PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFE8_LEIMA

TriTrypDb:

LmjF.35.3240 , LMJLV39_350039800 , LMJSD75_350039200

Length:

800

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	598	602	PF00656	0.662
CLV_NRD_NRD_1	122	124	PF00675	0.523
CLV_NRD_NRD_1	23	25	PF00675	0.476
CLV_NRD_NRD_1	263	265	PF00675	0.447
CLV_NRD_NRD_1	354	356	PF00675	0.480
CLV_NRD_NRD_1	437	439	PF00675	0.398
CLV_NRD_NRD_1	502	504	PF00675	0.556
CLV_NRD_NRD_1	604	606	PF00675	0.672
CLV_NRD_NRD_1	617	619	PF00675	0.601
CLV_NRD_NRD_1	705	707	PF00675	0.732
CLV_NRD_NRD_1	730	732	PF00675	0.647
CLV_NRD_NRD_1	80	82	PF00675	0.475
CLV_PCSK_FUR_1	261	265	PF00082	0.357
CLV_PCSK_KEX2_1	122	124	PF00082	0.594
CLV_PCSK_KEX2_1	214	216	PF00082	0.537
CLV_PCSK_KEX2_1	23	25	PF00082	0.476
CLV_PCSK_KEX2_1	261	263	PF00082	0.488
CLV_PCSK_KEX2_1	354	356	PF00082	0.493
CLV_PCSK_KEX2_1	426	428	PF00082	0.471
CLV_PCSK_KEX2_1	437	439	PF00082	0.342
CLV_PCSK_KEX2_1	501	503	PF00082	0.529
CLV_PCSK_KEX2_1	604	606	PF00082	0.645
CLV_PCSK_KEX2_1	617	619	PF00082	0.599
CLV_PCSK_KEX2_1	704	706	PF00082	0.792
CLV_PCSK_KEX2_1	729	731	PF00082	0.643
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.537
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.475
CLV_PCSK_PC7_1	613	619	PF00082	0.559
CLV_PCSK_SKI1_1	110	114	PF00082	0.580
CLV_PCSK_SKI1_1	193	197	PF00082	0.487
CLV_PCSK_SKI1_1	390	394	PF00082	0.503
CLV_PCSK_SKI1_1	5	9	PF00082	0.553
CLV_PCSK_SKI1_1	675	679	PF00082	0.732
CLV_PCSK_SKI1_1	88	92	PF00082	0.583
CLV_Separin_Metazoa	578	582	PF03568	0.756
DEG_APCC_DBOX_1	141	149	PF00400	0.504
DEG_APCC_DBOX_1	190	198	PF00400	0.537
DEG_Nend_UBRbox_2	1	3	PF02207	0.523
DOC_CYCLIN_yClb5_NLxxxL_5	402	411	PF00134	0.466
DOC_MAPK_gen_1	193	203	PF00069	0.386
DOC_MAPK_gen_1	261	269	PF00069	0.426
DOC_MAPK_gen_1	729	739	PF00069	0.623
DOC_MAPK_MEF2A_6	196	205	PF00069	0.359
DOC_MAPK_RevD_3	715	730	PF00069	0.524
DOC_USP7_MATH_1	115	119	PF00917	0.549
DOC_USP7_MATH_1	54	58	PF00917	0.540
DOC_USP7_MATH_1	599	603	PF00917	0.625
DOC_USP7_MATH_1	753	757	PF00917	0.612
DOC_USP7_MATH_1	759	763	PF00917	0.562
DOC_USP7_UBL2_3	106	110	PF12436	0.582
DOC_WW_Pin1_4	720	725	PF00397	0.644
DOC_WW_Pin1_4	743	748	PF00397	0.720
DOC_WW_Pin1_4	774	779	PF00397	0.711
LIG_14-3-3_CanoR_1	262	268	PF00244	0.486
LIG_14-3-3_CanoR_1	55	59	PF00244	0.545
LIG_14-3-3_CanoR_1	564	572	PF00244	0.578
LIG_14-3-3_CanoR_1	697	703	PF00244	0.811
LIG_APCC_ABBAyCdc20_2	264	270	PF00400	0.439
LIG_Clathr_ClatBox_1	194	198	PF01394	0.537
LIG_deltaCOP1_diTrp_1	430	439	PF00928	0.395
LIG_deltaCOP1_diTrp_1	773	783	PF00928	0.691
LIG_FHA_1	112	118	PF00498	0.536
LIG_FHA_1	324	330	PF00498	0.631
LIG_FHA_1	595	601	PF00498	0.626
LIG_FHA_1	782	788	PF00498	0.563
LIG_FHA_2	163	169	PF00498	0.474
LIG_FHA_2	207	213	PF00498	0.549
LIG_FHA_2	333	339	PF00498	0.574
LIG_FHA_2	384	390	PF00498	0.540
LIG_FHA_2	596	602	PF00498	0.703
LIG_Integrin_isoDGR_2	640	642	PF01839	0.604
LIG_KLC1_Yacidic_2	224	229	PF13176	0.446
LIG_LIR_Apic_2	681	687	PF02991	0.704
LIG_LIR_Gen_1	171	180	PF02991	0.490
LIG_LIR_Gen_1	782	789	PF02991	0.607
LIG_LIR_Nem_3	171	175	PF02991	0.465
LIG_LIR_Nem_3	782	786	PF02991	0.606
LIG_NRBOX	86	92	PF00104	0.615
LIG_PCNA_PIPBox_1	294	303	PF02747	0.485
LIG_Pex14_1	432	436	PF04695	0.389
LIG_RPA_C_Fungi	50	62	PF08784	0.450
LIG_SH2_SRC	227	230	PF00017	0.420
LIG_SH2_STAP1	172	176	PF00017	0.541
LIG_SH2_STAP1	346	350	PF00017	0.601
LIG_SH2_STAT5	172	175	PF00017	0.407
LIG_SH2_STAT5	227	230	PF00017	0.420
LIG_SH2_STAT5	300	303	PF00017	0.489
LIG_SH3_1	749	755	PF00018	0.661
LIG_SH3_2	724	729	PF14604	0.596
LIG_SH3_3	585	591	PF00018	0.751
LIG_SH3_3	674	680	PF00018	0.624
LIG_SH3_3	684	690	PF00018	0.696
LIG_SH3_3	714	720	PF00018	0.682
LIG_SH3_3	721	727	PF00018	0.697
LIG_SH3_3	749	755	PF00018	0.688
LIG_TRAF2_1	209	212	PF00917	0.536
LIG_TRAF2_1	284	287	PF00917	0.490
LIG_TRAF2_1	302	305	PF00917	0.333
LIG_TRAF2_1	317	320	PF00917	0.464
LIG_TRAF2_1	419	422	PF00917	0.548
LIG_TRAF2_1	449	452	PF00917	0.497
LIG_WW_2	724	727	PF00397	0.586
MOD_CDK_SPxK_1	743	749	PF00069	0.592
MOD_CK1_1	766	772	PF00069	0.613
MOD_CK1_1	779	785	PF00069	0.732
MOD_CK2_1	162	168	PF00069	0.472
MOD_CK2_1	206	212	PF00069	0.517
MOD_CK2_1	31	37	PF00069	0.505
MOD_CK2_1	381	387	PF00069	0.422
MOD_CK2_1	40	46	PF00069	0.529
MOD_CK2_1	425	431	PF00069	0.453
MOD_CK2_1	769	775	PF00069	0.750
MOD_Cter_Amidation	352	355	PF01082	0.394
MOD_Cter_Amidation	727	730	PF01082	0.529
MOD_GlcNHglycan	117	120	PF01048	0.488
MOD_GlcNHglycan	184	187	PF01048	0.517
MOD_GlcNHglycan	30	36	PF01048	0.454
MOD_GlcNHglycan	413	417	PF01048	0.451
MOD_GlcNHglycan	614	617	PF01048	0.770
MOD_GlcNHglycan	636	639	PF01048	0.726
MOD_GlcNHglycan	778	781	PF01048	0.680
MOD_GlcNHglycan	92	97	PF01048	0.712
MOD_GSK3_1	111	118	PF00069	0.458
MOD_GSK3_1	140	147	PF00069	0.557
MOD_GSK3_1	421	428	PF00069	0.487
MOD_GSK3_1	595	602	PF00069	0.769
MOD_GSK3_1	754	761	PF00069	0.602
MOD_GSK3_1	787	794	PF00069	0.599
MOD_N-GLC_1	763	768	PF02516	0.723
MOD_NEK2_1	170	175	PF00069	0.455
MOD_NEK2_1	197	202	PF00069	0.551
MOD_NEK2_1	246	251	PF00069	0.590
MOD_NEK2_1	378	383	PF00069	0.505
MOD_NEK2_1	461	466	PF00069	0.538
MOD_NEK2_1	792	797	PF00069	0.632
MOD_PIKK_1	162	168	PF00454	0.580
MOD_PIKK_1	206	212	PF00454	0.535
MOD_PIKK_1	378	384	PF00454	0.553
MOD_PIKK_1	395	401	PF00454	0.390
MOD_PIKK_1	40	46	PF00454	0.502
MOD_PIKK_1	519	525	PF00454	0.548
MOD_PIKK_1	565	571	PF00454	0.603
MOD_PIKK_1	763	769	PF00454	0.626
MOD_PIKK_1	793	799	PF00454	0.596
MOD_PKA_1	263	269	PF00069	0.341
MOD_PKA_1	323	329	PF00069	0.428
MOD_PKA_1	730	736	PF00069	0.531
MOD_PKA_2	263	269	PF00069	0.563
MOD_PKA_2	40	46	PF00069	0.607
MOD_PKA_2	54	60	PF00069	0.411
MOD_PKA_2	612	618	PF00069	0.757
MOD_PKA_2	698	704	PF00069	0.750
MOD_PKA_2	730	736	PF00069	0.733
MOD_PKB_1	261	269	PF00069	0.346
MOD_Plk_1	170	176	PF00069	0.487
MOD_Plk_1	197	203	PF00069	0.465
MOD_Plk_1	246	252	PF00069	0.475
MOD_Plk_1	412	418	PF00069	0.517
MOD_Plk_1	421	427	PF00069	0.466
MOD_Plk_1	709	715	PF00069	0.624
MOD_Plk_1	763	769	PF00069	0.655
MOD_Plk_4	144	150	PF00069	0.500
MOD_Plk_4	197	203	PF00069	0.462
MOD_ProDKin_1	720	726	PF00069	0.646
MOD_ProDKin_1	743	749	PF00069	0.725
MOD_ProDKin_1	774	780	PF00069	0.711
MOD_SUMO_for_1	62	65	PF00179	0.503
MOD_SUMO_rev_2	30	35	PF00179	0.437
MOD_SUMO_rev_2	320	325	PF00179	0.413
MOD_SUMO_rev_2	86	95	PF00179	0.466
TRG_DiLeu_BaEn_1	144	149	PF01217	0.486
TRG_DiLeu_BaEn_1	190	195	PF01217	0.536
TRG_DiLeu_BaEn_1	237	242	PF01217	0.531
TRG_DiLeu_BaEn_4	131	137	PF01217	0.637
TRG_DiLeu_LyEn_5	190	195	PF01217	0.536
TRG_DiLeu_LyEn_5	237	242	PF01217	0.460
TRG_ENDOCYTIC_2	172	175	PF00928	0.543
TRG_ER_diArg_1	121	123	PF00400	0.516
TRG_ER_diArg_1	22	24	PF00400	0.474
TRG_ER_diArg_1	261	264	PF00400	0.598
TRG_ER_diArg_1	436	438	PF00400	0.394
TRG_ER_diArg_1	500	503	PF00400	0.488
TRG_ER_diArg_1	604	606	PF00400	0.656
TRG_ER_diArg_1	617	619	PF00400	0.591
TRG_ER_diArg_1	703	706	PF00400	0.783
TRG_ER_diArg_1	729	731	PF00400	0.657
TRG_ER_diArg_1	739	742	PF00400	0.680
TRG_NES_CRM1_1	192	204	PF08389	0.447
TRG_NES_CRM1_1	456	471	PF08389	0.517
TRG_NES_CRM1_1	554	569	PF08389	0.587
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	193	198	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	409	413	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	473	478	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	88	92	PF00026	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJW5	Leptomonas seymouri	58%	82%
A0A0S4IKJ1	Bodo saltans	34%	100%
A0A1X0P6F2	Trypanosomatidae	34%	92%
A0A3Q8IIH8	Leishmania donovani	92%	100%
A0A422MWV3	Trypanosoma rangeli	34%	95%
A4HMZ1	Leishmania braziliensis	78%	100%
A4IBL5	Leishmania infantum	92%	100%
C9ZZ25	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	92%
E9B6K3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BCX8	Trypanosoma cruzi	32%	95%