Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 7

Species:

Leishmania major

UniProt:

E9AFD5_LEIMA

TriTrypDb:

LmjF.35.3110 , LMJLV39_350038400 , LMJSD75_350037800

Length:

602

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	5
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AFD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.587
CLV_C14_Caspase3-7	39	43	PF00656	0.676
CLV_NRD_NRD_1	194	196	PF00675	0.495
CLV_NRD_NRD_1	251	253	PF00675	0.561
CLV_NRD_NRD_1	28	30	PF00675	0.386
CLV_NRD_NRD_1	351	353	PF00675	0.475
CLV_NRD_NRD_1	37	39	PF00675	0.399
CLV_NRD_NRD_1	554	556	PF00675	0.373
CLV_NRD_NRD_1	8	10	PF00675	0.520
CLV_PCSK_KEX2_1	194	196	PF00082	0.495
CLV_PCSK_KEX2_1	253	255	PF00082	0.596
CLV_PCSK_KEX2_1	27	29	PF00082	0.395
CLV_PCSK_KEX2_1	32	34	PF00082	0.401
CLV_PCSK_KEX2_1	37	39	PF00082	0.419
CLV_PCSK_KEX2_1	554	556	PF00082	0.373
CLV_PCSK_KEX2_1	8	10	PF00082	0.441
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.486
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.422
CLV_PCSK_PC7_1	28	34	PF00082	0.426
CLV_PCSK_SKI1_1	563	567	PF00082	0.354
DEG_Nend_UBRbox_2	1	3	PF02207	0.464
DEG_SPOP_SBC_1	531	535	PF00917	0.557
DOC_ANK_TNKS_1	112	119	PF00023	0.606
DOC_ANK_TNKS_1	241	248	PF00023	0.664
DOC_MAPK_DCC_7	53	61	PF00069	0.575
DOC_MAPK_gen_1	317	326	PF00069	0.667
DOC_MAPK_HePTP_8	314	326	PF00069	0.609
DOC_MAPK_MEF2A_6	317	326	PF00069	0.609
DOC_MAPK_MEF2A_6	365	373	PF00069	0.586
DOC_MAPK_MEF2A_6	53	61	PF00069	0.595
DOC_PP2B_LxvP_1	324	327	PF13499	0.637
DOC_PP2B_LxvP_1	87	90	PF13499	0.624
DOC_PP4_FxxP_1	341	344	PF00568	0.794
DOC_PP4_FxxP_1	397	400	PF00568	0.523
DOC_PP4_FxxP_1	77	80	PF00568	0.579
DOC_USP7_MATH_1	106	110	PF00917	0.668
DOC_USP7_MATH_1	241	245	PF00917	0.658
DOC_USP7_MATH_1	287	291	PF00917	0.587
DOC_USP7_MATH_1	294	298	PF00917	0.566
DOC_USP7_MATH_1	300	304	PF00917	0.631
DOC_USP7_MATH_1	345	349	PF00917	0.744
DOC_USP7_MATH_1	351	355	PF00917	0.656
DOC_USP7_MATH_1	434	438	PF00917	0.714
DOC_WW_Pin1_4	168	173	PF00397	0.622
DOC_WW_Pin1_4	256	261	PF00397	0.830
DOC_WW_Pin1_4	371	376	PF00397	0.556
DOC_WW_Pin1_4	488	493	PF00397	0.582
LIG_14-3-3_CanoR_1	104	111	PF00244	0.773
LIG_14-3-3_CanoR_1	194	200	PF00244	0.711
LIG_14-3-3_CanoR_1	201	208	PF00244	0.582
LIG_14-3-3_CanoR_1	338	344	PF00244	0.603
LIG_14-3-3_CanoR_1	352	361	PF00244	0.619
LIG_14-3-3_CanoR_1	37	41	PF00244	0.638
LIG_14-3-3_CanoR_1	387	393	PF00244	0.540
LIG_14-3-3_CanoR_1	554	560	PF00244	0.574
LIG_14-3-3_CanoR_1	563	568	PF00244	0.591
LIG_14-3-3_CanoR_1	9	18	PF00244	0.297
LIG_BRCT_BRCA1_1	393	397	PF00533	0.600
