MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania major

UniProt:

E9AFA6_LEIMA

TriTrypDb:

LmjF.35.2820 , LMJLV39_350035400 , LMJSD75_350034700

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AFA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.267
CLV_MEL_PAP_1	641	647	PF00089	0.384
CLV_NRD_NRD_1	238	240	PF00675	0.415
CLV_NRD_NRD_1	80	82	PF00675	0.314
CLV_PCSK_FUR_1	236	240	PF00082	0.421
CLV_PCSK_KEX2_1	238	240	PF00082	0.415
CLV_PCSK_SKI1_1	436	440	PF00082	0.370
CLV_PCSK_SKI1_1	445	449	PF00082	0.318
CLV_PCSK_SKI1_1	505	509	PF00082	0.332
CLV_PCSK_SKI1_1	594	598	PF00082	0.318
DEG_Nend_UBRbox_1	1	4	PF02207	0.627
DOC_CDC14_PxL_1	626	634	PF14671	0.347
DOC_CKS1_1	530	535	PF01111	0.347
DOC_MAPK_gen_1	473	480	PF00069	0.416
DOC_MAPK_gen_1	81	89	PF00069	0.505
DOC_MAPK_MEF2A_6	445	452	PF00069	0.565
DOC_MAPK_MEF2A_6	78	87	PF00069	0.509
DOC_PP2B_LxvP_1	297	300	PF13499	0.693
DOC_PP2B_LxvP_1	30	33	PF13499	0.356
DOC_PP2B_LxvP_1	439	442	PF13499	0.523
DOC_USP7_MATH_1	216	220	PF00917	0.574
DOC_USP7_MATH_1	225	229	PF00917	0.599
DOC_USP7_MATH_1	252	256	PF00917	0.673
DOC_USP7_MATH_1	323	327	PF00917	0.699
DOC_USP7_MATH_1	358	362	PF00917	0.721
DOC_USP7_MATH_1	418	422	PF00917	0.672
DOC_USP7_MATH_1	539	543	PF00917	0.361
DOC_USP7_UBL2_3	2	6	PF12436	0.651
DOC_WW_Pin1_4	332	337	PF00397	0.698
DOC_WW_Pin1_4	387	392	PF00397	0.715
DOC_WW_Pin1_4	405	410	PF00397	0.602
DOC_WW_Pin1_4	529	534	PF00397	0.354
DOC_WW_Pin1_4	99	104	PF00397	0.356
LIG_14-3-3_CanoR_1	356	364	PF00244	0.827
LIG_14-3-3_CanoR_1	382	391	PF00244	0.645
LIG_14-3-3_CanoR_1	594	599	PF00244	0.347
LIG_14-3-3_CterR_2	644	647	PF00244	0.604
LIG_AP2alpha_2	224	226	PF02296	0.596
LIG_BRCT_BRCA1_1	17	21	PF00533	0.239
LIG_BRCT_BRCA1_1	499	503	PF00533	0.356
LIG_BRCT_BRCA1_1	541	545	PF00533	0.428
LIG_BRCT_BRCA1_1	563	567	PF00533	0.341
LIG_BRCT_BRCA1_1	95	99	PF00533	0.391
LIG_eIF4E_1	52	58	PF01652	0.361
LIG_FHA_1	10	16	PF00498	0.555
LIG_FHA_1	109	115	PF00498	0.318
LIG_FHA_1	135	141	PF00498	0.481
LIG_FHA_1	17	23	PF00498	0.353
LIG_FHA_1	205	211	PF00498	0.368
LIG_FHA_1	406	412	PF00498	0.671
LIG_FHA_1	444	450	PF00498	0.535
LIG_FHA_1	512	518	PF00498	0.577
LIG_FHA_1	525	531	PF00498	0.288
LIG_FHA_1	552	558	PF00498	0.353
LIG_FHA_1	66	72	PF00498	0.356
LIG_FHA_2	131	137	PF00498	0.509
LIG_FHA_2	402	408	PF00498	0.622
LIG_FHA_2	72	78	PF00498	0.509
LIG_GBD_Chelix_1	93	101	PF00786	0.239
LIG_IRF3_LxIS_1	485	492	PF10401	0.356
LIG_LIR_Gen_1	201	211	PF02991	0.318
LIG_LIR_Gen_1	224	233	PF02991	0.633
LIG_LIR_Gen_1	276	285	PF02991	0.693
LIG_LIR_Gen_1	493	503	PF02991	0.336
LIG_LIR_Gen_1	519	524	PF02991	0.316
LIG_LIR_Gen_1	560	571	PF02991	0.358
LIG_LIR_Gen_1	588	596	PF02991	0.473
LIG_LIR_Gen_1	9	17	PF02991	0.600
LIG_LIR_Nem_3	146	151	PF02991	0.295
LIG_LIR_Nem_3	201	206	PF02991	0.318
