Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFA7_LEIMA

TriTrypDb:

LmjF.35.2830 , LMJLV39_350035500 , LMJSD75_350034800

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AFA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.466
CLV_C14_Caspase3-7	456	460	PF00656	0.715
CLV_C14_Caspase3-7	485	489	PF00656	0.565
CLV_NRD_NRD_1	162	164	PF00675	0.450
CLV_NRD_NRD_1	318	320	PF00675	0.661
CLV_NRD_NRD_1	423	425	PF00675	0.532
CLV_NRD_NRD_1	511	513	PF00675	0.408
CLV_PCSK_FUR_1	421	425	PF00082	0.530
CLV_PCSK_KEX2_1	162	164	PF00082	0.450
CLV_PCSK_KEX2_1	318	320	PF00082	0.655
CLV_PCSK_KEX2_1	406	408	PF00082	0.675
CLV_PCSK_KEX2_1	423	425	PF00082	0.532
CLV_PCSK_KEX2_1	511	513	PF00082	0.408
CLV_PCSK_PC1ET2_1	406	408	PF00082	0.675
CLV_PCSK_SKI1_1	162	166	PF00082	0.544
CLV_PCSK_SKI1_1	226	230	PF00082	0.540
CLV_PCSK_SKI1_1	407	411	PF00082	0.714
CLV_PCSK_SKI1_1	523	527	PF00082	0.613
CLV_PCSK_SKI1_1	87	91	PF00082	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.459
DEG_SCF_FBW7_1	537	542	PF00400	0.642
DOC_ANK_TNKS_1	474	481	PF00023	0.736
DOC_CYCLIN_RxL_1	258	269	PF00134	0.572
DOC_MAPK_FxFP_2	5	8	PF00069	0.460
DOC_MAPK_gen_1	259	267	PF00069	0.562
DOC_MAPK_gen_1	421	431	PF00069	0.530
DOC_MAPK_JIP1_4	261	267	PF00069	0.543
DOC_MAPK_MEF2A_6	15	24	PF00069	0.463
DOC_MAPK_MEF2A_6	226	235	PF00069	0.522
DOC_MAPK_MEF2A_6	259	267	PF00069	0.449
DOC_PP2B_LxvP_1	471	474	PF13499	0.730
DOC_PP4_FxxP_1	118	121	PF00568	0.555
DOC_PP4_FxxP_1	5	8	PF00568	0.460
DOC_USP7_MATH_1	129	133	PF00917	0.618
DOC_USP7_MATH_1	250	254	PF00917	0.541
DOC_USP7_MATH_1	266	270	PF00917	0.439
DOC_USP7_MATH_1	380	384	PF00917	0.460
DOC_USP7_MATH_1	489	493	PF00917	0.518
DOC_USP7_MATH_1	53	57	PF00917	0.504
DOC_USP7_MATH_1	539	543	PF00917	0.647
DOC_USP7_MATH_1	550	554	PF00917	0.567
DOC_USP7_MATH_1	574	578	PF00917	0.591
DOC_WD40_RPTOR_TOS_1	63	69	PF00400	0.468
DOC_WW_Pin1_4	272	277	PF00397	0.542
DOC_WW_Pin1_4	342	347	PF00397	0.695
DOC_WW_Pin1_4	465	470	PF00397	0.667
DOC_WW_Pin1_4	535	540	PF00397	0.713
DOC_WW_Pin1_4	57	62	PF00397	0.616
LIG_14-3-3_CanoR_1	198	204	PF00244	0.522
LIG_14-3-3_CanoR_1	379	389	PF00244	0.641
LIG_14-3-3_CanoR_1	452	458	PF00244	0.571
LIG_Actin_WH2_2	184	202	PF00022	0.359
LIG_Actin_WH2_2	561	578	PF00022	0.558
LIG_BIR_III_2	246	250	PF00653	0.657
LIG_BRCT_BRCA1_1	179	183	PF00533	0.445
LIG_BRCT_BRCA1_1	28	32	PF00533	0.540
