RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-binding protein, putative

Species:

Leishmania major

UniProt:

E9AFE4_LEIMA

TriTrypDb:

LmjF.35.3200 , LMJLV39_350039400 , LMJSD75_350038800

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.427
CLV_C14_Caspase3-7	398	402	PF00656	0.555
CLV_C14_Caspase3-7	623	627	PF00656	0.679
CLV_NRD_NRD_1	287	289	PF00675	0.635
CLV_NRD_NRD_1	350	352	PF00675	0.292
CLV_NRD_NRD_1	362	364	PF00675	0.292
CLV_NRD_NRD_1	391	393	PF00675	0.506
CLV_NRD_NRD_1	46	48	PF00675	0.447
CLV_NRD_NRD_1	60	62	PF00675	0.404
CLV_NRD_NRD_1	69	71	PF00675	0.434
CLV_PCSK_KEX2_1	349	351	PF00082	0.294
CLV_PCSK_KEX2_1	391	393	PF00082	0.506
CLV_PCSK_KEX2_1	46	48	PF00082	0.452
CLV_PCSK_KEX2_1	570	572	PF00082	0.709
CLV_PCSK_KEX2_1	69	71	PF00082	0.492
CLV_PCSK_PC1ET2_1	570	572	PF00082	0.677
CLV_PCSK_SKI1_1	106	110	PF00082	0.511
CLV_PCSK_SKI1_1	27	31	PF00082	0.379
CLV_PCSK_SKI1_1	350	354	PF00082	0.418
CLV_PCSK_SKI1_1	363	367	PF00082	0.292
CLV_PCSK_SKI1_1	61	65	PF00082	0.506
DEG_Nend_UBRbox_1	1	4	PF02207	0.647
DOC_CDC14_PxL_1	276	284	PF14671	0.637
DOC_CYCLIN_RxL_1	58	65	PF00134	0.403
DOC_CYCLIN_yClb1_LxF_4	48	53	PF00134	0.507
DOC_CYCLIN_yCln2_LP_2	51	57	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	675	681	PF00134	0.736
DOC_MAPK_gen_1	349	356	PF00069	0.494
DOC_MAPK_gen_1	371	380	PF00069	0.492
DOC_MAPK_gen_1	46	53	PF00069	0.413
DOC_MAPK_JIP1_4	47	53	PF00069	0.516
DOC_MAPK_MEF2A_6	271	279	PF00069	0.604
DOC_MAPK_MEF2A_6	374	382	PF00069	0.492
DOC_PP1_RVXF_1	48	54	PF00149	0.513
DOC_PP1_RVXF_1	9	15	PF00149	0.411
DOC_PP2B_LxvP_1	20	23	PF13499	0.450
DOC_PP2B_LxvP_1	675	678	PF13499	0.731
DOC_PP2B_LxvP_1	695	698	PF13499	0.691
DOC_PP4_FxxP_1	329	332	PF00568	0.576
DOC_PP4_FxxP_1	630	633	PF00568	0.640
DOC_PP4_FxxP_1	690	693	PF00568	0.659
DOC_PP4_MxPP_1	689	692	PF00568	0.730
DOC_USP7_MATH_1	131	135	PF00917	0.700
DOC_USP7_MATH_1	150	154	PF00917	0.636
DOC_USP7_MATH_1	191	195	PF00917	0.459
DOC_USP7_MATH_1	278	282	PF00917	0.541
DOC_USP7_MATH_1	334	338	PF00917	0.576
DOC_USP7_MATH_1	417	421	PF00917	0.701
DOC_USP7_MATH_1	423	427	PF00917	0.615
DOC_USP7_MATH_1	542	546	PF00917	0.657
DOC_USP7_MATH_1	561	565	PF00917	0.523
DOC_USP7_MATH_1	578	582	PF00917	0.583
DOC_USP7_MATH_1	656	660	PF00917	0.769
DOC_USP7_MATH_1	666	670	PF00917	0.623
DOC_USP7_UBL2_3	115	119	PF12436	0.452
DOC_WW_Pin1_4	122	127	PF00397	0.652
DOC_WW_Pin1_4	271	276	PF00397	0.460
DOC_WW_Pin1_4	380	385	PF00397	0.466
DOC_WW_Pin1_4	428	433	PF00397	0.814
DOC_WW_Pin1_4	492	497	PF00397	0.637
DOC_WW_Pin1_4	547	552	PF00397	0.630
DOC_WW_Pin1_4	574	579	PF00397	0.826
DOC_WW_Pin1_4	597	602	PF00397	0.607
DOC_WW_Pin1_4	644	649	PF00397	0.756
DOC_WW_Pin1_4	664	669	PF00397	0.675
LIG_14-3-3_CanoR_1	351	357	PF00244	0.492
LIG_14-3-3_CanoR_1	374	379	PF00244	0.576
LIG_14-3-3_CanoR_1	490	496	PF00244	0.679
LIG_14-3-3_CanoR_1	61	67	PF00244	0.496
LIG_14-3-3_CanoR_1	660	668	PF00244	0.750
LIG_BRCT_BRCA1_1	152	156	PF00533	0.574
LIG_BRCT_BRCA1_1	24	28	PF00533	0.406
LIG_BRCT_BRCA1_1	336	340	PF00533	0.576
LIG_Clathr_ClatBox_1	29	33	PF01394	0.368
LIG_deltaCOP1_diTrp_1	292	302	PF00928	0.500
LIG_EVH1_1	630	634	PF00568	0.732
LIG_EVH1_1	690	694	PF00568	0.725
LIG_FHA_1	309	315	PF00498	0.453
LIG_FHA_1	322	328	PF00498	0.450
LIG_FHA_1	375	381	PF00498	0.492
LIG_FHA_1	442	448	PF00498	0.665
LIG_FHA_1	464	470	PF00498	0.733
LIG_FHA_2	1	7	PF00498	0.692
LIG_FHA_2	150	156	PF00498	0.543
LIG_FHA_2	320	326	PF00498	0.576
LIG_FHA_2	396	402	PF00498	0.622
LIG_LIR_Apic_2	328	332	PF02991	0.576
LIG_LIR_Apic_2	383	389	PF02991	0.624
LIG_LIR_Apic_2	687	693	PF02991	0.664
LIG_LIR_Gen_1	13	22	PF02991	0.560
LIG_LIR_Gen_1	162	169	PF02991	0.618
LIG_LIR_Gen_1	218	227	PF02991	0.440
LIG_LIR_Gen_1	33	40	PF02991	0.225
LIG_LIR_Gen_1	355	361	PF02991	0.576
LIG_LIR_Nem_3	13	17	PF02991	0.547
LIG_LIR_Nem_3	157	163	PF02991	0.471
LIG_LIR_Nem_3	213	217	PF02991	0.418
LIG_LIR_Nem_3	218	223	PF02991	0.437
LIG_LIR_Nem_3	292	298	PF02991	0.510
LIG_LIR_Nem_3	328	333	PF02991	0.576
LIG_LIR_Nem_3	33	37	PF02991	0.220
LIG_LIR_Nem_3	355	359	PF02991	0.578
LIG_LIR_Nem_3	518	523	PF02991	0.617
LIG_LIR_Nem_3	612	618	PF02991	0.785
LIG_MYND_1	668	672	PF01753	0.664
LIG_MYND_1	693	697	PF01753	0.715
LIG_MYND_3	279	283	PF01753	0.621
LIG_NRBOX	25	31	PF00104	0.385
LIG_NRBOX	59	65	PF00104	0.413
LIG_PAM2_1	62	74	PF00658	0.513
LIG_Pex14_2	156	160	PF04695	0.462
LIG_Pex14_2	201	205	PF04695	0.566
LIG_Pex14_2	49	53	PF04695	0.503
LIG_Pex14_2	590	594	PF04695	0.740
LIG_PROFILIN_1	631	637	PF00235	0.658
LIG_RPA_C_Fungi	532	544	PF08784	0.684
LIG_SH2_CRK	34	38	PF00017	0.381
LIG_SH2_CRK	618	622	PF00017	0.684
LIG_SH2_CRK	673	677	PF00017	0.616
LIG_SH2_NCK_1	673	677	PF00017	0.616
LIG_SH2_PTP2	386	389	PF00017	0.676
LIG_SH2_SRC	642	645	PF00017	0.767
LIG_SH2_SRC	98	101	PF00017	0.497
LIG_SH2_STAP1	34	38	PF00017	0.381
LIG_SH2_STAP1	95	99	PF00017	0.546
LIG_SH2_STAT3	500	503	PF00017	0.690
LIG_SH2_STAT5	181	184	PF00017	0.503
LIG_SH2_STAT5	386	389	PF00017	0.534
LIG_SH2_STAT5	500	503	PF00017	0.690
LIG_SH2_STAT5	642	645	PF00017	0.767
LIG_SH2_STAT5	679	682	PF00017	0.746
LIG_SH2_STAT5	699	702	PF00017	0.467
LIG_SH2_STAT5	98	101	PF00017	0.512
LIG_SH3_2	548	553	PF14604	0.749
LIG_SH3_2	605	610	PF14604	0.706
LIG_SH3_3	127	133	PF00018	0.656
LIG_SH3_3	269	275	PF00018	0.435
LIG_SH3_3	379	385	PF00018	0.466
LIG_SH3_3	52	58	PF00018	0.432
LIG_SH3_3	545	551	PF00018	0.622
LIG_SH3_3	602	608	PF00018	0.755
LIG_SH3_3	625	631	PF00018	0.657
LIG_SH3_3	632	638	PF00018	0.601
LIG_SH3_3	665	671	PF00018	0.738
LIG_SH3_3	688	694	PF00018	0.618
LIG_SH3_4	115	122	PF00018	0.443
LIG_TRFH_1	268	272	PF08558	0.408
LIG_TRFH_1	673	677	PF08558	0.734
LIG_TYR_ITIM	32	37	PF00017	0.370
LIG_UBA3_1	108	115	PF00899	0.370
LIG_WRC_WIRS_1	326	331	PF05994	0.453
LIG_WRC_WIRS_1	353	358	PF05994	0.335
LIG_WW_1	639	642	PF00397	0.679
LIG_WW_1	676	679	PF00397	0.646
LIG_WW_1	696	699	PF00397	0.710
LIG_WW_2	693	696	PF00397	0.720
MOD_CDC14_SPxK_1	388	391	PF00782	0.663
MOD_CDC14_SPxK_1	550	553	PF00782	0.749
MOD_CDK_SPxK_1	385	391	PF00069	0.648
MOD_CDK_SPxK_1	547	553	PF00069	0.628
MOD_CDK_SPxxK_3	385	392	PF00069	0.643
MOD_CDK_SPxxK_3	597	604	PF00069	0.711
MOD_CK1_1	136	142	PF00069	0.665
MOD_CK1_1	164	170	PF00069	0.677
MOD_CK1_1	189	195	PF00069	0.496
MOD_CK1_1	21	27	PF00069	0.447
MOD_CK1_1	218	224	PF00069	0.415
MOD_CK1_1	426	432	PF00069	0.782
MOD_CK1_1	434	440	PF00069	0.671
MOD_CK1_1	464	470	PF00069	0.644
MOD_CK1_1	478	484	PF00069	0.579
MOD_CK1_1	597	603	PF00069	0.573
MOD_CK1_1	659	665	PF00069	0.669
MOD_CK1_1	82	88	PF00069	0.399
MOD_CK2_1	149	155	PF00069	0.573
MOD_CK2_1	256	262	PF00069	0.521
MOD_CK2_1	319	325	PF00069	0.335
MOD_CK2_1	561	567	PF00069	0.706
MOD_CK2_1	638	644	PF00069	0.656
MOD_DYRK1A_RPxSP_1	271	275	PF00069	0.446
MOD_DYRK1A_RPxSP_1	428	432	PF00069	0.558
MOD_GlcNHglycan	133	136	PF01048	0.684
MOD_GlcNHglycan	216	220	PF01048	0.420
MOD_GlcNHglycan	337	340	PF01048	0.428
MOD_GlcNHglycan	428	431	PF01048	0.620
MOD_GlcNHglycan	544	547	PF01048	0.764
MOD_GlcNHglycan	563	566	PF01048	0.518
MOD_GlcNHglycan	596	599	PF01048	0.634
MOD_GSK3_1	136	143	PF00069	0.665
MOD_GSK3_1	146	153	PF00069	0.629
MOD_GSK3_1	161	168	PF00069	0.410
MOD_GSK3_1	18	25	PF00069	0.525
MOD_GSK3_1	321	328	PF00069	0.320
MOD_GSK3_1	370	377	PF00069	0.497
MOD_GSK3_1	395	402	PF00069	0.551
MOD_GSK3_1	426	433	PF00069	0.682
MOD_GSK3_1	461	468	PF00069	0.673
MOD_GSK3_1	574	581	PF00069	0.804
MOD_GSK3_1	655	662	PF00069	0.817
MOD_GSK3_1	82	89	PF00069	0.391
MOD_N-GLC_1	442	447	PF02516	0.677
MOD_N-GLC_1	515	520	PF02516	0.758
MOD_N-GLC_2	425	427	PF02516	0.690
MOD_NEK2_1	156	161	PF00069	0.440
MOD_NEK2_1	359	364	PF00069	0.453
MOD_NEK2_1	409	414	PF00069	0.674
MOD_NEK2_1	594	599	PF00069	0.674
MOD_NEK2_1	84	89	PF00069	0.462
MOD_NEK2_2	423	428	PF00069	0.560
MOD_NEK2_2	620	625	PF00069	0.568
MOD_PIKK_1	241	247	PF00454	0.548
MOD_PK_1	18	24	PF00069	0.444
MOD_PKA_2	399	405	PF00069	0.560
MOD_PKA_2	656	662	PF00069	0.767
MOD_Plk_1	156	162	PF00069	0.565
MOD_Plk_1	168	174	PF00069	0.545
MOD_Plk_1	283	289	PF00069	0.507
MOD_Plk_1	442	448	PF00069	0.563
MOD_Plk_1	464	470	PF00069	0.688
MOD_Plk_1	484	490	PF00069	0.670
MOD_Plk_1	515	521	PF00069	0.630
MOD_Plk_2-3	256	262	PF00069	0.521
MOD_Plk_2-3	319	325	PF00069	0.335
MOD_Plk_4	156	162	PF00069	0.447
MOD_Plk_4	308	314	PF00069	0.528
MOD_Plk_4	325	331	PF00069	0.183
MOD_Plk_4	443	449	PF00069	0.635
MOD_Plk_4	484	490	PF00069	0.670
MOD_Plk_4	638	644	PF00069	0.796
MOD_Plk_4	79	85	PF00069	0.424
MOD_ProDKin_1	122	128	PF00069	0.656
MOD_ProDKin_1	271	277	PF00069	0.468
MOD_ProDKin_1	380	386	PF00069	0.476
MOD_ProDKin_1	428	434	PF00069	0.815
MOD_ProDKin_1	492	498	PF00069	0.635
MOD_ProDKin_1	547	553	PF00069	0.634
MOD_ProDKin_1	574	580	PF00069	0.824
MOD_ProDKin_1	597	603	PF00069	0.609
MOD_ProDKin_1	644	650	PF00069	0.755
MOD_ProDKin_1	664	670	PF00069	0.674
MOD_SUMO_for_1	396	399	PF00179	0.689
MOD_SUMO_for_1	609	612	PF00179	0.738
MOD_SUMO_rev_2	13	20	PF00179	0.443
MOD_SUMO_rev_2	337	346	PF00179	0.453
MOD_SUMO_rev_2	367	373	PF00179	0.380
TRG_DiLeu_BaLyEn_6	88	93	PF01217	0.574
TRG_ENDOCYTIC_2	163	166	PF00928	0.622
TRG_ENDOCYTIC_2	181	184	PF00928	0.375
TRG_ENDOCYTIC_2	34	37	PF00928	0.374
TRG_ENDOCYTIC_2	618	621	PF00928	0.760
TRG_ER_diArg_1	349	351	PF00400	0.339
TRG_ER_diArg_1	46	48	PF00400	0.565
TRG_ER_diArg_1	69	71	PF00400	0.336
TRG_Pf-PMV_PEXEL_1	288	292	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMJ6	Leishmania donovani	94%	100%
A4HMY7	Leishmania braziliensis	81%	100%
A4IBL1	Leishmania infantum	94%	100%
E9B6J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5C2W3	Trypanosoma cruzi	42%	100%