Phosphoglycerate mutase family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania major

UniProt:

E9AFE3_LEIMA

TriTrypDb:

LmjF.35.3190 , LMJLV39_350039300 , LMJSD75_350038700

Length:

902

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

E9AFE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.518
CLV_C14_Caspase3-7	177	181	PF00656	0.464
CLV_C14_Caspase3-7	228	232	PF00656	0.392
CLV_C14_Caspase3-7	23	27	PF00656	0.363
CLV_C14_Caspase3-7	280	284	PF00656	0.456
CLV_C14_Caspase3-7	590	594	PF00656	0.534
CLV_C14_Caspase3-7	777	781	PF00656	0.648
CLV_C14_Caspase3-7	893	897	PF00656	0.604
CLV_NRD_NRD_1	189	191	PF00675	0.727
CLV_NRD_NRD_1	24	26	PF00675	0.563

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8II65	Leishmania donovani	83%	100%
A4HMY6	Leishmania braziliensis	52%	100%
A4IBL0	Leishmania infantum	83%	100%
E9B6J8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%

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