LeishMANIAdb
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Probable eukaryotic initiation factor 4A

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Probable eukaryotic initiation factor 4A
Gene product:
ATP-dependent RNA helicase, putative
Species:
Leishmania major
UniProt:
E9AFD4_LEIMA
TriTrypDb:
LmjF.35.3100 , LMJLV39_350038300 * , LMJSD75_350037700
Length:
923

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. yes yes: 2
Pissara et al. yes yes: 18
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. yes yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 3
GO:0043226 organelle 2 3
GO:0043227 membrane-bounded organelle 3 3
GO:0043229 intracellular organelle 3 3
GO:0043231 intracellular membrane-bounded organelle 4 3
GO:0110165 cellular anatomical entity 1 3
GO:0005737 cytoplasm 2 1
GO:0010494 cytoplasmic stress granule 5 1
GO:0034399 nuclear periphery 2 1
GO:0035770 ribonucleoprotein granule 3 1
GO:0036464 cytoplasmic ribonucleoprotein granule 4 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097165 nuclear stress granule 4 1
GO:0099080 supramolecular complex 2 1

Expansion

Sequence features

E9AFD4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 10
GO:0003676 nucleic acid binding 3 10
GO:0003723 RNA binding 4 3
GO:0003724 RNA helicase activity 3 10
GO:0003743 translation initiation factor activity 4 10
GO:0003824 catalytic activity 1 10
GO:0004386 helicase activity 2 10
GO:0005488 binding 1 10
GO:0005524 ATP binding 5 10
GO:0008135 translation factor activity, RNA binding 3 10
GO:0008186 ATP-dependent activity, acting on RNA 2 10
GO:0016787 hydrolase activity 2 10
GO:0017076 purine nucleotide binding 4 10
GO:0030554 adenyl nucleotide binding 5 10
GO:0032553 ribonucleotide binding 3 10
GO:0032555 purine ribonucleotide binding 4 10
GO:0032559 adenyl ribonucleotide binding 5 10
GO:0035639 purine ribonucleoside triphosphate binding 4 10
GO:0036094 small molecule binding 2 10
GO:0043167 ion binding 2 10
GO:0043168 anion binding 3 10
GO:0045182 translation regulator activity 1 10
GO:0090079 translation regulator activity, nucleic acid binding 2 10
GO:0097159 organic cyclic compound binding 2 10
GO:0097367 carbohydrate derivative binding 2 10
GO:0140098 catalytic activity, acting on RNA 3 10
GO:0140640 catalytic activity, acting on a nucleic acid 2 10
GO:0140657 ATP-dependent activity 1 10
GO:1901265 nucleoside phosphate binding 3 10
GO:1901363 heterocyclic compound binding 2 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 238 242 PF00656 0.649
