LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AFA3_LEIMA
TriTrypDb:
LmjF.35.2790 , LMJLV39_350035000 * , LMJSD75_350034300
Length:
402

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26167471
Might belong to a Kinetoplastid-specific lectin domain protein family. Experiments of homologues indicate them to localize to ER (PMID: 26167471). Extensively duplicated gene family.. Localization: ER (experimental)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. yes yes: 16
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 11, no: 0
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

E9AFA3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 221 225 PF00656 0.438
CLV_PCSK_SKI1_1 261 265 PF00082 0.622
DEG_APCC_DBOX_1 14 22 PF00400 0.427
DEG_APCC_DBOX_1 145 153 PF00400 0.453
DEG_COP1_1 111 121 PF00400 0.427
DEG_Nend_UBRbox_3 1 3 PF02207 0.507
DEG_SCF_FBW7_2 294 301 PF00400 0.647
DOC_CKS1_1 48 53 PF01111 0.482
DOC_PP1_RVXF_1 259 266 PF00149 0.438
DOC_PP2B_PxIxI_1 369 375 PF00149 0.659
DOC_USP7_MATH_1 117 121 PF00917 0.496
DOC_USP7_MATH_1 130 134 PF00917 0.404
DOC_USP7_MATH_1 218 222 PF00917 0.462
DOC_USP7_MATH_1 368 372 PF00917 0.715
DOC_WW_Pin1_4 132 137 PF00397 0.493
DOC_WW_Pin1_4 294 299 PF00397 0.643
DOC_WW_Pin1_4 47 52 PF00397 0.536
LIG_14-3-3_CanoR_1 10 14 PF00244 0.471
LIG_14-3-3_CanoR_1 123 132 PF00244 0.475
LIG_Actin_RPEL_3 139 158 PF02755 0.368
LIG_APCC_ABBA_1 232 237 PF00400 0.433
LIG_APCC_ABBAyCdc20_2 231 237 PF00400 0.437
LIG_BRCT_BRCA1_1 237 241 PF00533 0.441
LIG_BRCT_BRCA1_1 27 31 PF00533 0.492
LIG_deltaCOP1_diTrp_1 262 271 PF00928 0.435
LIG_FHA_1 153 159 PF00498 0.451
LIG_FHA_1 188 194 PF00498 0.450
LIG_FHA_1 205 211 PF00498 0.494
LIG_FHA_1 247 253 PF00498 0.494
LIG_FHA_1 285 291 PF00498 0.373
LIG_FHA_2 149 155 PF00498 0.448
LIG_FHA_2 96 102 PF00498 0.432
LIG_GBD_Chelix_1 277 285 PF00786 0.307
LIG_LIR_Gen_1 120 128 PF02991 0.525
LIG_LIR_Gen_1 268 279 PF02991 0.435
LIG_LIR_Gen_1 316 322 PF02991 0.679
LIG_LIR_Nem_3 105 110 PF02991 0.505
LIG_LIR_Nem_3 120 124 PF02991 0.466
LIG_LIR_Nem_3 144 150 PF02991 0.455
LIG_LIR_Nem_3 169 174 PF02991 0.510
LIG_LIR_Nem_3 230 235 PF02991 0.513
LIG_LIR_Nem_3 238 244 PF02991 0.582
LIG_LIR_Nem_3 268 274 PF02991 0.435
LIG_LIR_Nem_3 316 321 PF02991 0.680
LIG_LIR_Nem_3 40 46 PF02991 0.473
LIG_LIR_Nem_3 50 56 PF02991 0.424
LIG_LYPXL_S_1 170 174 PF13949 0.653
LIG_LYPXL_yS_3 171 174 PF13949 0.451
LIG_NRBOX 25 31 PF00104 0.594
LIG_NRBOX 281 287 PF00104 0.337
LIG_PCNA_PIPBox_1 161 170 PF02747 0.449
LIG_Pex14_1 20 24 PF04695 0.522
LIG_Pex14_1 270 274 PF04695 0.358
LIG_Pex14_2 143 147 PF04695 0.474
LIG_SH2_CRK 291 295 PF00017 0.369
LIG_SH2_CRK 48 52 PF00017 0.480
LIG_SH2_GRB2like 318 321 PF00017 0.721
LIG_SH2_NCK_1 48 52 PF00017 0.507
LIG_SH2_PTP2 244 247 PF00017 0.444
LIG_SH2_PTP2 318 321 PF00017 0.686
LIG_SH2_SRC 244 247 PF00017 0.468
LIG_SH2_SRC 318 321 PF00017 0.749
LIG_SH2_STAP1 184 188 PF00017 0.453
LIG_SH2_STAT3 56 59 PF00017 0.457
LIG_SH2_STAT3 74 77 PF00017 0.424
LIG_SH2_STAT5 107 110 PF00017 0.514
LIG_SH2_STAT5 199 202 PF00017 0.488
LIG_SH2_STAT5 226 229 PF00017 0.467
LIG_SH2_STAT5 235 238 PF00017 0.359
LIG_SH2_STAT5 244 247 PF00017 0.405
LIG_SH2_STAT5 291 294 PF00017 0.418
LIG_SH2_STAT5 318 321 PF00017 0.726
LIG_SH2_STAT5 53 56 PF00017 0.485
LIG_SH2_STAT5 74 77 PF00017 0.477
LIG_SH3_3 242 248 PF00018 0.526
LIG_SH3_3 301 307 PF00018 0.712
LIG_SH3_3 36 42 PF00018 0.584
LIG_SUMO_SIM_par_1 148 155 PF11976 0.447
LIG_SUMO_SIM_par_1 281 287 PF11976 0.336
LIG_TRFH_1 168 172 PF08558 0.535
LIG_TYR_ITIM 242 247 PF00017 0.765
LIG_TYR_ITIM 289 294 PF00017 0.369
LIG_WRC_WIRS_1 118 123 PF05994 0.528
MOD_CDK_SPxK_1 294 300 PF00069 0.534
MOD_CK1_1 225 231 PF00069 0.546
MOD_CK1_1 81 87 PF00069 0.685
MOD_CK2_1 110 116 PF00069 0.489
MOD_CK2_1 95 101 PF00069 0.532
MOD_GlcNHglycan 113 116 PF01048 0.564
MOD_GlcNHglycan 220 223 PF01048 0.690
MOD_GlcNHglycan 315 318 PF01048 0.619
MOD_GlcNHglycan 83 86 PF01048 0.615
MOD_GSK3_1 102 109 PF00069 0.648
MOD_GSK3_1 131 138 PF00069 0.576
MOD_GSK3_1 148 155 PF00069 0.461
MOD_GSK3_1 216 223 PF00069 0.726
MOD_GSK3_1 5 12 PF00069 0.546
MOD_N-GLC_1 313 318 PF02516 0.683
MOD_NEK2_1 102 107 PF00069 0.625
MOD_NEK2_1 108 113 PF00069 0.647
MOD_NEK2_1 201 206 PF00069 0.566
MOD_NEK2_2 141 146 PF00069 0.505
MOD_NEK2_2 5 10 PF00069 0.635
MOD_PIKK_1 123 129 PF00454 0.581
MOD_PIKK_1 235 241 PF00454 0.713
MOD_PKA_2 9 15 PF00069 0.524
MOD_Plk_1 188 194 PF00069 0.540
MOD_Plk_1 216 222 PF00069 0.723
MOD_Plk_1 261 267 PF00069 0.508
MOD_Plk_1 375 381 PF00069 0.825
MOD_Plk_4 148 154 PF00069 0.648
MOD_Plk_4 166 172 PF00069 0.550
MOD_Plk_4 222 228 PF00069 0.692
MOD_Plk_4 237 243 PF00069 0.612
MOD_Plk_4 246 252 PF00069 0.528
MOD_Plk_4 25 31 PF00069 0.501
MOD_Plk_4 284 290 PF00069 0.304
MOD_Plk_4 368 374 PF00069 0.617
MOD_Plk_4 78 84 PF00069 0.611
MOD_Plk_4 9 15 PF00069 0.581
MOD_ProDKin_1 132 138 PF00069 0.600
MOD_ProDKin_1 294 300 PF00069 0.544
MOD_ProDKin_1 47 53 PF00069 0.667
TRG_DiLeu_BaEn_2 236 242 PF01217 0.535
TRG_ENDOCYTIC_2 167 170 PF00928 0.510
TRG_ENDOCYTIC_2 171 174 PF00928 0.538
TRG_ENDOCYTIC_2 198 201 PF00928 0.527
TRG_ENDOCYTIC_2 244 247 PF00928 0.624
TRG_ENDOCYTIC_2 260 263 PF00928 0.425
TRG_ENDOCYTIC_2 291 294 PF00928 0.369
TRG_ENDOCYTIC_2 318 321 PF00928 0.594
TRG_Pf-PMV_PEXEL_1 339 344 PF00026 0.541

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2I6 Leptomonas seymouri 33% 85%
A0A0N1I9Y8 Leptomonas seymouri 38% 100%
A0A3S7WSM6 Leishmania donovani 35% 86%
A0A3S7X9E7 Leishmania donovani 93% 100%
A4HMU5 Leishmania braziliensis 76% 100%
A4HVR0 Leishmania infantum 35% 86%
E9AHW4 Leishmania infantum 93% 100%
E9APF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 86%
E9B6F8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4QG22 Leishmania major 35% 87%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS