VASt domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFD1_LEIMA

TriTrypDb:

LmjF.35.3070 , LMJLV39_350038000 , LMJSD75_350037400

Length:

822

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	636	640	PF00656	0.541
CLV_MEL_PAP_1	78	84	PF00089	0.386
CLV_NRD_NRD_1	331	333	PF00675	0.471
CLV_NRD_NRD_1	726	728	PF00675	0.460
CLV_PCSK_KEX2_1	331	333	PF00082	0.520
CLV_PCSK_KEX2_1	373	375	PF00082	0.275
CLV_PCSK_KEX2_1	505	507	PF00082	0.442
CLV_PCSK_KEX2_1	618	620	PF00082	0.503
CLV_PCSK_KEX2_1	726	728	PF00082	0.445
CLV_PCSK_KEX2_1	805	807	PF00082	0.431
CLV_PCSK_PC1ET2_1	373	375	PF00082	0.275
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.442
CLV_PCSK_PC1ET2_1	618	620	PF00082	0.389
CLV_PCSK_PC1ET2_1	805	807	PF00082	0.431
CLV_PCSK_SKI1_1	171	175	PF00082	0.334
CLV_PCSK_SKI1_1	27	31	PF00082	0.575
CLV_PCSK_SKI1_1	385	389	PF00082	0.470
CLV_PCSK_SKI1_1	531	535	PF00082	0.553
CLV_PCSK_SKI1_1	570	574	PF00082	0.387
CLV_PCSK_SKI1_1	579	583	PF00082	0.373
CLV_PCSK_SKI1_1	592	596	PF00082	0.257
CLV_PCSK_SKI1_1	648	652	PF00082	0.500
CLV_PCSK_SKI1_1	806	810	PF00082	0.428
CLV_PCSK_SKI1_1	87	91	PF00082	0.363
DEG_SPOP_SBC_1	795	799	PF00917	0.362
DOC_CYCLIN_RxL_1	645	656	PF00134	0.417
DOC_MAPK_gen_1	235	245	PF00069	0.470
DOC_MAPK_gen_1	286	296	PF00069	0.434
DOC_MAPK_gen_1	618	625	PF00069	0.357
DOC_MAPK_gen_1	726	733	PF00069	0.454
DOC_MAPK_gen_1	805	812	PF00069	0.449
DOC_MAPK_MEF2A_6	186	194	PF00069	0.457
DOC_MAPK_MEF2A_6	238	245	PF00069	0.376
DOC_MAPK_MEF2A_6	34	42	PF00069	0.589
DOC_MAPK_MEF2A_6	618	627	PF00069	0.398
DOC_MAPK_MEF2A_6	87	94	PF00069	0.319
DOC_PP1_RVXF_1	569	576	PF00149	0.465
DOC_PP2B_LxvP_1	172	175	PF13499	0.351
DOC_PP2B_LxvP_1	212	215	PF13499	0.435
DOC_PP2B_LxvP_1	652	655	PF13499	0.531
DOC_PP4_FxxP_1	643	646	PF00568	0.436
DOC_PP4_FxxP_1	792	795	PF00568	0.501
DOC_USP7_MATH_1	201	205	PF00917	0.374
DOC_USP7_MATH_1	447	451	PF00917	0.335
DOC_USP7_MATH_1	465	469	PF00917	0.460
DOC_USP7_MATH_1	50	54	PF00917	0.490
DOC_USP7_MATH_1	511	515	PF00917	0.538
DOC_USP7_MATH_1	795	799	PF00917	0.600
DOC_USP7_MATH_1	800	804	PF00917	0.415
DOC_USP7_MATH_1	98	102	PF00917	0.462
DOC_USP7_UBL2_3	196	200	PF12436	0.418
DOC_USP7_UBL2_3	531	535	PF12436	0.412
DOC_USP7_UBL2_3	805	809	PF12436	0.433
DOC_WW_Pin1_4	796	801	PF00397	0.355
DOC_WW_Pin1_4	813	818	PF00397	0.639
