BTB domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

btb/poz domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF92_LEIMA

TriTrypDb:

LmjF.35.2690 , LMJLV39_350033600 , LMJSD75_350033100

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF92

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0022607	cellular component assembly	4	11
GO:0043933	protein-containing complex organization	4	11
GO:0051259	protein complex oligomerization	6	11
GO:0051260	protein homooligomerization	7	11
GO:0065003	protein-containing complex assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.770
CLV_NRD_NRD_1	225	227	PF00675	0.420
CLV_NRD_NRD_1	336	338	PF00675	0.410
CLV_NRD_NRD_1	369	371	PF00675	0.411
CLV_NRD_NRD_1	379	381	PF00675	0.356
CLV_NRD_NRD_1	403	405	PF00675	0.418
CLV_PCSK_FUR_1	377	381	PF00082	0.519
CLV_PCSK_KEX2_1	225	227	PF00082	0.420
CLV_PCSK_KEX2_1	379	381	PF00082	0.511
CLV_PCSK_KEX2_1	402	404	PF00082	0.508
CLV_PCSK_SKI1_1	225	229	PF00082	0.374
CLV_PCSK_SKI1_1	382	386	PF00082	0.474
DEG_APCC_DBOX_1	263	271	PF00400	0.631
DEG_APCC_DBOX_1	401	409	PF00400	0.517
DOC_CDC14_PxL_1	233	241	PF14671	0.420
DOC_CYCLIN_RxL_1	376	386	PF00134	0.500
DOC_MAPK_gen_1	266	275	PF00069	0.503
DOC_MAPK_gen_1	367	375	PF00069	0.463
DOC_MAPK_gen_1	379	389	PF00069	0.337
DOC_MAPK_MEF2A_6	141	150	PF00069	0.526
DOC_PP1_RVXF_1	377	384	PF00149	0.374
DOC_PP4_FxxP_1	155	158	PF00568	0.291
DOC_SPAK_OSR1_1	108	112	PF12202	0.451
DOC_SPAK_OSR1_1	154	158	PF12202	0.388
DOC_USP7_MATH_1	17	21	PF00917	0.736
DOC_USP7_MATH_1	38	42	PF00917	0.757
DOC_USP7_MATH_1	94	98	PF00917	0.600
DOC_USP7_UBL2_3	367	371	PF12436	0.378
DOC_WW_Pin1_4	22	27	PF00397	0.704
DOC_WW_Pin1_4	252	257	PF00397	0.704
DOC_WW_Pin1_4	258	263	PF00397	0.683
DOC_WW_Pin1_4	403	408	PF00397	0.578
DOC_WW_Pin1_4	63	68	PF00397	0.790
LIG_14-3-3_CanoR_1	154	158	PF00244	0.388
LIG_14-3-3_CanoR_1	285	291	PF00244	0.353
LIG_14-3-3_CanoR_1	370	376	PF00244	0.538
LIG_14-3-3_CanoR_1	382	388	PF00244	0.436
LIG_Actin_WH2_2	368	384	PF00022	0.467
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BIR_III_4	73	77	PF00653	0.678
LIG_BRCT_BRCA1_1	325	329	PF00533	0.457
LIG_BRCT_BRCA1_1	65	69	PF00533	0.787
LIG_deltaCOP1_diTrp_1	178	187	PF00928	0.388
LIG_eIF4E_1	213	219	PF01652	0.370
LIG_eIF4E_1	234	240	PF01652	0.388
LIG_eIF4E_1	297	303	PF01652	0.321
LIG_FHA_1	154	160	PF00498	0.303
LIG_FHA_1	178	184	PF00498	0.388
LIG_FHA_1	191	197	PF00498	0.319
LIG_FHA_1	287	293	PF00498	0.348
LIG_FHA_1	350	356	PF00498	0.440
LIG_FHA_1	384	390	PF00498	0.486
LIG_FHA_2	112	118	PF00498	0.549
LIG_FHA_2	308	314	PF00498	0.463
LIG_FHA_2	77	83	PF00498	0.566
LIG_LIR_Apic_2	153	158	PF02991	0.294
LIG_LIR_Apic_2	179	185	PF02991	0.388
LIG_LIR_Gen_1	140	150	PF02991	0.444
LIG_LIR_Gen_1	311	322	PF02991	0.502
LIG_LIR_Gen_1	349	357	PF02991	0.328
LIG_LIR_Nem_3	140	145	PF02991	0.504
LIG_LIR_Nem_3	201	206	PF02991	0.284
LIG_LIR_Nem_3	230	236	PF02991	0.291
LIG_LIR_Nem_3	296	300	PF02991	0.357
LIG_LIR_Nem_3	311	317	PF02991	0.413
LIG_LIR_Nem_3	349	353	PF02991	0.343
LIG_LIR_Nem_3	358	364	PF02991	0.332
LIG_NRBOX	115	121	PF00104	0.517
LIG_PTB_Apo_2	329	336	PF02174	0.496
LIG_PTB_Apo_2	344	351	PF02174	0.505
LIG_PTB_Phospho_1	329	335	PF10480	0.491
LIG_RPA_C_Fungi	87	99	PF08784	0.559
LIG_SH2_CRK	234	238	PF00017	0.388
LIG_SH2_GRB2like	215	218	PF00017	0.420
LIG_SH2_GRB2like	330	333	PF00017	0.338
LIG_SH2_STAP1	290	294	PF00017	0.482
LIG_SH2_STAT5	170	173	PF00017	0.291
LIG_SH2_STAT5	205	208	PF00017	0.310
LIG_SH2_STAT5	209	212	PF00017	0.273
LIG_SH2_STAT5	215	218	PF00017	0.264
LIG_SH2_STAT5	297	300	PF00017	0.323
LIG_SH2_STAT5	330	333	PF00017	0.467
LIG_SH2_STAT5	361	364	PF00017	0.358
LIG_SH3_3	10	16	PF00018	0.588
LIG_SH3_3	2	8	PF00018	0.657
LIG_SH3_3	29	35	PF00018	0.611
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.500
LIG_TRAF2_1	310	313	PF00917	0.437
LIG_TRAF2_1	397	400	PF00917	0.424
LIG_TRAF2_1	411	414	PF00917	0.423
LIG_TRAF2_1	79	82	PF00917	0.563
MOD_CDC14_SPxK_1	261	264	PF00782	0.617
MOD_CDK_SPxK_1	258	264	PF00069	0.611
MOD_CDK_SPxxK_3	22	29	PF00069	0.750
MOD_CK1_1	104	110	PF00069	0.502
MOD_CK1_1	177	183	PF00069	0.398
MOD_CK1_1	20	26	PF00069	0.706
MOD_CK1_1	280	286	PF00069	0.530
MOD_CK1_1	37	43	PF00069	0.643
MOD_CK1_1	63	69	PF00069	0.656
MOD_CK2_1	307	313	PF00069	0.436
MOD_CK2_1	408	414	PF00069	0.531
MOD_CK2_1	76	82	PF00069	0.669
MOD_GlcNHglycan	20	23	PF01048	0.648
MOD_GlcNHglycan	325	328	PF01048	0.462
MOD_GlcNHglycan	36	39	PF01048	0.538
MOD_GlcNHglycan	56	60	PF01048	0.465
MOD_GSK3_1	111	118	PF00069	0.549
MOD_GSK3_1	153	160	PF00069	0.403
MOD_GSK3_1	18	25	PF00069	0.674
MOD_GSK3_1	280	287	PF00069	0.472
MOD_GSK3_1	303	310	PF00069	0.446
MOD_GSK3_1	34	41	PF00069	0.641
MOD_GSK3_1	63	70	PF00069	0.711
MOD_GSK3_1	76	83	PF00069	0.553
MOD_N-GLC_1	76	81	PF02516	0.548
MOD_NEK2_1	1	6	PF00069	0.649
MOD_NEK2_1	366	371	PF00069	0.368
MOD_NEK2_1	383	388	PF00069	0.362
MOD_NEK2_1	60	65	PF00069	0.731
MOD_NEK2_1	88	93	PF00069	0.613
MOD_NEK2_2	28	33	PF00069	0.601
MOD_PKA_2	153	159	PF00069	0.388
MOD_PKA_2	28	34	PF00069	0.746
MOD_PKA_2	284	290	PF00069	0.383
MOD_PKB_1	380	388	PF00069	0.493
MOD_Plk_1	220	226	PF00069	0.420
MOD_Plk_1	277	283	PF00069	0.504
MOD_Plk_4	115	121	PF00069	0.439
MOD_Plk_4	158	164	PF00069	0.341
MOD_Plk_4	190	196	PF00069	0.475
MOD_Plk_4	277	283	PF00069	0.504
MOD_ProDKin_1	22	28	PF00069	0.704
MOD_ProDKin_1	252	258	PF00069	0.704
MOD_ProDKin_1	403	409	PF00069	0.570
MOD_ProDKin_1	63	69	PF00069	0.790
MOD_SUMO_for_1	128	131	PF00179	0.564
MOD_SUMO_for_1	187	190	PF00179	0.420
MOD_SUMO_rev_2	122	128	PF00179	0.488
TRG_DiLeu_BaEn_2	345	351	PF01217	0.500
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.508
TRG_ENDOCYTIC_2	142	145	PF00928	0.515
TRG_ENDOCYTIC_2	170	173	PF00928	0.291
TRG_ENDOCYTIC_2	213	216	PF00928	0.310
TRG_ENDOCYTIC_2	233	236	PF00928	0.150
TRG_ENDOCYTIC_2	297	300	PF00928	0.323
TRG_ER_diArg_1	224	226	PF00400	0.420
TRG_ER_diArg_1	264	267	PF00400	0.554
TRG_ER_diArg_1	377	380	PF00400	0.513
TRG_ER_diArg_1	392	395	PF00400	0.424
TRG_ER_diArg_1	401	404	PF00400	0.478
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3C7	Leptomonas seymouri	69%	89%
A0A1X0P5J3	Trypanosomatidae	49%	80%
A0A3Q8II33	Leishmania donovani	97%	100%
A0A422P2R6	Trypanosoma rangeli	47%	81%
A4HMT5	Leishmania braziliensis	95%	100%
A4IBD6	Leishmania infantum	97%	100%
C9ZZ82	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	80%
E9B6E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5DUU9	Trypanosoma cruzi	48%	81%