LIG_deltaCOP1_diTrp_1	577	586	PF00928	0.602
LIG_FHA_1	11	17	PF00498	0.355
LIG_FHA_1	122	128	PF00498	0.569
LIG_FHA_1	278	284	PF00498	0.621
LIG_FHA_1	365	371	PF00498	0.525
LIG_FHA_1	439	445	PF00498	0.716
LIG_FHA_1	503	509	PF00498	0.663
LIG_FHA_1	556	562	PF00498	0.510
LIG_FHA_1	564	570	PF00498	0.501
LIG_FHA_1	590	596	PF00498	0.575
LIG_FHA_2	139	145	PF00498	0.686
LIG_FHA_2	260	266	PF00498	0.755
LIG_FHA_2	355	361	PF00498	0.689
LIG_FHA_2	37	43	PF00498	0.667
LIG_FHA_2	523	529	PF00498	0.640
LIG_FHA_2	533	539	PF00498	0.605
LIG_FHA_2	572	578	PF00498	0.580
LIG_GBD_Chelix_1	48	56	PF00786	0.403
LIG_HP1_1	284	288	PF01393	0.556
LIG_LIR_Apic_2	394	400	PF02991	0.563
LIG_LIR_Apic_2	445	451	PF02991	0.664
LIG_LIR_Apic_2	558	562	PF02991	0.499
LIG_LIR_Gen_1	202	208	PF02991	0.570
LIG_LIR_Gen_1	391	400	PF02991	0.641
LIG_LIR_Gen_1	505	510	PF02991	0.570
LIG_LIR_Nem_3	130	134	PF02991	0.638
LIG_LIR_Nem_3	202	206	PF02991	0.571
LIG_LIR_Nem_3	391	396	PF02991	0.630
LIG_LIR_Nem_3	476	482	PF02991	0.623
LIG_LIR_Nem_3	505	509	PF02991	0.570
LIG_Pex14_2	199	203	PF04695	0.655
LIG_Pex14_2	231	235	PF04695	0.610
LIG_Pex14_2	393	397	PF04695	0.502
LIG_Pex14_2	453	457	PF04695	0.619
LIG_PTB_Apo_2	516	523	PF02174	0.520
LIG_SH2_CRK	222	226	PF00017	0.508
LIG_SH2_CRK	311	315	PF00017	0.644
LIG_SH2_NCK_1	222	226	PF00017	0.508
LIG_SH2_PTP2	448	451	PF00017	0.617
LIG_SH2_PTP2	559	562	PF00017	0.499
LIG_SH2_SRC	361	364	PF00017	0.573
LIG_SH2_SRC	65	68	PF00017	0.604
LIG_SH2_STAP1	222	226	PF00017	0.508
LIG_SH2_STAT5	131	134	PF00017	0.609
LIG_SH2_STAT5	222	225	PF00017	0.503
LIG_SH2_STAT5	448	451	PF00017	0.684
LIG_SH2_STAT5	498	501	PF00017	0.615
LIG_SH2_STAT5	559	562	PF00017	0.512
LIG_SH2_STAT5	65	68	PF00017	0.602
LIG_SH3_2	347	352	PF14604	0.652
LIG_SH3_3	278	284	PF00018	0.633
LIG_SH3_3	334	340	PF00018	0.678
LIG_SH3_3	341	347	PF00018	0.725
LIG_SH3_3	413	419	PF00018	0.653
LIG_SH3_3	463	469	PF00018	0.609
LIG_SH3_3	497	503	PF00018	0.646
LIG_SH3_3	69	75	PF00018	0.593
LIG_SUMO_SIM_anti_2	223	230	PF11976	0.624
LIG_SUMO_SIM_anti_2	367	372	PF11976	0.480
LIG_SUMO_SIM_anti_2	566	571	PF11976	0.527
LIG_SUMO_SIM_par_1	284	291	PF11976	0.569
LIG_SUMO_SIM_par_1	366	372	PF11976	0.615
LIG_TYR_ITIM	477	482	PF00017	0.538
LIG_WRC_WIRS_1	370	375	PF05994	0.667
MOD_CDK_SPK_2	488	493	PF00069	0.582
MOD_CK1_1	105	111	PF00069	0.669
MOD_CK1_1	354	360	PF00069	0.734
MOD_CK1_1	364	370	PF00069	0.577
MOD_CK1_1	411	417	PF00069	0.650
MOD_CK2_1	106	112	PF00069	0.660
MOD_CK2_1	259	265	PF00069	0.718
MOD_CK2_1	354	360	PF00069	0.782
MOD_CK2_1	522	528	PF00069	0.630
MOD_CK2_1	532	538	PF00069	0.621
