Kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Kinase

Gene product:

inositol polyphosphate kinase, putative

Species:

Leishmania major

UniProt:

E9AFD8_LEIMA

TriTrypDb:

LmjF.35.3140 , LMJLV39_350038700 , LMJSD75_350038100

Length:

376

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AFD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD8

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019751	polyol metabolic process	4	11
GO:0032958	inositol phosphate biosynthetic process	5	11
GO:0043647	inositol phosphate metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity	6	2
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0051765	inositol tetrakisphosphate kinase activity	5	2
GO:0051766	inositol trisphosphate kinase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	212	214	PF00675	0.480
CLV_NRD_NRD_1	33	35	PF00675	0.501
CLV_NRD_NRD_1	351	353	PF00675	0.339
CLV_PCSK_KEX2_1	212	214	PF00082	0.468
CLV_PCSK_SKI1_1	191	195	PF00082	0.384
CLV_PCSK_SKI1_1	252	256	PF00082	0.341
CLV_PCSK_SKI1_1	300	304	PF00082	0.357
CLV_PCSK_SKI1_1	96	100	PF00082	0.548
DOC_CKS1_1	182	187	PF01111	0.355
DOC_CYCLIN_yClb5_NLxxxL_5	368	374	PF00134	0.480
DOC_MAPK_MEF2A_6	167	175	PF00069	0.434
DOC_PP1_RVXF_1	172	178	PF00149	0.408
DOC_USP7_MATH_1	122	126	PF00917	0.480
DOC_USP7_MATH_1	224	228	PF00917	0.402
DOC_USP7_MATH_1	320	324	PF00917	0.335
DOC_USP7_MATH_1	83	87	PF00917	0.501
DOC_USP7_UBL2_3	194	198	PF12436	0.285
DOC_USP7_UBL2_3	96	100	PF12436	0.582
DOC_WW_Pin1_4	178	183	PF00397	0.335
DOC_WW_Pin1_4	3	8	PF00397	0.674
DOC_WW_Pin1_4	332	337	PF00397	0.402
LIG_14-3-3_CanoR_1	34	44	PF00244	0.472
LIG_14-3-3_CanoR_1	348	352	PF00244	0.360
LIG_BIR_II_1	1	5	PF00653	0.708
LIG_BIR_III_4	11	15	PF00653	0.522
LIG_BRCT_BRCA1_1	17	21	PF00533	0.577
LIG_BRCT_BRCA1_1	85	89	PF00533	0.510
LIG_FHA_1	223	229	PF00498	0.246
LIG_FHA_1	311	317	PF00498	0.338
LIG_FHA_1	336	342	PF00498	0.403
LIG_FHA_2	182	188	PF00498	0.335
LIG_FHA_2	23	29	PF00498	0.520
LIG_FHA_2	262	268	PF00498	0.446
LIG_FHA_2	279	285	PF00498	0.448
LIG_FHA_2	36	42	PF00498	0.372
LIG_LIR_Gen_1	112	122	PF02991	0.421
LIG_LIR_Gen_1	253	262	PF02991	0.424
LIG_LIR_Gen_1	37	48	PF02991	0.370
LIG_LIR_Gen_1	371	376	PF02991	0.454
LIG_LIR_Nem_3	112	117	PF02991	0.391
LIG_LIR_Nem_3	253	257	PF02991	0.389
LIG_LIR_Nem_3	349	354	PF02991	0.378
LIG_LIR_Nem_3	371	376	PF02991	0.454
LIG_PDZ_Class_2	371	376	PF00595	0.449
LIG_Pex14_1	40	44	PF04695	0.463
LIG_Pex14_2	132	136	PF04695	0.487
LIG_Pex14_2	89	93	PF04695	0.475
LIG_Rb_pABgroove_1	324	332	PF01858	0.408
LIG_REV1ctd_RIR_1	303	309	PF16727	0.489
LIG_SH2_NCK_1	330	334	PF00017	0.355
LIG_SH2_SRC	214	217	PF00017	0.424
LIG_SH2_STAP1	330	334	PF00017	0.434
LIG_SH2_STAT5	214	217	PF00017	0.367
LIG_SH2_STAT5	373	376	PF00017	0.543
LIG_SH2_STAT5	45	48	PF00017	0.350
LIG_SH3_1	179	185	PF00018	0.355
LIG_SH3_3	124	130	PF00018	0.530
LIG_SH3_3	179	185	PF00018	0.355
LIG_SUMO_SIM_anti_2	325	331	PF11976	0.361
LIG_SUMO_SIM_par_1	325	331	PF11976	0.342
LIG_UBA3_1	88	96	PF00899	0.497
LIG_WRC_WIRS_1	251	256	PF05994	0.368
MOD_CDK_SPxxK_3	181	188	PF00069	0.355
MOD_CK1_1	181	187	PF00069	0.335
MOD_CK1_1	335	341	PF00069	0.373
MOD_CK2_1	103	109	PF00069	0.328
MOD_CK2_1	278	284	PF00069	0.447
MOD_CK2_1	35	41	PF00069	0.397
MOD_GlcNHglycan	1	4	PF01048	0.718
MOD_GlcNHglycan	100	103	PF01048	0.578
MOD_GlcNHglycan	160	165	PF01048	0.454
MOD_GlcNHglycan	322	325	PF01048	0.432
MOD_GSK3_1	218	225	PF00069	0.285
MOD_GSK3_1	246	253	PF00069	0.330
MOD_GSK3_1	276	283	PF00069	0.432
MOD_GSK3_1	83	90	PF00069	0.502
MOD_GSK3_1	96	103	PF00069	0.351
MOD_NEK2_1	346	351	PF00069	0.441
MOD_NEK2_1	356	361	PF00069	0.441
MOD_NEK2_1	84	89	PF00069	0.500
MOD_NEK2_1	98	103	PF00069	0.549
MOD_NEK2_2	29	34	PF00069	0.526
MOD_PKA_1	34	40	PF00069	0.385
MOD_PKA_2	201	207	PF00069	0.410
MOD_PKA_2	29	35	PF00069	0.506
MOD_PKA_2	347	353	PF00069	0.378
MOD_Plk_1	283	289	PF00069	0.490
MOD_Plk_1	356	362	PF00069	0.396
MOD_Plk_2-3	298	304	PF00069	0.363
MOD_Plk_4	103	109	PF00069	0.554
MOD_Plk_4	16	22	PF00069	0.573
MOD_Plk_4	250	256	PF00069	0.396
MOD_Plk_4	298	304	PF00069	0.454
MOD_Plk_4	310	316	PF00069	0.329
MOD_Plk_4	322	328	PF00069	0.302
MOD_Plk_4	369	375	PF00069	0.381
MOD_Plk_4	84	90	PF00069	0.370
MOD_ProDKin_1	178	184	PF00069	0.335
MOD_ProDKin_1	3	9	PF00069	0.666
MOD_ProDKin_1	332	338	PF00069	0.402
MOD_SUMO_rev_2	181	190	PF00179	0.408
MOD_SUMO_rev_2	301	310	PF00179	0.246
TRG_DiLeu_BaEn_1	266	271	PF01217	0.246
TRG_DiLeu_BaEn_1	298	303	PF01217	0.441
TRG_ENDOCYTIC_2	373	376	PF00928	0.532
TRG_ENDOCYTIC_2	45	48	PF00928	0.350
TRG_ER_diArg_1	212	214	PF00400	0.480
TRG_ER_diArg_1	285	288	PF00400	0.421
TRG_NES_CRM1_1	317	331	PF08389	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKC0	Leptomonas seymouri	60%	100%
A0A1X0NEH0	Trypanosomatidae	32%	100%
A0A3S7X9M0	Leishmania donovani	90%	100%
A0A422N9V2	Trypanosoma rangeli	31%	100%
A4HMY1	Leishmania braziliensis	75%	100%
A4IBK5	Leishmania infantum	90%	100%
C9ZZ39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B6J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BTG0	Trypanosoma cruzi	33%	100%