Putative QA-SNARE protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania major

UniProt:

E9AF95_LEIMA

TriTrypDb:

LmjF.35.2720 , LMJLV39_350033900 , LMJSD75_350033400

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0012505	endomembrane system	2	2
GO:0016020	membrane	2	11
GO:0031201	SNARE complex	3	13
GO:0032991	protein-containing complex	1	13
GO:0098796	membrane protein complex	2	13
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AF95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF95

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	13
GO:0006886	intracellular protein transport	4	13
GO:0006906	vesicle fusion	6	2
GO:0006996	organelle organization	4	2
GO:0008104	protein localization	4	13
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	13
GO:0016043	cellular component organization	3	2
GO:0016050	vesicle organization	5	2
GO:0022406	membrane docking	2	2
GO:0033036	macromolecule localization	2	13
GO:0045184	establishment of protein localization	3	13
GO:0046907	intracellular transport	3	13
GO:0048278	vesicle docking	4	2
GO:0048284	organelle fusion	5	2
GO:0051179	localization	1	13
GO:0051234	establishment of localization	2	13
GO:0051640	organelle localization	2	2
GO:0051641	cellular localization	2	13
GO:0051649	establishment of localization in cell	3	13
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070727	cellular macromolecule localization	3	13
GO:0071702	organic substance transport	4	13
GO:0071705	nitrogen compound transport	4	13
GO:0071840	cellular component organization or biogenesis	2	2
GO:0090174	organelle membrane fusion	6	2
GO:0140056	organelle localization by membrane tethering	3	2
GO:0016192	vesicle-mediated transport	4	11

