G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AFA0_LEIMA

TriTrypDb:

LmjF.35.2760 , LMJLV39_350034600 , LMJSD75_350033900

Length:

620

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AFA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AFA0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.770
CLV_NRD_NRD_1	115	117	PF00675	0.274
CLV_NRD_NRD_1	219	221	PF00675	0.446
CLV_NRD_NRD_1	24	26	PF00675	0.589
CLV_NRD_NRD_1	486	488	PF00675	0.616
CLV_NRD_NRD_1	492	494	PF00675	0.613
CLV_PCSK_KEX2_1	115	117	PF00082	0.276
CLV_PCSK_KEX2_1	23	25	PF00082	0.607
CLV_PCSK_KEX2_1	486	488	PF00082	0.616
CLV_PCSK_KEX2_1	587	589	PF00082	0.630
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.660
CLV_PCSK_PC7_1	19	25	PF00082	0.604
CLV_PCSK_SKI1_1	36	40	PF00082	0.718
CLV_PCSK_SKI1_1	427	431	PF00082	0.568
CLV_PCSK_SKI1_1	98	102	PF00082	0.276
DEG_APCC_DBOX_1	426	434	PF00400	0.658
DEG_SPOP_SBC_1	397	401	PF00917	0.733
DOC_CKS1_1	528	533	PF01111	0.704
DOC_CKS1_1	78	83	PF01111	0.519
DOC_CYCLIN_RxL_1	422	434	PF00134	0.662
DOC_CYCLIN_RxL_1	93	103	PF00134	0.500
DOC_MAPK_DCC_7	279	289	PF00069	0.724
DOC_MAPK_gen_1	112	121	PF00069	0.479
DOC_MAPK_MEF2A_6	158	165	PF00069	0.517
DOC_PP1_RVXF_1	503	510	PF00149	0.615
DOC_PP2B_LxvP_1	380	383	PF13499	0.698
DOC_PP2B_LxvP_1	596	599	PF13499	0.620
DOC_PP2B_LxvP_1	610	613	PF13499	0.622
DOC_PP4_FxxP_1	476	479	PF00568	0.512
DOC_PP4_FxxP_1	485	488	PF00568	0.648
DOC_USP7_MATH_1	311	315	PF00917	0.640
DOC_USP7_MATH_1	368	372	PF00917	0.785
DOC_USP7_MATH_1	397	401	PF00917	0.725
DOC_USP7_MATH_1	492	496	PF00917	0.766
DOC_USP7_UBL2_3	494	498	PF12436	0.689
DOC_WW_Pin1_4	434	439	PF00397	0.539
DOC_WW_Pin1_4	527	532	PF00397	0.703
DOC_WW_Pin1_4	612	617	PF00397	0.692
DOC_WW_Pin1_4	77	82	PF00397	0.531
LIG_14-3-3_CanoR_1	209	215	PF00244	0.542
LIG_14-3-3_CanoR_1	262	271	PF00244	0.571
LIG_14-3-3_CanoR_1	274	281	PF00244	0.528
LIG_14-3-3_CanoR_1	369	378	PF00244	0.770
LIG_14-3-3_CanoR_1	419	425	PF00244	0.646
LIG_14-3-3_CanoR_1	493	501	PF00244	0.717
LIG_14-3-3_CanoR_1	62	72	PF00244	0.589
LIG_BRCT_BRCA1_1	348	352	PF00533	0.591
LIG_FHA_1	195	201	PF00498	0.476
LIG_FHA_1	258	264	PF00498	0.591
LIG_FHA_1	78	84	PF00498	0.495
LIG_FHA_1	92	98	PF00498	0.446
LIG_FHA_2	199	205	PF00498	0.466
LIG_FHA_2	262	268	PF00498	0.569
LIG_FHA_2	325	331	PF00498	0.758
LIG_FHA_2	336	342	PF00498	0.676
LIG_HP1_1	81	85	PF01393	0.443
LIG_IBAR_NPY_1	468	470	PF08397	0.563
LIG_LIR_Apic_2	436	442	PF02991	0.533
LIG_LIR_Apic_2	474	479	PF02991	0.551
LIG_LIR_Apic_2	482	488	PF02991	0.596
LIG_LIR_Apic_2	586	592	PF02991	0.666
LIG_LIR_Gen_1	140	151	PF02991	0.483
LIG_LIR_Gen_1	245	255	PF02991	0.500
LIG_LIR_Gen_1	530	540	PF02991	0.699
LIG_LIR_Nem_3	140	146	PF02991	0.483
LIG_LIR_Nem_3	222	228	PF02991	0.434
LIG_LIR_Nem_3	245	251	PF02991	0.484
LIG_LIR_Nem_3	530	535	PF02991	0.704
LIG_LYPXL_SIV_4	416	424	PF13949	0.660
LIG_PCNA_yPIPBox_3	419	433	PF02747	0.565
LIG_Pex14_2	472	476	PF04695	0.661
LIG_SH2_CRK	225	229	PF00017	0.357
LIG_SH2_CRK	248	252	PF00017	0.527
LIG_SH2_CRK	514	518	PF00017	0.587
LIG_SH2_CRK	589	593	PF00017	0.579
LIG_SH2_NCK_1	344	348	PF00017	0.711
LIG_SH2_NCK_1	514	518	PF00017	0.587
LIG_SH2_NCK_1	557	561	PF00017	0.670
LIG_SH2_SRC	432	435	PF00017	0.662
LIG_SH2_STAP1	248	252	PF00017	0.490
LIG_SH2_STAP1	417	421	PF00017	0.635
LIG_SH2_STAT3	470	473	PF00017	0.559
LIG_SH2_STAT5	168	171	PF00017	0.476
LIG_SH2_STAT5	179	182	PF00017	0.476
LIG_SH2_STAT5	432	435	PF00017	0.557
LIG_SH2_STAT5	470	473	PF00017	0.559
LIG_SH2_STAT5	484	487	PF00017	0.615
LIG_SH2_STAT5	514	517	PF00017	0.572
LIG_SH2_STAT5	518	521	PF00017	0.567
LIG_SH3_1	514	520	PF00018	0.570
LIG_SH3_3	128	134	PF00018	0.487
LIG_SH3_3	384	390	PF00018	0.737
LIG_SH3_3	460	466	PF00018	0.556
LIG_SH3_3	514	520	PF00018	0.554
LIG_SH3_3	569	575	PF00018	0.604
LIG_SH3_3	610	616	PF00018	0.767
LIG_SH3_3	75	81	PF00018	0.518
LIG_SUMO_SIM_anti_2	182	187	PF11976	0.487
LIG_SUMO_SIM_par_1	196	201	PF11976	0.476
LIG_SUMO_SIM_par_1	230	236	PF11976	0.407
LIG_SxIP_EBH_1	397	409	PF03271	0.744
LIG_TRAF2_1	337	340	PF00917	0.771
LIG_TRAF2_1	383	386	PF00917	0.641
LIG_TRAF2_1	571	574	PF00917	0.564
LIG_TRAF2_2	291	296	PF00917	0.669
LIG_TYR_ITIM	223	228	PF00017	0.545
LIG_TYR_ITIM	246	251	PF00017	0.513
MOD_CDC14_SPxK_1	437	440	PF00782	0.536
MOD_CDK_SPxK_1	434	440	PF00069	0.540
MOD_CK1_1	254	260	PF00069	0.647
MOD_CK1_1	332	338	PF00069	0.613
MOD_CK1_1	398	404	PF00069	0.639
MOD_CK1_1	614	620	PF00069	0.737
MOD_CK2_1	100	106	PF00069	0.413
MOD_CK2_1	261	267	PF00069	0.576
MOD_CK2_1	274	280	PF00069	0.540
MOD_CK2_1	335	341	PF00069	0.765
MOD_CK2_1	34	40	PF00069	0.702
MOD_CK2_1	342	348	PF00069	0.721
MOD_CK2_1	368	374	PF00069	0.731
MOD_GlcNHglycan	102	105	PF01048	0.473
MOD_GlcNHglycan	235	238	PF01048	0.409
MOD_GlcNHglycan	271	274	PF01048	0.669
MOD_GlcNHglycan	348	351	PF01048	0.667
MOD_GlcNHglycan	359	362	PF01048	0.596
MOD_GlcNHglycan	605	608	PF01048	0.695
MOD_GlcNHglycan	65	68	PF01048	0.528
MOD_GSK3_1	137	144	PF00069	0.328
MOD_GSK3_1	194	201	PF00069	0.328
MOD_GSK3_1	250	257	PF00069	0.459
MOD_GSK3_1	312	319	PF00069	0.644
MOD_GSK3_1	342	349	PF00069	0.638
MOD_GSK3_1	368	375	PF00069	0.716
MOD_GSK3_1	391	398	PF00069	0.680
MOD_GSK3_1	612	619	PF00069	0.728
MOD_GSK3_1	92	99	PF00069	0.316
MOD_N-GLC_1	194	199	PF02516	0.328
MOD_NEK2_1	233	238	PF00069	0.400
MOD_NEK2_1	250	255	PF00069	0.241
MOD_NEK2_1	471	476	PF00069	0.644
MOD_NEK2_1	96	101	PF00069	0.310
MOD_NEK2_2	210	215	PF00069	0.556
MOD_NEK2_2	242	247	PF00069	0.471
MOD_PIKK_1	274	280	PF00454	0.544
MOD_PIKK_1	289	295	PF00454	0.596
MOD_PIKK_1	410	416	PF00454	0.621
MOD_PIKK_1	471	477	PF00454	0.459
MOD_PIKK_1	493	499	PF00454	0.725
MOD_PKA_1	493	499	PF00069	0.639
MOD_PKA_2	261	267	PF00069	0.592
MOD_PKA_2	269	275	PF00069	0.567
MOD_PKA_2	342	348	PF00069	0.774
MOD_PKA_2	368	374	PF00069	0.780
MOD_PKA_2	492	498	PF00069	0.662
MOD_PKB_1	15	23	PF00069	0.686
MOD_Plk_1	17	23	PF00069	0.691
MOD_Plk_1	194	200	PF00069	0.328
MOD_Plk_1	279	285	PF00069	0.684
MOD_Plk_1	312	318	PF00069	0.602
MOD_Plk_1	329	335	PF00069	0.708
MOD_Plk_2-3	261	267	PF00069	0.576
MOD_Plk_4	142	148	PF00069	0.331
MOD_Plk_4	329	335	PF00069	0.728
MOD_Plk_4	372	378	PF00069	0.783
MOD_Plk_4	92	98	PF00069	0.328
MOD_ProDKin_1	434	440	PF00069	0.540
MOD_ProDKin_1	527	533	PF00069	0.703
MOD_ProDKin_1	612	618	PF00069	0.729
MOD_ProDKin_1	77	83	PF00069	0.519
TRG_DiLeu_BaEn_1	329	334	PF01217	0.711
TRG_DiLeu_BaLyEn_6	425	430	PF01217	0.655
TRG_ENDOCYTIC_2	167	170	PF00928	0.328
TRG_ENDOCYTIC_2	225	228	PF00928	0.554
TRG_ENDOCYTIC_2	248	251	PF00928	0.521
TRG_ENDOCYTIC_2	417	420	PF00928	0.597
TRG_ER_diArg_1	114	116	PF00400	0.344
TRG_ER_diArg_1	23	25	PF00400	0.624
TRG_ER_diArg_1	305	308	PF00400	0.592
TRG_ER_diArg_1	424	427	PF00400	0.666
TRG_ER_diArg_1	485	487	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	36	40	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	427	431	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF63	Leptomonas seymouri	70%	94%
A0A0S4JFQ6	Bodo saltans	48%	94%
A0A1X0P5I3	Trypanosomatidae	56%	98%
A0A3Q8IJ54	Leishmania donovani	94%	100%
A0A3R7RSH5	Trypanosoma rangeli	57%	97%
A4HMU2	Leishmania braziliensis	83%	95%
A4IBE4	Leishmania infantum	94%	100%
C9ZZ76	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	98%
E9B6F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5C303	Trypanosoma cruzi	56%	91%