Dynein light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Dynein light chain

Gene product:

dynein light chain, putative

Species:

Leishmania major

UniProt:

E9AFB5_LEIMA

TriTrypDb:

LmjF.35.2910 , LMJLV39_350036300 , LMJSD75_350035600

Length:

123

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005868	cytoplasmic dynein complex	4	2
GO:0005875	microtubule associated complex	2	2
GO:0030286	dynein complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1902494	catalytic complex	2	2

Expansion

Sequence features

E9AFB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFB5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	2
GO:0007018	microtubule-based movement	3	2
GO:0009987	cellular process	1	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045505	dynein intermediate chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	96	100	PF00656	0.409
CLV_PCSK_SKI1_1	109	113	PF00082	0.411
CLV_PCSK_SKI1_1	30	34	PF00082	0.378
DEG_Nend_UBRbox_3	1	3	PF02207	0.654
DOC_CYCLIN_RxL_1	106	116	PF00134	0.412
DOC_USP7_UBL2_3	26	30	PF12436	0.455
DOC_USP7_UBL2_3	61	65	PF12436	0.455
LIG_eIF4E_1	106	112	PF01652	0.321
LIG_FHA_1	7	13	PF00498	0.569
LIG_FHA_2	55	61	PF00498	0.334
LIG_LIR_Gen_1	99	107	PF02991	0.334
LIG_LIR_Nem_3	116	121	PF02991	0.294
LIG_LIR_Nem_3	68	73	PF02991	0.454
LIG_LIR_Nem_3	99	105	PF02991	0.332
LIG_SH2_CRK	70	74	PF00017	0.454
LIG_SH2_STAT5	101	104	PF00017	0.322
LIG_SH2_STAT5	106	109	PF00017	0.314
LIG_SH3_4	26	33	PF00018	0.455
LIG_TRFH_1	10	14	PF08558	0.505
MOD_CK2_1	28	34	PF00069	0.319
MOD_GSK3_1	28	35	PF00069	0.344
MOD_NEK2_2	113	118	PF00069	0.334
MOD_Plk_1	5	11	PF00069	0.638
MOD_Plk_4	113	119	PF00069	0.325
MOD_Plk_4	28	34	PF00069	0.424
TRG_ENDOCYTIC_2	70	73	PF00928	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B2	Leptomonas seymouri	85%	100%
A0A0N1PFP4	Leptomonas seymouri	33%	98%
A0A0S4IQE7	Bodo saltans	26%	100%
A0A0S4JDH6	Bodo saltans	72%	88%
A0A1X0NYC6	Trypanosomatidae	28%	98%
A0A1X0P6I3	Trypanosomatidae	70%	99%
A0A3R7LJS7	Trypanosoma rangeli	25%	98%
A0A3S5H7J0	Leishmania donovani	31%	98%
A0A3S7X9I4	Leishmania donovani	99%	100%
A0A422P2R8	Trypanosoma rangeli	77%	99%
A2VDD2	Xenopus laevis	31%	70%
A4HGD9	Leishmania braziliensis	30%	98%
A4HMV8	Leishmania braziliensis	95%	100%
A4I3H2	Leishmania infantum	31%	98%
A4IBH9	Leishmania infantum	99%	100%
C9ZZ62	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	99%
E9AZR1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	98%
E9B6H0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
F1QMY1	Danio rerio	38%	82%
P63171	Bos taurus	26%	100%
P63172	Homo sapiens	26%	100%
Q32P71	Bos taurus	37%	81%
Q3B8D7	Xenopus laevis	30%	69%
Q4Q8H2	Leishmania major	30%	98%
Q54PG1	Dictyostelium discoideum	28%	100%
Q66IC8	Danio rerio	33%	71%
Q8N7M0	Homo sapiens	28%	69%
Q8WW35	Homo sapiens	38%	87%
Q94524	Drosophila melanogaster	24%	100%
Q9CQ66	Mus musculus	39%	85%
Q9D5I4	Mus musculus	20%	71%
Q9Z336	Rattus norvegicus	24%	100%
V5BTL3	Trypanosoma cruzi	73%	99%