CLV_C14_Caspase3-7 899 903 PF00656 0.759
CLV_NRD_NRD_1 175 177 PF00675 0.734
CLV_NRD_NRD_1 219 221 PF00675 0.729
CLV_NRD_NRD_1 234 236 PF00675 0.648
CLV_NRD_NRD_1 261 263 PF00675 0.730
CLV_NRD_NRD_1 274 276 PF00675 0.655
CLV_NRD_NRD_1 309 311 PF00675 0.742
CLV_NRD_NRD_1 316 318 PF00675 0.705
CLV_NRD_NRD_1 338 340 PF00675 0.802
CLV_NRD_NRD_1 418 420 PF00675 0.688
CLV_NRD_NRD_1 42 44 PF00675 0.753
CLV_NRD_NRD_1 427 429 PF00675 0.551
CLV_NRD_NRD_1 542 544 PF00675 0.444
CLV_NRD_NRD_1 566 568 PF00675 0.507
CLV_NRD_NRD_1 675 677 PF00675 0.533
CLV_NRD_NRD_1 737 739 PF00675 0.396
CLV_NRD_NRD_1 753 755 PF00675 0.319
CLV_NRD_NRD_1 828 830 PF00675 0.539
CLV_NRD_NRD_1 872 874 PF00675 0.749
CLV_NRD_NRD_1 913 915 PF00675 0.772
CLV_PCSK_FUR_1 314 318 PF00082 0.717
CLV_PCSK_FUR_1 40 44 PF00082 0.770
CLV_PCSK_KEX2_1 175 177 PF00082 0.734
CLV_PCSK_KEX2_1 219 221 PF00082 0.729
CLV_PCSK_KEX2_1 233 235 PF00082 0.662
CLV_PCSK_KEX2_1 261 263 PF00082 0.730
CLV_PCSK_KEX2_1 274 276 PF00082 0.655
CLV_PCSK_KEX2_1 309 311 PF00082 0.742
CLV_PCSK_KEX2_1 316 318 PF00082 0.705
CLV_PCSK_KEX2_1 338 340 PF00082 0.802
CLV_PCSK_KEX2_1 418 420 PF00082 0.720
CLV_PCSK_KEX2_1 42 44 PF00082 0.753
CLV_PCSK_KEX2_1 427 429 PF00082 0.581
CLV_PCSK_KEX2_1 671 673 PF00082 0.502
CLV_PCSK_KEX2_1 675 677 PF00082 0.506
CLV_PCSK_KEX2_1 737 739 PF00082 0.396
CLV_PCSK_KEX2_1 753 755 PF00082 0.319
CLV_PCSK_KEX2_1 828 830 PF00082 0.581
CLV_PCSK_KEX2_1 871 873 PF00082 0.745
CLV_PCSK_KEX2_1 913 915 PF00082 0.772
CLV_PCSK_PC1ET2_1 671 673 PF00082 0.502
CLV_PCSK_SKI1_1 418 422 PF00082 0.660
CLV_PCSK_SKI1_1 464 468 PF00082 0.601
CLV_PCSK_SKI1_1 567 571 PF00082 0.504
CLV_PCSK_SKI1_1 603 607 PF00082 0.396
CLV_PCSK_SKI1_1 691 695 PF00082 0.569
CLV_PCSK_SKI1_1 829 833 PF00082 0.540
DEG_Nend_UBRbox_2 1 3 PF02207 0.737
DEG_SPOP_SBC_1 686 690 PF00917 0.707
DOC_ANK_TNKS_1 883 890 PF00023 0.719
DOC_CYCLIN_RxL_1 614 625 PF00134 0.596
DOC_CYCLIN_yCln2_LP_2 476 482 PF00134 0.522
DOC_MAPK_DCC_7 766 774 PF00069 0.630
DOC_MAPK_gen_1 541 550 PF00069 0.596
DOC_MAPK_gen_1 675 683 PF00069 0.500
DOC_MAPK_gen_1 766 774 PF00069 0.661
DOC_MAPK_gen_1 825 834 PF00069 0.583
DOC_MAPK_MEF2A_6 498 505 PF00069 0.610
DOC_MAPK_MEF2A_6 543 552 PF00069 0.596
DOC_MAPK_MEF2A_6 825 834 PF00069 0.542
DOC_PP1_RVXF_1 565 572 PF00149 0.596
DOC_PP2B_LxvP_1 783 786 PF13499 0.732
DOC_PP4_FxxP_1 168 171 PF00568 0.706
DOC_PP4_FxxP_1 524 527 PF00568 0.596
DOC_PP4_FxxP_1 794 797 PF00568 0.596
DOC_USP7_MATH_1 111 115 PF00917 0.732
DOC_USP7_MATH_1 121 125 PF00917 0.704
DOC_USP7_MATH_1 361 365 PF00917 0.773
DOC_USP7_MATH_1 46 50 PF00917 0.765
DOC_WW_Pin1_4 107 112 PF00397 0.730
DOC_WW_Pin1_4 142 147 PF00397 0.706
DOC_WW_Pin1_4 362 367 PF00397 0.769
DOC_WW_Pin1_4 404 409 PF00397 0.778
DOC_WW_Pin1_4 491 496 PF00397 0.631
DOC_WW_Pin1_4 535 540 PF00397 0.596
DOC_WW_Pin1_4 767 772 PF00397 0.596
LIG_14-3-3_CanoR_1 541 547 PF00244 0.609
LIG_14-3-3_CanoR_1 567 572 PF00244 0.704
LIG_14-3-3_CanoR_1 643 650 PF00244 0.639
LIG_14-3-3_CanoR_1 653 657 PF00244 0.633
LIG_14-3-3_CanoR_1 685 693 PF00244 0.709
LIG_APCC_ABBA_1 560 565 PF00400 0.681
LIG_APCC_ABBA_1 722 727 PF00400 0.681
LIG_BIR_III_4 115 119 PF00653 0.718
LIG_BRCT_BRCA1_1 658 662 PF00533 0.681
LIG_Clathr_ClatBox_1 723 727 PF01394 0.681
LIG_CtBP_PxDLS_1 458 462 PF00389 0.559
LIG_EH1_1 715 723 PF00400 0.596
LIG_FHA_1 553 559 PF00498 0.681
LIG_FHA_1 688 694 PF00498 0.698
LIG_FHA_1 768 774 PF00498 0.596
LIG_FHA_1 802 808 PF00498 0.596
LIG_FHA_2 25 31 PF00498 0.744
LIG_FHA_2 291 297 PF00498 0.728
LIG_FHA_2 647 653 PF00498 0.596
LIG_FHA_2 97 103 PF00498 0.740
LIG_LIR_Apic_2 165 171 PF02991 0.710
LIG_LIR_Apic_2 323 329 PF02991 0.734
LIG_LIR_Apic_2 521 527 PF02991 0.681
LIG_LIR_Gen_1 452 462 PF02991 0.712
LIG_LIR_Gen_1 470 480 PF02991 0.656
LIG_LIR_Gen_1 574 581 PF02991 0.632
LIG_LIR_Gen_1 608 618 PF02991 0.669
LIG_LIR_Gen_1 642 650 PF02991 0.596
LIG_LIR_Nem_3 302 308 PF02991 0.705
LIG_LIR_Nem_3 340 344 PF02991 0.752
LIG_LIR_Nem_3 452 457 PF02991 0.740
LIG_LIR_Nem_3 470 475 PF02991 0.540
LIG_LIR_Nem_3 573 579 PF02991 0.653
LIG_LIR_Nem_3 608 613 PF02991 0.677
LIG_Pex14_2 658 662 PF04695 0.596
LIG_PTAP_UEV_1 904 909 PF05743 0.745
LIG_PTB_Apo_2 604 611 PF02174 0.596
LIG_PTB_Phospho_1 604 610 PF10480 0.596
LIG_SH2_CRK 326 330 PF00017 0.736
LIG_SH2_CRK 454 458 PF00017 0.605
LIG_SH2_CRK 490 494 PF00017 0.659
LIG_SH2_CRK 499 503 PF00017 0.518
LIG_SH2_CRK 531 535 PF00017 0.647
LIG_SH2_CRK 577 581 PF00017 0.599
LIG_SH2_GRB2like 3 6 PF00017 0.705
LIG_SH2_NCK_1 378 382 PF00017 0.651
LIG_SH2_NCK_1 454 458 PF00017 0.602
LIG_SH2_NCK_1 577 581 PF00017 0.596
LIG_SH2_SRC 237 240 PF00017 0.694
LIG_SH2_SRC 300 303 PF00017 0.716
LIG_SH2_SRC 378 381 PF00017 0.658
LIG_SH2_STAP1 247 251 PF00017 0.738
LIG_SH2_STAP1 577 581 PF00017 0.596
LIG_SH2_STAP1 803 807 PF00017 0.596
LIG_SH2_STAT5 3 6 PF00017 0.737
LIG_SH2_STAT5 610 613 PF00017 0.681
LIG_SH2_STAT5 644 647 PF00017 0.596
LIG_SH2_STAT5 673 676 PF00017 0.503
LIG_SH2_STAT5 679 682 PF00017 0.453
LIG_SH2_STAT5 803 806 PF00017 0.681
LIG_SH2_STAT5 837 840 PF00017 0.551
LIG_SH3_3 130 136 PF00018 0.658
LIG_SH3_3 148 154 PF00018 0.715
LIG_SH3_3 402 408 PF00018 0.770
LIG_SH3_3 548 554 PF00018 0.725
LIG_SH3_3 593 599 PF00018 0.681
LIG_SH3_3 902 908 PF00018 0.745
LIG_Sin3_3 473 480 PF02671 0.536
LIG_SUMO_SIM_par_1 148 155 PF11976 0.658
LIG_SUMO_SIM_par_1 501 506 PF11976 0.573
LIG_SUMO_SIM_par_1 770 777 PF11976 0.596
LIG_TRAF2_1 224 227 PF00917 0.734
LIG_TRAF2_1 350 353 PF00917 0.705
LIG_TRAF2_1 374 377 PF00917 0.708
LIG_TYR_ITIM 529 534 PF00017 0.596
LIG_TYR_ITIM 575 580 PF00017 0.596
LIG_UBA3_1 666 671 PF00899 0.491
LIG_WRC_WIRS_1 25 30 PF05994 0.742
LIG_WRC_WIRS_1 341 346 PF05994 0.749
LIG_WRC_WIRS_1 610 615 PF05994 0.596
MOD_CDC14_SPxK_1 538 541 PF00782 0.596
MOD_CDK_SPxK_1 535 541 PF00069 0.596
MOD_CDK_SPxxK_3 491 498 PF00069 0.554
MOD_CK1_1 124 130 PF00069 0.711
MOD_CK1_1 447 453 PF00069 0.622
MOD_CK1_1 518 524 PF00069 0.720
MOD_CK1_1 54 60 PF00069 0.729
MOD_CK1_1 642 648 PF00069 0.596
MOD_CK1_1 745 751 PF00069 0.596
MOD_CK1_1 903 909 PF00069 0.718
MOD_CK2_1 149 155 PF00069 0.719
MOD_CK2_1 290 296 PF00069 0.730
MOD_CK2_1 7 13 PF00069 0.745
MOD_CK2_1 96 102 PF00069 0.741
MOD_Cter_Amidation 217 220 PF01082 0.734
MOD_Cter_Amidation 272 275 PF01082 0.741
MOD_Cter_Amidation 336 339 PF01082 0.758
MOD_Cter_Amidation 40 43 PF01082 0.770
MOD_Cter_Amidation 869 872 PF01082 0.727
MOD_Cter_Amidation 911 914 PF01082 0.772
MOD_GlcNHglycan 133 136 PF01048 0.714
MOD_GlcNHglycan 147 150 PF01048 0.642
MOD_GlcNHglycan 200 203 PF01048 0.747
MOD_GlcNHglycan 252 255 PF01048 0.732
MOD_GlcNHglycan 352 356 PF01048 0.758
MOD_GlcNHglycan 392 395 PF01048 0.719
MOD_GlcNHglycan 414 417 PF01048 0.735
MOD_GlcNHglycan 446 449 PF01048 0.638
MOD_GlcNHglycan 505 508 PF01048 0.417
MOD_GlcNHglycan 517 520 PF01048 0.437
MOD_GlcNHglycan 55 59 PF01048 0.759
MOD_GlcNHglycan 613 616 PF01048 0.396
MOD_GlcNHglycan 658 661 PF01048 0.481
MOD_GlcNHglycan 80 83 PF01048 0.680
MOD_GlcNHglycan 884 887 PF01048 0.766
MOD_GlcNHglycan 905 908 PF01048 0.739
MOD_GSK3_1 107 114 PF00069 0.684
MOD_GSK3_1 121 128 PF00069 0.705
MOD_GSK3_1 145 152 PF00069 0.720
MOD_GSK3_1 198 205 PF00069 0.641
MOD_GSK3_1 362 369 PF00069 0.743
MOD_GSK3_1 642 649 PF00069 0.639
MOD_GSK3_1 652 659 PF00069 0.633
MOD_GSK3_1 687 694 PF00069 0.700
MOD_GSK3_1 773 780 PF00069 0.681
MOD_GSK3_1 896 903 PF00069 0.762
MOD_GSK3_1 96 103 PF00069 0.732
MOD_N-GLC_1 107 112 PF02516 0.716
