1-alkyl-2-acetylglycerophosphocholine esterase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phospholipase A1, putative

Species:

Leishmania major

UniProt:

E9AFC6_LEIMA

TriTrypDb:

LmjF.35.3020 , LMJLV39_350037500 , LMJSD75_350036900

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AFC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFC6

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0016042	lipid catabolic process	4	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity	5	12
GO:0004620	phospholipase activity	5	2
GO:0008970	phospholipase A1 activity	5	2
GO:0016298	lipase activity	4	2
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.335
CLV_C14_Caspase3-7	366	370	PF00656	0.251
CLV_NRD_NRD_1	130	132	PF00675	0.545
CLV_NRD_NRD_1	316	318	PF00675	0.403
CLV_PCSK_KEX2_1	232	234	PF00082	0.514
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.510
CLV_PCSK_SKI1_1	307	311	PF00082	0.531
CLV_PCSK_SKI1_1	373	377	PF00082	0.520
DEG_APCC_DBOX_1	106	114	PF00400	0.354
DEG_APCC_DBOX_1	224	232	PF00400	0.254
DOC_CKS1_1	323	328	PF01111	0.274
DOC_CYCLIN_yCln2_LP_2	398	404	PF00134	0.340
DOC_MAPK_gen_1	232	241	PF00069	0.328
DOC_MAPK_gen_1	317	323	PF00069	0.336
DOC_MAPK_MEF2A_6	216	224	PF00069	0.335
DOC_MAPK_MEF2A_6	235	243	PF00069	0.299
DOC_MAPK_MEF2A_6	77	86	PF00069	0.310
DOC_PP4_FxxP_1	323	326	PF00568	0.335
DOC_PP4_MxPP_1	80	83	PF00568	0.335
DOC_USP7_MATH_1	16	20	PF00917	0.465
DOC_USP7_MATH_1	363	367	PF00917	0.356
DOC_USP7_MATH_1	89	93	PF00917	0.354
DOC_USP7_UBL2_3	252	256	PF12436	0.270
DOC_WW_Pin1_4	322	327	PF00397	0.274
DOC_WW_Pin1_4	397	402	PF00397	0.297
DOC_WW_Pin1_4	409	414	PF00397	0.294
DOC_WW_Pin1_4	57	62	PF00397	0.384
DOC_WW_Pin1_4	91	96	PF00397	0.308
LIG_14-3-3_CanoR_1	286	296	PF00244	0.299
LIG_14-3-3_CanoR_1	357	365	PF00244	0.400
LIG_AP2alpha_2	299	301	PF02296	0.260
LIG_APCC_ABBA_1	328	333	PF00400	0.274
LIG_BIR_III_2	353	357	PF00653	0.299
LIG_BRCT_BRCA1_1	189	193	PF00533	0.233
LIG_FHA_1	323	329	PF00498	0.252
LIG_FHA_1	386	392	PF00498	0.324
LIG_FHA_1	437	443	PF00498	0.464
LIG_FHA_1	45	51	PF00498	0.254
LIG_FHA_1	68	74	PF00498	0.332
LIG_FHA_2	210	216	PF00498	0.340
LIG_FHA_2	356	362	PF00498	0.403
LIG_FHA_2	379	385	PF00498	0.374
LIG_FHA_2	390	396	PF00498	0.361
LIG_LIR_Apic_2	299	304	PF02991	0.249
LIG_LIR_Gen_1	115	124	PF02991	0.264
LIG_LIR_Gen_1	308	316	PF02991	0.354
LIG_LIR_Nem_3	115	119	PF02991	0.258
LIG_LIR_Nem_3	308	314	PF02991	0.335
LIG_LIR_Nem_3	377	382	PF02991	0.355
LIG_LIR_Nem_3	397	402	PF02991	0.368
LIG_Pex14_2	331	335	PF04695	0.310
LIG_SH2_CRK	116	120	PF00017	0.310
LIG_SH2_CRK	121	125	PF00017	0.310
LIG_SH2_CRK	167	171	PF00017	0.265
LIG_SH2_CRK	311	315	PF00017	0.314
LIG_SH2_NCK_1	116	120	PF00017	0.327
LIG_SH2_PTP2	52	55	PF00017	0.396
LIG_SH2_SRC	13	16	PF00017	0.400
LIG_SH2_STAP1	167	171	PF00017	0.274
LIG_SH2_STAT5	101	104	PF00017	0.254
LIG_SH2_STAT5	109	112	PF00017	0.241
LIG_SH2_STAT5	13	16	PF00017	0.359
LIG_SH2_STAT5	253	256	PF00017	0.274
LIG_SH2_STAT5	380	383	PF00017	0.363
LIG_SH2_STAT5	52	55	PF00017	0.392
LIG_SH2_STAT5	7	10	PF00017	0.343
LIG_SH3_3	294	300	PF00018	0.290
LIG_SH3_3	428	434	PF00018	0.375
LIG_SH3_5	3	7	PF00018	0.406
LIG_TRAF2_1	358	361	PF00917	0.442
LIG_TYR_ITIM	119	124	PF00017	0.335
LIG_UBA3_1	239	247	PF00899	0.327
LIG_UBA3_1	302	307	PF00899	0.346
MOD_CDK_SPK_2	409	414	PF00069	0.355
MOD_CDK_SPK_2	91	96	PF00069	0.337
MOD_CK1_1	291	297	PF00069	0.276
MOD_CK1_1	378	384	PF00069	0.394
MOD_CK1_1	397	403	PF00069	0.376
MOD_CK1_1	44	50	PF00069	0.371
MOD_CK2_1	355	361	PF00069	0.336
MOD_GlcNHglycan	188	192	PF01048	0.454
MOD_GlcNHglycan	235	238	PF01048	0.494
MOD_GlcNHglycan	360	364	PF01048	0.581
MOD_GlcNHglycan	365	368	PF01048	0.575
MOD_GlcNHglycan	431	434	PF01048	0.610
MOD_GlcNHglycan	444	447	PF01048	0.628
MOD_GlcNHglycan	91	94	PF01048	0.554
MOD_GlcNHglycan	96	99	PF01048	0.495
MOD_GSK3_1	16	23	PF00069	0.390
MOD_GSK3_1	277	284	PF00069	0.332
MOD_GSK3_1	287	294	PF00069	0.278
MOD_GSK3_1	355	362	PF00069	0.361
MOD_GSK3_1	37	44	PF00069	0.444
MOD_GSK3_1	374	381	PF00069	0.207
MOD_GSK3_1	385	392	PF00069	0.285
MOD_GSK3_1	87	94	PF00069	0.364
MOD_N-GLC_1	442	447	PF02516	0.646
MOD_NEK2_1	166	171	PF00069	0.311
MOD_NEK2_1	182	187	PF00069	0.335
MOD_NEK2_1	263	268	PF00069	0.246
MOD_NEK2_1	277	282	PF00069	0.171
MOD_NEK2_1	305	310	PF00069	0.354
MOD_NEK2_1	375	380	PF00069	0.360
MOD_NEK2_1	442	447	PF00069	0.459
MOD_NEK2_1	62	67	PF00069	0.321
MOD_NEK2_2	421	426	PF00069	0.299
MOD_NEK2_2	7	12	PF00069	0.351
MOD_OFUCOSY	36	41	PF10250	0.429
MOD_PIKK_1	204	210	PF00454	0.343
MOD_PIKK_1	277	283	PF00454	0.313
MOD_PKA_2	224	230	PF00069	0.262
MOD_PKA_2	356	362	PF00069	0.413
MOD_PKA_2	385	391	PF00069	0.321
MOD_Plk_1	105	111	PF00069	0.289
MOD_Plk_1	359	365	PF00069	0.399
MOD_Plk_1	394	400	PF00069	0.341
MOD_Plk_1	442	448	PF00069	0.496
MOD_Plk_2-3	246	252	PF00069	0.354
MOD_Plk_4	16	22	PF00069	0.385
MOD_Plk_4	166	172	PF00069	0.311
MOD_Plk_4	292	298	PF00069	0.281
MOD_Plk_4	305	311	PF00069	0.296
MOD_Plk_4	375	381	PF00069	0.331
MOD_Plk_4	394	400	PF00069	0.347
MOD_Plk_4	41	47	PF00069	0.409
MOD_Plk_4	82	88	PF00069	0.354
MOD_ProDKin_1	322	328	PF00069	0.274
MOD_ProDKin_1	397	403	PF00069	0.302
MOD_ProDKin_1	409	415	PF00069	0.296
MOD_ProDKin_1	57	63	PF00069	0.390
MOD_ProDKin_1	91	97	PF00069	0.308
MOD_SUMO_rev_2	312	320	PF00179	0.299
MOD_SUMO_rev_2	346	351	PF00179	0.354
MOD_SUMO_rev_2	366	372	PF00179	0.337
MOD_SUMO_rev_2	432	442	PF00179	0.491
TRG_DiLeu_BaEn_1	106	111	PF01217	0.271
TRG_DiLeu_BaEn_1	360	365	PF01217	0.428
TRG_DiLeu_BaEn_2	422	428	PF01217	0.310
TRG_DiLeu_BaEn_3	346	352	PF01217	0.299
TRG_ENDOCYTIC_2	101	104	PF00928	0.258
TRG_ENDOCYTIC_2	116	119	PF00928	0.212
TRG_ENDOCYTIC_2	121	124	PF00928	0.265
TRG_ENDOCYTIC_2	167	170	PF00928	0.256
TRG_ENDOCYTIC_2	311	314	PF00928	0.314
TRG_ER_diArg_1	222	225	PF00400	0.335
TRG_NLS_MonoExtC_3	130	135	PF00514	0.267
TRG_NLS_MonoExtN_4	131	136	PF00514	0.299

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4R1	Leptomonas seymouri	50%	100%
A0A0S4JLQ8	Bodo saltans	29%	95%
A0A1X0P5D8	Trypanosomatidae	36%	100%
A0A1X0P6A2	Trypanosomatidae	25%	100%
A0A3Q8IPQ3	Leishmania donovani	93%	100%
A0A3R7LD50	Trypanosoma rangeli	34%	100%
A0A3R7P367	Trypanosoma rangeli	26%	100%
A4HMW9	Leishmania braziliensis	76%	97%
A4IBJ0	Leishmania infantum	93%	100%
C9ZZ51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B6I1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q13093	Homo sapiens	28%	100%
Q28017	Bos taurus	27%	100%
Q28262	Canis lupus familiaris	27%	100%
V5BD01	Trypanosoma cruzi	33%	100%
V5BTH3	Trypanosoma cruzi	27%	100%