Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain type 1, putative

Species:

Leishmania major

UniProt:

E9AFD7_LEIMA

TriTrypDb:

LmjF.35.3130 , LMJLV39_350038600 , LMJSD75_350038000

Length:

173

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005874	microtubule	6	12
GO:0005875	microtubule associated complex	2	12
GO:0005930	axoneme	2	2
GO:0030286	dynein complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:1902494	catalytic complex	2	12

Expansion

Sequence features

E9AFD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD7

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.502
CLV_NRD_NRD_1	99	101	PF00675	0.518
CLV_PCSK_KEX2_1	106	108	PF00082	0.671
CLV_PCSK_KEX2_1	152	154	PF00082	0.302
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.336
CLV_PCSK_SKI1_1	115	119	PF00082	0.303
CLV_PCSK_SKI1_1	127	131	PF00082	0.258
DEG_APCC_DBOX_1	114	122	PF00400	0.284
DOC_PP1_RVXF_1	150	157	PF00149	0.536
LIG_14-3-3_CanoR_1	58	64	PF00244	0.538
LIG_14-3-3_CanoR_1	85	94	PF00244	0.511
LIG_14-3-3_CanoR_1	96	100	PF00244	0.426
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_BIR_III_4	48	52	PF00653	0.543
LIG_BRCT_BRCA1_1	40	44	PF00533	0.660
LIG_FHA_1	128	134	PF00498	0.528
LIG_KLC1_Yacidic_2	65	70	PF13176	0.428
LIG_LIR_Gen_1	144	149	PF02991	0.459
LIG_LIR_Gen_1	65	76	PF02991	0.415
LIG_LIR_Nem_3	144	148	PF02991	0.458
LIG_LIR_Nem_3	65	71	PF02991	0.415
LIG_Pex14_1	137	141	PF04695	0.433
LIG_SH2_PTP2	68	71	PF00017	0.432
LIG_SH2_STAT5	124	127	PF00017	0.450
LIG_SH2_STAT5	68	71	PF00017	0.373
LIG_SH3_3	88	94	PF00018	0.426
LIG_WRC_WIRS_1	145	150	PF05994	0.524
MOD_CK1_1	30	36	PF00069	0.556
MOD_CK2_1	20	26	PF00069	0.590
MOD_GlcNHglycan	81	84	PF01048	0.487
MOD_GSK3_1	12	19	PF00069	0.681
MOD_GSK3_1	29	36	PF00069	0.623
MOD_N-GLC_1	30	35	PF02516	0.617
MOD_NEK2_1	12	17	PF00069	0.678
MOD_PIKK_1	16	22	PF00454	0.638
MOD_PKA_2	16	22	PF00069	0.607
MOD_PKA_2	57	63	PF00069	0.619
MOD_PKA_2	95	101	PF00069	0.555
MOD_Plk_1	113	119	PF00069	0.314
MOD_Plk_1	12	18	PF00069	0.772
MOD_Plk_1	30	36	PF00069	0.697
MOD_Plk_4	144	150	PF00069	0.433
MOD_Plk_4	30	36	PF00069	0.694
TRG_ENDOCYTIC_2	68	71	PF00928	0.354
TRG_Pf-PMV_PEXEL_1	107	112	PF00026	0.642

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBR6	Leptomonas seymouri	63%	98%
A0A0S4JHJ3	Bodo saltans	51%	100%
A0A1X0NDA2	Trypanosomatidae	56%	100%
A0A3R7LS25	Trypanosoma rangeli	55%	100%
A0A3S7X9I0	Leishmania donovani	96%	100%
A4HMY0	Leishmania braziliensis	82%	99%
A4IBK4	Leishmania infantum	96%	100%
C9ZZ40	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B6J2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BTL8	Trypanosoma cruzi	58%	100%