MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter, putative

Species:

Leishmania major

UniProt:

E9AFA5_LEIMA

TriTrypDb:

LmjF.35.2810 , LMJLV39_350035300 , LMJSD75_350034600

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AFA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	367	371	PF00656	0.664
CLV_C14_Caspase3-7	442	446	PF00656	0.642
CLV_NRD_NRD_1	109	111	PF00675	0.301
CLV_NRD_NRD_1	212	214	PF00675	0.574
CLV_NRD_NRD_1	27	29	PF00675	0.492
CLV_NRD_NRD_1	31	33	PF00675	0.443
CLV_NRD_NRD_1	699	701	PF00675	0.378
CLV_PCSK_KEX2_1	109	111	PF00082	0.271
CLV_PCSK_KEX2_1	31	33	PF00082	0.466
CLV_PCSK_KEX2_1	461	463	PF00082	0.393
CLV_PCSK_KEX2_1	667	669	PF00082	0.307
CLV_PCSK_KEX2_1	699	701	PF00082	0.378
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.479
CLV_PCSK_PC1ET2_1	461	463	PF00082	0.393
CLV_PCSK_PC1ET2_1	667	669	PF00082	0.307
CLV_PCSK_SKI1_1	214	218	PF00082	0.519
CLV_PCSK_SKI1_1	32	36	PF00082	0.407
CLV_PCSK_SKI1_1	421	425	PF00082	0.485
CLV_PCSK_SKI1_1	466	470	PF00082	0.371
CLV_PCSK_SKI1_1	471	475	PF00082	0.375
CLV_PCSK_SKI1_1	584	588	PF00082	0.295
DEG_MDM2_SWIB_1	586	594	PF02201	0.359
DOC_CDC14_PxL_1	384	392	PF14671	0.606
DOC_CKS1_1	629	634	PF01111	0.359
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.287
DOC_MAPK_DCC_7	213	223	PF00069	0.311
DOC_MAPK_gen_1	511	520	PF00069	0.334
DOC_MAPK_MEF2A_6	214	223	PF00069	0.311
DOC_MAPK_MEF2A_6	8	16	PF00069	0.675
DOC_MAPK_RevD_3	652	668	PF00069	0.239
DOC_PP4_FxxP_1	266	269	PF00568	0.562
DOC_PP4_FxxP_1	385	388	PF00568	0.654
DOC_PP4_FxxP_1	469	472	PF00568	0.596
DOC_PP4_FxxP_1	572	575	PF00568	0.330
DOC_PP4_FxxP_1	629	632	PF00568	0.279
DOC_USP7_MATH_1	171	175	PF00917	0.365
DOC_USP7_MATH_1	194	198	PF00917	0.271
DOC_USP7_MATH_1	436	440	PF00917	0.787
DOC_USP7_MATH_1	441	445	PF00917	0.737
DOC_USP7_MATH_1	562	566	PF00917	0.319
DOC_USP7_UBL2_3	29	33	PF12436	0.729
DOC_WW_Pin1_4	32	37	PF00397	0.602
DOC_WW_Pin1_4	324	329	PF00397	0.691
DOC_WW_Pin1_4	628	633	PF00397	0.359
LIG_14-3-3_CanoR_1	548	553	PF00244	0.468
LIG_14-3-3_CanoR_1	584	594	PF00244	0.279
LIG_14-3-3_CterR_2	702	705	PF00244	0.608
LIG_Actin_WH2_2	338	356	PF00022	0.599
LIG_Actin_WH2_2	58	73	PF00022	0.359
LIG_BRCT_BRCA1_1	114	118	PF00533	0.328
LIG_BRCT_BRCA1_1	568	572	PF00533	0.437
LIG_deltaCOP1_diTrp_1	681	686	PF00928	0.616
LIG_DLG_GKlike_1	548	556	PF00625	0.468
LIG_EH1_1	176	184	PF00400	0.339
LIG_eIF4E_1	177	183	PF01652	0.339
LIG_eIF4E_1	80	86	PF01652	0.303
LIG_FHA_1	117	123	PF00498	0.284
LIG_FHA_1	233	239	PF00498	0.336
LIG_FHA_1	272	278	PF00498	0.655
LIG_FHA_1	315	321	PF00498	0.675
LIG_FHA_1	324	330	PF00498	0.625
LIG_FHA_1	397	403	PF00498	0.688
LIG_FHA_1	420	426	PF00498	0.719
LIG_FHA_1	44	50	PF00498	0.334
LIG_FHA_1	472	478	PF00498	0.602
LIG_FHA_1	519	525	PF00498	0.319
LIG_FHA_1	55	61	PF00498	0.353
LIG_FHA_1	562	568	PF00498	0.422
LIG_FHA_1	593	599	PF00498	0.343
LIG_FHA_1	685	691	PF00498	0.534
LIG_FHA_2	282	288	PF00498	0.693
LIG_FHA_2	365	371	PF00498	0.713
LIG_FHA_2	488	494	PF00498	0.319
LIG_FHA_2	669	675	PF00498	0.592
LIG_LIR_Apic_2	569	575	PF02991	0.340
LIG_LIR_Gen_1	333	342	PF02991	0.653
LIG_LIR_Gen_1	46	54	PF02991	0.379
LIG_LIR_Nem_3	333	339	PF02991	0.655
LIG_LIR_Nem_3	46	50	PF02991	0.319
LIG_LIR_Nem_3	551	556	PF02991	0.491
LIG_LIR_Nem_3	569	574	PF02991	0.257
LIG_LYPXL_S_1	255	259	PF13949	0.332
LIG_MLH1_MIPbox_1	568	572	PF16413	0.360
LIG_MYND_1	215	219	PF01753	0.479
LIG_NRBOX	649	655	PF00104	0.319
LIG_PCNA_yPIPBox_3	308	320	PF02747	0.646
LIG_Pex14_1	134	138	PF04695	0.282
LIG_Pex14_2	586	590	PF04695	0.359
LIG_REV1ctd_RIR_1	136	144	PF16727	0.319
LIG_SH2_CRK	226	230	PF00017	0.304
LIG_SH2_CRK	481	485	PF00017	0.320
LIG_SH2_GRB2like	226	229	PF00017	0.304
LIG_SH2_GRB2like	540	543	PF00017	0.568
LIG_SH2_NCK_1	192	196	PF00017	0.257
LIG_SH2_PTP2	254	257	PF00017	0.558
LIG_SH2_PTP2	517	520	PF00017	0.261
LIG_SH2_SRC	192	195	PF00017	0.257
LIG_SH2_SRC	254	257	PF00017	0.558
LIG_SH2_SRC	663	666	PF00017	0.381
LIG_SH2_STAP1	665	669	PF00017	0.544
LIG_SH2_STAT5	226	229	PF00017	0.304
LIG_SH2_STAT5	237	240	PF00017	0.510
LIG_SH2_STAT5	254	257	PF00017	0.528
LIG_SH2_STAT5	517	520	PF00017	0.304
LIG_SH2_STAT5	540	543	PF00017	0.542
LIG_SH2_STAT5	566	569	PF00017	0.358
LIG_SH2_STAT5	571	574	PF00017	0.349
LIG_SH2_STAT5	663	666	PF00017	0.421
LIG_SH3_3	6	12	PF00018	0.748
LIG_SUMO_SIM_anti_2	476	481	PF11976	0.329
LIG_SUMO_SIM_anti_2	557	562	PF11976	0.300
LIG_TRAF2_1	490	493	PF00917	0.413
LIG_TRAF2_1	671	674	PF00917	0.587
LIG_TRFH_1	571	575	PF08558	0.338
LIG_TYR_ITIM	479	484	PF00017	0.479
LIG_TYR_ITIM	515	520	PF00017	0.261
LIG_WRC_WIRS_1	233	238	PF05994	0.326
MOD_CK1_1	206	212	PF00069	0.369
MOD_CK1_1	270	276	PF00069	0.613
MOD_CK1_1	283	289	PF00069	0.627
MOD_CK1_1	346	352	PF00069	0.736
MOD_CK1_1	53	59	PF00069	0.377
MOD_CK1_1	637	643	PF00069	0.320
MOD_CK1_1	655	661	PF00069	0.234
MOD_CK2_1	281	287	PF00069	0.674
MOD_CK2_1	291	297	PF00069	0.708
MOD_CK2_1	392	398	PF00069	0.630
MOD_CK2_1	487	493	PF00069	0.319
MOD_CK2_1	668	674	PF00069	0.602
MOD_CK2_1	71	77	PF00069	0.311
MOD_Cter_Amidation	107	110	PF01082	0.303
MOD_GlcNHglycan	114	117	PF01048	0.257
MOD_GlcNHglycan	119	122	PF01048	0.304
MOD_GlcNHglycan	197	200	PF01048	0.583
MOD_GlcNHglycan	305	308	PF01048	0.567
MOD_GlcNHglycan	385	388	PF01048	0.437
MOD_GlcNHglycan	394	397	PF01048	0.458
MOD_GlcNHglycan	405	408	PF01048	0.505
MOD_GlcNHglycan	438	441	PF01048	0.517
MOD_GlcNHglycan	484	487	PF01048	0.327
MOD_GlcNHglycan	601	604	PF01048	0.356
MOD_GlcNHglycan	639	642	PF01048	0.575
MOD_GlcNHglycan	654	657	PF01048	0.417
MOD_GlcNHglycan	660	663	PF01048	0.304
MOD_GlcNHglycan	81	84	PF01048	0.349
MOD_GlcNHglycan	95	98	PF01048	0.189
MOD_GSK3_1	112	119	PF00069	0.304
MOD_GSK3_1	267	274	PF00069	0.681
MOD_GSK3_1	277	284	PF00069	0.652
MOD_GSK3_1	324	331	PF00069	0.707
MOD_GSK3_1	360	367	PF00069	0.699
MOD_GSK3_1	392	399	PF00069	0.663
MOD_GSK3_1	436	443	PF00069	0.678
MOD_GSK3_1	50	57	PF00069	0.409
MOD_GSK3_1	562	569	PF00069	0.387
MOD_GSK3_1	592	599	PF00069	0.375
MOD_GSK3_1	603	610	PF00069	0.622
MOD_GSK3_1	636	643	PF00069	0.360
MOD_GSK3_1	680	687	PF00069	0.571
MOD_LATS_1	69	75	PF00433	0.311
MOD_N-GLC_1	16	21	PF02516	0.496
MOD_N-GLC_1	195	200	PF02516	0.579
MOD_N-GLC_1	346	351	PF02516	0.453
MOD_N-GLC_1	419	424	PF02516	0.443
MOD_N-GLC_1	50	55	PF02516	0.304
MOD_NEK2_1	117	122	PF00069	0.325
MOD_NEK2_1	127	132	PF00069	0.320
MOD_NEK2_1	224	229	PF00069	0.424
MOD_NEK2_1	232	237	PF00069	0.419
MOD_NEK2_1	277	282	PF00069	0.673
MOD_NEK2_1	341	346	PF00069	0.652
MOD_NEK2_1	364	369	PF00069	0.713
MOD_NEK2_1	402	407	PF00069	0.708
MOD_NEK2_1	50	55	PF00069	0.340
MOD_NEK2_1	520	525	PF00069	0.402
MOD_NEK2_1	531	536	PF00069	0.425
MOD_NEK2_1	578	583	PF00069	0.370
MOD_NEK2_1	586	591	PF00069	0.489
MOD_NEK2_1	612	617	PF00069	0.527
MOD_NEK2_1	634	639	PF00069	0.335
MOD_NEK2_1	652	657	PF00069	0.348
MOD_NEK2_2	686	691	PF00069	0.532
MOD_PIKK_1	314	320	PF00454	0.675
MOD_PIKK_1	612	618	PF00454	0.499
MOD_PK_1	71	77	PF00069	0.311
MOD_PKA_2	271	277	PF00069	0.654
MOD_PKA_2	403	409	PF00069	0.715
MOD_Plk_1	195	201	PF00069	0.385
MOD_Plk_1	419	425	PF00069	0.643
MOD_Plk_1	487	493	PF00069	0.353
MOD_Plk_1	50	56	PF00069	0.304
MOD_Plk_1	680	686	PF00069	0.619
MOD_Plk_2-3	291	297	PF00069	0.646
MOD_Plk_2-3	413	419	PF00069	0.665
MOD_Plk_4	129	135	PF00069	0.360
MOD_Plk_4	152	158	PF00069	0.502
MOD_Plk_4	206	212	PF00069	0.397
MOD_Plk_4	217	223	PF00069	0.252
MOD_Plk_4	232	238	PF00069	0.324
MOD_Plk_4	360	366	PF00069	0.660
MOD_Plk_4	43	49	PF00069	0.320
MOD_Plk_4	54	60	PF00069	0.365
MOD_Plk_4	542	548	PF00069	0.564
MOD_Plk_4	554	560	PF00069	0.317
MOD_Plk_4	562	568	PF00069	0.433
MOD_Plk_4	593	599	PF00069	0.366
MOD_Plk_4	607	613	PF00069	0.513
MOD_ProDKin_1	32	38	PF00069	0.591
MOD_ProDKin_1	324	330	PF00069	0.690
MOD_ProDKin_1	628	634	PF00069	0.359
MOD_SUMO_rev_2	439	448	PF00179	0.690
MOD_SUMO_rev_2	456	463	PF00179	0.638
TRG_DiLeu_BaEn_2	261	267	PF01217	0.575
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.657
TRG_ENDOCYTIC_2	226	229	PF00928	0.304
TRG_ENDOCYTIC_2	256	259	PF00928	0.529
TRG_ENDOCYTIC_2	481	484	PF00928	0.348
TRG_ENDOCYTIC_2	517	520	PF00928	0.305
TRG_ENDOCYTIC_2	571	574	PF00928	0.321
TRG_ENDOCYTIC_2	698	701	PF00928	0.609
TRG_ER_diArg_1	109	111	PF00400	0.471
TRG_ER_diArg_1	698	700	PF00400	0.571
TRG_NES_CRM1_1	41	52	PF08389	0.511
TRG_NLS_MonoCore_2	27	32	PF00514	0.649
TRG_NLS_MonoExtC_3	27	32	PF00514	0.706
TRG_NLS_MonoExtN_4	28	35	PF00514	0.672

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMM8	Leptomonas seymouri	44%	100%
A0A3Q8II42	Leishmania donovani	31%	100%
A0A3Q8IPN7	Leishmania donovani	89%	100%
A4HMU7	Leishmania braziliensis	63%	99%
A4IBH0	Leishmania infantum	89%	100%
A4IBH1	Leishmania infantum	31%	98%
E8NHI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9AFA6	Leishmania major	30%	100%
E9B6G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%