Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF94_LEIMA

TriTrypDb:

LmjF.35.2710 , LMJLV39_350033800 , LMJSD75_350033300

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.603
CLV_NRD_NRD_1	492	494	PF00675	0.561
CLV_NRD_NRD_1	7	9	PF00675	0.584
CLV_NRD_NRD_1	78	80	PF00675	0.573
CLV_PCSK_KEX2_1	444	446	PF00082	0.732
CLV_PCSK_KEX2_1	491	493	PF00082	0.574
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.732
CLV_PCSK_PC1ET2_1	491	493	PF00082	0.574
CLV_PCSK_SKI1_1	139	143	PF00082	0.593
CLV_PCSK_SKI1_1	29	33	PF00082	0.526
CLV_PCSK_SKI1_1	294	298	PF00082	0.523
CLV_PCSK_SKI1_1	350	354	PF00082	0.322
CLV_PCSK_SKI1_1	482	486	PF00082	0.547
CLV_PCSK_SKI1_1	8	12	PF00082	0.451
DEG_APCC_DBOX_1	293	301	PF00400	0.581
DEG_APCC_DBOX_1	349	357	PF00400	0.568
DEG_APCC_DBOX_1	7	15	PF00400	0.443
DEG_Nend_UBRbox_1	1	4	PF02207	0.646
DEG_SPOP_SBC_1	48	52	PF00917	0.766
DEG_SPOP_SBC_1	74	78	PF00917	0.689
DOC_CYCLIN_RxL_1	136	146	PF00134	0.552
DOC_CYCLIN_RxL_1	344	357	PF00134	0.334
DOC_CYCLIN_yCln2_LP_2	352	358	PF00134	0.355
DOC_MAPK_gen_1	137	144	PF00069	0.552
DOC_MAPK_RevD_3	479	493	PF00069	0.498
DOC_PP1_RVXF_1	137	144	PF00149	0.474
DOC_PP1_RVXF_1	346	352	PF00149	0.527
DOC_PP2B_LxvP_1	352	355	PF13499	0.323
DOC_PP4_FxxP_1	427	430	PF00568	0.652
DOC_USP7_MATH_1	208	212	PF00917	0.767
DOC_USP7_MATH_1	223	227	PF00917	0.538
DOC_USP7_MATH_1	314	318	PF00917	0.546
DOC_USP7_MATH_1	438	442	PF00917	0.735
DOC_USP7_MATH_1	461	465	PF00917	0.612
DOC_USP7_MATH_1	68	72	PF00917	0.812
DOC_USP7_MATH_1	74	78	PF00917	0.706
DOC_USP7_UBL2_3	12	16	PF12436	0.518
DOC_USP7_UBL2_3	304	308	PF12436	0.355
DOC_WW_Pin1_4	354	359	PF00397	0.547
DOC_WW_Pin1_4	451	456	PF00397	0.742
DOC_WW_Pin1_4	63	68	PF00397	0.679
DOC_WW_Pin1_4	70	75	PF00397	0.671
LIG_14-3-3_CanoR_1	150	159	PF00244	0.640
LIG_14-3-3_CanoR_1	29	35	PF00244	0.540
LIG_14-3-3_CanoR_1	465	470	PF00244	0.522
LIG_14-3-3_CanoR_1	55	63	PF00244	0.793
LIG_14-3-3_CanoR_1	79	87	PF00244	0.751
LIG_14-3-3_CanoR_1	93	101	PF00244	0.654
LIG_BRCT_BRCA1_1	103	107	PF00533	0.349
LIG_BRCT_BRCA1_1	463	467	PF00533	0.572
LIG_FHA_1	101	107	PF00498	0.522
LIG_FHA_1	154	160	PF00498	0.567
LIG_FHA_1	296	302	PF00498	0.516
LIG_FHA_1	364	370	PF00498	0.470
LIG_FHA_2	281	287	PF00498	0.569
LIG_FHA_2	308	314	PF00498	0.565
