LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
E9AF96_LEIMA
TriTrypDb:
LMJLV39_350034000 * , LMJLV39_350034100 * , LMJSD75_350033500 *
Length:
570

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF96
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF96

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 96 100 PF00656 0.589
CLV_NRD_NRD_1 125 127 PF00675 0.613
CLV_NRD_NRD_1 172 174 PF00675 0.752
CLV_NRD_NRD_1 298 300 PF00675 0.796
CLV_NRD_NRD_1 446 448 PF00675 0.531
CLV_NRD_NRD_1 457 459 PF00675 0.650
CLV_NRD_NRD_1 555 557 PF00675 0.463
CLV_NRD_NRD_1 561 563 PF00675 0.480
CLV_NRD_NRD_1 565 567 PF00675 0.486
CLV_NRD_NRD_1 82 84 PF00675 0.594
CLV_PCSK_FUR_1 13 17 PF00082 0.546
CLV_PCSK_FUR_1 51 55 PF00082 0.484
CLV_PCSK_FUR_1 559 563 PF00082 0.489
CLV_PCSK_KEX2_1 125 127 PF00082 0.613
CLV_PCSK_KEX2_1 15 17 PF00082 0.542
CLV_PCSK_KEX2_1 172 174 PF00082 0.752
CLV_PCSK_KEX2_1 298 300 PF00082 0.810
CLV_PCSK_KEX2_1 367 369 PF00082 0.516
CLV_PCSK_KEX2_1 446 448 PF00082 0.405
CLV_PCSK_KEX2_1 53 55 PF00082 0.487
CLV_PCSK_KEX2_1 555 557 PF00082 0.467
CLV_PCSK_KEX2_1 559 561 PF00082 0.480
CLV_PCSK_KEX2_1 565 567 PF00082 0.492
CLV_PCSK_KEX2_1 82 84 PF00082 0.541
CLV_PCSK_PC1ET2_1 15 17 PF00082 0.542
CLV_PCSK_PC1ET2_1 367 369 PF00082 0.516
CLV_PCSK_PC1ET2_1 53 55 PF00082 0.487
CLV_PCSK_PC7_1 11 17 PF00082 0.545
CLV_PCSK_PC7_1 555 561 PF00082 0.474
CLV_PCSK_SKI1_1 371 375 PF00082 0.740
CLV_PCSK_SKI1_1 377 381 PF00082 0.738
CLV_PCSK_SKI1_1 508 512 PF00082 0.524
DEG_APCC_KENBOX_2 100 104 PF00400 0.518
DEG_SPOP_SBC_1 111 115 PF00917 0.575
DEG_SPOP_SBC_1 320 324 PF00917 0.498
DOC_CKS1_1 341 346 PF01111 0.500
DOC_CYCLIN_RxL_1 505 514 PF00134 0.426
DOC_MAPK_gen_1 82 92 PF00069 0.532
DOC_MAPK_MEF2A_6 345 354 PF00069 0.490
DOC_PP1_RVXF_1 450 457 PF00149 0.654
DOC_PP2B_LxvP_1 121 124 PF13499 0.538
DOC_PP2B_LxvP_1 357 360 PF13499 0.482
DOC_PP2B_LxvP_1 510 513 PF13499 0.688
DOC_PP2B_LxvP_1 530 533 PF13499 0.698
DOC_PP4_FxxP_1 531 534 PF00568 0.536
DOC_PP4_MxPP_1 127 130 PF00568 0.534
DOC_SPAK_OSR1_1 262 266 PF12202 0.517
DOC_USP7_MATH_1 111 115 PF00917 0.747
DOC_USP7_MATH_1 149 153 PF00917 0.671
DOC_USP7_MATH_1 228 232 PF00917 0.572
DOC_USP7_MATH_1 320 324 PF00917 0.498
DOC_USP7_MATH_1 375 379 PF00917 0.583
DOC_WW_Pin1_4 104 109 PF00397 0.530
DOC_WW_Pin1_4 230 235 PF00397 0.593
DOC_WW_Pin1_4 303 308 PF00397 0.506
DOC_WW_Pin1_4 340 345 PF00397 0.504
DOC_WW_Pin1_4 346 351 PF00397 0.553
DOC_WW_Pin1_4 38 43 PF00397 0.490
DOC_WW_Pin1_4 554 559 PF00397 0.462
LIG_14-3-3_CanoR_1 218 228 PF00244 0.522
LIG_14-3-3_CanoR_1 241 245 PF00244 0.544
LIG_14-3-3_CanoR_1 271 279 PF00244 0.504
LIG_14-3-3_CanoR_1 281 291 PF00244 0.488
LIG_14-3-3_CanoR_1 299 309 PF00244 0.482
LIG_14-3-3_CanoR_1 458 467 PF00244 0.419
LIG_14-3-3_CanoR_1 83 92 PF00244 0.532
LIG_14-3-3_CterR_2 566 570 PF00244 0.500
