Ribosomal protein L31

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal subunit protein L31, putative

Species:

Leishmania major

UniProt:

E9AFF2_LEIMA

TriTrypDb:

LmjF.35.3290 , LMJLV39_350040300 , LMJSD75_350039600

Length:

188

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0015934	large ribosomal subunit	4	2
GO:0022625	cytosolic large ribosomal subunit	5	2
GO:0032991	protein-containing complex	1	14
GO:0043226	organelle	2	14
GO:0043228	non-membrane-bounded organelle	3	14
GO:0043229	intracellular organelle	3	14
GO:0043232	intracellular non-membrane-bounded organelle	4	14
GO:0044391	ribosomal subunit	3	2
GO:0110165	cellular anatomical entity	1	14
GO:1990904	ribonucleoprotein complex	2	14
GO:0005840	ribosome	5	12

Expansion

Sequence features

E9AFF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF2

PDB structure(s): 6az3_e

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	2
GO:0006412	translation	4	14
GO:0006518	peptide metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009058	biosynthetic process	2	14
GO:0009059	macromolecule biosynthetic process	4	14
GO:0009987	cellular process	1	14
GO:0019538	protein metabolic process	3	14
GO:0034641	cellular nitrogen compound metabolic process	3	14
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	14
GO:0043043	peptide biosynthetic process	5	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043603	amide metabolic process	3	14
GO:0043604	amide biosynthetic process	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0044249	cellular biosynthetic process	3	14
GO:0044260	obsolete cellular macromolecule metabolic process	3	14
GO:0044271	cellular nitrogen compound biosynthetic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901566	organonitrogen compound biosynthetic process	4	14
GO:1901576	organic substance biosynthetic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	14
GO:0005198	structural molecule activity	1	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.359
CLV_NRD_NRD_1	22	24	PF00675	0.605
CLV_NRD_NRD_1	29	31	PF00675	0.607
CLV_NRD_NRD_1	49	51	PF00675	0.665
CLV_NRD_NRD_1	78	80	PF00675	0.523
CLV_PCSK_FUR_1	37	41	PF00082	0.585
CLV_PCSK_KEX2_1	103	105	PF00082	0.352
CLV_PCSK_KEX2_1	110	112	PF00082	0.354
CLV_PCSK_KEX2_1	36	38	PF00082	0.582
CLV_PCSK_KEX2_1	39	41	PF00082	0.572
CLV_PCSK_KEX2_1	49	51	PF00082	0.403
CLV_PCSK_KEX2_1	75	77	PF00082	0.603
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.352
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.354
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.602
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.567
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.403
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.603
CLV_PCSK_SKI1_1	110	114	PF00082	0.340
CLV_PCSK_SKI1_1	118	122	PF00082	0.329
CLV_PCSK_SKI1_1	138	142	PF00082	0.179
CLV_PCSK_SKI1_1	179	183	PF00082	0.459
CLV_PCSK_SKI1_1	39	43	PF00082	0.562
CLV_PCSK_SKI1_1	66	70	PF00082	0.591
CLV_PCSK_SKI1_1	94	98	PF00082	0.340
DOC_MAPK_gen_1	103	109	PF00069	0.340
DOC_USP7_MATH_1	174	178	PF00917	0.470
DOC_USP7_MATH_1	26	30	PF00917	0.535
DOC_USP7_MATH_1	60	64	PF00917	0.612
DOC_USP7_UBL2_3	9	13	PF12436	0.601
DOC_USP7_UBL2_3	94	98	PF12436	0.346
DOC_USP7_UBL2_3	99	103	PF12436	0.343
LIG_14-3-3_CanoR_1	70	74	PF00244	0.646
LIG_FHA_1	181	187	PF00498	0.482
LIG_FHA_1	87	93	PF00498	0.353
LIG_LIR_Nem_3	177	181	PF02991	0.464
LIG_LIR_Nem_3	35	41	PF02991	0.586
LIG_NRBOX	91	97	PF00104	0.340
LIG_SH2_CRK	167	171	PF00017	0.385
LIG_SH2_NCK_1	167	171	PF00017	0.385
LIG_SH2_STAT5	134	137	PF00017	0.353
LIG_SH2_STAT5	167	170	PF00017	0.386
LIG_WRC_WIRS_1	175	180	PF05994	0.465
MOD_CK1_1	130	136	PF00069	0.340
MOD_CK1_1	155	161	PF00069	0.465
MOD_Cter_Amidation	77	80	PF01082	0.526
MOD_GSK3_1	56	63	PF00069	0.609
MOD_GSK3_1	82	89	PF00069	0.325
MOD_NEK2_1	74	79	PF00069	0.597
MOD_NEK2_1	86	91	PF00069	0.386
MOD_NEK2_2	174	179	PF00069	0.477
MOD_PKA_1	97	103	PF00069	0.340
MOD_PKA_2	152	158	PF00069	0.359
MOD_PKA_2	69	75	PF00069	0.593
MOD_PKB_1	64	72	PF00069	0.594
MOD_Plk_1	127	133	PF00069	0.340
MOD_Plk_1	86	92	PF00069	0.350
MOD_Plk_2-3	82	88	PF00069	0.369
MOD_Plk_4	130	136	PF00069	0.358
MOD_Plk_4	165	171	PF00069	0.388
MOD_Plk_4	69	75	PF00069	0.628
TRG_ENDOCYTIC_2	167	170	PF00928	0.386
TRG_ER_diArg_1	146	149	PF00400	0.348
TRG_NLS_Bipartite_1	36	54	PF00514	0.584
TRG_NLS_Bipartite_1	79	101	PF00514	0.340
TRG_NLS_MonoExtC_3	22	28	PF00514	0.660
TRG_NLS_MonoExtN_4	49	54	PF00514	0.584
TRG_NLS_MonoExtN_4	94	101	PF00514	0.340
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0D7	Leptomonas seymouri	97%	100%
A0A1X0P5A7	Trypanosomatidae	81%	100%
A0A3Q8IJL7	Leishmania donovani	99%	100%
A0A3R7MZQ5	Trypanosoma rangeli	83%	100%
A0A3R7NE06	Trypanosoma rangeli	81%	100%
A0A3R7R8B8	Trypanosoma rangeli	81%	100%
A4HMZ5	Leishmania braziliensis	93%	100%
A4IBL9	Leishmania infantum	99%	100%
C9ZZ18	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	80%	100%
E9AHW6	Leishmania infantum	99%	82%
E9B6K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5C333	Trypanosoma cruzi	82%	100%