LIG_LIR_Nem_3	224	229	PF02991	0.635
LIG_LIR_Nem_3	276	282	PF02991	0.696
LIG_LIR_Nem_3	493	499	PF02991	0.336
LIG_LIR_Nem_3	500	506	PF02991	0.375
LIG_LIR_Nem_3	519	523	PF02991	0.300
LIG_LIR_Nem_3	560	566	PF02991	0.344
LIG_LIR_Nem_3	588	592	PF02991	0.426
LIG_LIR_Nem_3	96	101	PF02991	0.387
LIG_MLH1_MIPbox_1	95	99	PF16413	0.356
LIG_MYND_1	170	174	PF01753	0.290
LIG_MYND_1	192	196	PF01753	0.402
LIG_Pex14_2	226	230	PF04695	0.653
LIG_Pex14_2	34	38	PF04695	0.285
LIG_SH2_CRK	451	455	PF00017	0.338
LIG_SH2_CRK	563	567	PF00017	0.468
LIG_SH2_CRK	620	624	PF00017	0.302
LIG_SH2_NCK_1	563	567	PF00017	0.248
LIG_SH2_PTP2	496	499	PF00017	0.347
LIG_SH2_STAP1	11	15	PF00017	0.562
LIG_SH2_STAP1	546	550	PF00017	0.308
LIG_SH2_STAP1	563	567	PF00017	0.331
LIG_SH2_STAT5	11	14	PF00017	0.558
LIG_SH2_STAT5	162	165	PF00017	0.318
LIG_SH2_STAT5	496	499	PF00017	0.381
LIG_SH2_STAT5	52	55	PF00017	0.395
LIG_SH2_STAT5	537	540	PF00017	0.369
LIG_SH2_STAT5	569	572	PF00017	0.507
LIG_SH3_3	151	157	PF00018	0.356
LIG_SH3_3	168	174	PF00018	0.209
LIG_SH3_3	186	192	PF00018	0.201
LIG_SH3_3	219	225	PF00018	0.631
LIG_SH3_3	385	391	PF00018	0.695
LIG_SH3_3	609	615	PF00018	0.391
LIG_SH3_4	82	89	PF00018	0.509
LIG_SUMO_SIM_anti_2	204	210	PF11976	0.350
LIG_SUMO_SIM_anti_2	259	265	PF11976	0.730
LIG_SUMO_SIM_anti_2	446	451	PF11976	0.337
LIG_SUMO_SIM_par_1	12	19	PF11976	0.484
LIG_SUMO_SIM_par_1	629	634	PF11976	0.347
LIG_SxIP_EBH_1	594	607	PF03271	0.318
LIG_TRAF2_1	313	316	PF00917	0.683
LIG_TRFH_1	188	192	PF08558	0.281
LIG_TRFH_1	99	103	PF08558	0.318
LIG_TYR_ITIM	449	454	PF00017	0.522
LIG_TYR_ITIM	494	499	PF00017	0.347
LIG_TYR_ITIM	618	623	PF00017	0.254
LIG_UBA3_1	97	106	PF00899	0.356
LIG_WRC_WIRS_1	200	205	PF05994	0.373
LIG_WRC_WIRS_1	632	637	PF05994	0.347
MOD_CDK_SPxxK_3	99	106	PF00069	0.356
MOD_CK1_1	201	207	PF00069	0.330
MOD_CK1_1	302	308	PF00069	0.702
MOD_CK1_1	359	365	PF00069	0.682
MOD_CK1_1	421	427	PF00069	0.673
MOD_CK1_1	511	517	PF00069	0.481
MOD_CK1_1	529	535	PF00069	0.296
MOD_CK1_1	588	594	PF00069	0.551
MOD_CK1_1	9	15	PF00069	0.581
MOD_CK2_1	310	316	PF00069	0.737
MOD_CK2_1	550	556	PF00069	0.347
MOD_Cter_Amidation	236	239	PF01082	0.361
MOD_Cter_Amidation	79	82	PF01082	0.312
MOD_GlcNHglycan	203	206	PF01048	0.318
MOD_GlcNHglycan	231	234	PF01048	0.415
MOD_GlcNHglycan	26	29	PF01048	0.356
MOD_GlcNHglycan	288	291	PF01048	0.524
MOD_GlcNHglycan	342	345	PF01048	0.511
MOD_GlcNHglycan	361	364	PF01048	0.470
MOD_GlcNHglycan	458	461	PF01048	0.362
MOD_GlcNHglycan	510	513	PF01048	0.410
MOD_GlcNHglycan	53	56	PF01048	0.361
MOD_GlcNHglycan	572	575	PF01048	0.356
MOD_GlcNHglycan	598	601	PF01048	0.264
MOD_GSK3_1	130	137	PF00069	0.509
MOD_GSK3_1	16	23	PF00069	0.339
MOD_GSK3_1	225	232	PF00069	0.660
MOD_GSK3_1	302	309	PF00069	0.700
MOD_GSK3_1	310	317	PF00069	0.807
MOD_GSK3_1	328	335	PF00069	0.676
MOD_GSK3_1	347	354	PF00069	0.838
MOD_GSK3_1	401	408	PF00069	0.670
MOD_GSK3_1	418	425	PF00069	0.740
MOD_GSK3_1	497	504	PF00069	0.356
MOD_GSK3_1	525	532	PF00069	0.393
MOD_GSK3_1	551	558	PF00069	0.443
MOD_GSK3_1	590	597	PF00069	0.356
MOD_GSK3_1	6	13	PF00069	0.558
MOD_GSK3_1	631	638	PF00069	0.368
MOD_N-GLC_1	280	285	PF02516	0.446
MOD_NEK2_1	10	15	PF00069	0.568
MOD_NEK2_1	229	234	PF00069	0.649
MOD_NEK2_1	26	31	PF00069	0.359
MOD_NEK2_1	340	345	PF00069	0.733
MOD_NEK2_1	478	483	PF00069	0.343
MOD_NEK2_1	489	494	PF00069	0.407
MOD_NEK2_1	501	506	PF00069	0.419
MOD_NEK2_1	524	529	PF00069	0.420
MOD_NEK2_1	596	601	PF00069	0.373
MOD_NEK2_1	605	610	PF00069	0.410
MOD_NEK2_1	624	629	PF00069	0.358
MOD_NEK2_1	631	636	PF00069	0.358
MOD_NEK2_1	71	76	PF00069	0.573
MOD_NEK2_2	143	148	PF00069	0.318
MOD_NEK2_2	225	230	PF00069	0.651
MOD_PIKK_1	311	317	PF00454	0.672
MOD_PIKK_1	330	336	PF00454	0.678
MOD_PIKK_1	395	401	PF00454	0.696
MOD_PIKK_1	45	51	PF00454	0.219
MOD_PKA_1	238	244	PF00069	0.601
MOD_PKA_2	238	244	PF00069	0.667
MOD_PKA_2	328	334	PF00069	0.698
MOD_PKA_2	351	357	PF00069	0.736
MOD_PKB_1	236	244	PF00069	0.597
MOD_Plk_1	518	524	PF00069	0.347
MOD_Plk_1	539	545	PF00069	0.324
MOD_Plk_1	555	561	PF00069	0.321
MOD_Plk_2-3	416	422	PF00069	0.619
MOD_Plk_4	124	130	PF00069	0.508
MOD_Plk_4	150	156	PF00069	0.378
MOD_Plk_4	16	22	PF00069	0.328
MOD_Plk_4	225	231	PF00069	0.739
MOD_Plk_4	26	32	PF00069	0.377
MOD_Plk_4	490	496	PF00069	0.356
MOD_Plk_4	526	532	PF00069	0.322
MOD_Plk_4	540	546	PF00069	0.406
MOD_Plk_4	561	567	PF00069	0.499
MOD_Plk_4	6	12	PF00069	0.614
MOD_Plk_4	631	637	PF00069	0.378
MOD_Plk_4	93	99	PF00069	0.430
MOD_ProDKin_1	332	338	PF00069	0.699
MOD_ProDKin_1	387	393	PF00069	0.715
MOD_ProDKin_1	405	411	PF00069	0.603
MOD_ProDKin_1	529	535	PF00069	0.354
MOD_ProDKin_1	99	105	PF00069	0.356
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.667
TRG_DiLeu_BaLyEn_6	627	632	PF01217	0.347
TRG_ENDOCYTIC_2	11	14	PF00928	0.558
TRG_ENDOCYTIC_2	451	454	PF00928	0.405
TRG_ENDOCYTIC_2	496	499	PF00928	0.368
TRG_ENDOCYTIC_2	563	566	PF00928	0.497
TRG_ENDOCYTIC_2	620	623	PF00928	0.302
TRG_ER_diArg_1	236	239	PF00400	0.603
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.508
TRG_Pf-PMV_PEXEL_1	515	519	PF00026	0.309

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	30%	98%
A0A3Q8II42	Leishmania donovani	87%	100%
A0A3Q8IPN7	Leishmania donovani	31%	92%
A4HMU7	Leishmania braziliensis	30%	91%
A4HMU9	Leishmania braziliensis	68%	100%
A4IBH0	Leishmania infantum	31%	92%
A4IBH1	Leishmania infantum	88%	100%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
E9AFA5	Leishmania major	30%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9B6G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%