LeishMANIAdb
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SURF6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
SURF6 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFB0_LEIMA
TriTrypDb:
LmjF.35.2860 , LMJLV39_350035800 * , LMJSD75_350035100 *
Length:
151

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 5
GO:0005737 cytoplasm 2 5
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

E9AFB0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFB0

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 106 108 PF00675 0.476
CLV_NRD_NRD_1 111 113 PF00675 0.458
CLV_NRD_NRD_1 132 134 PF00675 0.402
CLV_NRD_NRD_1 17 19 PF00675 0.468
CLV_NRD_NRD_1 23 25 PF00675 0.433
CLV_NRD_NRD_1 35 37 PF00675 0.386
CLV_NRD_NRD_1 5 7 PF00675 0.473
CLV_PCSK_KEX2_1 111 113 PF00082 0.457
CLV_PCSK_KEX2_1 14 16 PF00082 0.458
CLV_PCSK_KEX2_1 23 25 PF00082 0.462
CLV_PCSK_KEX2_1 35 37 PF00082 0.461
CLV_PCSK_KEX2_1 84 86 PF00082 0.629
CLV_PCSK_PC1ET2_1 111 113 PF00082 0.440
CLV_PCSK_PC1ET2_1 14 16 PF00082 0.446
CLV_PCSK_PC1ET2_1 23 25 PF00082 0.483
CLV_PCSK_PC1ET2_1 84 86 PF00082 0.629
CLV_PCSK_PC7_1 107 113 PF00082 0.455
CLV_PCSK_PC7_1 31 37 PF00082 0.564
CLV_PCSK_SKI1_1 103 107 PF00082 0.500
CLV_PCSK_SKI1_1 108 112 PF00082 0.449
CLV_PCSK_SKI1_1 6 10 PF00082 0.451
DOC_MAPK_gen_1 129 140 PF00069 0.456
DOC_MAPK_gen_1 84 95 PF00069 0.481
DOC_MAPK_MEF2A_6 133 140 PF00069 0.305
DOC_PP2B_LxvP_1 95 98 PF13499 0.510
DOC_USP7_UBL2_3 111 115 PF12436 0.474
DOC_USP7_UBL2_3 130 134 PF12436 0.401
DOC_USP7_UBL2_3 135 139 PF12436 0.395
DOC_USP7_UBL2_3 19 23 PF12436 0.400
DOC_USP7_UBL2_3 3 7 PF12436 0.447
DOC_USP7_UBL2_3 9 13 PF12436 0.451
LIG_14-3-3_CanoR_1 18 22 PF00244 0.449
LIG_FHA_1 77 83 PF00498 0.553
LIG_SH3_3 66 72 PF00018 0.501
MOD_GlcNHglycan 69 72 PF01048 0.725
MOD_GSK3_1 34 41 PF00069 0.526
MOD_N-GLC_1 123 128 PF02516 0.419
MOD_PKA_2 17 23 PF00069 0.447
MOD_PKA_2 34 40 PF00069 0.446
MOD_Plk_1 123 129 PF00069 0.420
MOD_SUMO_rev_2 126 136 PF00179 0.306
TRG_NLS_Bipartite_1 84 105 PF00514 0.502
TRG_NLS_MonoExtN_4 3 10 PF00514 0.453
TRG_NLS_MonoExtN_4 98 105 PF00514 0.514
TRG_Pf-PMV_PEXEL_1 6 10 PF00026 0.453
TRG_Pf-PMV_PEXEL_1 88 92 PF00026 0.499

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1S0 Leptomonas seymouri 77% 100%
A0A0S4JBT2 Bodo saltans 44% 92%
A0A1X0P5F8 Trypanosomatidae 55% 95%
A0A3Q8IIF2 Leishmania donovani 94% 100%
A0A3R7MVM6 Trypanosoma rangeli 55% 100%
A4HMV3 Leishmania braziliensis 81% 99%
A4IBH4 Leishmania infantum 93% 100%
C9ZZ68 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 52% 100%
E9B6G5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS