Transporter-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transporter-like protein

Species:

Leishmania major

UniProt:

E9AFA2_LEIMA

TriTrypDb:

LmjF.35.2780 , LMJLV39_350034800 , LMJSD75_350034100

Length:

698

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

E9AFA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	13
GO:0022857	transmembrane transporter activity	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	551	555	PF00656	0.722
CLV_NRD_NRD_1	105	107	PF00675	0.254
CLV_NRD_NRD_1	326	328	PF00675	0.375
CLV_NRD_NRD_1	433	435	PF00675	0.547
CLV_NRD_NRD_1	549	551	PF00675	0.559
CLV_NRD_NRD_1	626	628	PF00675	0.464
CLV_PCSK_KEX2_1	326	328	PF00082	0.375
CLV_PCSK_KEX2_1	549	551	PF00082	0.562
CLV_PCSK_KEX2_1	626	628	PF00082	0.464
CLV_PCSK_SKI1_1	246	250	PF00082	0.419
CLV_PCSK_SKI1_1	317	321	PF00082	0.324
DEG_APCC_DBOX_1	35	43	PF00400	0.388
DEG_SCF_TRCP1_1	554	559	PF00400	0.784
DEG_SPOP_SBC_1	191	195	PF00917	0.244
DEG_SPOP_SBC_1	417	421	PF00917	0.317
DOC_CKS1_1	488	493	PF01111	0.390
DOC_MAPK_gen_1	103	112	PF00069	0.457
DOC_MAPK_gen_1	163	172	PF00069	0.540
DOC_MAPK_MEF2A_6	103	112	PF00069	0.459
DOC_MAPK_MEF2A_6	255	263	PF00069	0.629
DOC_MAPK_MEF2A_6	423	432	PF00069	0.218
DOC_PP1_RVXF_1	324	331	PF00149	0.496
DOC_PP2B_LxvP_1	451	454	PF13499	0.428
DOC_PP4_FxxP_1	256	259	PF00568	0.553
DOC_PP4_FxxP_1	263	266	PF00568	0.546
DOC_PP4_FxxP_1	320	323	PF00568	0.573
DOC_USP7_MATH_1	144	148	PF00917	0.417
DOC_USP7_MATH_1	168	172	PF00917	0.369
DOC_USP7_MATH_1	191	195	PF00917	0.275
DOC_USP7_MATH_1	351	355	PF00917	0.355
DOC_USP7_MATH_1	629	633	PF00917	0.772
DOC_USP7_UBL2_3	103	107	PF12436	0.499
DOC_WW_Pin1_4	200	205	PF00397	0.355
DOC_WW_Pin1_4	29	34	PF00397	0.584
DOC_WW_Pin1_4	292	297	PF00397	0.789
DOC_WW_Pin1_4	359	364	PF00397	0.409
DOC_WW_Pin1_4	487	492	PF00397	0.353
DOC_WW_Pin1_4	609	614	PF00397	0.774
LIG_14-3-3_CanoR_1	423	429	PF00244	0.379
LIG_14-3-3_CanoR_1	561	567	PF00244	0.709
LIG_14-3-3_CanoR_1	6	15	PF00244	0.759
LIG_Actin_WH2_2	221	238	PF00022	0.379
LIG_Actin_WH2_2	421	436	PF00022	0.366
LIG_BRCT_BRCA1_1	230	234	PF00533	0.375
LIG_BRCT_BRCA1_1	438	442	PF00533	0.349
LIG_deltaCOP1_diTrp_1	438	442	PF00928	0.411
LIG_EH1_1	363	371	PF00400	0.355
LIG_FHA_1	10	16	PF00498	0.672
LIG_FHA_1	171	177	PF00498	0.364
LIG_FHA_1	407	413	PF00498	0.408
LIG_FHA_1	425	431	PF00498	0.299
LIG_FHA_1	46	52	PF00498	0.337
LIG_FHA_1	569	575	PF00498	0.739
LIG_FHA_1	585	591	PF00498	0.550
LIG_FHA_2	605	611	PF00498	0.744
LIG_FHA_2	652	658	PF00498	0.772
LIG_IRF3_LxIS_1	197	203	PF10401	0.244
LIG_LIR_Gen_1	339	350	PF02991	0.411
LIG_LIR_Gen_1	439	449	PF02991	0.346
LIG_LIR_Gen_1	50	61	PF02991	0.449
LIG_LIR_Gen_1	562	570	PF02991	0.762
LIG_LIR_Gen_1	584	593	PF02991	0.663
LIG_LIR_Gen_1	651	659	PF02991	0.781
LIG_LIR_Nem_3	339	345	PF02991	0.353
LIG_LIR_Nem_3	439	445	PF02991	0.334
LIG_LIR_Nem_3	50	56	PF02991	0.457
LIG_LIR_Nem_3	562	567	PF02991	0.734
LIG_LIR_Nem_3	584	588	PF02991	0.661
LIG_LIR_Nem_3	62	66	PF02991	0.342
LIG_LIR_Nem_3	651	655	PF02991	0.789
LIG_NRBOX	138	144	PF00104	0.372
LIG_NRBOX	499	505	PF00104	0.428
LIG_PCNA_PIPBox_1	132	141	PF02747	0.360
LIG_Pex14_2	316	320	PF04695	0.608
LIG_Pex14_2	342	346	PF04695	0.441
LIG_Pex14_2	480	484	PF04695	0.428
LIG_Pex14_2	59	63	PF04695	0.347
LIG_PTAP_UEV_1	691	696	PF05743	0.613
LIG_PTB_Apo_2	378	385	PF02174	0.347
LIG_PTB_Apo_2	600	607	PF02174	0.681
LIG_SH2_CRK	564	568	PF00017	0.692
LIG_SH2_CRK	652	656	PF00017	0.787
LIG_SH2_NCK_1	189	193	PF00017	0.298
LIG_SH2_SRC	520	523	PF00017	0.534
LIG_SH2_STAT5	499	502	PF00017	0.372
LIG_SH2_STAT5	514	517	PF00017	0.245
LIG_SH2_STAT5	520	523	PF00017	0.438
LIG_SH2_STAT5	652	655	PF00017	0.726
LIG_SH2_STAT5	66	69	PF00017	0.298
LIG_SH3_3	263	269	PF00018	0.682
LIG_SH3_3	304	310	PF00018	0.690
LIG_SH3_3	516	522	PF00018	0.417
LIG_SH3_3	52	58	PF00018	0.393
LIG_SH3_3	611	617	PF00018	0.771
LIG_SH3_3	658	664	PF00018	0.759
LIG_SH3_3	689	695	PF00018	0.615
LIG_Sin3_3	408	415	PF02671	0.333
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.749
LIG_SUMO_SIM_anti_2	528	534	PF11976	0.713
LIG_SUMO_SIM_par_1	168	173	PF11976	0.354
LIG_SUMO_SIM_par_1	43	50	PF11976	0.289
LIG_SUMO_SIM_par_1	586	592	PF11976	0.619
LIG_TRAF2_1	639	642	PF00917	0.777
LIG_WRC_WIRS_1	60	65	PF05994	0.343
MOD_CDK_SPK_2	487	492	PF00069	0.265
MOD_CDK_SPxxK_3	29	36	PF00069	0.587
MOD_CK1_1	155	161	PF00069	0.548
MOD_CK1_1	203	209	PF00069	0.365
MOD_CK1_1	22	28	PF00069	0.712
MOD_CK1_1	238	244	PF00069	0.575
MOD_CK1_1	295	301	PF00069	0.678
MOD_CK1_1	398	404	PF00069	0.317
MOD_CK1_1	419	425	PF00069	0.338
MOD_CK1_1	487	493	PF00069	0.323
MOD_CK1_1	523	529	PF00069	0.688
MOD_CK1_1	559	565	PF00069	0.736
MOD_CK1_1	584	590	PF00069	0.676
MOD_CK1_1	609	615	PF00069	0.693
MOD_CK1_1	632	638	PF00069	0.746
MOD_CK1_1	9	15	PF00069	0.765
MOD_CK2_1	536	542	PF00069	0.779
MOD_CK2_1	604	610	PF00069	0.739
MOD_CK2_1	636	642	PF00069	0.777
MOD_Cter_Amidation	104	107	PF01082	0.258
MOD_GlcNHglycan	126	129	PF01048	0.367
MOD_GlcNHglycan	20	24	PF01048	0.490
MOD_GlcNHglycan	230	233	PF01048	0.317
MOD_GlcNHglycan	240	243	PF01048	0.461
MOD_GlcNHglycan	297	300	PF01048	0.515
MOD_GlcNHglycan	466	469	PF01048	0.323
MOD_GlcNHglycan	524	528	PF01048	0.451
MOD_GlcNHglycan	550	553	PF01048	0.538
MOD_GlcNHglycan	554	557	PF01048	0.543
MOD_GlcNHglycan	597	600	PF01048	0.483
MOD_GlcNHglycan	692	695	PF01048	0.415
MOD_GlcNHglycan	73	77	PF01048	0.482
MOD_GlcNHglycan	78	81	PF01048	0.302
MOD_GlcNHglycan	92	95	PF01048	0.157
MOD_GSK3_1	15	22	PF00069	0.692
MOD_GSK3_1	305	312	PF00069	0.689
MOD_GSK3_1	413	420	PF00069	0.367
MOD_GSK3_1	47	54	PF00069	0.302
MOD_GSK3_1	5	12	PF00069	0.737
MOD_GSK3_1	544	551	PF00069	0.735
MOD_GSK3_1	552	559	PF00069	0.726
MOD_GSK3_1	562	569	PF00069	0.721
MOD_GSK3_1	632	639	PF00069	0.747
MOD_GSK3_1	690	697	PF00069	0.767
MOD_GSK3_1	72	79	PF00069	0.338
MOD_N-GLC_1	238	243	PF02516	0.436
MOD_N-GLC_1	544	549	PF02516	0.417
MOD_N-GLC_1	637	642	PF02516	0.592
MOD_NEK2_1	126	131	PF00069	0.264
MOD_NEK2_1	157	162	PF00069	0.495
MOD_NEK2_1	235	240	PF00069	0.551
MOD_NEK2_1	418	423	PF00069	0.510
MOD_NEK2_1	424	429	PF00069	0.346
MOD_NEK2_1	447	452	PF00069	0.417
MOD_NEK2_1	47	52	PF00069	0.347
MOD_NEK2_1	484	489	PF00069	0.349
MOD_NEK2_1	502	507	PF00069	0.331
MOD_NEK2_1	566	571	PF00069	0.737
MOD_NEK2_1	581	586	PF00069	0.655
MOD_NEK2_2	175	180	PF00069	0.391
MOD_NEK2_2	556	561	PF00069	0.742
MOD_PIKK_1	351	357	PF00454	0.281
MOD_PIKK_1	398	404	PF00454	0.404
MOD_PIKK_1	637	643	PF00454	0.776
MOD_PKA_2	235	241	PF00069	0.628
MOD_PKA_2	395	401	PF00069	0.449
MOD_PKA_2	5	11	PF00069	0.764
MOD_PKA_2	548	554	PF00069	0.744
MOD_PKA_2	556	562	PF00069	0.712
MOD_PKB_1	4	12	PF00069	0.598
MOD_Plk_1	274	280	PF00069	0.711
MOD_Plk_1	650	656	PF00069	0.750
MOD_Plk_2-3	651	657	PF00069	0.773
MOD_Plk_4	126	132	PF00069	0.338
MOD_Plk_4	144	150	PF00069	0.184
MOD_Plk_4	175	181	PF00069	0.327
MOD_Plk_4	203	209	PF00069	0.319
MOD_Plk_4	215	221	PF00069	0.260
MOD_Plk_4	274	280	PF00069	0.694
MOD_Plk_4	374	380	PF00069	0.364
MOD_Plk_4	383	389	PF00069	0.435
MOD_Plk_4	502	508	PF00069	0.352
MOD_Plk_4	562	568	PF00069	0.760
MOD_Plk_4	576	582	PF00069	0.668
MOD_Plk_4	59	65	PF00069	0.357
MOD_ProDKin_1	200	206	PF00069	0.355
MOD_ProDKin_1	29	35	PF00069	0.576
MOD_ProDKin_1	292	298	PF00069	0.788
MOD_ProDKin_1	359	365	PF00069	0.408
MOD_ProDKin_1	487	493	PF00069	0.356
MOD_ProDKin_1	609	615	PF00069	0.776
TRG_DiLeu_BaEn_1	576	581	PF01217	0.680
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.582
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.687
TRG_ENDOCYTIC_2	223	226	PF00928	0.360
TRG_ENDOCYTIC_2	405	408	PF00928	0.411
TRG_ENDOCYTIC_2	499	502	PF00928	0.397
TRG_ENDOCYTIC_2	564	567	PF00928	0.741
TRG_ENDOCYTIC_2	652	655	PF00928	0.789
TRG_ER_diArg_1	325	327	PF00400	0.576
TRG_ER_diArg_1	560	563	PF00400	0.733
TRG_ER_diArg_1	626	628	PF00400	0.664
TRG_NES_CRM1_1	38	49	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBQ3	Leptomonas seymouri	35%	100%
A0A0N1PGE0	Leptomonas seymouri	56%	100%
A0A1X0P5R5	Trypanosomatidae	31%	100%
A0A286LF01	Psilocybe cyanescens	25%	100%
A0A3R7KR66	Trypanosoma rangeli	30%	100%
A0A3S7X9E2	Leishmania donovani	88%	100%
A4HMU4	Leishmania braziliensis	63%	100%
A4IBE5	Leishmania infantum	88%	100%
C9ZZ72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B6F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
P0DPB2	Psilocybe cubensis	24%	100%
Q94BZ1	Arabidopsis thaliana	22%	100%
V5BTI8	Trypanosoma cruzi	35%	100%
V5C2Z8	Trypanosoma cruzi	30%	100%