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	2
GO:0005484	SNAP receptor activity	3	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0030674	protein-macromolecule adaptor activity	2	2
GO:0060090	molecular adaptor activity	1	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.595
CLV_NRD_NRD_1	152	154	PF00675	0.324
CLV_NRD_NRD_1	19	21	PF00675	0.466
CLV_NRD_NRD_1	50	52	PF00675	0.370
CLV_NRD_NRD_1	66	68	PF00675	0.294
CLV_PCSK_FUR_1	17	21	PF00082	0.486
CLV_PCSK_KEX2_1	152	154	PF00082	0.325
CLV_PCSK_KEX2_1	19	21	PF00082	0.466
CLV_PCSK_KEX2_1	50	52	PF00082	0.400
CLV_PCSK_PC7_1	148	154	PF00082	0.326
CLV_PCSK_SKI1_1	104	108	PF00082	0.332
CLV_PCSK_SKI1_1	130	134	PF00082	0.318
CLV_PCSK_SKI1_1	193	197	PF00082	0.393
CLV_PCSK_SKI1_1	97	101	PF00082	0.369
DOC_ANK_TNKS_1	114	121	PF00023	0.660
DOC_CKS1_1	37	42	PF01111	0.577
DOC_MAPK_DCC_7	35	43	PF00069	0.655
DOC_MAPK_gen_1	152	158	PF00069	0.548
DOC_MAPK_gen_1	65	75	PF00069	0.578
DOC_MAPK_MEF2A_6	67	75	PF00069	0.564
DOC_PP1_RVXF_1	70	76	PF00149	0.579
DOC_PP1_SILK_1	126	131	PF00149	0.545
DOC_USP7_UBL2_3	100	104	PF12436	0.532
DOC_USP7_UBL2_3	68	72	PF12436	0.547
DOC_WW_Pin1_4	36	41	PF00397	0.572
LIG_14-3-3_CanoR_1	219	227	PF00244	0.542
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_EH1_1	283	291	PF00400	0.328
LIG_FHA_1	112	118	PF00498	0.638
LIG_FHA_1	200	206	PF00498	0.624
LIG_FHA_1	21	27	PF00498	0.677
LIG_FHA_1	234	240	PF00498	0.539
LIG_FHA_1	275	281	PF00498	0.490
LIG_FHA_2	120	126	PF00498	0.564
LIG_FHA_2	76	82	PF00498	0.668
LIG_LIR_Gen_1	216	224	PF02991	0.520
LIG_LIR_Nem_3	216	220	PF02991	0.515
LIG_LIR_Nem_3	7	13	PF02991	0.561
LIG_PCNA_PIPBox_1	92	101	PF02747	0.550
LIG_PCNA_yPIPBox_3	92	104	PF02747	0.559
LIG_SH2_CRK	13	17	PF00017	0.618
LIG_SH2_CRK	221	225	PF00017	0.525
LIG_SH2_PTP2	37	40	PF00017	0.601
LIG_SH2_STAP1	113	117	PF00017	0.636
LIG_SH2_STAT5	113	116	PF00017	0.650
LIG_SH2_STAT5	190	193	PF00017	0.588
LIG_SH2_STAT5	37	40	PF00017	0.601
LIG_SUMO_SIM_anti_2	125	130	PF11976	0.549
LIG_SUMO_SIM_par_1	235	240	PF11976	0.556
LIG_TRAF2_1	28	31	PF00917	0.692
LIG_TYR_ITIM	11	16	PF00017	0.595
LIG_UBA3_1	292	299	PF00899	0.308
MOD_CK1_1	223	229	PF00069	0.512
MOD_CK1_1	274	280	PF00069	0.517
MOD_CK2_1	119	125	PF00069	0.573
MOD_CK2_1	223	229	PF00069	0.524
MOD_CK2_1	75	81	PF00069	0.620
MOD_GlcNHglycan	273	276	PF01048	0.329
MOD_GSK3_1	219	226	PF00069	0.555
MOD_GSK3_1	250	257	PF00069	0.459
MOD_N-GLC_1	141	146	PF02516	0.345
MOD_N-GLC_1	250	255	PF02516	0.222
MOD_NEK2_1	109	114	PF00069	0.598
MOD_NEK2_1	252	257	PF00069	0.491
MOD_PIKK_1	147	153	PF00454	0.606
MOD_PIKK_1	162	168	PF00454	0.663
MOD_PIKK_1	193	199	PF00454	0.584
MOD_PKA_2	147	153	PF00069	0.560
MOD_Plk_1	109	115	PF00069	0.610
MOD_Plk_1	124	130	PF00069	0.474
MOD_Plk_1	250	256	PF00069	0.429
MOD_Plk_2-3	119	125	PF00069	0.573
MOD_Plk_4	124	130	PF00069	0.550
MOD_Plk_4	199	205	PF00069	0.602
MOD_Plk_4	233	239	PF00069	0.521
MOD_ProDKin_1	36	42	PF00069	0.565
MOD_SUMO_for_1	71	74	PF00179	0.576
TRG_DiLeu_BaEn_1	182	187	PF01217	0.658
TRG_DiLeu_BaEn_1	22	27	PF01217	0.689
TRG_DiLeu_BaEn_1	240	245	PF01217	0.688
TRG_ENDOCYTIC_2	13	16	PF00928	0.615
TRG_ENDOCYTIC_2	221	224	PF00928	0.523
TRG_ER_diArg_1	152	154	PF00400	0.532
TRG_ER_diArg_1	16	19	PF00400	0.614
TRG_ER_diArg_1	49	51	PF00400	0.622
TRG_NES_CRM1_1	229	240	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	115	119	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I246	Leptomonas seymouri	27%	100%
A0A0N1IMN0	Leptomonas seymouri	92%	100%
A0A0S4J7F1	Bodo saltans	26%	100%
A0A0S4JKJ1	Bodo saltans	54%	100%
A0A1X0P0Y0	Trypanosomatidae	30%	100%
A0A1X0P5S4	Trypanosomatidae	73%	100%
A0A3Q8IK46	Leishmania donovani	25%	100%
A0A3R7MIN3	Trypanosoma rangeli	27%	100%
A0A3S7X9G5	Leishmania donovani	97%	100%
A0A422P2Q8	Trypanosoma rangeli	75%	100%
A4HLJ5	Leishmania braziliensis	24%	100%
A4HMT8	Leishmania braziliensis	94%	100%
A4HN16	Leishmania braziliensis	24%	96%
A4I905	Leishmania infantum	25%	100%
A4IBD9	Leishmania infantum	97%	100%
C9ZZ78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
D0A501	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B3X0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B6F0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O14662	Homo sapiens	28%	93%
O16000	Caenorhabditis elegans	26%	100%
O65359	Arabidopsis thaliana	27%	94%
P32856	Homo sapiens	24%	100%
P50279	Rattus norvegicus	25%	100%
P61264	Mus musculus	25%	100%
P61265	Rattus norvegicus	25%	100%
P61266	Homo sapiens	25%	100%
P61267	Bos taurus	25%	100%
P61268	Ovis aries	25%	100%
Q00262	Mus musculus	25%	100%
Q08144	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	76%
Q4Q454	Leishmania major	28%	100%
Q5RBW6	Pongo abelii	24%	100%
Q86Y82	Homo sapiens	24%	100%
Q8BVI5	Mus musculus	27%	93%
Q9P6P1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9SUJ1	Arabidopsis thaliana	26%	91%
Q9SWH4	Arabidopsis thaliana	25%	93%
V5BLU5	Trypanosoma cruzi	26%	100%
V5C306	Trypanosoma cruzi	75%	100%