MOD_CK2_1	571	577	PF00069	0.565
MOD_Cter_Amidation	192	195	PF01082	0.470
MOD_Cter_Amidation	250	253	PF01082	0.525
MOD_GlcNHglycan	104	107	PF01048	0.468
MOD_GlcNHglycan	13	16	PF01048	0.390
MOD_GlcNHglycan	185	188	PF01048	0.558
MOD_GlcNHglycan	243	246	PF01048	0.611
MOD_GlcNHglycan	248	252	PF01048	0.540
MOD_GlcNHglycan	256	259	PF01048	0.471
MOD_GlcNHglycan	388	391	PF01048	0.449
MOD_GlcNHglycan	393	396	PF01048	0.453
MOD_GlcNHglycan	410	413	PF01048	0.463
MOD_GlcNHglycan	462	465	PF01048	0.471
MOD_GlcNHglycan	538	542	PF01048	0.352
MOD_GlcNHglycan	99	103	PF01048	0.591
MOD_GSK3_1	117	124	PF00069	0.661
MOD_GSK3_1	179	186	PF00069	0.750
MOD_GSK3_1	195	202	PF00069	0.630
MOD_GSK3_1	237	244	PF00069	0.720
MOD_GSK3_1	252	259	PF00069	0.834
MOD_GSK3_1	369	376	PF00069	0.612
MOD_GSK3_1	434	441	PF00069	0.730
MOD_GSK3_1	469	476	PF00069	0.665
MOD_GSK3_1	488	495	PF00069	0.571
MOD_GSK3_1	530	537	PF00069	0.599
MOD_GSK3_1	571	578	PF00069	0.606
MOD_GSK3_1	98	105	PF00069	0.755
MOD_N-GLC_1	547	552	PF02516	0.271
MOD_N-GLC_2	334	336	PF02516	0.358
MOD_NEK2_1	127	132	PF00069	0.603
MOD_NEK2_1	237	242	PF00069	0.693
MOD_NEK2_1	369	374	PF00069	0.630
MOD_NEK2_1	52	57	PF00069	0.701
MOD_NEK2_1	522	527	PF00069	0.569
MOD_NEK2_2	328	333	PF00069	0.600
MOD_PKA_1	252	258	PF00069	0.716
MOD_PKA_2	241	247	PF00069	0.661
MOD_PKA_2	351	357	PF00069	0.625
MOD_PKA_2	36	42	PF00069	0.636
MOD_PKA_2	386	392	PF00069	0.504
MOD_PKA_2	492	498	PF00069	0.567
MOD_PKA_2	550	556	PF00069	0.642
MOD_PKB_1	252	260	PF00069	0.714
MOD_Plk_1	328	334	PF00069	0.634
MOD_Plk_4	220	226	PF00069	0.497
MOD_Plk_4	364	370	PF00069	0.566
MOD_Plk_4	374	380	PF00069	0.659
MOD_Plk_4	403	409	PF00069	0.652
MOD_Plk_4	442	448	PF00069	0.638
MOD_Plk_4	473	479	PF00069	0.651
MOD_Plk_4	52	58	PF00069	0.619
MOD_Plk_4	563	569	PF00069	0.609
MOD_ProDKin_1	168	174	PF00069	0.627
MOD_ProDKin_1	256	262	PF00069	0.830
MOD_ProDKin_1	371	377	PF00069	0.565
MOD_ProDKin_1	488	494	PF00069	0.574
MOD_SUMO_rev_2	358	367	PF00179	0.614
TRG_ENDOCYTIC_2	222	225	PF00928	0.571
TRG_ENDOCYTIC_2	310	313	PF00928	0.654
TRG_ENDOCYTIC_2	479	482	PF00928	0.546
TRG_ER_diArg_1	26	29	PF00400	0.615
TRG_ER_diArg_1	554	557	PF00400	0.570
TRG_ER_diArg_1	8	10	PF00400	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVZ7	Leptomonas seymouri	45%	94%
A0A3R7NG87	Trypanosoma rangeli	27%	100%
A0A3S7X9K3	Leishmania donovani	89%	100%
A4HMX8	Leishmania braziliensis	70%	100%
A4IBK2	Leishmania infantum	89%	100%
C9ZZ42	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B6J0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5DUQ9	Trypanosoma cruzi	23%	100%