Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF89_LEIMA

TriTrypDb:

LmjF.35.2660 , LMJLV39_350033300 , LMJSD75_350032800

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF89

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	213	217	PF00656	0.531
CLV_C14_Caspase3-7	413	417	PF00656	0.642
CLV_NRD_NRD_1	209	211	PF00675	0.600
CLV_NRD_NRD_1	225	227	PF00675	0.447
CLV_NRD_NRD_1	228	230	PF00675	0.411
CLV_NRD_NRD_1	250	252	PF00675	0.462
CLV_NRD_NRD_1	456	458	PF00675	0.643
CLV_NRD_NRD_1	492	494	PF00675	0.608
CLV_NRD_NRD_1	513	515	PF00675	0.477
CLV_NRD_NRD_1	607	609	PF00675	0.531
CLV_NRD_NRD_1	634	636	PF00675	0.488
CLV_PCSK_FUR_1	207	211	PF00082	0.576
CLV_PCSK_FUR_1	226	230	PF00082	0.462
CLV_PCSK_KEX2_1	206	208	PF00082	0.603
CLV_PCSK_KEX2_1	209	211	PF00082	0.588
CLV_PCSK_KEX2_1	227	229	PF00082	0.687
CLV_PCSK_KEX2_1	364	366	PF00082	0.467
CLV_PCSK_KEX2_1	456	458	PF00082	0.669
CLV_PCSK_KEX2_1	607	609	PF00082	0.531
CLV_PCSK_KEX2_1	634	636	PF00082	0.488
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.607
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.719
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.543
CLV_PCSK_SKI1_1	252	256	PF00082	0.472
CLV_PCSK_SKI1_1	260	264	PF00082	0.459
CLV_PCSK_SKI1_1	374	378	PF00082	0.483
CLV_PCSK_SKI1_1	545	549	PF00082	0.450
CLV_PCSK_SKI1_1	90	94	PF00082	0.523
DEG_Nend_UBRbox_4	1	3	PF02207	0.621
DEG_SPOP_SBC_1	338	342	PF00917	0.659
DEG_SPOP_SBC_1	445	449	PF00917	0.688
DOC_CKS1_1	423	428	PF01111	0.625
DOC_CYCLIN_RxL_1	260	271	PF00134	0.516
DOC_CYCLIN_yCln2_LP_2	269	275	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.561
DOC_MAPK_gen_1	524	534	PF00069	0.434
DOC_PP1_RVXF_1	644	651	PF00149	0.544
DOC_PP2B_LxvP_1	267	270	PF13499	0.522
DOC_PP4_FxxP_1	423	426	PF00568	0.597
DOC_USP7_MATH_1	159	163	PF00917	0.485
DOC_USP7_MATH_1	177	181	PF00917	0.605
DOC_USP7_MATH_1	338	342	PF00917	0.613
DOC_USP7_MATH_1	444	448	PF00917	0.642
DOC_USP7_MATH_1	474	478	PF00917	0.739
DOC_USP7_MATH_1	489	493	PF00917	0.513
DOC_USP7_MATH_1	552	556	PF00917	0.546
DOC_USP7_MATH_1	573	577	PF00917	0.606
DOC_USP7_MATH_1	82	86	PF00917	0.777
DOC_USP7_UBL2_3	223	227	PF12436	0.574
DOC_WW_Pin1_4	111	116	PF00397	0.660
DOC_WW_Pin1_4	2	7	PF00397	0.692
DOC_WW_Pin1_4	268	273	PF00397	0.680
DOC_WW_Pin1_4	279	284	PF00397	0.544
DOC_WW_Pin1_4	305	310	PF00397	0.798
DOC_WW_Pin1_4	313	318	PF00397	0.614
DOC_WW_Pin1_4	321	326	PF00397	0.637
DOC_WW_Pin1_4	331	336	PF00397	0.521
DOC_WW_Pin1_4	342	347	PF00397	0.650
DOC_WW_Pin1_4	35	40	PF00397	0.599
DOC_WW_Pin1_4	422	427	PF00397	0.571
DOC_WW_Pin1_4	446	451	PF00397	0.612
DOC_WW_Pin1_4	485	490	PF00397	0.594
DOC_WW_Pin1_4	623	628	PF00397	0.492
LIG_14-3-3_CanoR_1	265	270	PF00244	0.483
LIG_14-3-3_CanoR_1	412	419	PF00244	0.693
LIG_14-3-3_CanoR_1	634	640	PF00244	0.571
LIG_BRCT_BRCA1_1	178	182	PF00533	0.544
LIG_BRCT_BRCA1_1	323	327	PF00533	0.601
LIG_BRCT_BRCA1_1	554	558	PF00533	0.485
LIG_BRCT_BRCA1_1	583	587	PF00533	0.591
LIG_CaM_IQ_9	357	372	PF13499	0.540
LIG_Clathr_ClatBox_1	92	96	PF01394	0.516
LIG_CSL_BTD_1	343	346	PF09270	0.605
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.574
LIG_EVH1_1	112	116	PF00568	0.585
LIG_EVH1_2	115	119	PF00568	0.632
LIG_FHA_1	194	200	PF00498	0.669
LIG_FHA_1	264	270	PF00498	0.574
LIG_FHA_1	275	281	PF00498	0.535
LIG_FHA_1	383	389	PF00498	0.706
LIG_FHA_1	612	618	PF00498	0.679
LIG_FHA_1	642	648	PF00498	0.614
LIG_FHA_1	89	95	PF00498	0.593
LIG_FHA_2	411	417	PF00498	0.638
LIG_FHA_2	423	429	PF00498	0.531
LIG_FHA_2	463	469	PF00498	0.656
LIG_FHA_2	486	492	PF00498	0.669
LIG_FHA_2	51	57	PF00498	0.667
LIG_FHA_2	656	662	PF00498	0.590
LIG_Integrin_RGD_1	403	405	PF01839	0.538
LIG_Integrin_RGD_1	566	568	PF01839	0.658
LIG_LIR_Apic_2	422	426	PF02991	0.607
LIG_LIR_Nem_3	589	595	PF02991	0.637
LIG_Pex14_1	170	174	PF04695	0.575
LIG_Pex14_2	588	592	PF04695	0.638
LIG_PTAP_UEV_1	5	10	PF05743	0.645
LIG_SH2_NCK_1	595	599	PF00017	0.528
LIG_SH2_STAP1	595	599	PF00017	0.504
LIG_SH3_3	110	116	PF00018	0.565
LIG_SH3_3	13	19	PF00018	0.583
LIG_SH3_3	3	9	PF00018	0.686
LIG_SH3_3	311	317	PF00018	0.677
LIG_SH3_3	319	325	PF00018	0.570
LIG_SH3_3	332	338	PF00018	0.580
LIG_SH3_3	557	563	PF00018	0.604
LIG_SUMO_SIM_anti_2	29	35	PF11976	0.613
LIG_SUMO_SIM_par_1	264	271	PF11976	0.531
LIG_TRAF2_1	476	479	PF00917	0.561
LIG_TRAF2_1	501	504	PF00917	0.462
LIG_WRC_WIRS_1	482	487	PF05994	0.633
LIG_WRC_WIRS_1	636	641	PF05994	0.523
LIG_WW_3	18	22	PF00397	0.538
MOD_CK1_1	162	168	PF00069	0.533
MOD_CK1_1	268	274	PF00069	0.536
MOD_CK1_1	282	288	PF00069	0.686
MOD_CK1_1	296	302	PF00069	0.587
MOD_CK1_1	316	322	PF00069	0.600
MOD_CK1_1	328	334	PF00069	0.616
MOD_CK1_1	336	342	PF00069	0.517
MOD_CK1_1	35	41	PF00069	0.683
MOD_CK1_1	448	454	PF00069	0.628
MOD_CK1_1	484	490	PF00069	0.586
MOD_CK1_1	581	587	PF00069	0.637
MOD_CK1_1	655	661	PF00069	0.588
MOD_CK1_1	7	13	PF00069	0.635
MOD_CK1_1	85	91	PF00069	0.563
MOD_CK2_1	115	121	PF00069	0.642
MOD_CK2_1	305	311	PF00069	0.544
MOD_CK2_1	462	468	PF00069	0.712
MOD_CK2_1	472	478	PF00069	0.689
MOD_CK2_1	485	491	PF00069	0.533
MOD_CK2_1	573	579	PF00069	0.627
MOD_CK2_1	655	661	PF00069	0.588
MOD_Cter_Amidation	605	608	PF01082	0.525
MOD_DYRK1A_RPxSP_1	321	325	PF00069	0.529
MOD_GlcNHglycan	199	202	PF01048	0.598
MOD_GlcNHglycan	34	37	PF01048	0.659
MOD_GlcNHglycan	341	344	PF01048	0.542
MOD_GlcNHglycan	416	419	PF01048	0.610
MOD_GlcNHglycan	46	49	PF01048	0.539
MOD_GlcNHglycan	545	548	PF01048	0.504
MOD_GlcNHglycan	554	557	PF01048	0.499
MOD_GlcNHglycan	570	573	PF01048	0.637
MOD_GlcNHglycan	575	578	PF01048	0.749
MOD_GlcNHglycan	579	583	PF01048	0.530
MOD_GlcNHglycan	6	9	PF01048	0.640
MOD_GlcNHglycan	603	607	PF01048	0.777
MOD_GlcNHglycan	611	614	PF01048	0.538
MOD_GlcNHglycan	87	90	PF01048	0.523
MOD_GSK3_1	111	118	PF00069	0.613
MOD_GSK3_1	183	190	PF00069	0.618
MOD_GSK3_1	193	200	PF00069	0.621
MOD_GSK3_1	261	268	PF00069	0.474
MOD_GSK3_1	292	299	PF00069	0.628
MOD_GSK3_1	305	312	PF00069	0.564
MOD_GSK3_1	321	328	PF00069	0.598
