Riboflavin kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Riboflavin kinase

Gene product:

riboflavin kinase/fmn adenylyltransferase-like protein

Species:

Leishmania major

UniProt:

E9AFE0_LEIMA

TriTrypDb:

LmjF.35.3160 , LMJLV39_350039000 , LMJSD75_350038400

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFE0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006766	vitamin metabolic process	3	12
GO:0006767	water-soluble vitamin metabolic process	4	12
GO:0006771	riboflavin metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009110	vitamin biosynthetic process	4	12
GO:0009117	nucleotide metabolic process	5	12
GO:0009123	nucleoside monophosphate metabolic process	5	12
GO:0009124	nucleoside monophosphate biosynthetic process	6	12
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	12
GO:0009161	ribonucleoside monophosphate metabolic process	6	12
GO:0009165	nucleotide biosynthetic process	6	12
GO:0009231	riboflavin biosynthetic process	6	12
GO:0009259	ribonucleotide metabolic process	5	12
GO:0009260	ribonucleotide biosynthetic process	6	12
GO:0009398	FMN biosynthetic process	6	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0019637	organophosphate metabolic process	3	12
GO:0019693	ribose phosphate metabolic process	4	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0042364	water-soluble vitamin biosynthetic process	5	12
GO:0042726	flavin-containing compound metabolic process	4	12
GO:0042727	flavin-containing compound biosynthetic process	5	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0044281	small molecule metabolic process	2	12
GO:0044283	small molecule biosynthetic process	3	12
GO:0046390	ribose phosphate biosynthetic process	5	12
GO:0046444	FMN metabolic process	5	12
GO:0046483	heterocycle metabolic process	3	12
GO:0055086	nucleobase-containing small molecule metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901293	nucleoside phosphate biosynthetic process	5	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901566	organonitrogen compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008531	riboflavin kinase activity	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0016779	nucleotidyltransferase activity	4	7
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	112	116	PF00082	0.455
DOC_PP2B_LxvP_1	146	149	PF13499	0.571
DOC_PP4_FxxP_1	37	40	PF00568	0.422
LIG_14-3-3_CanoR_1	112	117	PF00244	0.419
LIG_14-3-3_CanoR_1	118	125	PF00244	0.419
LIG_BRCT_BRCA1_1	176	180	PF00533	0.527
LIG_FHA_1	23	29	PF00498	0.322
LIG_FHA_2	124	130	PF00498	0.378
LIG_LIR_Apic_2	36	40	PF02991	0.422
LIG_LIR_Gen_1	123	132	PF02991	0.435
LIG_LIR_Gen_1	177	183	PF02991	0.569
LIG_LIR_Nem_3	105	110	PF02991	0.353
LIG_LIR_Nem_3	123	128	PF02991	0.275
LIG_LIR_Nem_3	150	154	PF02991	0.513
LIG_LIR_Nem_3	177	183	PF02991	0.542
LIG_PDZ_Class_2	178	183	PF00595	0.544
LIG_Pex14_2	98	102	PF04695	0.359
LIG_PTB_Apo_2	81	88	PF02174	0.350
LIG_SH2_CRK	107	111	PF00017	0.312
LIG_SH2_GRB2like	41	44	PF00017	0.450
LIG_SH2_STAP1	41	45	PF00017	0.450
LIG_SH3_3	68	74	PF00018	0.498
LIG_SUMO_SIM_par_1	112	117	PF11976	0.365
LIG_TRAF2_1	127	130	PF00917	0.481
MOD_CK1_1	123	129	PF00069	0.395
MOD_CK2_1	123	129	PF00069	0.402
MOD_GlcNHglycan	122	125	PF01048	0.455
MOD_GlcNHglycan	91	95	PF01048	0.413
MOD_GSK3_1	120	127	PF00069	0.455
MOD_NEK2_1	77	82	PF00069	0.348
MOD_PIKK_1	118	124	PF00454	0.481
MOD_PIKK_1	16	22	PF00454	0.350
MOD_PKB_1	118	126	PF00069	0.404
MOD_Plk_2-3	56	62	PF00069	0.365
TRG_ENDOCYTIC_2	107	110	PF00928	0.350
TRG_ENDOCYTIC_2	41	44	PF00928	0.347
TRG_ER_diArg_1	6	9	PF00400	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K3	Leptomonas seymouri	64%	98%
A0A0S4JJJ4	Bodo saltans	46%	98%
A0A1X0P5M5	Trypanosomatidae	43%	100%
A0A3R7RGI7	Trypanosoma rangeli	47%	100%
A0A3S7X9I7	Leishmania donovani	95%	100%
A1C603	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	31%	86%
A1DG00	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	29%	84%
A2QFH1	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	30%	86%
A3M0C9	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	35%	100%
A4HMY3	Leishmania braziliensis	84%	100%
A4IBK7	Leishmania infantum	95%	100%
A4QQ05	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	37%	92%
A5DAH9	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	31%	100%
A5E1A0	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	31%	100%
C9ZZ35	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9B6J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O74866	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	100%
O76206	Drosophila melanogaster	33%	100%
P0C5D9	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	34%	78%
Q03778	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	84%
Q0CHR1	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	31%	89%
Q2UMM4	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	30%	92%
Q4WHD2	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	30%	86%
Q5AW61	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	32%	87%
Q6CG11	Yarrowia lipolytica (strain CLIB 122 / E 150)	30%	95%
Q6CT57	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	32%	99%
Q6FM49	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	27%	97%
Q6M923	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	31%	77%
Q75DY2	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	31%	98%
Q8CFV9	Mus musculus	37%	100%
Q969G6	Homo sapiens	36%	100%
V5DUW4	Trypanosoma cruzi	46%	100%