DNA helicase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

DNA helicase

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFB4_LEIMA

TriTrypDb:

LmjF.35.2900 , LMJLV39_350036200 , LMJSD75_350035500

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.669
CLV_C14_Caspase3-7	664	668	PF00656	0.661
CLV_NRD_NRD_1	202	204	PF00675	0.575
CLV_NRD_NRD_1	292	294	PF00675	0.726
CLV_NRD_NRD_1	432	434	PF00675	0.544
CLV_NRD_NRD_1	581	583	PF00675	0.755
CLV_NRD_NRD_1	651	653	PF00675	0.802
CLV_PCSK_KEX2_1	201	203	PF00082	0.562
CLV_PCSK_KEX2_1	280	282	PF00082	0.699
CLV_PCSK_KEX2_1	292	294	PF00082	0.733
CLV_PCSK_KEX2_1	432	434	PF00082	0.544
CLV_PCSK_KEX2_1	581	583	PF00082	0.730
CLV_PCSK_KEX2_1	651	653	PF00082	0.802
CLV_PCSK_PC1ET2_1	280	282	PF00082	0.699
CLV_PCSK_SKI1_1	168	172	PF00082	0.345
CLV_PCSK_SKI1_1	225	229	PF00082	0.508
CLV_PCSK_SKI1_1	490	494	PF00082	0.481
DEG_APCC_DBOX_1	63	71	PF00400	0.460
DEG_Nend_UBRbox_1	1	4	PF02207	0.665
DEG_SPOP_SBC_1	414	418	PF00917	0.636
DOC_CDC14_PxL_1	179	187	PF14671	0.607
DOC_CKS1_1	340	345	PF01111	0.483
DOC_CYCLIN_RxL_1	576	587	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.523
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.413
DOC_MAPK_gen_1	137	146	PF00069	0.330
DOC_MAPK_gen_1	168	177	PF00069	0.397
DOC_MAPK_gen_1	61	69	PF00069	0.471
DOC_MAPK_HePTP_8	491	503	PF00069	0.554
DOC_MAPK_MEF2A_6	168	177	PF00069	0.397
DOC_MAPK_MEF2A_6	494	503	PF00069	0.556
DOC_MAPK_MEF2A_6	652	661	PF00069	0.793
DOC_PP1_RVXF_1	351	357	PF00149	0.524
DOC_PP1_RVXF_1	375	381	PF00149	0.602
DOC_PP2B_LxvP_1	228	231	PF13499	0.511
DOC_PP4_FxxP_1	100	103	PF00568	0.502
DOC_PP4_FxxP_1	156	159	PF00568	0.588
DOC_PP4_FxxP_1	207	210	PF00568	0.516
DOC_PP4_FxxP_1	275	278	PF00568	0.719
DOC_PP4_FxxP_1	37	40	PF00568	0.543
DOC_PP4_FxxP_1	389	392	PF00568	0.542
DOC_PP4_FxxP_1	54	57	PF00568	0.582
DOC_SPAK_OSR1_1	632	636	PF12202	0.645
DOC_USP7_MATH_1	211	215	PF00917	0.494
DOC_USP7_MATH_1	326	330	PF00917	0.680
DOC_USP7_MATH_1	4	8	PF00917	0.676
DOC_USP7_MATH_1	480	484	PF00917	0.435
DOC_USP7_MATH_1	608	612	PF00917	0.747
DOC_USP7_MATH_1	619	623	PF00917	0.658
DOC_USP7_MATH_2	323	329	PF00917	0.571
DOC_USP7_UBL2_3	713	717	PF12436	0.641
DOC_WW_Pin1_4	295	300	PF00397	0.644
DOC_WW_Pin1_4	339	344	PF00397	0.497
DOC_WW_Pin1_4	359	364	PF00397	0.559
DOC_WW_Pin1_4	415	420	PF00397	0.627
DOC_WW_Pin1_4	43	48	PF00397	0.568
DOC_WW_Pin1_4	588	593	PF00397	0.689
DOC_WW_Pin1_4	646	651	PF00397	0.545
LIG_14-3-3_CanoR_1	137	142	PF00244	0.356
LIG_14-3-3_CanoR_1	16	22	PF00244	0.543
LIG_14-3-3_CanoR_1	225	231	PF00244	0.523
LIG_14-3-3_CanoR_1	266	275	PF00244	0.667
LIG_14-3-3_CanoR_1	281	291	PF00244	0.726
LIG_14-3-3_CanoR_1	403	407	PF00244	0.575
LIG_14-3-3_CanoR_1	413	419	PF00244	0.571
LIG_14-3-3_CanoR_1	450	454	PF00244	0.462
LIG_14-3-3_CanoR_1	504	514	PF00244	0.570
LIG_14-3-3_CanoR_1	528	532	PF00244	0.584
LIG_14-3-3_CanoR_1	651	659	PF00244	0.767
LIG_Actin_WH2_2	500	515	PF00022	0.569
LIG_AP2alpha_1	367	371	PF02296	0.587
LIG_AP2alpha_2	273	275	PF02296	0.713
LIG_APCC_ABBA_1	356	361	PF00400	0.490
LIG_BRCT_BRCA1_1	120	124	PF00533	0.440
LIG_BRCT_BRCA1_1	213	217	PF00533	0.485
LIG_BRCT_BRCA1_1	228	232	PF00533	0.524
LIG_BRCT_BRCA1_1	403	407	PF00533	0.495
LIG_BRCT_BRCA1_1	483	487	PF00533	0.489
LIG_Clathr_ClatBox_1	630	634	PF01394	0.645
LIG_FHA_1	106	112	PF00498	0.492
LIG_FHA_1	216	222	PF00498	0.504
LIG_FHA_1	282	288	PF00498	0.635
LIG_FHA_1	336	342	PF00498	0.677
LIG_FHA_1	4	10	PF00498	0.623
LIG_FHA_1	406	412	PF00498	0.528
LIG_FHA_1	476	482	PF00498	0.465
LIG_FHA_1	562	568	PF00498	0.756
LIG_FHA_1	57	63	PF00498	0.603
LIG_FHA_1	667	673	PF00498	0.627
LIG_FHA_1	719	725	PF00498	0.581
LIG_FHA_2	374	380	PF00498	0.609
LIG_FHA_2	567	573	PF00498	0.749
LIG_FHA_2	658	664	PF00498	0.753
LIG_FHA_2	66	72	PF00498	0.566
LIG_IBAR_NPY_1	383	385	PF08397	0.681
LIG_IRF3_LxIS_1	705	712	PF10401	0.587
LIG_LIR_Apic_2	153	159	PF02991	0.568
LIG_LIR_Apic_2	205	210	PF02991	0.526
LIG_LIR_Apic_2	273	278	PF02991	0.716
LIG_LIR_Apic_2	35	40	PF02991	0.457
LIG_LIR_Apic_2	52	57	PF02991	0.525
LIG_LIR_Apic_2	587	592	PF02991	0.699
LIG_LIR_Gen_1	118	126	PF02991	0.458
LIG_LIR_Gen_1	365	374	PF02991	0.511
LIG_LIR_Nem_3	118	122	PF02991	0.464
LIG_LIR_Nem_3	365	370	PF02991	0.530
LIG_LIR_Nem_3	454	460	PF02991	0.593
LIG_LIR_Nem_3	52	56	PF02991	0.543
LIG_LIR_Nem_3	599	605	PF02991	0.716
LIG_LIR_Nem_3	89	94	PF02991	0.427
LIG_LYPXL_yS_3	385	388	PF13949	0.604
LIG_MAD2	490	498	PF02301	0.525
LIG_MLH1_MIPbox_1	120	124	PF16413	0.476
LIG_MLH1_MIPbox_1	403	407	PF16413	0.556
LIG_PCNA_TLS_4	201	208	PF02747	0.538
LIG_Pex14_1	119	123	PF04695	0.489
LIG_Pex14_2	146	150	PF04695	0.590
LIG_Pex14_2	232	236	PF04695	0.572
LIG_Pex14_2	367	371	PF04695	0.587
LIG_Pex14_2	37	41	PF04695	0.531
LIG_Pex14_2	470	474	PF04695	0.435
LIG_Pex14_2	629	633	PF04695	0.469
LIG_Pex14_2	84	88	PF04695	0.554
LIG_Rb_LxCxE_1	550	571	PF01857	0.720
LIG_REV1ctd_RIR_1	485	494	PF16727	0.553
LIG_SH2_CRK	457	461	PF00017	0.558
LIG_SH2_CRK	589	593	PF00017	0.696
LIG_SH2_CRK	706	710	PF00017	0.663
LIG_SH2_STAP1	195	199	PF00017	0.621
LIG_SH2_STAP1	720	724	PF00017	0.563
LIG_SH2_STAT3	517	520	PF00017	0.713
LIG_SH2_STAT5	123	126	PF00017	0.488
LIG_SH2_STAT5	195	198	PF00017	0.684
LIG_SH2_STAT5	226	229	PF00017	0.466
LIG_SH2_STAT5	254	257	PF00017	0.530
LIG_SH2_STAT5	264	267	PF00017	0.581
LIG_SH2_STAT5	424	427	PF00017	0.499
LIG_SH2_STAT5	553	556	PF00017	0.701
LIG_SH2_STAT5	675	678	PF00017	0.521
LIG_SH2_STAT5	720	723	PF00017	0.608
LIG_SH3_2	288	293	PF14604	0.694
LIG_SH3_3	285	291	PF00018	0.769
LIG_SH3_3	409	415	PF00018	0.527
LIG_SH3_3	556	562	PF00018	0.691
LIG_SH3_3	668	674	PF00018	0.702
LIG_SH3_3	695	701	PF00018	0.481
LIG_SUMO_SIM_anti_2	342	348	PF11976	0.436
LIG_SUMO_SIM_anti_2	65	71	PF11976	0.631
LIG_SUMO_SIM_par_1	102	108	PF11976	0.532
LIG_SUMO_SIM_par_1	342	348	PF11976	0.514
LIG_SxIP_EBH_1	280	293	PF03271	0.536
LIG_TRAF2_1	623	626	PF00917	0.725
LIG_TRAF2_1	660	663	PF00917	0.659
LIG_WRC_WIRS_1	147	152	PF05994	0.608
LIG_WRC_WIRS_1	204	209	PF05994	0.604
MOD_CDC14_SPxK_1	649	652	PF00782	0.550
MOD_CDK_SPK_2	646	651	PF00069	0.545
MOD_CDK_SPxK_1	646	652	PF00069	0.547
MOD_CK1_1	118	124	PF00069	0.537
MOD_CK1_1	267	273	PF00069	0.561
MOD_CK1_1	283	289	PF00069	0.555
MOD_CK1_1	313	319	PF00069	0.740
MOD_CK1_1	328	334	PF00069	0.536
MOD_CK1_1	345	351	PF00069	0.624
MOD_CK1_1	405	411	PF00069	0.622
MOD_CK1_1	469	475	PF00069	0.480
MOD_CK1_1	611	617	PF00069	0.714
MOD_CK1_1	666	672	PF00069	0.659
MOD_CK2_1	373	379	PF00069	0.617
MOD_CK2_1	503	509	PF00069	0.505
MOD_CK2_1	554	560	PF00069	0.694
MOD_CK2_1	620	626	PF00069	0.748
MOD_CK2_1	657	663	PF00069	0.789
MOD_CK2_1	685	691	PF00069	0.641
MOD_Cter_Amidation	199	202	PF01082	0.575
MOD_Cter_Amidation	574	577	PF01082	0.635
MOD_GlcNHglycan	228	231	PF01048	0.515
MOD_GlcNHglycan	243	246	PF01048	0.576
MOD_GlcNHglycan	270	273	PF01048	0.626
MOD_GlcNHglycan	308	311	PF01048	0.515
MOD_GlcNHglycan	364	367	PF01048	0.614
MOD_GlcNHglycan	379	383	PF01048	0.666
MOD_GlcNHglycan	653	656	PF01048	0.741
MOD_GSK3_1	142	149	PF00069	0.463
MOD_GSK3_1	211	218	PF00069	0.392
MOD_GSK3_1	237	244	PF00069	0.610
MOD_GSK3_1	264	271	PF00069	0.509
MOD_GSK3_1	306	313	PF00069	0.535
MOD_GSK3_1	335	342	PF00069	0.575
MOD_GSK3_1	401	408	PF00069	0.597
MOD_GSK3_1	413	420	PF00069	0.557
MOD_GSK3_1	466	473	PF00069	0.443
MOD_GSK3_1	52	59	PF00069	0.565
MOD_GSK3_1	567	574	PF00069	0.779
MOD_N-GLC_1	268	273	PF02516	0.582
MOD_N-GLC_1	359	364	PF02516	0.480
MOD_N-GLC_1	521	526	PF02516	0.645
MOD_NEK2_1	124	129	PF00069	0.479
MOD_NEK2_1	146	151	PF00069	0.500
MOD_NEK2_1	17	22	PF00069	0.513
MOD_NEK2_1	215	220	PF00069	0.568
MOD_NEK2_1	402	407	PF00069	0.588
MOD_NEK2_1	41	46	PF00069	0.566
MOD_NEK2_1	470	475	PF00069	0.491
MOD_NEK2_1	481	486	PF00069	0.453
MOD_NEK2_1	503	508	PF00069	0.474
MOD_NEK2_1	536	541	PF00069	0.650
MOD_NEK2_1	709	714	PF00069	0.568
MOD_OFUCOSY	38	45	PF10250	0.516
MOD_PIKK_1	264	270	PF00454	0.567
MOD_PIKK_1	310	316	PF00454	0.617
MOD_PIKK_1	620	626	PF00454	0.734
MOD_PK_1	137	143	PF00069	0.379
MOD_PKA_1	280	286	PF00069	0.698
MOD_PKA_1	651	657	PF00069	0.754
MOD_PKA_2	280	286	PF00069	0.698
MOD_PKA_2	402	408	PF00069	0.568
MOD_PKA_2	449	455	PF00069	0.460
MOD_PKA_2	503	509	PF00069	0.552
MOD_PKA_2	527	533	PF00069	0.592
MOD_PKA_2	651	657	PF00069	0.736
MOD_PKB_1	201	209	PF00069	0.561
MOD_Plk_1	142	148	PF00069	0.531
MOD_Plk_1	237	243	PF00069	0.586
MOD_Plk_1	470	476	PF00069	0.477
MOD_Plk_1	597	603	PF00069	0.719
MOD_Plk_1	65	71	PF00069	0.646
MOD_Plk_2-3	598	604	PF00069	0.723
MOD_Plk_2-3	65	71	PF00069	0.571
MOD_Plk_2-3	685	691	PF00069	0.662
MOD_Plk_4	115	121	PF00069	0.471
MOD_Plk_4	203	209	PF00069	0.515
MOD_Plk_4	402	408	PF00069	0.577
MOD_Plk_4	470	476	PF00069	0.464
MOD_Plk_4	49	55	PF00069	0.597
MOD_Plk_4	536	542	PF00069	0.594
MOD_Plk_4	598	604	PF00069	0.723
MOD_Plk_4	637	643	PF00069	0.730
MOD_Plk_4	65	71	PF00069	0.448
MOD_ProDKin_1	295	301	PF00069	0.643
MOD_ProDKin_1	339	345	PF00069	0.488
MOD_ProDKin_1	359	365	PF00069	0.566
MOD_ProDKin_1	415	421	PF00069	0.628
MOD_ProDKin_1	43	49	PF00069	0.568
MOD_ProDKin_1	588	594	PF00069	0.688
MOD_ProDKin_1	646	652	PF00069	0.547
MOD_SUMO_for_1	689	692	PF00179	0.622
MOD_SUMO_rev_2	163	173	PF00179	0.467
MOD_SUMO_rev_2	256	263	PF00179	0.535
TRG_DiLeu_BaEn_1	626	631	PF01217	0.691
TRG_DiLeu_BaEn_1	65	70	PF01217	0.575
TRG_DiLeu_BaEn_1	692	697	PF01217	0.525
TRG_ENDOCYTIC_2	123	126	PF00928	0.459
TRG_ENDOCYTIC_2	385	388	PF00928	0.594
TRG_ENDOCYTIC_2	457	460	PF00928	0.562
TRG_ENDOCYTIC_2	602	605	PF00928	0.729
TRG_ENDOCYTIC_2	706	709	PF00928	0.663
TRG_ENDOCYTIC_2	85	88	PF00928	0.511
TRG_ER_diArg_1	201	203	PF00400	0.565
TRG_ER_diArg_1	291	293	PF00400	0.776
TRG_ER_diArg_1	431	433	PF00400	0.519
TRG_ER_diArg_1	581	583	PF00400	0.763
TRG_ER_diArg_1	650	652	PF00400	0.779
TRG_NES_CRM1_1	169	180	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q5	Leptomonas seymouri	68%	100%
A0A1X0P6X0	Trypanosomatidae	37%	100%
A0A3Q8IF92	Leishmania donovani	93%	93%
A0A3S5ISL4	Trypanosoma rangeli	39%	100%
A4HMV7	Leishmania braziliensis	76%	99%
A4IBH8	Leishmania infantum	93%	100%
C9ZZ63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B6G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%