LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFC4_LEIMA
TriTrypDb:
LmjF.35.3000 , LMJLV39_350037300 * , LMJSD75_350036600 *
Length:
460

Annotations

LeishMANIAdb annotations

Possesses a conserved Fe2+ binding catalytic pocket. Might be involved in some unknown metabolic pathway.. Most similar to Chlamydomonas proteins A0A2K3DQH2 and A0A835WMM9.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 9
GO:0110165 cellular anatomical entity 1 9

Expansion

Sequence features

E9AFC4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFC4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 46 50 PF00656 0.713
CLV_MEL_PAP_1 284 290 PF00089 0.527
CLV_NRD_NRD_1 139 141 PF00675 0.416
CLV_NRD_NRD_1 24 26 PF00675 0.425
CLV_NRD_NRD_1 270 272 PF00675 0.369
CLV_NRD_NRD_1 56 58 PF00675 0.478
CLV_PCSK_KEX2_1 26 28 PF00082 0.427
CLV_PCSK_KEX2_1 270 272 PF00082 0.369
CLV_PCSK_KEX2_1 56 58 PF00082 0.478
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.427
CLV_PCSK_SKI1_1 119 123 PF00082 0.395
CLV_PCSK_SKI1_1 155 159 PF00082 0.482
CLV_PCSK_SKI1_1 407 411 PF00082 0.432
CLV_Separin_Metazoa 293 297 PF03568 0.592
DEG_APCC_DBOX_1 208 216 PF00400 0.606
DEG_APCC_DBOX_1 450 458 PF00400 0.662
DEG_APCC_KENBOX_2 101 105 PF00400 0.686
DEG_COP1_1 6 16 PF00400 0.408
DEG_Nend_Nbox_1 1 3 PF02207 0.416
DEG_SPOP_SBC_1 173 177 PF00917 0.760
DEG_SPOP_SBC_1 400 404 PF00917 0.691
DOC_CKS1_1 82 87 PF01111 0.709
DOC_CYCLIN_RxL_1 401 414 PF00134 0.629
DOC_MAPK_MEF2A_6 102 109 PF00069 0.605
DOC_MAPK_RevD_3 11 26 PF00069 0.369
DOC_PP2B_LxvP_1 11 14 PF13499 0.369
DOC_PP2B_LxvP_1 370 373 PF13499 0.705
DOC_PP2B_PxIxI_1 13 19 PF00149 0.429
DOC_PP2B_PxIxI_1 412 418 PF00149 0.627
DOC_USP7_MATH_1 157 161 PF00917 0.679
DOC_USP7_MATH_1 165 169 PF00917 0.752
DOC_USP7_MATH_1 173 177 PF00917 0.732
DOC_USP7_MATH_1 203 207 PF00917 0.656
DOC_USP7_MATH_1 373 377 PF00917 0.745
DOC_USP7_MATH_1 382 386 PF00917 0.694
DOC_USP7_MATH_1 400 404 PF00917 0.589
DOC_WW_Pin1_4 174 179 PF00397 0.746
DOC_WW_Pin1_4 241 246 PF00397 0.528
DOC_WW_Pin1_4 278 283 PF00397 0.560
DOC_WW_Pin1_4 340 345 PF00397 0.694
DOC_WW_Pin1_4 81 86 PF00397 0.729
LIG_14-3-3_CanoR_1 128 134 PF00244 0.581
LIG_14-3-3_CanoR_1 225 231 PF00244 0.639
LIG_14-3-3_CanoR_1 285 295 PF00244 0.607
LIG_14-3-3_CanoR_1 296 300 PF00244 0.610
LIG_14-3-3_CanoR_1 365 370 PF00244 0.670
LIG_14-3-3_CanoR_1 401 409 PF00244 0.710
LIG_APCC_ABBA_1 393 398 PF00400 0.528
LIG_BIR_III_4 438 442 PF00653 0.665
LIG_CtBP_PxDLS_1 115 119 PF00389 0.616
LIG_DCNL_PONY_1 1 4 PF03556 0.529
LIG_deltaCOP1_diTrp_1 224 230 PF00928 0.468
LIG_deltaCOP1_diTrp_1 323 326 PF00928 0.535
LIG_deltaCOP1_diTrp_1 414 418 PF00928 0.681
LIG_FHA_1 13 19 PF00498 0.358
LIG_FHA_1 185 191 PF00498 0.617
LIG_FHA_2 175 181 PF00498 0.705
LIG_FHA_2 298 304 PF00498 0.565
LIG_FHA_2 427 433 PF00498 0.736
LIG_FHA_2 44 50 PF00498 0.659
LIG_FHA_2 98 104 PF00498 0.672
LIG_LIR_Gen_1 224 233 PF02991 0.475
LIG_LIR_Gen_1 263 269 PF02991 0.526
LIG_LIR_Gen_1 6 16 PF02991 0.444
LIG_LIR_LC3C_4 389 394 PF02991 0.512
LIG_LIR_Nem_3 180 184 PF02991 0.661
LIG_LIR_Nem_3 224 230 PF02991 0.468
LIG_LIR_Nem_3 263 267 PF02991 0.541
LIG_LIR_Nem_3 53 58 PF02991 0.708
LIG_LIR_Nem_3 6 11 PF02991 0.344
LIG_LYPXL_yS_3 44 47 PF13949 0.642
LIG_REV1ctd_RIR_1 52 59 PF16727 0.674
LIG_SH2_CRK 250 254 PF00017 0.641
LIG_SH2_CRK 8 12 PF00017 0.444
LIG_SH2_PTP2 264 267 PF00017 0.524
LIG_SH2_STAP1 8 12 PF00017 0.444
LIG_SH2_STAT5 221 224 PF00017 0.607
LIG_SH2_STAT5 240 243 PF00017 0.514
LIG_SH2_STAT5 264 267 PF00017 0.514
LIG_SH2_STAT5 369 372 PF00017 0.693
LIG_SH2_STAT5 453 456 PF00017 0.620
LIG_SH2_STAT5 8 11 PF00017 0.444
LIG_SH3_1 250 256 PF00018 0.643
LIG_SH3_1 338 344 PF00018 0.747
LIG_SH3_2 341 346 PF14604 0.761
LIG_SH3_3 110 116 PF00018 0.661
LIG_SH3_3 250 256 PF00018 0.608
LIG_SH3_3 262 268 PF00018 0.485
LIG_SH3_3 303 309 PF00018 0.597
LIG_SH3_3 338 344 PF00018 0.747
LIG_SH3_3 376 382 PF00018 0.645
LIG_SH3_3 67 73 PF00018 0.698
LIG_SUMO_SIM_anti_2 303 308 PF11976 0.591
LIG_SUMO_SIM_par_1 455 460 PF11976 0.698
LIG_UBA3_1 358 363 PF00899 0.582
LIG_WRC_WIRS_1 424 429 PF05994 0.648
MOD_CDC14_SPxK_1 343 346 PF00782 0.653
MOD_CDK_SPxK_1 340 346 PF00069 0.637
MOD_CDK_SPxxK_3 278 285 PF00069 0.487
MOD_CK1_1 286 292 PF00069 0.505
MOD_CK1_1 385 391 PF00069 0.563
MOD_CK1_1 423 429 PF00069 0.654
MOD_CK1_1 6 12 PF00069 0.444
MOD_CK2_1 426 432 PF00069 0.716
MOD_CK2_1 97 103 PF00069 0.629
MOD_GlcNHglycan 159 162 PF01048 0.684
MOD_GlcNHglycan 205 208 PF01048 0.565
MOD_GlcNHglycan 309 312 PF01048 0.501
MOD_GlcNHglycan 384 387 PF01048 0.619
MOD_GlcNHglycan 61 64 PF01048 0.650
MOD_GSK3_1 129 136 PF00069 0.576
MOD_GSK3_1 330 337 PF00069 0.615
MOD_GSK3_1 401 408 PF00069 0.686
MOD_NEK2_1 184 189 PF00069 0.526
MOD_NEK2_1 21 26 PF00069 0.542
MOD_PIKK_1 127 133 PF00454 0.510
MOD_PK_1 420 426 PF00069 0.633
MOD_PKA_2 127 133 PF00069 0.545
MOD_PKA_2 165 171 PF00069 0.713
MOD_PKA_2 286 292 PF00069 0.592
MOD_PKA_2 295 301 PF00069 0.532
MOD_PKA_2 400 406 PF00069 0.629
MOD_PKA_2 433 439 PF00069 0.565
MOD_Plk_1 145 151 PF00069 0.527
MOD_Plk_2-3 428 434 PF00069 0.687
MOD_Plk_4 12 18 PF00069 0.352
MOD_Plk_4 273 279 PF00069 0.463
MOD_Plk_4 3 9 PF00069 0.340
MOD_Plk_4 330 336 PF00069 0.649
MOD_ProDKin_1 174 180 PF00069 0.697
MOD_ProDKin_1 241 247 PF00069 0.398
MOD_ProDKin_1 278 284 PF00069 0.461
MOD_ProDKin_1 340 346 PF00069 0.637
MOD_ProDKin_1 81 87 PF00069 0.673
TRG_DiLeu_BaEn_1 195 200 PF01217 0.543
TRG_ENDOCYTIC_2 264 267 PF00928 0.392
TRG_ENDOCYTIC_2 369 372 PF00928 0.628
TRG_ENDOCYTIC_2 44 47 PF00928 0.549
TRG_ENDOCYTIC_2 453 456 PF00928 0.502
TRG_ENDOCYTIC_2 8 11 PF00928 0.444
TRG_ER_diArg_1 209 212 PF00400 0.538
TRG_ER_diArg_1 25 28 PF00400 0.536
TRG_ER_diArg_1 269 271 PF00400 0.429
TRG_ER_diArg_1 284 287 PF00400 0.573
TRG_ER_diArg_1 55 57 PF00400 0.615
TRG_NES_CRM1_1 231 242 PF08389 0.503
TRG_NLS_MonoExtN_4 139 144 PF00514 0.502
TRG_Pf-PMV_PEXEL_1 188 192 PF00026 0.510
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.505
TRG_Pf-PMV_PEXEL_1 407 412 PF00026 0.593

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I3G4 Leptomonas seymouri 62% 95%
A0A1X0P5E8 Trypanosomatidae 49% 100%
A0A3S7X9P9 Leishmania donovani 94% 100%
A4HMW7 Leishmania braziliensis 83% 100%
A4IBI8 Leishmania infantum 95% 100%
C9ZZ52 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9B6H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
V5DUR9 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS