Trafficking protein particle complex subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sybindin-like family, putative

Species:

Leishmania major

UniProt:

E9AFB2_LEIMA

TriTrypDb:

LmjF.35.2880 , LMJLV39_350036000 , LMJSD75_350035300

Length:

141

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	11
GO:0005794	Golgi apparatus	5	11
GO:0030008	TRAPP complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0099023	vesicle tethering complex	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	11

Expansion

Sequence features

E9AFB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFB2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006888	endoplasmic reticulum to Golgi vesicle-mediated transport	4	11
GO:0009987	cellular process	1	11
GO:0016192	vesicle-mediated transport	4	11
GO:0046907	intracellular transport	3	11
GO:0048193	Golgi vesicle transport	5	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	22	24	PF00082	0.327
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.316
CLV_PCSK_SKI1_1	100	104	PF00082	0.267
CLV_PCSK_SKI1_1	105	109	PF00082	0.257
CLV_PCSK_SKI1_1	117	121	PF00082	0.380
CLV_PCSK_SKI1_1	137	141	PF00082	0.388
CLV_PCSK_SKI1_1	77	81	PF00082	0.248
DOC_CKS1_1	60	65	PF01111	0.248
DOC_CYCLIN_RxL_1	134	141	PF00134	0.351
DOC_WW_Pin1_4	59	64	PF00397	0.248
LIG_Actin_WH2_2	42	60	PF00022	0.291
LIG_Actin_WH2_2	86	102	PF00022	0.355
LIG_APCC_ABBA_1	78	83	PF00400	0.374
LIG_APCC_ABBAyCdc20_2	77	83	PF00400	0.381
LIG_FHA_1	22	28	PF00498	0.309
LIG_FHA_1	86	92	PF00498	0.301
LIG_FHA_1	94	100	PF00498	0.304
LIG_FHA_2	120	126	PF00498	0.336
LIG_LIR_Nem_3	2	7	PF02991	0.248
LIG_NRBOX	94	100	PF00104	0.313
LIG_PCNA_yPIPBox_3	92	105	PF02747	0.338
LIG_PTB_Apo_2	107	114	PF02174	0.381
LIG_PTB_Phospho_1	107	113	PF10480	0.381
LIG_SH2_STAP1	17	21	PF00017	0.248
LIG_SH2_STAP1	4	8	PF00017	0.248
LIG_SH2_STAT3	17	20	PF00017	0.381
LIG_SH2_STAT3	40	43	PF00017	0.248
LIG_SH2_STAT5	17	20	PF00017	0.267
LIG_SH2_STAT5	40	43	PF00017	0.248
LIG_SH2_STAT5	69	72	PF00017	0.271
LIG_SH2_STAT5	7	10	PF00017	0.267
LIG_SH3_3	57	63	PF00018	0.267
MOD_CDK_SPxxK_3	59	66	PF00069	0.248
MOD_CK1_1	47	53	PF00069	0.248
MOD_CK2_1	119	125	PF00069	0.367
MOD_GlcNHglycan	24	27	PF01048	0.268
MOD_GSK3_1	105	112	PF00069	0.411
MOD_GSK3_1	43	50	PF00069	0.256
MOD_NEK2_1	103	108	PF00069	0.371
MOD_NEK2_1	119	124	PF00069	0.269
MOD_NEK2_1	38	43	PF00069	0.287
MOD_NEK2_1	49	54	PF00069	0.291
MOD_NEK2_2	12	17	PF00069	0.381
MOD_PIKK_1	44	50	PF00454	0.248
MOD_PKA_1	22	28	PF00069	0.327
MOD_PKA_2	22	28	PF00069	0.266
MOD_Plk_4	12	18	PF00069	0.248
MOD_Plk_4	2	8	PF00069	0.248
MOD_ProDKin_1	59	65	PF00069	0.248
TRG_DiLeu_BaEn_1	116	121	PF01217	0.313
TRG_ER_diLys_1	137	141	PF00400	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8G3	Leptomonas seymouri	84%	100%
A0A0S4JI68	Bodo saltans	46%	98%
A0A1X0P5H3	Trypanosomatidae	71%	100%
A0A3S7X9F2	Leishmania donovani	94%	100%
A0A422P2R5	Trypanosoma rangeli	69%	100%
A4HMV5	Leishmania braziliensis	88%	100%
A4IBH6	Leishmania infantum	94%	100%
C9ZZ66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9B6G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O43041	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q17QI1	Bos taurus	28%	97%
Q2KMM2	Rattus norvegicus	27%	97%
Q557G3	Dictyostelium discoideum	27%	99%
Q5NCF2	Mus musculus	27%	97%
Q9UT70	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	22%	91%
Q9Y5R8	Homo sapiens	28%	97%