LeishMANIAdb
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PABC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PABC domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFE2_LEIMA
TriTrypDb:
LmjF.35.3180 * , LMJLV39_350039200 * , LMJSD75_350038600 *
Length:
192

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFE2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE2

Putative motif mimicry

Leishmania From To Domain/Motif Score
DEG_MDM2_SWIB_1 43 51 PF02201 0.407
DEG_Nend_UBRbox_1 1 4 PF02207 0.578
DOC_CKS1_1 1 6 PF01111 0.580
DOC_PP4_MxPP_1 65 68 PF00568 0.488
DOC_USP7_MATH_2 17 23 PF00917 0.616
LIG_APCC_ABBA_1 160 165 PF00400 0.641
LIG_Clathr_ClatBox_1 112 116 PF01394 0.378
LIG_EH1_1 56 64 PF00400 0.418
LIG_FHA_1 1 7 PF00498 0.629
LIG_FHA_2 36 42 PF00498 0.441
LIG_Integrin_RGD_1 140 142 PF01839 0.636
LIG_LIR_Gen_1 41 51 PF02991 0.397
LIG_Pex14_2 43 47 PF04695 0.416
LIG_SH2_STAP1 74 78 PF00017 0.467
LIG_SH2_STAT3 49 52 PF00017 0.464
LIG_SH2_STAT5 49 52 PF00017 0.464
LIG_SH2_STAT5 82 85 PF00017 0.503
LIG_SH3_3 9 15 PF00018 0.772
LIG_TRAF2_1 170 173 PF00917 0.525
MOD_CK2_1 167 173 PF00069 0.686
MOD_CK2_1 35 41 PF00069 0.435
MOD_GlcNHglycan 187 190 PF01048 0.646
MOD_GlcNHglycan 21 24 PF01048 0.686
MOD_GSK3_1 72 79 PF00069 0.508
MOD_N-GLC_2 130 132 PF02516 0.583
MOD_NEK2_1 18 23 PF00069 0.738
MOD_PKA_2 41 47 PF00069 0.448
MOD_Plk_2-3 35 41 PF00069 0.434
MOD_Plk_2-3 76 82 PF00069 0.418
TRG_DiLeu_BaEn_1 172 177 PF01217 0.506
TRG_DiLeu_BaEn_1 58 63 PF01217 0.412
TRG_DiLeu_BaEn_4 172 178 PF01217 0.507

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P562 Leptomonas seymouri 57% 70%
A0A3S7X9I8 Leishmania donovani 89% 100%
A4HMY5 Leishmania braziliensis 70% 98%
A4IBK9 Leishmania infantum 88% 100%
E9B6J7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS