Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AFF4_LEIMA

TriTrypDb:

LmjF.35.3300 , LMJLV39_350040400 , LMJSD75_350039800

Length:

636

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	368	372	PF00656	0.577
CLV_NRD_NRD_1	178	180	PF00675	0.761
CLV_NRD_NRD_1	302	304	PF00675	0.552
CLV_NRD_NRD_1	345	347	PF00675	0.584
CLV_NRD_NRD_1	379	381	PF00675	0.688
CLV_NRD_NRD_1	387	389	PF00675	0.473
CLV_NRD_NRD_1	539	541	PF00675	0.543
CLV_PCSK_FUR_1	176	180	PF00082	0.767
CLV_PCSK_KEX2_1	178	180	PF00082	0.765
CLV_PCSK_KEX2_1	301	303	PF00082	0.552
CLV_PCSK_KEX2_1	379	381	PF00082	0.691
CLV_PCSK_KEX2_1	386	388	PF00082	0.564
CLV_PCSK_KEX2_1	484	486	PF00082	0.696
CLV_PCSK_KEX2_1	539	541	PF00082	0.529
CLV_PCSK_KEX2_1	587	589	PF00082	0.822
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.594
CLV_PCSK_PC1ET2_1	484	486	PF00082	0.696
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.822
CLV_PCSK_PC7_1	383	389	PF00082	0.578
CLV_PCSK_PC7_1	535	541	PF00082	0.439
CLV_PCSK_SKI1_1	114	118	PF00082	0.453
CLV_PCSK_SKI1_1	292	296	PF00082	0.628
CLV_PCSK_SKI1_1	356	360	PF00082	0.743
CLV_PCSK_SKI1_1	387	391	PF00082	0.466
CLV_PCSK_SKI1_1	434	438	PF00082	0.425
CLV_PCSK_SKI1_1	489	493	PF00082	0.742
CLV_PCSK_SKI1_1	535	539	PF00082	0.504
DEG_APCC_DBOX_1	422	430	PF00400	0.563
DEG_Nend_UBRbox_4	1	3	PF02207	0.531
DEG_SPOP_SBC_1	577	581	PF00917	0.830
DOC_ANK_TNKS_1	538	545	PF00023	0.434
DOC_CKS1_1	235	240	PF01111	0.510
DOC_CYCLIN_yCln2_LP_2	235	241	PF00134	0.502
DOC_MAPK_DCC_7	423	431	PF00069	0.479
DOC_MAPK_MEF2A_6	423	432	PF00069	0.568
DOC_MAPK_NFAT4_5	423	431	PF00069	0.674
DOC_PP1_RVXF_1	432	439	PF00149	0.497
DOC_PP2B_LxvP_1	82	85	PF13499	0.765
DOC_USP7_MATH_1	163	167	PF00917	0.779
DOC_USP7_MATH_1	334	338	PF00917	0.692
DOC_USP7_MATH_1	36	40	PF00917	0.552
DOC_USP7_MATH_1	398	402	PF00917	0.690
DOC_USP7_MATH_1	490	494	PF00917	0.715
DOC_USP7_MATH_1	577	581	PF00917	0.830
DOC_USP7_MATH_1	586	590	PF00917	0.763
DOC_USP7_MATH_1	593	597	PF00917	0.600
DOC_USP7_MATH_1	7	11	PF00917	0.621
DOC_USP7_MATH_1	75	79	PF00917	0.669
DOC_USP7_UBL2_3	468	472	PF12436	0.763
DOC_USP7_UBL2_3	630	634	PF12436	0.656
DOC_WW_Pin1_4	153	158	PF00397	0.600
DOC_WW_Pin1_4	234	239	PF00397	0.520
DOC_WW_Pin1_4	322	327	PF00397	0.674
DOC_WW_Pin1_4	392	397	PF00397	0.571
DOC_WW_Pin1_4	492	497	PF00397	0.723
DOC_WW_Pin1_4	503	508	PF00397	0.683
DOC_WW_Pin1_4	511	516	PF00397	0.575
DOC_WW_Pin1_4	556	561	PF00397	0.717
DOC_WW_Pin1_4	86	91	PF00397	0.643
LIG_14-3-3_CanoR_1	203	211	PF00244	0.605
LIG_14-3-3_CanoR_1	292	298	PF00244	0.579
LIG_14-3-3_CanoR_1	387	396	PF00244	0.571
LIG_Actin_WH2_2	419	435	PF00022	0.640
LIG_FHA_1	17	23	PF00498	0.414
LIG_FHA_1	235	241	PF00498	0.598
LIG_FHA_1	246	252	PF00498	0.469
LIG_FHA_1	411	417	PF00498	0.450
LIG_FHA_1	48	54	PF00498	0.521
LIG_FHA_1	508	514	PF00498	0.621
LIG_FHA_1	621	627	PF00498	0.553
LIG_FHA_2	116	122	PF00498	0.458
LIG_FHA_2	256	262	PF00498	0.457
LIG_FHA_2	566	572	PF00498	0.598
LIG_Integrin_isoDGR_2	572	574	PF01839	0.753
LIG_LIR_Apic_2	227	231	PF02991	0.587
LIG_LIR_Apic_2	78	84	PF02991	0.553
LIG_LIR_LC3C_4	106	109	PF02991	0.671
LIG_LIR_LC3C_4	237	242	PF02991	0.581
LIG_LIR_Nem_3	325	331	PF02991	0.713
LIG_LYPXL_yS_3	15	18	PF13949	0.388
LIG_SH2_NCK_1	499	503	PF00017	0.627
LIG_SH2_PTP2	228	231	PF00017	0.592
LIG_SH2_PTP2	328	331	PF00017	0.677
LIG_SH2_SRC	406	409	PF00017	0.613
LIG_SH2_STAT3	133	136	PF00017	0.496
LIG_SH2_STAT5	200	203	PF00017	0.488
LIG_SH2_STAT5	228	231	PF00017	0.592
LIG_SH2_STAT5	328	331	PF00017	0.754
LIG_SH2_STAT5	406	409	PF00017	0.613
LIG_SH2_STAT5	529	532	PF00017	0.557
LIG_SH2_STAT5	607	610	PF00017	0.481
LIG_SH3_3	124	130	PF00018	0.438
LIG_SH3_3	280	286	PF00018	0.701
LIG_SH3_3	87	93	PF00018	0.581
LIG_SUMO_SIM_anti_2	208	215	PF11976	0.574
LIG_SUMO_SIM_anti_2	236	243	PF11976	0.591
LIG_SUMO_SIM_anti_2	339	345	PF11976	0.623
LIG_SUMO_SIM_anti_2	514	520	PF11976	0.610
LIG_SUMO_SIM_anti_2	623	632	PF11976	0.697
LIG_TRAF2_1	312	315	PF00917	0.691
LIG_UBA3_1	428	434	PF00899	0.509
LIG_UBA3_1	473	481	PF00899	0.675
LIG_WRC_WIRS_1	294	299	PF05994	0.506
LIG_WRC_WIRS_1	567	572	PF05994	0.754
LIG_WRC_WIRS_1	8	13	PF05994	0.653
MOD_CDK_SPxK_1	492	498	PF00069	0.695
MOD_CK1_1	234	240	PF00069	0.613
MOD_CK1_1	458	464	PF00069	0.601
MOD_CK1_1	554	560	PF00069	0.643
MOD_CK1_1	600	606	PF00069	0.593
MOD_CK1_1	74	80	PF00069	0.642
MOD_CK2_1	115	121	PF00069	0.498
MOD_CK2_1	163	169	PF00069	0.713
MOD_CK2_1	279	285	PF00069	0.609
MOD_CK2_1	351	357	PF00069	0.518
MOD_CK2_1	503	509	PF00069	0.734
MOD_CK2_1	511	517	PF00069	0.580
MOD_CK2_1	577	583	PF00069	0.717
MOD_GlcNHglycan	336	339	PF01048	0.623
MOD_GlcNHglycan	353	356	PF01048	0.622
MOD_GlcNHglycan	39	42	PF01048	0.442
MOD_GlcNHglycan	408	411	PF01048	0.523
MOD_GlcNHglycan	455	458	PF01048	0.636
MOD_GlcNHglycan	553	556	PF01048	0.607
MOD_GlcNHglycan	588	591	PF01048	0.750
MOD_GlcNHglycan	599	602	PF01048	0.626
MOD_GlcNHglycan	631	634	PF01048	0.758
MOD_GlcNHglycan	73	76	PF01048	0.709
MOD_GlcNHglycan	77	80	PF01048	0.692
MOD_GlcNHglycan	96	99	PF01048	0.626
MOD_GSK3_1	159	166	PF00069	0.616
MOD_GSK3_1	202	209	PF00069	0.549
MOD_GSK3_1	229	236	PF00069	0.610
MOD_GSK3_1	255	262	PF00069	0.461
MOD_GSK3_1	347	354	PF00069	0.537
MOD_GSK3_1	392	399	PF00069	0.567
MOD_GSK3_1	402	409	PF00069	0.508
MOD_GSK3_1	449	456	PF00069	0.658
MOD_GSK3_1	490	497	PF00069	0.733
MOD_GSK3_1	503	510	PF00069	0.611
MOD_GSK3_1	593	600	PF00069	0.771
MOD_GSK3_1	71	78	PF00069	0.632
MOD_N-GLC_1	163	168	PF02516	0.704
MOD_N-GLC_2	446	448	PF02516	0.497
MOD_NEK2_1	202	207	PF00069	0.493
MOD_NEK2_1	233	238	PF00069	0.638
MOD_NEK2_1	418	423	PF00069	0.627
MOD_NEK2_1	453	458	PF00069	0.611
MOD_NEK2_1	508	513	PF00069	0.677
MOD_NEK2_1	628	633	PF00069	0.668
MOD_NEK2_1	71	76	PF00069	0.664
MOD_NEK2_2	192	197	PF00069	0.469
MOD_NEK2_2	449	454	PF00069	0.562
MOD_NEK2_2	7	12	PF00069	0.664
MOD_PIKK_1	455	461	PF00454	0.683
MOD_PIKK_1	47	53	PF00454	0.560
MOD_PK_1	134	140	PF00069	0.523
MOD_PKA_1	178	184	PF00069	0.666
MOD_PKA_1	387	393	PF00069	0.476
MOD_PKA_2	178	184	PF00069	0.701
MOD_PKA_2	202	208	PF00069	0.598
MOD_PKA_2	387	393	PF00069	0.521
MOD_PKA_2	593	599	PF00069	0.712
MOD_PKB_1	176	184	PF00069	0.710
MOD_Plk_1	508	514	PF00069	0.603
MOD_Plk_2-3	279	285	PF00069	0.711
MOD_Plk_4	134	140	PF00069	0.406
MOD_Plk_4	224	230	PF00069	0.507
MOD_Plk_4	293	299	PF00069	0.625
MOD_Plk_4	402	408	PF00069	0.653
MOD_Plk_4	77	83	PF00069	0.585
MOD_ProDKin_1	153	159	PF00069	0.610
MOD_ProDKin_1	234	240	PF00069	0.511
MOD_ProDKin_1	322	328	PF00069	0.676
MOD_ProDKin_1	392	398	PF00069	0.577
MOD_ProDKin_1	492	498	PF00069	0.724
MOD_ProDKin_1	503	509	PF00069	0.677
MOD_ProDKin_1	511	517	PF00069	0.565
MOD_ProDKin_1	556	562	PF00069	0.724
MOD_ProDKin_1	86	92	PF00069	0.643
TRG_DiLeu_BaEn_1	425	430	PF01217	0.673
TRG_DiLeu_BaEn_1	624	629	PF01217	0.682
TRG_DiLeu_BaLyEn_6	235	240	PF01217	0.510
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.563
TRG_ENDOCYTIC_2	15	18	PF00928	0.543
TRG_ENDOCYTIC_2	328	331	PF00928	0.716
TRG_ENDOCYTIC_2	607	610	PF00928	0.422
TRG_ER_diArg_1	177	179	PF00400	0.764
TRG_ER_diArg_1	301	303	PF00400	0.531
TRG_ER_diArg_1	387	389	PF00400	0.492
TRG_ER_diArg_1	485	488	PF00400	0.587
TRG_ER_diArg_1	53	56	PF00400	0.528
TRG_ER_diArg_1	538	540	PF00400	0.495
TRG_NLS_MonoExtC_3	483	488	PF00514	0.612
TRG_NLS_MonoExtN_4	481	488	PF00514	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD2	Leptomonas seymouri	45%	100%
A0A3Q8IJ91	Leishmania donovani	90%	100%
A4HMZ7	Leishmania braziliensis	70%	100%
A4IBM0	Leishmania infantum	90%	100%
E9B6K9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%