MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania major

UniProt:

E9AFA5_LEIMA

TriTrypDb:

LmjF.35.2810 , LMJLV39_350035300 , LMJSD75_350034600

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

E9AFA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.664
CLV_C14_Caspase3-7	442	446	PF00656	0.642
CLV_NRD_NRD_1	109	111	PF00675	0.301
CLV_NRD_NRD_1	212	214	PF00675	0.574
CLV_NRD_NRD_1	27	29	PF00675	0.492
CLV_NRD_NRD_1	31	33	PF00675	0.443
CLV_NRD_NRD_1	699	701	PF00675	0.378
CLV_PCSK_KEX2_1	109	111	PF00082	0.271
CLV_PCSK_KEX2_1	31	33	PF00082	0.466
CLV_PCSK_KEX2_1	461	463	PF00082	0.393

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	44%	100%
A0A3Q8II42	Leishmania donovani	31%	100%
A0A3Q8IPN7	Leishmania donovani	89%	100%
A4HMU7	Leishmania braziliensis	63%	99%
A4IBH0	Leishmania infantum	89%	100%
A4IBH1	Leishmania infantum	31%	98%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AFA6	Leishmania major	30%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%

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