Protein CUSTOS

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Protein CUSTOS

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFF1_LEIMA

TriTrypDb:

LmjF.35.3270 , LMJLV39_350040100 , LMJSD75_350039500

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	10	14	PF00656	0.537
CLV_NRD_NRD_1	164	166	PF00675	0.529
CLV_NRD_NRD_1	168	170	PF00675	0.535
CLV_NRD_NRD_1	181	183	PF00675	0.571
CLV_NRD_NRD_1	33	35	PF00675	0.568
CLV_NRD_NRD_1	53	55	PF00675	0.563
CLV_NRD_NRD_1	67	69	PF00675	0.517
CLV_PCSK_KEX2_1	155	157	PF00082	0.547
CLV_PCSK_KEX2_1	181	183	PF00082	0.571
CLV_PCSK_KEX2_1	33	35	PF00082	0.570
CLV_PCSK_KEX2_1	53	55	PF00082	0.621
CLV_PCSK_KEX2_1	66	68	PF00082	0.516
CLV_PCSK_PC1ET2_1	155	157	PF00082	0.507
CLV_PCSK_PC7_1	151	157	PF00082	0.555
CLV_PCSK_PC7_1	177	183	PF00082	0.558
CLV_PCSK_SKI1_1	181	185	PF00082	0.553
CLV_PCSK_SKI1_1	67	71	PF00082	0.471
CLV_PCSK_SKI1_1	87	91	PF00082	0.537
DOC_USP7_MATH_1	145	149	PF00917	0.703
DOC_USP7_UBL2_3	154	158	PF12436	0.557
DOC_USP7_UBL2_3	162	166	PF12436	0.554
DOC_USP7_UBL2_3	170	174	PF12436	0.439
DOC_USP7_UBL2_3	90	94	PF12436	0.558
DOC_WW_Pin1_4	127	132	PF00397	0.613
LIG_14-3-3_CanoR_1	66	74	PF00244	0.503
LIG_14-3-3_CanoR_1	76	82	PF00244	0.637
LIG_BIR_II_1	1	5	PF00653	0.686
LIG_deltaCOP1_diTrp_1	7	18	PF00928	0.536
LIG_FHA_1	1	7	PF00498	0.653
LIG_FHA_1	68	74	PF00498	0.469
LIG_FHA_2	76	82	PF00498	0.599
LIG_LIR_Gen_1	16	26	PF02991	0.487
LIG_LIR_Nem_3	16	22	PF02991	0.483
LIG_NRP_CendR_1	186	189	PF00754	0.595
LIG_PCNA_PIPBox_1	12	21	PF02747	0.541
LIG_Pex14_2	18	22	PF04695	0.480
LIG_SH2_CRK	180	184	PF00017	0.569
LIG_TRAF2_1	61	64	PF00917	0.571
LIG_TYR_ITIM	178	183	PF00017	0.563
LIG_WRC_WIRS_1	111	116	PF05994	0.572
MOD_CDK_SPxxK_3	127	134	PF00069	0.614
MOD_CK1_1	106	112	PF00069	0.549
MOD_CK1_1	75	81	PF00069	0.514
MOD_CK2_1	112	118	PF00069	0.639
MOD_CK2_1	58	64	PF00069	0.544
MOD_CK2_1	75	81	PF00069	0.514
MOD_Cter_Amidation	152	155	PF01082	0.468
MOD_GlcNHglycan	108	111	PF01048	0.656
MOD_GlcNHglycan	60	63	PF01048	0.537
MOD_GSK3_1	110	117	PF00069	0.531
MOD_GSK3_1	121	128	PF00069	0.635
MOD_GSK3_1	20	27	PF00069	0.519
MOD_GSK3_1	40	47	PF00069	0.639
MOD_GSK3_1	99	106	PF00069	0.669
MOD_NEK2_2	103	108	PF00069	0.600
MOD_PIKK_1	44	50	PF00454	0.681
MOD_PKA_1	67	73	PF00069	0.471
MOD_PKA_2	164	170	PF00069	0.590
MOD_PKA_2	67	73	PF00069	0.493
MOD_PKA_2	75	81	PF00069	0.537
MOD_Plk_1	20	26	PF00069	0.577
MOD_ProDKin_1	127	133	PF00069	0.614
TRG_ENDOCYTIC_2	180	183	PF00928	0.569
TRG_ER_diArg_1	180	182	PF00400	0.598
TRG_ER_diArg_1	66	68	PF00400	0.516
TRG_NLS_MonoExtC_3	153	158	PF00514	0.499
TRG_NLS_MonoExtN_4	151	158	PF00514	0.510
TRG_Pf-PMV_PEXEL_1	182	187	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDT8	Leptomonas seymouri	53%	100%
A0A3S7X9J2	Leishmania donovani	92%	100%
A4HMZ4	Leishmania braziliensis	69%	100%
A4IBL8	Leishmania infantum	92%	100%
E9B6K6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%