Heat shock factor-binding protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

heat shock factor binding protein 1, putative

Species:

Leishmania major

UniProt:

E9AF91_LEIMA

TriTrypDb:

LmjF.35.2680 , LMJLV39_350033500 , LMJSD75_350033000

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9AF91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF91

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	2
GO:0009266	response to temperature stimulus	3	2
GO:0009408	response to heat	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	2
GO:0010286	heat acclimation	4	2
GO:0033554	cellular response to stress	3	2
GO:0034605	cellular response to heat	4	2
GO:0050896	response to stimulus	1	2
GO:0051716	cellular response to stimulus	2	2
GO:0070370	cellular heat acclimation	5	2

Molecular functions
Term	Name	Level	Count
GO:0003712	transcription coregulator activity	2	7
GO:0003714	transcription corepressor activity	3	7
GO:0140110	transcription regulator activity	1	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_MAPK_MEF2A_6	39	47	PF00069	0.147
DOC_USP7_MATH_1	63	67	PF00917	0.545
LIG_EH1_1	51	59	PF00400	0.226
LIG_FHA_1	9	15	PF00498	0.215
MOD_CK2_1	58	64	PF00069	0.247
MOD_GlcNHglycan	60	63	PF01048	0.268
MOD_GSK3_1	8	15	PF00069	0.414
MOD_NEK2_1	1	6	PF00069	0.577
MOD_NEK2_1	58	63	PF00069	0.268
MOD_PIKK_1	63	69	PF00454	0.503
MOD_PIKK_1	8	14	PF00454	0.413
MOD_Plk_1	41	47	PF00069	0.225
MOD_Plk_1	50	56	PF00069	0.206

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R1	Leptomonas seymouri	71%	71%
A0A3Q8IPM3	Leishmania donovani	92%	100%
A0A422P2Q0	Trypanosoma rangeli	51%	76%
A4IBD5	Leishmania infantum	92%	100%
C9ZZ83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	91%
E9B6E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
O75506	Homo sapiens	55%	99%
Q3ZC22	Bos taurus	61%	99%
Q5RDI2	Pongo abelii	61%	99%
Q8GW48	Arabidopsis thaliana	48%	87%
Q8K3X8	Rattus norvegicus	57%	99%
Q9CQZ1	Mus musculus	57%	99%
V5C320	Trypanosoma cruzi	64%	79%