PF00069	0.608
MOD_NEK2_1	47	52	PF00069	0.362
MOD_NEK2_1	83	88	PF00069	0.377
MOD_PIKK_1	27	33	PF00454	0.410
MOD_PKA_1	195	201	PF00069	0.606
MOD_Plk_1	172	178	PF00069	0.469
MOD_ProDKin_1	156	162	PF00069	0.597
MOD_ProDKin_1	224	230	PF00069	0.601
MOD_ProDKin_1	245	251	PF00069	0.711
MOD_ProDKin_1	283	289	PF00069	0.616
TRG_DiLeu_BaEn_1	92	97	PF01217	0.268
TRG_ENDOCYTIC_2	107	110	PF00928	0.294
TRG_ENDOCYTIC_2	259	262	PF00928	0.745
TRG_ER_diArg_1	107	109	PF00400	0.315
TRG_ER_diArg_1	19	21	PF00400	0.533
TRG_ER_diArg_1	293	295	PF00400	0.455
TRG_ER_diArg_1	64	66	PF00400	0.319
TRG_NES_CRM1_1	17	31	PF08389	0.373
TRG_NES_CRM1_1	33	45	PF08389	0.499
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	64	68	PF00026	0.312
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.319

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V8	Leptomonas seymouri	32%	100%
A0A0N1IJM3	Leptomonas seymouri	63%	99%
A0A0S4JGU9	Bodo saltans	42%	96%
A0A1X0P674	Trypanosomatidae	48%	96%
A0A3S7X9J5	Leishmania donovani	95%	100%
A0A422N788	Trypanosoma rangeli	49%	100%
A4HMZ8	Leishmania braziliensis	79%	100%
A4IBM1	Leishmania infantum	95%	100%
C9ZZ14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A2P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B6L0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DRP5	Trypanosoma cruzi	29%	100%
V5DUQ3	Trypanosoma cruzi	50%	100%