LIG_14-3-3_CanoR_1	186	194	PF00244	0.418
LIG_14-3-3_CanoR_1	216	220	PF00244	0.428
LIG_14-3-3_CanoR_1	258	266	PF00244	0.418
LIG_14-3-3_CanoR_1	289	296	PF00244	0.398
LIG_14-3-3_CanoR_1	32	38	PF00244	0.459
LIG_14-3-3_CanoR_1	363	372	PF00244	0.341
LIG_14-3-3_CanoR_1	579	584	PF00244	0.509
LIG_14-3-3_CanoR_1	592	597	PF00244	0.317
LIG_14-3-3_CanoR_1	75	79	PF00244	0.533
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.388
LIG_BRCT_BRCA1_1	629	633	PF00533	0.605
LIG_BRCT_BRCA1_1	639	643	PF00533	0.462
LIG_deltaCOP1_diTrp_1	737	740	PF00928	0.488
LIG_deltaCOP1_diTrp_1	74	82	PF00928	0.387
LIG_deltaCOP1_diTrp_1	772	778	PF00928	0.394
LIG_FHA_1	216	222	PF00498	0.384
LIG_FHA_1	255	261	PF00498	0.599
LIG_FHA_1	276	282	PF00498	0.396
LIG_FHA_1	367	373	PF00498	0.438
LIG_FHA_1	407	413	PF00498	0.296
LIG_FHA_1	453	459	PF00498	0.315
LIG_FHA_1	591	597	PF00498	0.302
LIG_FHA_1	703	709	PF00498	0.396
LIG_FHA_2	121	127	PF00498	0.437
LIG_FHA_2	186	192	PF00498	0.490
LIG_FHA_2	6	12	PF00498	0.730
LIG_FHA_2	720	726	PF00498	0.469
LIG_Integrin_RGD_1	473	475	PF01839	0.385
LIG_KLC1_Yacidic_2	760	764	PF13176	0.453
LIG_LIR_Apic_2	640	646	PF02991	0.457
LIG_LIR_Gen_1	514	522	PF02991	0.391
LIG_LIR_Gen_1	55	62	PF02991	0.349
LIG_LIR_Gen_1	737	748	PF02991	0.436
LIG_LIR_Gen_1	93	100	PF02991	0.389
LIG_LIR_Nem_3	310	316	PF02991	0.446
LIG_LIR_Nem_3	36	40	PF02991	0.415
LIG_LIR_Nem_3	491	496	PF02991	0.547
LIG_LIR_Nem_3	514	518	PF02991	0.388
LIG_LIR_Nem_3	55	61	PF02991	0.427
LIG_LIR_Nem_3	555	559	PF02991	0.338
LIG_LIR_Nem_3	737	743	PF02991	0.399
LIG_LIR_Nem_3	772	778	PF02991	0.335
LIG_LIR_Nem_3	93	97	PF02991	0.303
LIG_NRBOX	548	554	PF00104	0.383
LIG_Pex14_1	580	584	PF04695	0.385
LIG_PTB_Apo_2	487	494	PF02174	0.334
LIG_PTB_Apo_2	785	792	PF02174	0.396
LIG_PTB_Phospho_1	785	791	PF10480	0.394
LIG_Rb_pABgroove_1	346	354	PF01858	0.383
LIG_SH2_CRK	556	560	PF00017	0.320
LIG_SH2_CRK	591	595	PF00017	0.422
LIG_SH2_SRC	558	561	PF00017	0.306
LIG_SH2_STAP1	217	221	PF00017	0.393
LIG_SH2_STAP1	352	356	PF00017	0.376
LIG_SH2_STAT3	776	779	PF00017	0.471
LIG_SH2_STAT5	217	220	PF00017	0.447
LIG_SH2_STAT5	273	276	PF00017	0.354
LIG_SH2_STAT5	558	561	PF00017	0.289
LIG_SH2_STAT5	762	765	PF00017	0.429
LIG_SH2_STAT5	791	794	PF00017	0.566
LIG_SH3_3	100	106	PF00018	0.492
LIG_SH3_3	408	414	PF00018	0.341
LIG_SH3_3	416	422	PF00018	0.277
LIG_SH3_3	669	675	PF00018	0.373
LIG_SH3_3	7	13	PF00018	0.642
LIG_SH3_3	811	817	PF00018	0.589
LIG_SUMO_SIM_anti_2	96	102	PF11976	0.364
LIG_SUMO_SIM_par_1	239	244	PF11976	0.358
LIG_SUMO_SIM_par_1	453	459	PF11976	0.210
LIG_SUMO_SIM_par_1	656	661	PF11976	0.362
LIG_SUMO_SIM_par_1	729	734	PF11976	0.412
LIG_TRAF2_1	23	26	PF00917	0.468
LIG_TRAF2_1	320	323	PF00917	0.490
LIG_TRAF2_1	438	441	PF00917	0.335
LIG_TRAF2_2	175	180	PF00917	0.426
LIG_TYR_ITIM	589	594	PF00017	0.420
LIG_UBA3_1	143	151	PF00899	0.466
LIG_UBA3_1	348	354	PF00899	0.458
MOD_CK1_1	110	116	PF00069	0.429
MOD_CK1_1	231	237	PF00069	0.505
MOD_CK1_1	366	372	PF00069	0.481
MOD_CK1_1	381	387	PF00069	0.305
MOD_CK1_1	397	403	PF00069	0.315
MOD_CK1_1	406	412	PF00069	0.285
MOD_CK1_1	697	703	PF00069	0.498
MOD_CK1_1	816	822	PF00069	0.618
MOD_CK2_1	120	126	PF00069	0.428
MOD_CK2_1	20	26	PF00069	0.481
MOD_CK2_1	223	229	PF00069	0.420
MOD_CK2_1	317	323	PF00069	0.421
MOD_CK2_1	447	453	PF00069	0.349
MOD_CK2_1	465	471	PF00069	0.517
MOD_CK2_1	5	11	PF00069	0.728
MOD_CK2_1	653	659	PF00069	0.441
MOD_CK2_1	719	725	PF00069	0.464
MOD_GlcNHglycan	203	206	PF01048	0.466
MOD_GlcNHglycan	365	368	PF01048	0.393
MOD_GlcNHglycan	380	383	PF01048	0.282
MOD_GlcNHglycan	391	394	PF01048	0.345
MOD_GlcNHglycan	500	503	PF01048	0.551
MOD_GlcNHglycan	52	55	PF01048	0.474
MOD_GlcNHglycan	586	589	PF01048	0.470
MOD_GlcNHglycan	755	758	PF01048	0.494
MOD_GlcNHglycan	818	821	PF01048	0.629
MOD_GSK3_1	181	188	PF00069	0.421
MOD_GSK3_1	281	288	PF00069	0.401
MOD_GSK3_1	359	366	PF00069	0.425
MOD_GSK3_1	400	407	PF00069	0.313
MOD_GSK3_1	452	459	PF00069	0.263
MOD_GSK3_1	48	55	PF00069	0.511
MOD_GSK3_1	637	644	PF00069	0.456
MOD_GSK3_1	70	77	PF00069	0.415
MOD_GSK3_1	749	756	PF00069	0.413
MOD_GSK3_1	790	797	PF00069	0.453
MOD_N-GLC_1	118	123	PF02516	0.496
MOD_NEK2_1	254	259	PF00069	0.566
MOD_NEK2_1	275	280	PF00069	0.422
MOD_NEK2_1	281	286	PF00069	0.380
MOD_NEK2_1	309	314	PF00069	0.317
MOD_NEK2_1	33	38	PF00069	0.457
MOD_NEK2_1	359	364	PF00069	0.372
MOD_NEK2_1	433	438	PF00069	0.320
MOD_NEK2_1	477	482	PF00069	0.471
MOD_NEK2_1	539	544	PF00069	0.358
MOD_NEK2_1	552	557	PF00069	0.321
MOD_NEK2_1	658	663	PF00069	0.412
MOD_NEK2_1	667	672	PF00069	0.376
MOD_NEK2_1	694	699	PF00069	0.361
MOD_NEK2_1	790	795	PF00069	0.516
MOD_NEK2_1	90	95	PF00069	0.405
MOD_NEK2_2	195	200	PF00069	0.440
MOD_NEK2_2	215	220	PF00069	0.410
MOD_NEK2_2	375	380	PF00069	0.341
MOD_NEK2_2	800	805	PF00069	0.424
MOD_PIKK_1	541	547	PF00454	0.467
MOD_PIKK_1	658	664	PF00454	0.373
MOD_PK_1	48	54	PF00069	0.509
MOD_PKA_2	185	191	PF00069	0.473
MOD_PKA_2	215	221	PF00069	0.547
MOD_PKA_2	285	291	PF00069	0.378
MOD_PKA_2	303	309	PF00069	0.323
MOD_PKA_2	33	39	PF00069	0.439
MOD_PKA_2	74	80	PF00069	0.530
MOD_PKB_1	745	753	PF00069	0.296
MOD_Plk_1	107	113	PF00069	0.553
MOD_Plk_1	118	124	PF00069	0.361
MOD_Plk_1	20	26	PF00069	0.505
MOD_Plk_1	241	247	PF00069	0.372
MOD_Plk_1	269	275	PF00069	0.382
MOD_Plk_1	309	315	PF00069	0.434
MOD_Plk_1	375	381	PF00069	0.493
MOD_Plk_1	400	406	PF00069	0.374
MOD_Plk_1	658	664	PF00069	0.341
MOD_Plk_1	719	725	PF00069	0.489
MOD_Plk_1	736	742	PF00069	0.518
MOD_Plk_1	781	787	PF00069	0.567
MOD_Plk_2-3	20	26	PF00069	0.505
MOD_Plk_2-3	719	725	PF00069	0.485
MOD_Plk_4	107	113	PF00069	0.539
MOD_Plk_4	241	247	PF00069	0.451
MOD_Plk_4	303	309	PF00069	0.477
MOD_Plk_4	400	406	PF00069	0.424
MOD_Plk_4	579	585	PF00069	0.416
MOD_Plk_4	653	659	PF00069	0.511
MOD_Plk_4	667	673	PF00069	0.344
MOD_Plk_4	702	708	PF00069	0.456
MOD_Plk_4	719	725	PF00069	0.285
MOD_Plk_4	781	787	PF00069	0.463
MOD_ProDKin_1	796	802	PF00069	0.346
MOD_ProDKin_1	813	819	PF00069	0.643
MOD_SUMO_rev_2	20	29	PF00179	0.490
MOD_SUMO_rev_2	41	50	PF00179	0.490
MOD_SUMO_rev_2	565	572	PF00179	0.358
TRG_DiLeu_BaEn_1	520	525	PF01217	0.369
TRG_DiLeu_BaEn_2	321	327	PF01217	0.459
TRG_DiLeu_BaEn_2	724	730	PF01217	0.491
TRG_DiLeu_BaEn_3	337	343	PF01217	0.420
TRG_DiLeu_BaLyEn_6	276	281	PF01217	0.394
TRG_ENDOCYTIC_2	130	133	PF00928	0.393
TRG_ENDOCYTIC_2	352	355	PF00928	0.275
TRG_ENDOCYTIC_2	556	559	PF00928	0.312
TRG_ENDOCYTIC_2	591	594	PF00928	0.369
TRG_ER_diArg_1	16	19	PF00400	0.684
TRG_ER_diArg_1	330	332	PF00400	0.515
TRG_ER_diArg_1	78	81	PF00400	0.435
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.557
TRG_Pf-PMV_PEXEL_1	648	653	PF00026	0.491
TRG_Pf-PMV_PEXEL_1	759	764	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV37	Leptomonas seymouri	61%	100%
A0A0S4JPI8	Bodo saltans	26%	100%
A0A1X0P5E4	Trypanosomatidae	32%	100%
A0A3Q8IVD1	Leishmania donovani	94%	100%
A4HMX4	Leishmania braziliensis	81%	100%
A4IBJ5	Leishmania infantum	94%	100%
E9B6I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5C2X4	Trypanosoma cruzi	32%	100%