Peroxin 19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin 19

Gene product:

Peroxin 19

Species:

Leishmania major

UniProt:

E9AFF0_LEIMA

TriTrypDb:

LmjF.35.3260 , LMJLV39_350040000 , LMJSD75_350039400

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	11
GO:0005778	peroxisomal membrane	6	2
GO:0016020	membrane	2	2
GO:0020015	glycosome	7	2
GO:0031090	organelle membrane	3	2
GO:0031903	microbody membrane	5	2
GO:0042579	microbody	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AFF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFF0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006625	protein targeting to peroxisome	5	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007031	peroxisome organization	5	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0015919	peroxisomal membrane transport	5	2
GO:0016043	cellular component organization	3	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0043574	peroxisomal transport	4	2
GO:0045046	protein import into peroxisome membrane	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072657	protein localization to membrane	4	2
GO:0072662	protein localization to peroxisome	6	2
GO:0072663	establishment of protein localization to peroxisome	5	2
GO:0090150	establishment of protein localization to membrane	4	2

Molecular functions
Term	Name	Level	Count
GO:0000268	peroxisome targeting sequence binding	5	2
GO:0005048	signal sequence binding	4	2
GO:0005488	binding	1	2
GO:0033218	amide binding	2	2
GO:0033328	peroxisome membrane targeting sequence binding	6	2
GO:0042277	peptide binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.600
CLV_NRD_NRD_1	21	23	PF00675	0.528
CLV_PCSK_KEX2_1	149	151	PF00082	0.627
CLV_PCSK_SKI1_1	31	35	PF00082	0.570
CLV_Separin_Metazoa	107	111	PF03568	0.621
DEG_APCC_KENBOX_2	98	102	PF00400	0.414
DEG_SPOP_SBC_1	175	179	PF00917	0.790
DOC_MAPK_gen_1	104	111	PF00069	0.591
DOC_MAPK_gen_1	22	30	PF00069	0.616
DOC_PIKK_1	115	123	PF02985	0.580
DOC_PP4_FxxP_1	218	221	PF00568	0.447
DOC_USP7_MATH_1	175	179	PF00917	0.695
DOC_USP7_MATH_1	204	208	PF00917	0.649
DOC_USP7_MATH_1	235	239	PF00917	0.534
DOC_USP7_UBL2_3	128	132	PF12436	0.699
DOC_WW_Pin1_4	169	174	PF00397	0.711
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_FHA_2	210	216	PF00498	0.611
LIG_LIR_Apic_2	215	221	PF02991	0.570
LIG_LIR_Nem_3	227	232	PF02991	0.562
LIG_NRBOX	273	279	PF00104	0.586
LIG_NRBOX	5	11	PF00104	0.505
LIG_SH2_STAT3	248	251	PF00017	0.482
LIG_TRAF2_1	87	90	PF00917	0.565
LIG_UBA3_1	123	132	PF00899	0.685
LIG_UBA3_1	274	283	PF00899	0.530
LIG_WRC_WIRS_1	74	79	PF05994	0.600
LIG_WW_3	289	293	PF00397	0.578
MOD_CK1_1	159	165	PF00069	0.669
MOD_CK1_1	177	183	PF00069	0.535
MOD_CK1_1	238	244	PF00069	0.513
MOD_CK1_1	73	79	PF00069	0.631
MOD_CK1_1	80	86	PF00069	0.578
MOD_CK2_1	264	270	PF00069	0.574
MOD_CK2_1	83	89	PF00069	0.560
MOD_GlcNHglycan	159	162	PF01048	0.625
MOD_GlcNHglycan	179	182	PF01048	0.591
MOD_GlcNHglycan	206	209	PF01048	0.585
MOD_GlcNHglycan	266	269	PF01048	0.369
MOD_GlcNHglycan	44	49	PF01048	0.634
MOD_GSK3_1	204	211	PF00069	0.617
MOD_GSK3_1	66	73	PF00069	0.564
MOD_GSK3_1	80	87	PF00069	0.561
MOD_NEK2_1	209	214	PF00069	0.575
MOD_NEK2_1	225	230	PF00069	0.534
MOD_NEK2_1	43	48	PF00069	0.642
MOD_NEK2_1	59	64	PF00069	0.525
MOD_NEK2_1	77	82	PF00069	0.599
MOD_PIKK_1	159	165	PF00454	0.726
MOD_PIKK_1	238	244	PF00454	0.593
MOD_PKA_2	199	205	PF00069	0.671
MOD_PKA_2	225	231	PF00069	0.562
MOD_Plk_1	70	76	PF00069	0.617
MOD_Plk_2-3	70	76	PF00069	0.654
MOD_Plk_4	59	65	PF00069	0.560
MOD_Plk_4	77	83	PF00069	0.566
MOD_ProDKin_1	169	175	PF00069	0.711
MOD_SUMO_for_1	127	130	PF00179	0.676
MOD_SUMO_for_1	33	36	PF00179	0.609
MOD_SUMO_rev_2	125	134	PF00179	0.683
MOD_SUMO_rev_2	26	35	PF00179	0.588
TRG_DiLeu_BaEn_1	220	225	PF01217	0.562
TRG_DiLeu_BaEn_1	257	262	PF01217	0.586
TRG_DiLeu_BaEn_1	270	275	PF01217	0.420
TRG_DiLeu_BaEn_4	89	95	PF01217	0.451
TRG_DiLeu_LyEn_5	270	275	PF01217	0.530
TRG_ENDOCYTIC_2	284	287	PF00928	0.562
TRG_ER_diArg_1	28	31	PF00400	0.548
TRG_NES_CRM1_1	100	115	PF08389	0.403
TRG_NES_CRM1_1	5	19	PF08389	0.615
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.247
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.682

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K6	Leptomonas seymouri	62%	100%
A0A1X0P5C4	Trypanosomatidae	28%	100%
A0A3Q8IFB3	Leishmania donovani	91%	100%
A0A422MWS6	Trypanosoma rangeli	29%	100%
A4HMZ3	Leishmania braziliensis	86%	99%
A4IBL7	Leishmania infantum	92%	100%
C9ZZ22	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B6K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BY33	Trypanosoma cruzi	23%	100%