MOD_N-GLC_1 691 696 PF02516 0.688
MOD_NEK2_1 351 356 PF00069 0.781
MOD_NEK2_1 611 616 PF00069 0.596
MOD_NEK2_1 639 644 PF00069 0.609
MOD_NEK2_1 656 661 PF00069 0.599
MOD_NEK2_1 725 730 PF00069 0.596
MOD_PIKK_1 691 697 PF00454 0.681
MOD_PKA_1 418 424 PF00069 0.661
MOD_PKA_1 567 573 PF00069 0.704
MOD_PKA_1 7 13 PF00069 0.745
MOD_PKA_2 100 106 PF00069 0.672
MOD_PKA_2 418 424 PF00069 0.661
MOD_PKA_2 444 450 PF00069 0.725
MOD_PKA_2 542 548 PF00069 0.596
MOD_PKA_2 642 648 PF00069 0.639
MOD_PKA_2 652 658 PF00069 0.633
MOD_PKA_2 903 909 PF00069 0.746
MOD_PKA_2 91 97 PF00069 0.748
MOD_Plk_2-3 24 30 PF00069 0.744
MOD_Plk_2-3 646 652 PF00069 0.596
MOD_Plk_4 652 658 PF00069 0.681
MOD_ProDKin_1 107 113 PF00069 0.732
MOD_ProDKin_1 142 148 PF00069 0.706
MOD_ProDKin_1 362 368 PF00069 0.763
MOD_ProDKin_1 404 410 PF00069 0.778
MOD_ProDKin_1 491 497 PF00069 0.540
MOD_ProDKin_1 535 541 PF00069 0.596
MOD_ProDKin_1 767 773 PF00069 0.596
MOD_SUMO_rev_2 2 10 PF00179 0.741
MOD_SUMO_rev_2 432 437 PF00179 0.589
MOD_SUMO_rev_2 460 469 PF00179 0.556
TRG_DiLeu_BaEn_1 591 596 PF01217 0.596
TRG_DiLeu_BaEn_1 857 862 PF01217 0.595
TRG_DiLeu_BaLyEn_6 705 710 PF01217 0.596
TRG_ENDOCYTIC_2 454 457 PF00928 0.725
TRG_ENDOCYTIC_2 531 534 PF00928 0.647
TRG_ENDOCYTIC_2 577 580 PF00928 0.599
TRG_ENDOCYTIC_2 610 613 PF00928 0.669
TRG_ENDOCYTIC_2 644 647 PF00928 0.596
TRG_ENDOCYTIC_2 678 681 PF00928 0.522
TRG_ER_diArg_1 219 221 PF00400 0.729
TRG_ER_diArg_1 232 235 PF00400 0.669
TRG_ER_diArg_1 260 262 PF00400 0.728
TRG_ER_diArg_1 274 276 PF00400 0.648
TRG_ER_diArg_1 308 310 PF00400 0.740
TRG_ER_diArg_1 315 317 PF00400 0.703
TRG_ER_diArg_1 329 332 PF00400 0.681
TRG_ER_diArg_1 40 43 PF00400 0.770
TRG_ER_diArg_1 417 419 PF00400 0.752
TRG_ER_diArg_1 426 428 PF00400 0.583
TRG_ER_diArg_1 674 676 PF00400 0.501
TRG_ER_diArg_1 737 739 PF00400 0.596
TRG_ER_diArg_1 828 830 PF00400 0.539
TRG_ER_diArg_1 871 873 PF00400 0.816
TRG_Pf-PMV_PEXEL_1 556 561 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 737 742 PF00026 0.481
TRG_Pf-PMV_PEXEL_1 828 833 PF00026 0.642

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IF94 Leishmania donovani 51% 100%
A0A3Q8IJ79 Leishmania donovani 94% 100%
A4HMX7 Leishmania braziliensis 91% 100%
A4I7K4 Leishmania infantum 51% 100%
A4IBK1 Leishmania infantum 94% 100%
E9B2G1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%
E9B6I9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
Q4Q5P5 Leishmania major 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS