Dolichol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dolichol kinase

Gene product:

dolichol kinase, putative

Species:

Leishmania major

UniProt:

E9AFB7_LEIMA

TriTrypDb:

LmjF.35.2930 , LMJLV39_350036500 , LMJSD75_350035800

Length:

553

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	9
GO:0016020	membrane	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AFB7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFB7

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	11
GO:0006644	phospholipid metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0008610	lipid biosynthetic process	4	11
GO:0008654	phospholipid biosynthetic process	5	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	9
GO:0019637	organophosphate metabolic process	3	11
GO:0043048	dolichyl monophosphate biosynthetic process	6	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044255	cellular lipid metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004168	dolichol kinase activity	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	348	352	PF00656	0.565
CLV_C14_Caspase3-7	490	494	PF00656	0.293
CLV_NRD_NRD_1	207	209	PF00675	0.419
CLV_NRD_NRD_1	210	212	PF00675	0.384
CLV_NRD_NRD_1	285	287	PF00675	0.280
CLV_NRD_NRD_1	418	420	PF00675	0.315
CLV_NRD_NRD_1	525	527	PF00675	0.394
CLV_NRD_NRD_1	66	68	PF00675	0.392
CLV_PCSK_KEX2_1	206	208	PF00082	0.439
CLV_PCSK_KEX2_1	212	214	PF00082	0.377
CLV_PCSK_KEX2_1	285	287	PF00082	0.274
CLV_PCSK_KEX2_1	418	420	PF00082	0.315
CLV_PCSK_KEX2_1	525	527	PF00082	0.394
CLV_PCSK_KEX2_1	66	68	PF00082	0.384
CLV_PCSK_PC1ET2_1	212	214	PF00082	0.377
CLV_PCSK_PC7_1	208	214	PF00082	0.304
CLV_PCSK_PC7_1	281	287	PF00082	0.301
CLV_PCSK_SKI1_1	243	247	PF00082	0.537
CLV_PCSK_SKI1_1	286	290	PF00082	0.236
CLV_PCSK_SKI1_1	423	427	PF00082	0.364
DEG_Nend_UBRbox_3	1	3	PF02207	0.377
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.320
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.236
DOC_MAPK_gen_1	206	218	PF00069	0.596
DOC_MAPK_gen_1	285	294	PF00069	0.436
DOC_MAPK_MEF2A_6	211	218	PF00069	0.524
DOC_MAPK_MEF2A_6	22	30	PF00069	0.278
DOC_MAPK_MEF2A_6	355	364	PF00069	0.404
DOC_MAPK_NFAT4_5	22	30	PF00069	0.321
DOC_MAPK_NFAT4_5	355	363	PF00069	0.384
DOC_PP2B_LxvP_1	159	162	PF13499	0.440
DOC_PP2B_LxvP_1	23	26	PF13499	0.303
DOC_PP2B_LxvP_1	495	498	PF13499	0.256
DOC_PP2B_LxvP_1	511	514	PF13499	0.271
DOC_PP4_FxxP_1	546	549	PF00568	0.626
DOC_USP7_MATH_1	13	17	PF00917	0.421
DOC_USP7_MATH_1	434	438	PF00917	0.514
DOC_WW_Pin1_4	295	300	PF00397	0.271
DOC_WW_Pin1_4	41	46	PF00397	0.305
DOC_WW_Pin1_4	538	543	PF00397	0.702
DOC_WW_Pin1_4	545	550	PF00397	0.681
DOC_WW_Pin1_4	67	72	PF00397	0.571
LIG_14-3-3_CanoR_1	165	169	PF00244	0.298
LIG_14-3-3_CanoR_1	255	260	PF00244	0.306
LIG_14-3-3_CanoR_1	418	422	PF00244	0.599
LIG_14-3-3_CanoR_1	98	103	PF00244	0.251
LIG_Actin_WH2_2	265	283	PF00022	0.397
LIG_APCC_ABBAyCdc20_2	426	432	PF00400	0.675
LIG_BRCT_BRCA1_1	214	218	PF00533	0.481
LIG_BRCT_BRCA1_1	233	237	PF00533	0.325
LIG_BRCT_BRCA1_1	250	254	PF00533	0.339
LIG_BRCT_BRCA1_1	410	414	PF00533	0.388
LIG_Clathr_ClatBox_1	512	516	PF01394	0.292
LIG_EH1_1	363	371	PF00400	0.281
LIG_eIF4E_1	424	430	PF01652	0.571
LIG_FHA_1	442	448	PF00498	0.453
LIG_FHA_1	9	15	PF00498	0.353
LIG_FHA_2	299	305	PF00498	0.335
LIG_FHA_2	481	487	PF00498	0.349
LIG_GBD_Chelix_1	224	232	PF00786	0.337
LIG_GBD_Chelix_1	272	280	PF00786	0.473
LIG_HP1_1	498	502	PF01393	0.404
LIG_IRF3_LxIS_1	227	234	PF10401	0.393
LIG_LIR_Apic_2	516	522	PF02991	0.625
LIG_LIR_Gen_1	110	120	PF02991	0.349
LIG_LIR_Gen_1	191	197	PF02991	0.566
LIG_LIR_Gen_1	304	315	PF02991	0.236
LIG_LIR_Gen_1	356	366	PF02991	0.404
LIG_LIR_Gen_1	475	484	PF02991	0.281
LIG_LIR_Gen_1	55	64	PF02991	0.289
LIG_LIR_Gen_1	80	91	PF02991	0.335
LIG_LIR_Nem_3	110	115	PF02991	0.370
LIG_LIR_Nem_3	166	171	PF02991	0.346
LIG_LIR_Nem_3	191	196	PF02991	0.531
LIG_LIR_Nem_3	304	310	PF02991	0.247
LIG_LIR_Nem_3	356	362	PF02991	0.271
LIG_LIR_Nem_3	475	479	PF02991	0.274
LIG_LIR_Nem_3	541	546	PF02991	0.689
LIG_LIR_Nem_3	55	59	PF02991	0.289
LIG_LIR_Nem_3	80	86	PF02991	0.335
LIG_LYPXL_yS_3	168	171	PF13949	0.213
LIG_NRBOX	507	513	PF00104	0.404
LIG_PALB2_WD40_1	258	266	PF16756	0.292
LIG_PCNA_TLS_4	418	426	PF02747	0.607
LIG_Pex14_1	244	248	PF04695	0.275
LIG_PTB_Apo_2	424	431	PF02174	0.526
LIG_REV1ctd_RIR_1	112	119	PF16727	0.404
LIG_REV1ctd_RIR_1	90	100	PF16727	0.303
LIG_SH2_CRK	83	87	PF00017	0.394
LIG_SH2_GRB2like	327	330	PF00017	0.597
LIG_SH2_NCK_1	83	87	PF00017	0.394
LIG_SH2_PTP2	182	185	PF00017	0.313
LIG_SH2_STAP1	474	478	PF00017	0.367
LIG_SH2_STAP1	49	53	PF00017	0.281
LIG_SH2_STAT5	107	110	PF00017	0.318
LIG_SH2_STAT5	112	115	PF00017	0.320
LIG_SH2_STAT5	137	140	PF00017	0.349
LIG_SH2_STAT5	182	185	PF00017	0.309
LIG_SH2_STAT5	248	251	PF00017	0.289
LIG_SH2_STAT5	271	274	PF00017	0.349
LIG_SH2_STAT5	359	362	PF00017	0.319
LIG_SH2_STAT5	424	427	PF00017	0.533
LIG_SH2_STAT5	56	59	PF00017	0.289
LIG_SH3_3	377	383	PF00018	0.420
LIG_SUMO_SIM_anti_2	5	11	PF11976	0.358
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.289
LIG_SUMO_SIM_par_1	182	188	PF11976	0.411
LIG_SUMO_SIM_par_1	384	389	PF11976	0.323
LIG_SUMO_SIM_par_1	459	465	PF11976	0.343
LIG_SUMO_SIM_par_1	5	11	PF11976	0.351
LIG_TRFH_1	263	267	PF08558	0.292
LIG_TYR_ITIM	54	59	PF00017	0.289
LIG_TYR_ITIM	81	86	PF00017	0.313
LIG_TYR_ITSM	164	171	PF00017	0.374
LIG_UBA3_1	113	117	PF00899	0.292
LIG_WRC_WIRS_1	473	478	PF05994	0.292
MOD_CDC14_SPxK_1	541	544	PF00782	0.609
MOD_CDK_SPK_2	67	72	PF00069	0.571
MOD_CDK_SPxK_1	538	544	PF00069	0.608
MOD_CDK_SPxxK_3	67	74	PF00069	0.570
MOD_CK1_1	155	161	PF00069	0.494
MOD_CK1_1	188	194	PF00069	0.396
MOD_CK1_1	202	208	PF00069	0.500
MOD_CK1_1	417	423	PF00069	0.574
MOD_CK1_1	55	61	PF00069	0.283
MOD_CK2_1	480	486	PF00069	0.299
MOD_GlcNHglycan	109	112	PF01048	0.404
MOD_GSK3_1	195	202	PF00069	0.580
MOD_GSK3_1	310	317	PF00069	0.285
MOD_GSK3_1	330	337	PF00069	0.405
MOD_GSK3_1	349	356	PF00069	0.586
MOD_GSK3_1	409	416	PF00069	0.294
MOD_GSK3_1	436	443	PF00069	0.516
MOD_GSK3_1	48	55	PF00069	0.280
MOD_GSK3_1	527	534	PF00069	0.682
MOD_GSK3_1	544	551	PF00069	0.705
MOD_GSK3_1	8	15	PF00069	0.383
MOD_N-GLC_1	145	150	PF02516	0.570
MOD_N-GLC_1	434	439	PF02516	0.310
MOD_NEK2_1	129	134	PF00069	0.284
MOD_NEK2_1	218	223	PF00069	0.291
MOD_NEK2_1	231	236	PF00069	0.349
MOD_NEK2_1	249	254	PF00069	0.378
MOD_NEK2_1	310	315	PF00069	0.276
MOD_NEK2_1	364	369	PF00069	0.304
MOD_NEK2_1	413	418	PF00069	0.427
MOD_NEK2_1	48	53	PF00069	0.298
MOD_PK_1	212	218	PF00069	0.458
MOD_PK_1	373	379	PF00069	0.368
MOD_PKA_1	207	213	PF00069	0.609
MOD_PKA_2	152	158	PF00069	0.488
MOD_PKA_2	164	170	PF00069	0.222
MOD_PKA_2	207	213	PF00069	0.521
MOD_PKA_2	280	286	PF00069	0.513
MOD_PKA_2	417	423	PF00069	0.609
MOD_PKB_1	253	261	PF00069	0.284
MOD_PKB_1	371	379	PF00069	0.358
MOD_PKB_1	96	104	PF00069	0.189
MOD_Plk_1	145	151	PF00069	0.372
MOD_Plk_1	386	392	PF00069	0.288
MOD_Plk_1	434	440	PF00069	0.529
MOD_Plk_4	129	135	PF00069	0.314
MOD_Plk_4	152	158	PF00069	0.453
MOD_Plk_4	185	191	PF00069	0.339
MOD_Plk_4	2	8	PF00069	0.350
MOD_Plk_4	298	304	PF00069	0.341
MOD_Plk_4	349	355	PF00069	0.509
MOD_Plk_4	409	415	PF00069	0.271
MOD_Plk_4	49	55	PF00069	0.288
MOD_Plk_4	77	83	PF00069	0.341
MOD_ProDKin_1	295	301	PF00069	0.271
MOD_ProDKin_1	41	47	PF00069	0.302
MOD_ProDKin_1	538	544	PF00069	0.703
MOD_ProDKin_1	545	551	PF00069	0.683
MOD_ProDKin_1	67	73	PF00069	0.568
MOD_SUMO_for_1	62	65	PF00179	0.550
TRG_DiLeu_BaEn_1	20	25	PF01217	0.289
TRG_DiLeu_BaLyEn_6	19	24	PF01217	0.322
TRG_ENDOCYTIC_2	112	115	PF00928	0.333
TRG_ENDOCYTIC_2	168	171	PF00928	0.355
TRG_ENDOCYTIC_2	182	185	PF00928	0.404
TRG_ENDOCYTIC_2	327	330	PF00928	0.536
TRG_ENDOCYTIC_2	359	362	PF00928	0.404
TRG_ENDOCYTIC_2	56	59	PF00928	0.289
TRG_ENDOCYTIC_2	83	86	PF00928	0.338
TRG_ER_diArg_1	206	208	PF00400	0.650
TRG_ER_diArg_1	211	214	PF00400	0.566
TRG_ER_diArg_1	284	286	PF00400	0.505
TRG_ER_diArg_1	370	373	PF00400	0.356
TRG_ER_diArg_1	524	526	PF00400	0.561
TRG_NLS_MonoExtN_4	208	215	PF00514	0.499
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	373	378	PF00026	0.615

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ90	Leptomonas seymouri	77%	91%
A0A1X0P5F5	Trypanosomatidae	50%	100%
A0A3Q8IJJ2	Leishmania donovani	95%	100%
A0A3R7KY54	Trypanosoma rangeli	50%	100%
A4HMW0	Leishmania braziliensis	88%	100%
A4IBI1	Leishmania infantum	96%	100%
C9ZZ59	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9B6H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTH9	Trypanosoma cruzi	50%	100%