LIG_APCC_ABBAyCdc20_2 413 419 PF00400 0.705
LIG_BIR_II_1 1 5 PF00653 0.542
LIG_BIR_III_2 369 373 PF00653 0.507
LIG_BRCT_BRCA1_1 259 263 PF00533 0.530
LIG_BRCT_BRCA1_1 311 315 PF00533 0.502
LIG_deltaCOP1_diTrp_1 290 294 PF00928 0.519
LIG_FHA_1 105 111 PF00498 0.600
LIG_FHA_1 212 218 PF00498 0.516
LIG_FHA_1 304 310 PF00498 0.534
LIG_FHA_1 341 347 PF00498 0.493
LIG_FHA_1 485 491 PF00498 0.605
LIG_FHA_1 507 513 PF00498 0.591
LIG_FHA_2 427 433 PF00498 0.668
LIG_FHA_2 5 11 PF00498 0.555
LIG_FHA_2 514 520 PF00498 0.665
LIG_FHA_2 539 545 PF00498 0.452
LIG_LIR_Apic_2 328 333 PF02991 0.507
LIG_LIR_Apic_2 528 534 PF02991 0.521
LIG_LIR_Gen_1 310 321 PF02991 0.504
LIG_LIR_Gen_1 418 426 PF02991 0.688
LIG_LIR_Gen_1 544 554 PF02991 0.661
LIG_LIR_Nem_3 184 188 PF02991 0.742
LIG_LIR_Nem_3 290 294 PF02991 0.771
LIG_LIR_Nem_3 310 316 PF02991 0.467
LIG_LIR_Nem_3 418 423 PF02991 0.698
LIG_LIR_Nem_3 541 546 PF02991 0.636
LIG_LYPXL_yS_3 185 188 PF13949 0.747
LIG_MYND_1 119 123 PF01753 0.537
LIG_MYND_1 307 311 PF01753 0.491
LIG_MYND_1 344 348 PF01753 0.477
LIG_REV1ctd_RIR_1 44 52 PF16727 0.497
LIG_SH2_CRK 313 317 PF00017 0.512
LIG_SH2_SRC 518 521 PF00017 0.640
LIG_SH2_STAP1 518 522 PF00017 0.635
LIG_SH2_STAP1 543 547 PF00017 0.655
LIG_SH2_STAT5 313 316 PF00017 0.710
LIG_SH2_STAT5 546 549 PF00017 0.632
LIG_SH3_2 356 361 PF14604 0.485
LIG_SH3_2 372 377 PF14604 0.483
LIG_SH3_3 117 123 PF00018 0.539
LIG_SH3_3 156 162 PF00018 0.494
LIG_SH3_3 22 28 PF00018 0.743
LIG_SH3_3 244 250 PF00018 0.504
LIG_SH3_3 341 347 PF00018 0.503
LIG_SH3_3 350 356 PF00018 0.522
LIG_SH3_3 36 42 PF00018 0.505
LIG_SH3_3 369 375 PF00018 0.533
LIG_SH3_3 531 537 PF00018 0.632
LIG_SH3_3 55 61 PF00018 0.692
LIG_SUMO_SIM_par_1 196 204 PF11976 0.549
LIG_UBA3_1 453 459 PF00899 0.662
LIG_WRC_WIRS_1 212 217 PF05994 0.514
LIG_WW_1 359 362 PF00397 0.487
LIG_WW_3 122 126 PF00397 0.755
LIG_WW_3 358 362 PF00397 0.487
MOD_CDC14_SPxK_1 557 560 PF00782 0.475
MOD_CDK_SPK_2 340 345 PF00069 0.504
MOD_CDK_SPK_2 554 559 PF00069 0.462
MOD_CDK_SPxK_1 554 560 PF00069 0.466
MOD_CDK_SPxxK_3 234 241 PF00069 0.541
MOD_CDK_SPxxK_3 554 561 PF00069 0.470
MOD_CK1_1 106 112 PF00069 0.574
MOD_CK1_1 208 214 PF00069 0.505
MOD_CK1_1 274 280 PF00069 0.505
MOD_CK1_1 300 306 PF00069 0.519
MOD_CK1_1 462 468 PF00069 0.708
MOD_CK1_1 539 545 PF00069 0.652
MOD_CK1_1 94 100 PF00069 0.700
MOD_CK2_1 4 10 PF00069 0.543
MOD_CK2_1 426 432 PF00069 0.681
MOD_CK2_1 458 464 PF00069 0.500
MOD_CK2_1 538 544 PF00069 0.456
MOD_Cter_Amidation 13 16 PF01082 0.557
MOD_GlcNHglycan 147 150 PF01048 0.728
MOD_GlcNHglycan 189 192 PF01048 0.670
MOD_GlcNHglycan 230 233 PF01048 0.548
MOD_GlcNHglycan 234 237 PF01048 0.535
MOD_GlcNHglycan 242 245 PF01048 0.490
MOD_GlcNHglycan 259 262 PF01048 0.482
MOD_GlcNHglycan 284 287 PF01048 0.505
MOD_GlcNHglycan 377 380 PF01048 0.661
MOD_GlcNHglycan 399 402 PF01048 0.759
MOD_GSK3_1 106 113 PF00069 0.592
MOD_GSK3_1 145 152 PF00069 0.788
MOD_GSK3_1 213 220 PF00069 0.533
MOD_GSK3_1 228 235 PF00069 0.703
MOD_GSK3_1 236 243 PF00069 0.611
MOD_GSK3_1 253 260 PF00069 0.612
MOD_GSK3_1 267 274 PF00069 0.481
MOD_GSK3_1 275 282 PF00069 0.487
MOD_GSK3_1 297 304 PF00069 0.539
MOD_GSK3_1 305 312 PF00069 0.609
MOD_GSK3_1 321 328 PF00069 0.689
MOD_GSK3_1 458 465 PF00069 0.422
MOD_GSK3_1 538 545 PF00069 0.443
MOD_N-GLC_1 326 331 PF02516 0.671
MOD_N-GLC_2 103 105 PF02516 0.737
MOD_NEK2_1 110 115 PF00069 0.671
MOD_NEK2_1 145 150 PF00069 0.790
MOD_NEK2_1 165 170 PF00069 0.462
MOD_NEK2_1 221 226 PF00069 0.526
MOD_NEK2_1 257 262 PF00069 0.674
MOD_NEK2_1 272 277 PF00069 0.501
MOD_NEK2_1 279 284 PF00069 0.496
MOD_NEK2_1 390 395 PF00069 0.718
MOD_NEK2_1 397 402 PF00069 0.643
MOD_NEK2_1 4 9 PF00069 0.554
MOD_NEK2_1 426 431 PF00069 0.684
MOD_NEK2_2 506 511 PF00069 0.616
MOD_NEK2_2 513 518 PF00069 0.534
MOD_OFUCOSY 57 63 PF10250 0.503
MOD_PIKK_1 128 134 PF00454 0.752
MOD_PIKK_1 223 229 PF00454 0.530
MOD_PIKK_1 72 78 PF00454 0.538
MOD_PK_1 298 304 PF00069 0.525
MOD_PKA_1 172 178 PF00069 0.728
MOD_PKA_1 298 304 PF00069 0.525
MOD_PKA_1 458 464 PF00069 0.418
MOD_PKA_2 172 178 PF00069 0.728
MOD_PKA_2 208 214 PF00069 0.505
MOD_PKA_2 217 223 PF00069 0.498
MOD_PKA_2 240 246 PF00069 0.670
MOD_PKA_2 270 276 PF00069 0.503
MOD_PKA_2 297 303 PF00069 0.568
MOD_PKA_2 4 10 PF00069 0.566
MOD_PKA_2 59 65 PF00069 0.513
MOD_Plk_1 326 332 PF00069 0.512
MOD_Plk_1 388 394 PF00069 0.708
MOD_Plk_1 518 524 PF00069 0.639
MOD_Plk_4 172 178 PF00069 0.728
MOD_Plk_4 208 214 PF00069 0.505
MOD_Plk_4 35 41 PF00069 0.487
MOD_Plk_4 462 468 PF00069 0.708
MOD_Plk_4 506 512 PF00069 0.717
MOD_Plk_4 513 519 PF00069 0.551
MOD_Plk_4 542 548 PF00069 0.651
MOD_ProDKin_1 104 110 PF00069 0.530
MOD_ProDKin_1 230 236 PF00069 0.596
MOD_ProDKin_1 303 309 PF00069 0.507
MOD_ProDKin_1 340 346 PF00069 0.502
MOD_ProDKin_1 38 44 PF00069 0.492
MOD_ProDKin_1 554 560 PF00069 0.466
MOD_SUMO_for_1 200 203 PF00179 0.481
MOD_SUMO_rev_2 88 93 PF00179 0.766
TRG_DiLeu_BaLyEn_6 244 249 PF01217 0.509
TRG_DiLeu_BaLyEn_6 350 355 PF01217 0.499
TRG_DiLeu_BaLyEn_6 439 444 PF01217 0.568
TRG_DiLeu_BaLyEn_6 449 454 PF01217 0.636
TRG_ENDOCYTIC_2 185 188 PF00928 0.747
TRG_ENDOCYTIC_2 313 316 PF00928 0.514
TRG_ENDOCYTIC_2 546 549 PF00928 0.507
TRG_ER_diArg_1 124 126 PF00400 0.606
TRG_ER_diArg_1 554 556 PF00400 0.455
TRG_ER_diArg_1 558 561 PF00400 0.475
TRG_ER_diArg_1 564 566 PF00400 0.486
TRG_NES_CRM1_1 414 428 PF08389 0.488
TRG_NLS_MonoCore_2 14 19 PF00514 0.550
TRG_NLS_MonoExtN_4 13 19 PF00514 0.551
TRG_Pf-PMV_PEXEL_1 410 414 PF00026 0.709
TRG_Pf-PMV_PEXEL_1 48 52 PF00026 0.487

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IIE1 Leishmania donovani 56% 100%
A4IBE0 Leishmania infantum 56% 100%
E9B6F1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS