LeishMANIAdb
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Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycerate mutase family protein
Gene product:
Histidine phosphatase superfamily (branch 1), putative
Species:
Leishmania major
UniProt:
E9AFE3_LEIMA
TriTrypDb:
LmjF.35.3190 , LMJLV39_350039300 * , LMJSD75_350038700 *
Length:
902

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AFE3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 163 167 PF00656 0.518
CLV_C14_Caspase3-7 177 181 PF00656 0.464
CLV_C14_Caspase3-7 228 232 PF00656 0.392
CLV_C14_Caspase3-7 23 27 PF00656 0.363
CLV_C14_Caspase3-7 280 284 PF00656 0.456
CLV_C14_Caspase3-7 590 594 PF00656 0.534
CLV_C14_Caspase3-7 777 781 PF00656 0.648
CLV_C14_Caspase3-7 893 897 PF00656 0.604
CLV_NRD_NRD_1 189 191 PF00675 0.727
CLV_NRD_NRD_1 24 26 PF00675 0.563
CLV_NRD_NRD_1 258 260 PF00675 0.558
CLV_NRD_NRD_1 671 673 PF00675 0.449
CLV_NRD_NRD_1 74 76 PF00675 0.447
CLV_NRD_NRD_1 740 742 PF00675 0.499
CLV_PCSK_FUR_1 738 742 PF00082 0.499
CLV_PCSK_KEX2_1 211 213 PF00082 0.658
CLV_PCSK_KEX2_1 24 26 PF00082 0.563
CLV_PCSK_KEX2_1 258 260 PF00082 0.558
CLV_PCSK_KEX2_1 671 673 PF00082 0.449
CLV_PCSK_KEX2_1 74 76 PF00082 0.447
CLV_PCSK_KEX2_1 740 742 PF00082 0.499
CLV_PCSK_KEX2_1 819 821 PF00082 0.410
CLV_PCSK_PC1ET2_1 211 213 PF00082 0.658
CLV_PCSK_PC1ET2_1 819 821 PF00082 0.410
CLV_PCSK_PC7_1 20 26 PF00082 0.563
DEG_COP1_1 177 186 PF00400 0.439
DEG_MDM2_SWIB_1 716 723 PF02201 0.294
DEG_SCF_FBW7_1 475 482 PF00400 0.588
DEG_SPOP_SBC_1 167 171 PF00917 0.429
DEG_SPOP_SBC_1 3 7 PF00917 0.475
DEG_SPOP_SBC_1 447 451 PF00917 0.477
DOC_ANK_TNKS_1 297 304 PF00023 0.430
DOC_CKS1_1 408 413 PF01111 0.556
DOC_CYCLIN_yCln2_LP_2 574 580 PF00134 0.522
DOC_MAPK_MEF2A_6 287 294 PF00069 0.405
DOC_MAPK_MEF2A_6 830 839 PF00069 0.348
DOC_PP2B_LxvP_1 117 120 PF13499 0.363
DOC_PP2B_LxvP_1 380 383 PF13499 0.465
DOC_PP2B_LxvP_1 574 577 PF13499 0.526
DOC_USP7_MATH_1 10 14 PF00917 0.417
DOC_USP7_MATH_1 118 122 PF00917 0.324
DOC_USP7_MATH_1 160 164 PF00917 0.481
DOC_USP7_MATH_1 168 172 PF00917 0.459
DOC_USP7_MATH_1 232 236 PF00917 0.381
DOC_USP7_MATH_1 3 7 PF00917 0.518
DOC_USP7_MATH_1 301 305 PF00917 0.374
DOC_USP7_MATH_1 32 36 PF00917 0.344
DOC_USP7_MATH_1 363 367 PF00917 0.488
DOC_USP7_MATH_1 397 401 PF00917 0.515
DOC_USP7_MATH_1 416 420 PF00917 0.491
DOC_USP7_MATH_1 448 452 PF00917 0.588
DOC_USP7_MATH_1 453 457 PF00917 0.552
DOC_USP7_MATH_1 479 483 PF00917 0.555
DOC_USP7_MATH_1 62 66 PF00917 0.332
DOC_USP7_MATH_1 624 628 PF00917 0.743
DOC_USP7_MATH_1 683 687 PF00917 0.428
DOC_USP7_MATH_1 818 822 PF00917 0.567
DOC_USP7_MATH_1 898 902 PF00917 0.652
DOC_USP7_MATH_1 90 94 PF00917 0.324
DOC_WD40_RPTOR_TOS_1 628 634 PF00400 0.635
DOC_WW_Pin1_4 217 222 PF00397 0.423
DOC_WW_Pin1_4 369 374 PF00397 0.556
DOC_WW_Pin1_4 407 412 PF00397 0.588
DOC_WW_Pin1_4 475 480 PF00397 0.586
DOC_WW_Pin1_4 593 598 PF00397 0.511
DOC_WW_Pin1_4 606 611 PF00397 0.255
DOC_WW_Pin1_4 68 73 PF00397 0.363
DOC_WW_Pin1_4 809 814 PF00397 0.682
LIG_14-3-3_CanoR_1 108 117 PF00244 0.286
LIG_14-3-3_CanoR_1 142 148 PF00244 0.358
LIG_14-3-3_CanoR_1 198 205 PF00244 0.549
LIG_14-3-3_CanoR_1 212 217 PF00244 0.478
LIG_14-3-3_CanoR_1 359 368 PF00244 0.542
LIG_14-3-3_CanoR_1 398 405 PF00244 0.538
LIG_14-3-3_CanoR_1 569 575 PF00244 0.576
LIG_14-3-3_CanoR_1 645 651 PF00244 0.742
LIG_14-3-3_CanoR_1 675 680 PF00244 0.678
LIG_14-3-3_CanoR_1 74 78 PF00244 0.357
LIG_14-3-3_CanoR_1 740 749 PF00244 0.694
LIG_14-3-3_CanoR_1 759 765 PF00244 0.577
LIG_Actin_WH2_2 150 167 PF00022 0.422
LIG_Actin_WH2_2 330 347 PF00022 0.454
LIG_Actin_WH2_2 841 858 PF00022 0.269
LIG_BIR_III_2 283 287 PF00653 0.447
LIG_BRCT_BRCA1_1 100 104 PF00533 0.286
LIG_BRCT_BRCA1_1 346 350 PF00533 0.465
LIG_BRCT_BRCA1_1 845 849 PF00533 0.401
LIG_Clathr_ClatBox_1 291 295 PF01394 0.451
LIG_CtBP_PxDLS_1 334 338 PF00389 0.448
LIG_deltaCOP1_diTrp_1 799 805 PF00928 0.625
LIG_FHA_1 159 165 PF00498 0.465
LIG_FHA_1 247 253 PF00498 0.364
LIG_FHA_1 501 507 PF00498 0.541
LIG_FHA_1 664 670 PF00498 0.701
LIG_FHA_1 812 818 PF00498 0.683
LIG_FHA_1 869 875 PF00498 0.305
LIG_FHA_2 168 174 PF00498 0.499
LIG_FHA_2 175 181 PF00498 0.485
LIG_FHA_2 213 219 PF00498 0.488
LIG_FHA_2 226 232 PF00498 0.362
LIG_FHA_2 891 897 PF00498 0.598
LIG_FHA_2 97 103 PF00498 0.363
LIG_GBD_Chelix_1 50 58 PF00786 0.563
LIG_LIR_Apic_2 547 553 PF02991 0.438
LIG_LIR_Gen_1 248 257 PF02991 0.358
LIG_LIR_Gen_1 721 730 PF02991 0.428
LIG_LIR_Gen_1 846 857 PF02991 0.484
LIG_LIR_LC3C_4 65 70 PF02991 0.305
LIG_LIR_Nem_3 101 107 PF02991 0.320
LIG_LIR_Nem_3 152 157 PF02991 0.443
LIG_LIR_Nem_3 248 254 PF02991 0.395
LIG_LIR_Nem_3 710 716 PF02991 0.407
LIG_LIR_Nem_3 721 727 PF02991 0.302
LIG_LIR_Nem_3 846 852 PF02991 0.401
LIG_NRBOX 873 879 PF00104 0.401
LIG_PDZ_Class_3 897 902 PF00595 0.684
LIG_Pex14_1 712 716 PF04695 0.428
LIG_Pex14_1 720 724 PF04695 0.337
LIG_Pex14_2 695 699 PF04695 0.408
LIG_Pex14_2 716 720 PF04695 0.428
LIG_Pex14_2 849 853 PF04695 0.396
LIG_PTB_Apo_2 261 268 PF02174 0.421
LIG_PTB_Phospho_1 261 267 PF10480 0.423
LIG_SH2_CRK 154 158 PF00017 0.426
LIG_SH2_CRK 880 884 PF00017 0.428
LIG_SH2_STAP1 247 251 PF00017 0.441
LIG_SH2_STAT3 11 14 PF00017 0.440
LIG_SH2_STAT5 143 146 PF00017 0.372
LIG_SH2_STAT5 616 619 PF00017 0.506
LIG_SH3_2 577 582 PF14604 0.460
LIG_SH3_3 100 106 PF00018 0.363
LIG_SH3_3 112 118 PF00018 0.265
LIG_SH3_3 26 32 PF00018 0.354
LIG_SH3_3 283 289 PF00018 0.443
LIG_SH3_3 348 354 PF00018 0.456
LIG_SH3_3 367 373 PF00018 0.447
LIG_SH3_3 376 382 PF00018 0.497
LIG_SH3_3 405 411 PF00018 0.520
LIG_SH3_3 574 580 PF00018 0.561
LIG_SH3_3 604 610 PF00018 0.315
LIG_SH3_3 66 72 PF00018 0.324
LIG_SH3_3 864 870 PF00018 0.364
LIG_Sin3_3 872 879 PF02671 0.267
LIG_SUMO_SIM_anti_2 223 228 PF11976 0.400
LIG_SUMO_SIM_anti_2 288 295 PF11976 0.404
LIG_SUMO_SIM_par_1 223 228 PF11976 0.400
LIG_SUMO_SIM_par_1 288 295 PF11976 0.404
LIG_SUMO_SIM_par_1 321 328 PF11976 0.437
LIG_TYR_ITIM 878 883 PF00017 0.428
LIG_UBA3_1 290 296 PF00899 0.450
LIG_UBA3_1 620 626 PF00899 0.683
LIG_UBA3_1 831 838 PF00899 0.375
LIG_WRC_WIRS_1 144 149 PF05994 0.364
LIG_WRC_WIRS_1 251 256 PF05994 0.323
LIG_WW_3 195 199 PF00397 0.577
MOD_CDC14_SPxK_1 71 74 PF00782 0.248
MOD_CDK_SPK_2 217 222 PF00069 0.392
MOD_CDK_SPxK_1 68 74 PF00069 0.248
MOD_CDK_SPxxK_3 595 602 PF00069 0.438
MOD_CDK_SPxxK_3 68 75 PF00069 0.363
MOD_CDK_SPxxK_3 809 816 PF00069 0.679
MOD_CK1_1 201 207 PF00069 0.557
MOD_CK1_1 214 220 PF00069 0.443
MOD_CK1_1 235 241 PF00069 0.339
MOD_CK1_1 304 310 PF00069 0.421
MOD_CK1_1 361 367 PF00069 0.502
MOD_CK1_1 389 395 PF00069 0.491
MOD_CK1_1 439 445 PF00069 0.560
MOD_CK1_1 483 489 PF00069 0.588
MOD_CK1_1 512 518 PF00069 0.489
MOD_CK1_1 615 621 PF00069 0.558
MOD_CK1_1 758 764 PF00069 0.644
MOD_CK1_1 812 818 PF00069 0.610
MOD_CK1_1 843 849 PF00069 0.428
MOD_CK2_1 167 173 PF00069 0.516
MOD_CK2_1 204 210 PF00069 0.496
MOD_CK2_1 212 218 PF00069 0.450
MOD_CK2_1 363 369 PF00069 0.547
MOD_CK2_1 741 747 PF00069 0.689
MOD_CK2_1 793 799 PF00069 0.666
MOD_CK2_1 863 869 PF00069 0.313
MOD_CK2_1 96 102 PF00069 0.363
MOD_GlcNHglycan 170 173 PF01048 0.752
MOD_GlcNHglycan 206 209 PF01048 0.674
MOD_GlcNHglycan 304 307 PF01048 0.724
MOD_GlcNHglycan 346 349 PF01048 0.724
MOD_GlcNHglycan 361 364 PF01048 0.645
MOD_GlcNHglycan 388 391 PF01048 0.721
MOD_GlcNHglycan 401 404 PF01048 0.740
MOD_GlcNHglycan 420 423 PF01048 0.766
MOD_GlcNHglycan 431 434 PF01048 0.694
MOD_GlcNHglycan 438 441 PF01048 0.663
MOD_GlcNHglycan 450 453 PF01048 0.664
MOD_GlcNHglycan 528 531 PF01048 0.720
MOD_GlcNHglycan 6 9 PF01048 0.603
MOD_GlcNHglycan 64 67 PF01048 0.525
MOD_GlcNHglycan 661 664 PF01048 0.509
MOD_GlcNHglycan 686 689 PF01048 0.348
MOD_GlcNHglycan 743 746 PF01048 0.465
MOD_GlcNHglycan 795 798 PF01048 0.525
MOD_GlcNHglycan 842 845 PF01048 0.375
MOD_GSK3_1 156 163 PF00069 0.468
MOD_GSK3_1 197 204 PF00069 0.556
MOD_GSK3_1 210 217 PF00069 0.483
MOD_GSK3_1 246 253 PF00069 0.414
MOD_GSK3_1 359 366 PF00069 0.544
MOD_GSK3_1 399 406 PF00069 0.539
MOD_GSK3_1 416 423 PF00069 0.509
MOD_GSK3_1 431 438 PF00069 0.551
MOD_GSK3_1 442 449 PF00069 0.520
MOD_GSK3_1 453 460 PF00069 0.475
MOD_GSK3_1 475 482 PF00069 0.588
MOD_GSK3_1 509 516 PF00069 0.516
MOD_GSK3_1 612 619 PF00069 0.321
MOD_GSK3_1 659 666 PF00069 0.716
MOD_GSK3_1 778 785 PF00069 0.655
MOD_N-GLC_1 109 114 PF02516 0.447
MOD_N-GLC_1 198 203 PF02516 0.692
MOD_N-GLC_1 435 440 PF02516 0.795
MOD_N-GLC_1 509 514 PF02516 0.764
MOD_N-GLC_1 570 575 PF02516 0.754
MOD_NEK2_1 158 163 PF00069 0.513
MOD_NEK2_1 216 221 PF00069 0.410
MOD_NEK2_1 358 363 PF00069 0.473
MOD_NEK2_1 418 423 PF00069 0.500
MOD_NEK2_1 557 562 PF00069 0.544
MOD_NEK2_1 665 670 PF00069 0.661
MOD_NEK2_1 684 689 PF00069 0.208
MOD_NEK2_1 73 78 PF00069 0.363
MOD_NEK2_1 792 797 PF00069 0.716
MOD_NEK2_1 840 845 PF00069 0.375
MOD_NEK2_1 855 860 PF00069 0.296
MOD_NEK2_2 160 165 PF00069 0.465
MOD_NEK2_2 863 868 PF00069 0.297
MOD_PIKK_1 10 16 PF00454 0.439
MOD_PIKK_1 403 409 PF00454 0.558
MOD_PK_1 24 30 PF00069 0.248
MOD_PK_1 675 681 PF00069 0.677
MOD_PKA_1 190 196 PF00069 0.516
MOD_PKA_1 211 217 PF00069 0.453
MOD_PKA_1 24 30 PF00069 0.363
MOD_PKA_2 197 203 PF00069 0.573
MOD_PKA_2 211 217 PF00069 0.542
MOD_PKA_2 24 30 PF00069 0.363
MOD_PKA_2 344 350 PF00069 0.529
MOD_PKA_2 358 364 PF00069 0.475
MOD_PKA_2 397 403 PF00069 0.550
MOD_PKA_2 436 442 PF00069 0.486
MOD_PKA_2 457 463 PF00069 0.472
MOD_PKA_2 73 79 PF00069 0.248
MOD_PKA_2 758 764 PF00069 0.675
MOD_PKA_2 855 861 PF00069 0.314
MOD_PKB_1 471 479 PF00069 0.591
MOD_Plk_1 570 576 PF00069 0.533
MOD_Plk_1 634 640 PF00069 0.733
MOD_Plk_1 96 102 PF00069 0.363
MOD_Plk_2-3 316 322 PF00069 0.524
MOD_Plk_4 143 149 PF00069 0.362
MOD_Plk_4 232 238 PF00069 0.354
MOD_Plk_4 250 256 PF00069 0.267
MOD_Plk_4 551 557 PF00069 0.437
MOD_Plk_4 616 622 PF00069 0.513
MOD_Plk_4 707 713 PF00069 0.348
MOD_Plk_4 843 849 PF00069 0.399
MOD_Plk_4 863 869 PF00069 0.286
MOD_Plk_4 90 96 PF00069 0.324
MOD_ProDKin_1 217 223 PF00069 0.410
MOD_ProDKin_1 369 375 PF00069 0.557
MOD_ProDKin_1 407 413 PF00069 0.588
MOD_ProDKin_1 475 481 PF00069 0.588
MOD_ProDKin_1 593 599 PF00069 0.509
MOD_ProDKin_1 606 612 PF00069 0.255
MOD_ProDKin_1 68 74 PF00069 0.363
MOD_ProDKin_1 809 815 PF00069 0.680
MOD_SUMO_rev_2 891 895 PF00179 0.614
TRG_AP2beta_CARGO_1 248 258 PF09066 0.352
TRG_DiLeu_BaLyEn_6 827 832 PF01217 0.579
TRG_ENDOCYTIC_2 154 157 PF00928 0.412
TRG_ENDOCYTIC_2 880 883 PF00928 0.428
TRG_ER_diArg_1 257 259 PF00400 0.349
TRG_ER_diArg_1 341 344 PF00400 0.472
TRG_ER_diArg_1 471 474 PF00400 0.596
TRG_ER_diArg_1 671 673 PF00400 0.649
TRG_ER_diArg_1 73 75 PF00400 0.248
TRG_ER_diArg_1 737 740 PF00400 0.698
TRG_Pf-PMV_PEXEL_1 494 498 PF00026 0.738
TRG_Pf-PMV_PEXEL_1 887 891 PF00026 0.428

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8II65 Leishmania donovani 83% 100%
A4HMY6 Leishmania braziliensis 52% 100%
A4IBL0 Leishmania infantum 83% 100%
E9B6J8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 76% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS