CCHC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleic acid binding protein, putative

Species:

Leishmania major

UniProt:

E9AFC9_LEIMA

TriTrypDb:

LmjF.35.3050 , LMJLV39_350037800 , LMJSD75_350037200

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFC9

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004842	ubiquitin-protein transferase activity	4	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0016740	transferase activity	2	12
GO:0019787	ubiquitin-like protein transferase activity	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0061630	ubiquitin protein ligase activity	5	12
GO:0061659	ubiquitin-like protein ligase activity	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.434
CLV_C14_Caspase3-7	92	96	PF00656	0.590
CLV_NRD_NRD_1	142	144	PF00675	0.727
CLV_NRD_NRD_1	257	259	PF00675	0.473
CLV_NRD_NRD_1	402	404	PF00675	0.502
CLV_PCSK_FUR_1	140	144	PF00082	0.625
CLV_PCSK_KEX2_1	142	144	PF00082	0.727
CLV_PCSK_KEX2_1	256	258	PF00082	0.466
CLV_PCSK_KEX2_1	404	406	PF00082	0.465
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.423
CLV_PCSK_PC1ET2_1	404	406	PF00082	0.465
CLV_PCSK_PC7_1	253	259	PF00082	0.440
CLV_PCSK_SKI1_1	219	223	PF00082	0.495
CLV_PCSK_SKI1_1	246	250	PF00082	0.425
CLV_PCSK_SKI1_1	253	257	PF00082	0.447
CLV_PCSK_SKI1_1	397	401	PF00082	0.671
CLV_PCSK_SKI1_1	78	82	PF00082	0.696
DOC_CYCLIN_RxL_1	393	402	PF00134	0.651
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.546
DOC_MAPK_gen_1	216	226	PF00069	0.479
DOC_PP1_RVXF_1	220	227	PF00149	0.586
DOC_PP2B_LxvP_1	38	41	PF13499	0.538
DOC_PP4_FxxP_1	103	106	PF00568	0.563
DOC_PP4_FxxP_1	190	193	PF00568	0.474
DOC_USP7_MATH_1	312	316	PF00917	0.735
DOC_USP7_MATH_1	98	102	PF00917	0.651
DOC_WW_Pin1_4	289	294	PF00397	0.749
DOC_WW_Pin1_4	310	315	PF00397	0.740
LIG_14-3-3_CanoR_1	72	80	PF00244	0.573
LIG_14-3-3_CanoR_1	8	15	PF00244	0.418
LIG_14-3-3_CanoR_1	86	91	PF00244	0.631
LIG_BRCT_BRCA1_1	137	141	PF00533	0.595
LIG_BRCT_BRCA1_1	167	171	PF00533	0.565
LIG_BRCT_BRCA1_1	3	7	PF00533	0.442
LIG_BRCT_BRCA1_1	99	103	PF00533	0.603
LIG_FHA_1	359	365	PF00498	0.680
LIG_FHA_1	4	10	PF00498	0.342
LIG_FHA_1	51	57	PF00498	0.583
LIG_FHA_2	114	120	PF00498	0.476
LIG_FHA_2	130	136	PF00498	0.477
LIG_FHA_2	237	243	PF00498	0.462
LIG_FHA_2	278	284	PF00498	0.635
LIG_FHA_2	306	312	PF00498	0.790
LIG_Integrin_RGD_1	178	180	PF01839	0.658
LIG_LIR_Apic_2	100	106	PF02991	0.559
LIG_LIR_Apic_2	187	193	PF02991	0.500
LIG_LIR_Gen_1	262	272	PF02991	0.640
LIG_LIR_Gen_1	348	358	PF02991	0.507
LIG_LIR_Nem_3	262	267	PF02991	0.484
LIG_SH2_NCK_1	65	69	PF00017	0.409
LIG_SH2_STAT5	197	200	PF00017	0.266
LIG_SH3_3	225	231	PF00018	0.538
LIG_SH3_3	369	375	PF00018	0.565
LIG_TRAF2_1	116	119	PF00917	0.469
LIG_TRAF2_1	389	392	PF00917	0.450
LIG_TRAF2_1	41	44	PF00917	0.417
MOD_CDK_SPxxK_3	310	317	PF00069	0.500
MOD_CK1_1	162	168	PF00069	0.718
MOD_CK1_1	23	29	PF00069	0.534
MOD_CK1_1	262	268	PF00069	0.530
MOD_CK1_1	277	283	PF00069	0.556
MOD_CK1_1	306	312	PF00069	0.693
MOD_CK1_1	313	319	PF00069	0.648
MOD_CK1_1	348	354	PF00069	0.480
MOD_CK1_1	89	95	PF00069	0.600
MOD_CK1_1	96	102	PF00069	0.607
MOD_CK2_1	113	119	PF00069	0.490
MOD_CK2_1	305	311	PF00069	0.776
MOD_GlcNHglycan	100	103	PF01048	0.627
MOD_GlcNHglycan	161	164	PF01048	0.586
MOD_GlcNHglycan	165	168	PF01048	0.567
MOD_GlcNHglycan	213	216	PF01048	0.608
MOD_GlcNHglycan	275	279	PF01048	0.745
MOD_GlcNHglycan	303	306	PF01048	0.661
MOD_GlcNHglycan	75	78	PF01048	0.538
MOD_GSK3_1	159	166	PF00069	0.621
MOD_GSK3_1	297	304	PF00069	0.703
MOD_GSK3_1	306	313	PF00069	0.655
MOD_GSK3_1	86	93	PF00069	0.573
MOD_N-GLC_1	294	299	PF02516	0.747
MOD_NEK2_1	1	6	PF00069	0.367
MOD_NEK2_1	159	164	PF00069	0.494
MOD_NEK2_1	20	25	PF00069	0.355
MOD_NEK2_1	345	350	PF00069	0.329
MOD_NEK2_1	358	363	PF00069	0.558
MOD_NEK2_1	49	54	PF00069	0.575
MOD_NEK2_1	80	85	PF00069	0.697
MOD_NEK2_1	9	14	PF00069	0.396
MOD_NEK2_2	3	8	PF00069	0.349
MOD_PKA_2	71	77	PF00069	0.582
MOD_PKB_1	84	92	PF00069	0.616
MOD_Plk_1	236	242	PF00069	0.448
MOD_Plk_2-3	360	366	PF00069	0.667
MOD_Plk_4	20	26	PF00069	0.549
MOD_Plk_4	230	236	PF00069	0.406
MOD_Plk_4	259	265	PF00069	0.584
MOD_ProDKin_1	289	295	PF00069	0.749
MOD_ProDKin_1	310	316	PF00069	0.738
TRG_DiLeu_BaEn_3	43	49	PF01217	0.403
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.510
TRG_ENDOCYTIC_2	65	68	PF00928	0.394
TRG_ER_diArg_1	141	143	PF00400	0.584
TRG_ER_diArg_1	257	259	PF00400	0.461
TRG_ER_diArg_1	84	87	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	362	366	PF00026	0.745
TRG_Pf-PMV_PEXEL_1	397	402	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJT3	Leptomonas seymouri	64%	97%
A0A0S4JGE6	Bodo saltans	32%	100%
A0A1X0P6U9	Trypanosomatidae	44%	100%
A0A3Q8IMI0	Leishmania donovani	92%	100%
A0A3S5ISL5	Trypanosoma rangeli	43%	100%
A4HMX2	Leishmania braziliensis	83%	100%
A4IBJ3	Leishmania infantum	92%	100%
C9ZZ48	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B6I4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DUR5	Trypanosoma cruzi	43%	100%