LIG_BRCT_BRCA1_1	59	63	PF00533	0.513
LIG_DCNL_PONY_1	1	4	PF03556	0.458
LIG_deltaCOP1_diTrp_1	286	295	PF00928	0.417
LIG_EH_1	299	303	PF12763	0.368
LIG_eIF4E_1	160	166	PF01652	0.491
LIG_FHA_1	441	447	PF00498	0.588
LIG_FHA_2	107	113	PF00498	0.629
LIG_FHA_2	148	154	PF00498	0.545
LIG_FHA_2	218	224	PF00498	0.583
LIG_FHA_2	445	451	PF00498	0.658
LIG_FHA_2	565	571	PF00498	0.560
LIG_LIR_Apic_2	117	121	PF02991	0.554
LIG_LIR_Apic_2	3	8	PF02991	0.457
LIG_LIR_Gen_1	180	191	PF02991	0.408
LIG_LIR_Gen_1	515	525	PF02991	0.680
LIG_LIR_Nem_3	180	186	PF02991	0.429
LIG_LIR_Nem_3	227	232	PF02991	0.416
LIG_LIR_Nem_3	29	35	PF02991	0.549
LIG_LIR_Nem_3	515	521	PF02991	0.614
LIG_LIR_Nem_3	82	88	PF02991	0.542
LIG_MYND_1	494	498	PF01753	0.663
LIG_NRBOX	427	433	PF00104	0.484
LIG_Pex14_1	288	292	PF04695	0.376
LIG_Pex14_2	5	9	PF04695	0.458
LIG_SH2_GRB2like	136	139	PF00017	0.525
LIG_SH2_NCK_1	73	77	PF00017	0.331
LIG_SH2_SRC	244	247	PF00017	0.445
LIG_SH2_SRC	73	76	PF00017	0.327
LIG_SH2_STAP1	136	140	PF00017	0.553
LIG_SH2_STAP1	160	164	PF00017	0.462
LIG_SH2_STAP1	368	372	PF00017	0.464
LIG_SH2_STAP1	73	77	PF00017	0.394
LIG_SH2_STAT3	148	151	PF00017	0.652
LIG_SH2_STAT5	136	139	PF00017	0.518
LIG_SH2_STAT5	185	188	PF00017	0.381
LIG_SH2_STAT5	23	26	PF00017	0.518
LIG_SH2_STAT5	244	247	PF00017	0.445
LIG_SH3_3	270	276	PF00018	0.503
LIG_SH3_3	443	449	PF00018	0.533
LIG_SH3_3	463	469	PF00018	0.669
LIG_Sin3_3	229	236	PF02671	0.507
LIG_SUMO_SIM_anti_2	433	441	PF11976	0.555
LIG_SUMO_SIM_par_1	263	269	PF11976	0.439
LIG_SUMO_SIM_par_1	558	564	PF11976	0.579
LIG_TRAF2_1	150	153	PF00917	0.511
LIG_TRAF2_1	412	415	PF00917	0.671
LIG_TRAF2_1	97	100	PF00917	0.627
LIG_UBA3_1	428	435	PF00899	0.529
MOD_CDK_SPxxK_3	465	472	PF00069	0.716
MOD_CK1_1	134	140	PF00069	0.565
MOD_CK1_1	213	219	PF00069	0.637
MOD_CK1_1	25	31	PF00069	0.508
MOD_CK1_1	253	259	PF00069	0.664
MOD_CK1_1	331	337	PF00069	0.674
MOD_CK1_1	345	351	PF00069	0.548
MOD_CK1_1	444	450	PF00069	0.620
MOD_CK1_1	462	468	PF00069	0.647
MOD_CK1_1	553	559	PF00069	0.577
MOD_CK1_1	564	570	PF00069	0.630
MOD_CK2_1	106	112	PF00069	0.554
MOD_CK2_1	147	153	PF00069	0.543
MOD_CK2_1	274	280	PF00069	0.728
MOD_CK2_1	444	450	PF00069	0.612
MOD_CK2_1	94	100	PF00069	0.620
MOD_DYRK1A_RPxSP_1	576	580	PF00069	0.616
MOD_GlcNHglycan	121	124	PF01048	0.605
MOD_GlcNHglycan	187	190	PF01048	0.483
MOD_GlcNHglycan	252	255	PF01048	0.698
MOD_GlcNHglycan	279	283	PF01048	0.518
MOD_GlcNHglycan	330	333	PF01048	0.678
MOD_GlcNHglycan	484	487	PF01048	0.560
MOD_GlcNHglycan	541	544	PF01048	0.616
MOD_GlcNHglycan	554	558	PF01048	0.602
MOD_GlcNHglycan	96	99	PF01048	0.552
MOD_GSK3_1	213	220	PF00069	0.640
MOD_GSK3_1	22	29	PF00069	0.572
MOD_GSK3_1	274	281	PF00069	0.537
MOD_GSK3_1	328	335	PF00069	0.677
MOD_GSK3_1	342	349	PF00069	0.634
MOD_GSK3_1	415	422	PF00069	0.551
MOD_GSK3_1	440	447	PF00069	0.641
MOD_GSK3_1	49	56	PF00069	0.543
MOD_GSK3_1	535	542	PF00069	0.682
MOD_GSK3_1	560	567	PF00069	0.564
MOD_GSK3_1	57	64	PF00069	0.534
MOD_NEK2_1	147	152	PF00069	0.612
MOD_NEK2_1	193	198	PF00069	0.461
MOD_NEK2_1	199	204	PF00069	0.537
MOD_NEK2_1	278	283	PF00069	0.512
MOD_NEK2_1	310	315	PF00069	0.541
MOD_NEK2_1	357	362	PF00069	0.513
MOD_NEK2_1	389	394	PF00069	0.591
MOD_NEK2_1	453	458	PF00069	0.666
MOD_NEK2_2	131	136	PF00069	0.583
MOD_OFUCOSY	19	26	PF10250	0.511
MOD_PIKK_1	147	153	PF00454	0.613
MOD_PIKK_1	253	259	PF00454	0.664
MOD_PIKK_1	320	326	PF00454	0.653
MOD_PIKK_1	332	338	PF00454	0.744
MOD_PIKK_1	35	41	PF00454	0.450
MOD_PIKK_1	363	369	PF00454	0.487
MOD_PKA_2	199	205	PF00069	0.510
MOD_PKA_2	210	216	PF00069	0.686
MOD_PKA_2	444	450	PF00069	0.612
MOD_PKA_2	462	468	PF00069	0.635
MOD_Plk_1	489	495	PF00069	0.539
MOD_Plk_1	560	566	PF00069	0.681
MOD_Plk_4	114	120	PF00069	0.555
MOD_Plk_4	131	137	PF00069	0.522
MOD_Plk_4	26	32	PF00069	0.534
MOD_Plk_4	305	311	PF00069	0.548
MOD_Plk_4	357	363	PF00069	0.415
MOD_Plk_4	526	532	PF00069	0.597
MOD_ProDKin_1	272	278	PF00069	0.546
MOD_ProDKin_1	342	348	PF00069	0.692
MOD_ProDKin_1	465	471	PF00069	0.669
MOD_ProDKin_1	535	541	PF00069	0.714
MOD_ProDKin_1	57	63	PF00069	0.597
MOD_SUMO_rev_2	64	72	PF00179	0.526
TRG_DiLeu_BaLyEn_6	427	432	PF01217	0.489
TRG_ENDOCYTIC_2	292	295	PF00928	0.408
TRG_ENDOCYTIC_2	73	76	PF00928	0.390
TRG_ER_diArg_1	317	319	PF00400	0.635
TRG_ER_diArg_1	421	424	PF00400	0.539
TRG_ER_diArg_1	511	513	PF00400	0.408
TRG_NES_CRM1_1	427	441	PF08389	0.545
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	430	434	PF00026	0.606

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Q6	Leptomonas seymouri	37%	93%
A0A3S7X9F0	Leishmania donovani	87%	100%
A4HMV0	Leishmania braziliensis	72%	100%
A4IBH2	Leishmania infantum	85%	95%
E9B6G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%