MOD_GSK3_1	333	340	PF00069	0.623
MOD_GSK3_1	35	42	PF00069	0.614
MOD_GSK3_1	370	377	PF00069	0.481
MOD_GSK3_1	380	387	PF00069	0.518
MOD_GSK3_1	410	417	PF00069	0.621
MOD_GSK3_1	444	451	PF00069	0.623
MOD_GSK3_1	481	488	PF00069	0.617
MOD_GSK3_1	552	559	PF00069	0.576
MOD_GSK3_1	568	575	PF00069	0.527
MOD_GSK3_1	635	642	PF00069	0.707
MOD_GSK3_1	655	662	PF00069	0.433
MOD_N-GLC_1	640	645	PF02516	0.689
MOD_NEK2_1	1	6	PF00069	0.680
MOD_NEK2_1	104	109	PF00069	0.632
MOD_NEK2_1	183	188	PF00069	0.649
MOD_NEK2_1	243	248	PF00069	0.453
MOD_NEK2_1	263	268	PF00069	0.353
MOD_NEK2_1	292	297	PF00069	0.609
MOD_NEK2_1	376	381	PF00069	0.482
MOD_NEK2_1	382	387	PF00069	0.568
MOD_NEK2_1	44	49	PF00069	0.605
MOD_NEK2_1	472	477	PF00069	0.606
MOD_NEK2_1	639	644	PF00069	0.536
MOD_NEK2_2	177	182	PF00069	0.543
MOD_PIKK_1	105	111	PF00454	0.604
MOD_PIKK_1	14	20	PF00454	0.646
MOD_PIKK_1	193	199	PF00454	0.526
MOD_PIKK_1	243	249	PF00454	0.442
MOD_PIKK_1	374	380	PF00454	0.483
MOD_PIKK_1	449	455	PF00454	0.630
MOD_PIKK_1	499	505	PF00454	0.586
MOD_PIKK_1	641	647	PF00454	0.617
MOD_PKA_2	85	91	PF00069	0.572
MOD_PKB_1	412	420	PF00069	0.616
MOD_Plk_1	177	183	PF00069	0.545
MOD_Plk_1	193	199	PF00069	0.482
MOD_Plk_1	29	35	PF00069	0.587
MOD_Plk_1	293	299	PF00069	0.553
MOD_Plk_1	628	634	PF00069	0.487
MOD_Plk_4	177	183	PF00069	0.618
MOD_Plk_4	29	35	PF00069	0.587
MOD_Plk_4	328	334	PF00069	0.630
MOD_ProDKin_1	111	117	PF00069	0.664
MOD_ProDKin_1	2	8	PF00069	0.691
MOD_ProDKin_1	268	274	PF00069	0.685
MOD_ProDKin_1	279	285	PF00069	0.544
MOD_ProDKin_1	305	311	PF00069	0.800
MOD_ProDKin_1	313	319	PF00069	0.611
MOD_ProDKin_1	321	327	PF00069	0.639
MOD_ProDKin_1	331	337	PF00069	0.519
MOD_ProDKin_1	342	348	PF00069	0.644
MOD_ProDKin_1	35	41	PF00069	0.598
MOD_ProDKin_1	422	428	PF00069	0.572
MOD_ProDKin_1	446	452	PF00069	0.614
MOD_ProDKin_1	485	491	PF00069	0.593
MOD_ProDKin_1	623	629	PF00069	0.484
MOD_SUMO_rev_2	140	146	PF00179	0.556
MOD_SUMO_rev_2	54	59	PF00179	0.582
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.601
TRG_ENDOCYTIC_2	660	663	PF00928	0.528
TRG_ER_diArg_1	207	210	PF00400	0.614
TRG_ER_diArg_1	226	229	PF00400	0.415
TRG_ER_diArg_1	411	414	PF00400	0.611
TRG_ER_diArg_1	456	458	PF00400	0.669
TRG_ER_diArg_1	633	635	PF00400	0.612
TRG_NLS_Bipartite_1	209	231	PF00514	0.573
TRG_NLS_MonoCore_2	205	210	PF00514	0.573
TRG_NLS_MonoExtC_3	205	210	PF00514	0.666
TRG_NLS_MonoExtC_3	226	232	PF00514	0.545
TRG_NLS_MonoExtC_3	363	369	PF00514	0.545
TRG_NLS_MonoExtN_4	205	210	PF00514	0.672
TRG_NLS_MonoExtN_4	226	231	PF00514	0.597
TRG_Pf-PMV_PEXEL_1	248	253	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	386	390	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	524	529	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR5	Leptomonas seymouri	41%	100%
A0A3Q8IGC1	Leishmania donovani	86%	100%
A4HMT4	Leishmania braziliensis	61%	100%
A4IBD3	Leishmania infantum	86%	100%
E9B6E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%