Present in the outer mitochondrial membrane proteome 34

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 8

Species:

Leishmania major

UniProt:

E9AF88_LEIMA

TriTrypDb:

LmjF.35.2650 , LMJLV39_350033200 , LMJSD75_350032700

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0016020	membrane	2	8
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

E9AF88

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF88

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.694
CLV_C14_Caspase3-7	26	30	PF00656	0.698
CLV_NRD_NRD_1	147	149	PF00675	0.559
CLV_NRD_NRD_1	158	160	PF00675	0.585
CLV_NRD_NRD_1	234	236	PF00675	0.386
CLV_NRD_NRD_1	260	262	PF00675	0.593
CLV_NRD_NRD_1	36	38	PF00675	0.505
CLV_PCSK_KEX2_1	158	160	PF00082	0.585
CLV_PCSK_KEX2_1	234	236	PF00082	0.386
CLV_PCSK_KEX2_1	36	38	PF00082	0.438
CLV_PCSK_SKI1_1	180	184	PF00082	0.667
DEG_APCC_DBOX_1	234	242	PF00400	0.638
DEG_SPOP_SBC_1	152	156	PF00917	0.319
DOC_CYCLIN_RxL_1	33	43	PF00134	0.686
DOC_USP7_MATH_1	152	156	PF00917	0.426
DOC_USP7_MATH_1	165	169	PF00917	0.379
DOC_USP7_MATH_1	242	246	PF00917	0.659
LIG_14-3-3_CanoR_1	174	183	PF00244	0.418
LIG_14-3-3_CanoR_1	79	85	PF00244	0.414
LIG_14-3-3_CanoR_1	89	97	PF00244	0.382
LIG_APCC_ABBA_1	72	77	PF00400	0.378
LIG_BIR_II_1	1	5	PF00653	0.718
LIG_BRCT_BRCA1_1	178	182	PF00533	0.475
LIG_deltaCOP1_diTrp_1	111	121	PF00928	0.564
LIG_FHA_1	124	130	PF00498	0.610
LIG_FHA_1	135	141	PF00498	0.307
LIG_FHA_1	187	193	PF00498	0.409
LIG_FHA_1	89	95	PF00498	0.382
LIG_FHA_2	12	18	PF00498	0.708
LIG_LIR_Gen_1	91	101	PF02991	0.440
LIG_LIR_Nem_3	91	96	PF02991	0.440
LIG_SH2_CRK	53	57	PF00017	0.394
LIG_SH2_STAT5	107	110	PF00017	0.398
LIG_SH2_STAT5	216	219	PF00017	0.557
LIG_SH2_STAT5	82	85	PF00017	0.399
LIG_SH3_1	164	170	PF00018	0.396
LIG_SH3_3	164	170	PF00018	0.396
LIG_SH3_3	248	254	PF00018	0.811
LIG_SH3_4	253	260	PF00018	0.818
LIG_SUMO_SIM_anti_2	6	12	PF11976	0.639
LIG_TYR_ITIM	51	56	PF00017	0.437
MOD_CK1_1	245	251	PF00069	0.569
MOD_CK1_1	6	12	PF00069	0.586
MOD_CK2_1	175	181	PF00069	0.545
MOD_Cter_Amidation	156	159	PF01082	0.457
MOD_GlcNHglycan	11	14	PF01048	0.498
MOD_GlcNHglycan	192	195	PF01048	0.337
MOD_GlcNHglycan	196	199	PF01048	0.337
MOD_GlcNHglycan	210	213	PF01048	0.469
MOD_GSK3_1	113	120	PF00069	0.548
MOD_GSK3_1	186	193	PF00069	0.430
MOD_GSK3_1	20	27	PF00069	0.609
MOD_GSK3_1	204	211	PF00069	0.391
MOD_GSK3_1	245	252	PF00069	0.573
MOD_GSK3_1	63	70	PF00069	0.405
MOD_N-GLC_1	80	85	PF02516	0.502
MOD_NEK2_1	11	16	PF00069	0.529
MOD_NEK2_1	113	118	PF00069	0.534
MOD_NEK2_1	153	158	PF00069	0.435
MOD_NEK2_1	175	180	PF00069	0.569
MOD_NEK2_1	186	191	PF00069	0.399
MOD_NEK2_1	208	213	PF00069	0.592
MOD_NEK2_1	3	8	PF00069	0.538
MOD_NEK2_1	56	61	PF00069	0.331
MOD_NEK2_1	63	68	PF00069	0.318
MOD_NEK2_1	75	80	PF00069	0.346
MOD_NEK2_1	88	93	PF00069	0.416
MOD_NEK2_2	101	106	PF00069	0.437
MOD_PK_1	20	26	PF00069	0.633
MOD_PKA_2	176	182	PF00069	0.615
MOD_PKA_2	6	12	PF00069	0.616
MOD_PKA_2	88	94	PF00069	0.468
MOD_Plk_1	3	9	PF00069	0.651
MOD_Plk_1	80	86	PF00069	0.494
MOD_Plk_4	186	192	PF00069	0.559
MOD_Plk_4	27	33	PF00069	0.621
MOD_Plk_4	70	76	PF00069	0.574
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.606
TRG_ENDOCYTIC_2	216	219	PF00928	0.426
TRG_ENDOCYTIC_2	227	230	PF00928	0.435
TRG_ENDOCYTIC_2	53	56	PF00928	0.394
TRG_ER_diArg_1	158	160	PF00400	0.479
TRG_ER_diArg_1	233	235	PF00400	0.430
TRG_ER_diArg_1	36	38	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8R5	Leptomonas seymouri	77%	100%
A0A1X0P5Q2	Trypanosomatidae	59%	100%
A0A3Q8IJ41	Leishmania donovani	94%	100%
A4IBD2	Leishmania infantum	94%	100%
C9ZZ87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B6E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5C312	Trypanosoma cruzi	57%	100%