TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFC1_LEIMA

TriTrypDb:

LmjF.35.2970 , LMJLV39_350036900 , LMJSD75_350036200

Length:

381

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFC1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.429
CLV_PCSK_SKI1_1	152	156	PF00082	0.591
CLV_PCSK_SKI1_1	354	358	PF00082	0.465
CLV_PCSK_SKI1_1	55	59	PF00082	0.420
CLV_PCSK_SKI1_1	93	97	PF00082	0.434
DEG_Nend_Nbox_1	1	3	PF02207	0.617
DOC_CYCLIN_RxL_1	90	97	PF00134	0.477
DOC_CYCLIN_yCln2_LP_2	358	364	PF00134	0.429
DOC_MAPK_gen_1	321	331	PF00069	0.432
DOC_PP2B_LxvP_1	358	361	PF13499	0.596
DOC_USP7_MATH_1	115	119	PF00917	0.546
DOC_USP7_MATH_1	168	172	PF00917	0.705
DOC_USP7_MATH_1	179	183	PF00917	0.591
DOC_USP7_MATH_1	362	366	PF00917	0.680
DOC_USP7_MATH_1	83	87	PF00917	0.363
DOC_WW_Pin1_4	152	157	PF00397	0.684
DOC_WW_Pin1_4	202	207	PF00397	0.628
DOC_WW_Pin1_4	360	365	PF00397	0.630
DOC_WW_Pin1_4	79	84	PF00397	0.407
LIG_14-3-3_CanoR_1	107	112	PF00244	0.336
LIG_14-3-3_CanoR_1	146	156	PF00244	0.495
LIG_Actin_WH2_2	342	359	PF00022	0.410
LIG_AP2alpha_1	133	137	PF02296	0.414
LIG_BRCT_BRCA1_1	13	17	PF00533	0.514
LIG_BRCT_BRCA1_1	362	366	PF00533	0.446
LIG_FHA_1	178	184	PF00498	0.572
LIG_FHA_1	195	201	PF00498	0.638
LIG_FHA_1	234	240	PF00498	0.370
LIG_FHA_1	82	88	PF00498	0.376
LIG_FHA_2	32	38	PF00498	0.473
LIG_FHA_2	341	347	PF00498	0.552
LIG_LIR_Apic_2	26	32	PF02991	0.500
LIG_LIR_Gen_1	22	32	PF02991	0.509
LIG_LIR_Gen_1	236	246	PF02991	0.319
LIG_LIR_Nem_3	110	114	PF02991	0.367
LIG_LIR_Nem_3	22	28	PF02991	0.525
LIG_LIR_Nem_3	236	241	PF02991	0.367
LIG_NRBOX	274	280	PF00104	0.377
LIG_NRBOX	90	96	PF00104	0.480
LIG_Pex14_2	133	137	PF04695	0.370
LIG_Pex14_2	25	29	PF04695	0.493
LIG_SH2_SRC	312	315	PF00017	0.369
LIG_SH2_STAT5	111	114	PF00017	0.349
LIG_SH2_STAT5	312	315	PF00017	0.325
LIG_SH2_STAT5	42	45	PF00017	0.453
LIG_SH3_3	160	166	PF00018	0.695
LIG_SH3_3	358	364	PF00018	0.472
LIG_SUMO_SIM_anti_2	326	333	PF11976	0.468
LIG_TRAF2_1	192	195	PF00917	0.696
LIG_TRAF2_1	373	376	PF00917	0.732
LIG_TRFH_1	111	115	PF08558	0.357
LIG_UBA3_1	278	282	PF00899	0.346
LIG_UBA3_1	66	73	PF00899	0.401
LIG_UBA3_1	74	81	PF00899	0.385
MOD_CK1_1	118	124	PF00069	0.575
MOD_CK1_1	212	218	PF00069	0.647
MOD_CK1_1	365	371	PF00069	0.632
MOD_CK2_1	118	124	PF00069	0.654
MOD_CK2_1	189	195	PF00069	0.732
MOD_CK2_1	223	229	PF00069	0.566
MOD_CK2_1	31	37	PF00069	0.487
MOD_CK2_1	340	346	PF00069	0.556
MOD_GlcNHglycan	117	120	PF01048	0.515
MOD_GlcNHglycan	149	152	PF01048	0.462
MOD_GlcNHglycan	157	160	PF01048	0.612
MOD_GlcNHglycan	186	189	PF01048	0.729
MOD_GlcNHglycan	191	194	PF01048	0.680
MOD_GlcNHglycan	304	308	PF01048	0.388
MOD_GlcNHglycan	367	370	PF01048	0.565
MOD_GlcNHglycan	4	7	PF01048	0.639
MOD_GSK3_1	114	121	PF00069	0.543
MOD_GSK3_1	19	26	PF00069	0.498
MOD_GSK3_1	360	367	PF00069	0.619
MOD_GSK3_1	77	84	PF00069	0.425
MOD_LATS_1	268	274	PF00433	0.427
MOD_N-GLC_1	115	120	PF02516	0.549
MOD_N-GLC_1	19	24	PF02516	0.588
MOD_N-GLC_2	147	149	PF02516	0.482
MOD_NEK2_1	129	134	PF00069	0.555
MOD_NEK2_1	2	7	PF00069	0.530
MOD_NEK2_1	233	238	PF00069	0.346
MOD_NEK2_1	24	29	PF00069	0.461
MOD_NEK2_1	58	63	PF00069	0.426
MOD_PIKK_1	212	218	PF00454	0.579
MOD_PIKK_1	340	346	PF00454	0.442
MOD_PIKK_1	371	377	PF00454	0.468
MOD_Plk_1	115	121	PF00069	0.614
MOD_Plk_1	233	239	PF00069	0.329
MOD_Plk_1	270	276	PF00069	0.431
MOD_Plk_1	47	53	PF00069	0.460
MOD_Plk_1	58	64	PF00069	0.476
MOD_Plk_4	107	113	PF00069	0.383
MOD_Plk_4	24	30	PF00069	0.455
MOD_ProDKin_1	152	158	PF00069	0.686
MOD_ProDKin_1	202	208	PF00069	0.630
MOD_ProDKin_1	360	366	PF00069	0.587
MOD_ProDKin_1	79	85	PF00069	0.409
MOD_SUMO_rev_2	350	359	PF00179	0.434
MOD_SUMO_rev_2	77	83	PF00179	0.410
TRG_DiLeu_BaEn_1	327	332	PF01217	0.379
TRG_ENDOCYTIC_2	230	233	PF00928	0.519
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.291
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.380

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBE1	Leptomonas seymouri	66%	100%
A0A0S4JHH3	Bodo saltans	47%	100%
A0A1X0P5G2	Trypanosomatidae	56%	100%
A0A3S7X9G6	Leishmania donovani	91%	100%
A0A422P2T5	Trypanosoma rangeli	58%	100%
A4HMW4	Leishmania braziliensis	80%	100%
A4IBI5	Leishmania infantum	90%	100%
C9ZZ56	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B6H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BD06	Trypanosoma cruzi	60%	100%