Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

class I transcription factor A, subunit 2, putative

Species:

Leishmania major

UniProt:

E9AFD9_LEIMA

TriTrypDb:

LmjF.35.3150 , LMJLV39_350038800 , LMJSD75_350038200

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.617
CLV_C14_Caspase3-7	405	409	PF00656	0.724
CLV_NRD_NRD_1	143	145	PF00675	0.629
CLV_NRD_NRD_1	155	157	PF00675	0.675
CLV_NRD_NRD_1	226	228	PF00675	0.549
CLV_NRD_NRD_1	249	251	PF00675	0.464
CLV_NRD_NRD_1	295	297	PF00675	0.651
CLV_NRD_NRD_1	316	318	PF00675	0.604
CLV_NRD_NRD_1	375	377	PF00675	0.730
CLV_NRD_NRD_1	436	438	PF00675	0.708
CLV_NRD_NRD_1	486	488	PF00675	0.663
CLV_NRD_NRD_1	496	498	PF00675	0.561
CLV_NRD_NRD_1	91	93	PF00675	0.596
CLV_PCSK_KEX2_1	143	145	PF00082	0.629
CLV_PCSK_KEX2_1	155	157	PF00082	0.675
CLV_PCSK_KEX2_1	226	228	PF00082	0.484
CLV_PCSK_KEX2_1	249	251	PF00082	0.466
CLV_PCSK_KEX2_1	316	318	PF00082	0.575
CLV_PCSK_KEX2_1	34	36	PF00082	0.584
CLV_PCSK_KEX2_1	362	364	PF00082	0.754
CLV_PCSK_KEX2_1	436	438	PF00082	0.704
CLV_PCSK_KEX2_1	485	487	PF00082	0.689
CLV_PCSK_KEX2_1	496	498	PF00082	0.608
CLV_PCSK_KEX2_1	91	93	PF00082	0.579
CLV_PCSK_PC1ET2_1	34	36	PF00082	0.584
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.754
CLV_PCSK_PC7_1	358	364	PF00082	0.756
CLV_PCSK_PC7_1	492	498	PF00082	0.646
CLV_PCSK_SKI1_1	115	119	PF00082	0.526
CLV_PCSK_SKI1_1	270	274	PF00082	0.569
CLV_PCSK_SKI1_1	316	320	PF00082	0.656
CLV_PCSK_SKI1_1	496	500	PF00082	0.645
CLV_PCSK_SKI1_1	86	90	PF00082	0.629
DEG_APCC_DBOX_1	229	237	PF00400	0.588
DEG_SPOP_SBC_1	423	427	PF00917	0.694
DOC_CKS1_1	13	18	PF01111	0.571
DOC_CKS1_1	271	276	PF01111	0.574
DOC_CYCLIN_RxL_1	218	229	PF00134	0.527
DOC_MAPK_gen_1	237	245	PF00069	0.496
DOC_MAPK_gen_1	316	324	PF00069	0.595
DOC_MAPK_gen_1	376	386	PF00069	0.736
DOC_MAPK_MEF2A_6	377	386	PF00069	0.615
DOC_MAPK_MEF2A_6	468	477	PF00069	0.664
DOC_PP1_RVXF_1	219	226	PF00149	0.503
DOC_PP1_RVXF_1	84	91	PF00149	0.627
DOC_PP2B_LxvP_1	475	478	PF13499	0.715
DOC_USP7_MATH_1	166	170	PF00917	0.692
DOC_USP7_MATH_1	424	428	PF00917	0.652
DOC_USP7_MATH_1	500	504	PF00917	0.597
DOC_USP7_MATH_1	54	58	PF00917	0.612
DOC_USP7_MATH_1	62	66	PF00917	0.531
DOC_WW_Pin1_4	12	17	PF00397	0.582
DOC_WW_Pin1_4	270	275	PF00397	0.589
DOC_WW_Pin1_4	285	290	PF00397	0.615
DOC_WW_Pin1_4	417	422	PF00397	0.708
DOC_WW_Pin1_4	97	102	PF00397	0.468
LIG_14-3-3_CanoR_1	115	125	PF00244	0.509
LIG_14-3-3_CanoR_1	128	132	PF00244	0.413
LIG_14-3-3_CanoR_1	181	191	PF00244	0.734
LIG_14-3-3_CanoR_1	237	247	PF00244	0.614
LIG_14-3-3_CanoR_1	316	324	PF00244	0.675
LIG_14-3-3_CanoR_1	509	514	PF00244	0.708
LIG_BRCT_BRCA1_1	502	506	PF00533	0.538
LIG_deltaCOP1_diTrp_1	435	445	PF00928	0.678
LIG_FHA_1	165	171	PF00498	0.636
LIG_FHA_1	200	206	PF00498	0.500
LIG_FHA_1	317	323	PF00498	0.726
LIG_FHA_1	418	424	PF00498	0.712
LIG_FHA_1	427	433	PF00498	0.661
LIG_FHA_1	446	452	PF00498	0.525
LIG_FHA_1	79	85	PF00498	0.683
LIG_FHA_2	211	217	PF00498	0.496
LIG_FHA_2	324	330	PF00498	0.640
LIG_GBD_Chelix_1	104	112	PF00786	0.522
LIG_LIR_Gen_1	259	268	PF02991	0.535
LIG_LIR_Nem_3	130	136	PF02991	0.589
LIG_LIR_Nem_3	259	265	PF02991	0.532
LIG_Pex14_2	262	266	PF04695	0.520
LIG_RPA_C_Fungi	216	228	PF08784	0.486
LIG_SH2_CRK	248	252	PF00017	0.503
LIG_SH2_CRK	471	475	PF00017	0.711
LIG_SH2_CRK	495	499	PF00017	0.655
LIG_SH3_2	16	21	PF14604	0.610
LIG_SH3_3	13	19	PF00018	0.662
LIG_SH3_3	91	97	PF00018	0.558
LIG_SUMO_SIM_anti_2	241	247	PF11976	0.448
LIG_SUMO_SIM_par_1	250	256	PF11976	0.518
LIG_SUMO_SIM_par_1	329	337	PF11976	0.563
LIG_SxIP_EBH_1	52	66	PF03271	0.619
LIG_TYR_ITIM	246	251	PF00017	0.509
MOD_CDK_SPK_2	12	17	PF00069	0.539
MOD_CK1_1	169	175	PF00069	0.681
MOD_CK1_1	187	193	PF00069	0.771
MOD_CK1_1	194	200	PF00069	0.645
MOD_CK1_1	323	329	PF00069	0.655
MOD_CK1_1	426	432	PF00069	0.693
MOD_CK1_1	446	452	PF00069	0.454
MOD_CK2_1	210	216	PF00069	0.536
MOD_CK2_1	238	244	PF00069	0.632
MOD_CK2_1	424	430	PF00069	0.693
MOD_CK2_1	62	68	PF00069	0.693
MOD_GlcNHglycan	193	196	PF01048	0.676
MOD_GlcNHglycan	279	282	PF01048	0.548
MOD_GlcNHglycan	358	361	PF01048	0.676
MOD_GlcNHglycan	426	429	PF01048	0.723
MOD_GlcNHglycan	440	443	PF01048	0.625
MOD_GlcNHglycan	445	448	PF01048	0.608
MOD_GSK3_1	183	190	PF00069	0.763
MOD_GSK3_1	266	273	PF00069	0.571
MOD_GSK3_1	316	323	PF00069	0.678
MOD_GSK3_1	352	359	PF00069	0.723
MOD_GSK3_1	419	426	PF00069	0.623
MOD_GSK3_1	44	51	PF00069	0.678
MOD_N-GLC_1	320	325	PF02516	0.643
MOD_NEK2_1	136	141	PF00069	0.624
MOD_NEK2_1	182	187	PF00069	0.697
MOD_NEK2_1	205	210	PF00069	0.498
MOD_NEK2_1	266	271	PF00069	0.525
MOD_NEK2_1	277	282	PF00069	0.593
MOD_NEK2_1	445	450	PF00069	0.776
MOD_NEK2_1	451	456	PF00069	0.676
MOD_NEK2_1	55	60	PF00069	0.626
MOD_PIKK_1	134	140	PF00454	0.500
MOD_PIKK_1	169	175	PF00454	0.607
MOD_PIKK_1	184	190	PF00454	0.739
MOD_PIKK_1	3	9	PF00454	0.566
MOD_PIKK_1	300	306	PF00454	0.579
MOD_PIKK_1	446	452	PF00454	0.671
MOD_PK_1	239	245	PF00069	0.627
MOD_PKA_1	226	232	PF00069	0.556
MOD_PKA_1	316	322	PF00069	0.676
MOD_PKA_1	486	492	PF00069	0.674
MOD_PKA_2	127	133	PF00069	0.619
MOD_PKA_2	226	232	PF00069	0.556
MOD_PKA_2	238	244	PF00069	0.617
MOD_PKA_2	316	322	PF00069	0.676
MOD_PKA_2	486	492	PF00069	0.688
MOD_PKA_2	78	84	PF00069	0.611
MOD_PKB_1	237	245	PF00069	0.638
MOD_Plk_1	320	326	PF00069	0.643
MOD_Plk_4	166	172	PF00069	0.690
MOD_Plk_4	205	211	PF00069	0.533
MOD_ProDKin_1	12	18	PF00069	0.575
MOD_ProDKin_1	270	276	PF00069	0.594
MOD_ProDKin_1	285	291	PF00069	0.616
MOD_ProDKin_1	417	423	PF00069	0.710
MOD_ProDKin_1	97	103	PF00069	0.470
MOD_SUMO_rev_2	280	289	PF00179	0.602
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.714
TRG_DiLeu_BaLyEn_6	494	499	PF01217	0.599
TRG_ENDOCYTIC_2	248	251	PF00928	0.591
TRG_ENDOCYTIC_2	471	474	PF00928	0.710
TRG_ENDOCYTIC_2	495	498	PF00928	0.664
TRG_ER_diArg_1	112	115	PF00400	0.586
TRG_ER_diArg_1	225	227	PF00400	0.532
TRG_ER_diArg_1	236	239	PF00400	0.547
TRG_ER_diArg_1	248	250	PF00400	0.411
TRG_ER_diArg_1	315	317	PF00400	0.599
TRG_ER_diArg_1	436	438	PF00400	0.696
TRG_ER_diArg_1	485	487	PF00400	0.689
TRG_ER_diArg_1	495	497	PF00400	0.586
TRG_ER_diArg_1	90	92	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	380	385	PF00026	0.549

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5S0	Leptomonas seymouri	41%	99%
A0A3R7MGU2	Trypanosoma rangeli	27%	100%
A0A3S7X9K7	Leishmania donovani	93%	100%
A4HMY2	Leishmania braziliensis	73%	100%
A4IBK6	Leishmania infantum	93%	100%
E9B6J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5C2W6	Trypanosoma cruzi	25%	100%