LIG_FHA_2	328	334	PF00498	0.301
LIG_FHA_2	37	43	PF00498	0.729
LIG_FHA_2	438	444	PF00498	0.740
LIG_FHA_2	457	463	PF00498	0.646
LIG_FHA_2	64	70	PF00498	0.717
LIG_FHA_2	80	86	PF00498	0.477
LIG_IRF3_LxIS_1	160	167	PF10401	0.702
LIG_IRF3_LxIS_1	316	321	PF10401	0.309
LIG_LIR_Apic_2	424	430	PF02991	0.643
LIG_LIR_Gen_1	373	383	PF02991	0.442
LIG_LIR_Gen_1	408	418	PF02991	0.667
LIG_LIR_LC3C_4	366	371	PF02991	0.547
LIG_LIR_Nem_3	373	378	PF02991	0.435
LIG_LIR_Nem_3	408	413	PF02991	0.616
LIG_LIR_Nem_3	464	470	PF02991	0.554
LIG_MLH1_MIPbox_1	467	471	PF16413	0.531
LIG_NRBOX	480	486	PF00104	0.536
LIG_PCNA_yPIPBox_3	139	152	PF02747	0.615
LIG_Pex14_2	275	279	PF04695	0.581
LIG_Pex14_2	30	34	PF04695	0.647
LIG_Pex14_2	347	351	PF04695	0.409
LIG_Pex14_2	467	471	PF04695	0.423
LIG_PTB_Apo_2	369	376	PF02174	0.454
LIG_SH2_CRK	138	142	PF00017	0.592
LIG_SH2_CRK	19	23	PF00017	0.484
LIG_SH2_CRK	7	11	PF00017	0.441
LIG_SH2_SRC	391	394	PF00017	0.538
LIG_SH2_STAP1	325	329	PF00017	0.635
LIG_SH2_STAT3	325	328	PF00017	0.565
LIG_SH2_STAT5	111	114	PF00017	0.524
LIG_SH2_STAT5	180	183	PF00017	0.613
LIG_SH2_STAT5	19	22	PF00017	0.627
LIG_SH2_STAT5	24	27	PF00017	0.576
LIG_SH2_STAT5	329	332	PF00017	0.579
LIG_SH2_STAT5	339	342	PF00017	0.533
LIG_SH2_STAT5	374	377	PF00017	0.414
LIG_SH2_STAT5	391	394	PF00017	0.538
LIG_SH2_STAT5	470	473	PF00017	0.500
LIG_SH3_3	352	358	PF00018	0.463
LIG_SUMO_SIM_anti_2	366	373	PF11976	0.522
LIG_SUMO_SIM_par_1	366	373	PF11976	0.548
LIG_TRAF2_1	219	222	PF00917	0.546
LIG_TRFH_1	351	355	PF08558	0.427
LIG_TYR_ITIM	136	141	PF00017	0.593
LIG_TYR_ITIM	484	489	PF00017	0.544
MOD_CDK_SPK_2	70	75	PF00069	0.686
MOD_CK1_1	153	159	PF00069	0.534
MOD_CK1_1	185	191	PF00069	0.695
MOD_CK1_1	194	200	PF00069	0.753
MOD_CK1_1	211	217	PF00069	0.754
MOD_CK1_1	41	47	PF00069	0.726
MOD_CK1_1	451	457	PF00069	0.727
MOD_CK1_1	53	59	PF00069	0.779
MOD_CK1_1	73	79	PF00069	0.499
MOD_CK2_1	280	286	PF00069	0.587
MOD_CK2_1	327	333	PF00069	0.608
MOD_CK2_1	358	364	PF00069	0.673
MOD_CK2_1	36	42	PF00069	0.688
MOD_CK2_1	443	449	PF00069	0.729
MOD_CK2_1	456	462	PF00069	0.593
MOD_Cter_Amidation	489	492	PF01082	0.541
MOD_GlcNHglycan	120	123	PF01048	0.631
MOD_GlcNHglycan	189	192	PF01048	0.739
MOD_GlcNHglycan	193	196	PF01048	0.754
MOD_GlcNHglycan	215	218	PF01048	0.793
MOD_GlcNHglycan	249	252	PF01048	0.603
MOD_GlcNHglycan	359	363	PF01048	0.571
MOD_GlcNHglycan	415	418	PF01048	0.631
MOD_GlcNHglycan	449	453	PF01048	0.721
MOD_GlcNHglycan	58	61	PF01048	0.730
MOD_GSK3_1	160	167	PF00069	0.704
MOD_GSK3_1	187	194	PF00069	0.719
MOD_GSK3_1	204	211	PF00069	0.707
MOD_GSK3_1	213	220	PF00069	0.673
MOD_GSK3_1	314	321	PF00069	0.428
MOD_GSK3_1	354	361	PF00069	0.634
MOD_GSK3_1	38	45	PF00069	0.663
MOD_GSK3_1	443	450	PF00069	0.746
MOD_GSK3_1	461	468	PF00069	0.558
MOD_GSK3_1	47	54	PF00069	0.666
MOD_GSK3_1	70	77	PF00069	0.640
MOD_N-GLC_1	314	319	PF02516	0.522
MOD_N-GLC_1	472	477	PF02516	0.569
MOD_NEK2_1	159	164	PF00069	0.632
MOD_NEK2_1	193	198	PF00069	0.748
MOD_NEK2_1	30	35	PF00069	0.548
MOD_NEK2_1	327	332	PF00069	0.463
MOD_NEK2_1	36	41	PF00069	0.599
MOD_NEK2_1	413	418	PF00069	0.694
MOD_PIKK_1	153	159	PF00454	0.568
MOD_PIKK_1	182	188	PF00454	0.679
MOD_PIKK_1	196	202	PF00454	0.692
MOD_PIKK_1	217	223	PF00454	0.549
MOD_PIKK_1	295	301	PF00454	0.516
MOD_PKA_1	79	85	PF00069	0.584
MOD_PKA_2	118	124	PF00069	0.497
MOD_PKA_2	212	218	PF00069	0.750
MOD_PKA_2	78	84	PF00069	0.738
MOD_PKA_2	92	98	PF00069	0.699
MOD_Plk_1	101	107	PF00069	0.593
MOD_Plk_1	314	320	PF00069	0.414
MOD_Plk_4	101	107	PF00069	0.582
MOD_Plk_4	370	376	PF00069	0.440
MOD_ProDKin_1	354	360	PF00069	0.558
MOD_ProDKin_1	451	457	PF00069	0.736
MOD_ProDKin_1	63	69	PF00069	0.682
MOD_ProDKin_1	70	76	PF00069	0.673
MOD_SUMO_rev_2	178	185	PF00179	0.654
TRG_DiLeu_BaEn_1	381	386	PF01217	0.561
TRG_DiLeu_BaEn_4	387	393	PF01217	0.588
TRG_ENDOCYTIC_2	111	114	PF00928	0.569
TRG_ENDOCYTIC_2	138	141	PF00928	0.589
TRG_ENDOCYTIC_2	486	489	PF00928	0.429
TRG_ENDOCYTIC_2	7	10	PF00928	0.451
TRG_ER_diArg_1	263	266	PF00400	0.589
TRG_ER_diArg_1	347	350	PF00400	0.558
TRG_NLS_MonoExtN_4	488	495	PF00514	0.522
TRG_Pf-PMV_PEXEL_1	399	403	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IBR0	Leptomonas seymouri	51%	97%
A0A1X0P6J4	Trypanosomatidae	23%	100%
A0A3S7X9M3	Leishmania donovani	93%	100%
A0A422P2R2	Trypanosoma rangeli	27%	100%
A4HMT7	Leishmania braziliensis	72%	97%
A4IBD8	Leishmania infantum	93%	100%
C9ZZ79	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B6E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BTJ6	Trypanosoma cruzi	29%	100%