Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AF84_LEIMA

TriTrypDb:

LmjF.35.2610 , LMJLV39_350032800 , LMJSD75_350032300

Length:

327

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.712
CLV_NRD_NRD_1	140	142	PF00675	0.674
CLV_NRD_NRD_1	151	153	PF00675	0.608
CLV_NRD_NRD_1	192	194	PF00675	0.761
CLV_NRD_NRD_1	211	213	PF00675	0.495
CLV_NRD_NRD_1	271	273	PF00675	0.539
CLV_NRD_NRD_1	36	38	PF00675	0.673
CLV_NRD_NRD_1	8	10	PF00675	0.703
CLV_PCSK_FUR_1	33	37	PF00082	0.661
CLV_PCSK_FUR_1	6	10	PF00082	0.705
CLV_PCSK_KEX2_1	103	105	PF00082	0.749
CLV_PCSK_KEX2_1	210	212	PF00082	0.747
CLV_PCSK_KEX2_1	270	272	PF00082	0.540
CLV_PCSK_KEX2_1	35	37	PF00082	0.713
CLV_PCSK_KEX2_1	8	10	PF00082	0.703
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.786
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.540
CLV_PCSK_PC1ET2_1	35	37	PF00082	0.713
CLV_PCSK_SKI1_1	131	135	PF00082	0.690
CLV_PCSK_SKI1_1	142	146	PF00082	0.630
CLV_PCSK_SKI1_1	271	275	PF00082	0.539
CLV_PCSK_SKI1_1	41	45	PF00082	0.769
CLV_PCSK_SKI1_1	77	81	PF00082	0.639
CLV_PCSK_SKI1_1	93	97	PF00082	0.640
DEG_APCC_DBOX_1	270	278	PF00400	0.544
DEG_Nend_UBRbox_1	1	4	PF02207	0.758
DEG_SCF_FBW7_1	188	195	PF00400	0.670
DOC_CDC14_PxL_1	289	297	PF14671	0.507
DOC_CKS1_1	184	189	PF01111	0.672
DOC_CKS1_1	225	230	PF01111	0.698
DOC_CKS1_1	42	47	PF01111	0.589
DOC_CKS1_1	83	88	PF01111	0.713
DOC_CYCLIN_yCln2_LP_2	42	48	PF00134	0.587
DOC_MAPK_gen_1	270	276	PF00069	0.538
DOC_MAPK_MEF2A_6	270	278	PF00069	0.544
DOC_PP4_FxxP_1	323	326	PF00568	0.601
DOC_USP7_MATH_1	175	179	PF00917	0.677
DOC_USP7_MATH_1	259	263	PF00917	0.493
DOC_USP7_MATH_1	46	50	PF00917	0.614
DOC_USP7_MATH_1	68	72	PF00917	0.696
DOC_USP7_UBL2_3	138	142	PF12436	0.782
DOC_USP7_UBL2_3	35	39	PF12436	0.730
DOC_USP7_UBL2_3	57	61	PF12436	0.720
DOC_WW_Pin1_4	111	116	PF00397	0.660
DOC_WW_Pin1_4	132	137	PF00397	0.638
DOC_WW_Pin1_4	183	188	PF00397	0.672
DOC_WW_Pin1_4	224	229	PF00397	0.694
DOC_WW_Pin1_4	282	287	PF00397	0.629
DOC_WW_Pin1_4	41	46	PF00397	0.770
DOC_WW_Pin1_4	82	87	PF00397	0.676
DOC_WW_Pin1_4	96	101	PF00397	0.631
LIG_14-3-3_CanoR_1	108	118	PF00244	0.762
LIG_14-3-3_CanoR_1	131	136	PF00244	0.648
LIG_14-3-3_CanoR_1	193	199	PF00244	0.761
LIG_14-3-3_CanoR_1	257	267	PF00244	0.481
LIG_14-3-3_CanoR_1	313	321	PF00244	0.486
LIG_14-3-3_CanoR_1	8	16	PF00244	0.635
LIG_FHA_1	193	199	PF00498	0.754
LIG_FHA_1	225	231	PF00498	0.701
LIG_FHA_1	243	249	PF00498	0.311
LIG_FHA_1	304	310	PF00498	0.556
LIG_FHA_1	51	57	PF00498	0.623
LIG_FHA_2	263	269	PF00498	0.499
LIG_Integrin_isoDGR_2	298	300	PF01839	0.607
LIG_LIR_Apic_2	318	324	PF02991	0.530
LIG_SH2_STAT5	14	17	PF00017	0.686
LIG_SH2_STAT5	28	31	PF00017	0.504
LIG_SH2_STAT5	321	324	PF00017	0.549
LIG_SH3_1	216	222	PF00018	0.654
LIG_SH3_2	189	194	PF14604	0.745
LIG_SH3_2	83	88	PF14604	0.764
LIG_SH3_3	181	187	PF00018	0.763
LIG_SH3_3	216	222	PF00018	0.715
LIG_SH3_3	273	279	PF00018	0.513
LIG_SH3_3	287	293	PF00018	0.476
LIG_SH3_3	45	51	PF00018	0.735
LIG_SH3_3	80	86	PF00018	0.739
LIG_SH3_5	10	14	PF00018	0.541
LIG_SUMO_SIM_anti_2	241	248	PF11976	0.525
LIG_SUMO_SIM_par_1	241	250	PF11976	0.462
MOD_CDK_SPK_2	188	193	PF00069	0.671
MOD_CDK_SPxK_1	132	138	PF00069	0.643
MOD_CDK_SPxK_1	188	194	PF00069	0.670
MOD_CDK_SPxK_1	82	88	PF00069	0.710
MOD_CDK_SPxxK_3	96	103	PF00069	0.620
MOD_CK1_1	161	167	PF00069	0.666
MOD_CK1_1	262	268	PF00069	0.443
MOD_CK1_1	285	291	PF00069	0.563
MOD_CK1_1	315	321	PF00069	0.546
MOD_CK1_1	59	65	PF00069	0.635
MOD_CK1_1	72	78	PF00069	0.654
MOD_CK2_1	262	268	PF00069	0.352
MOD_GlcNHglycan	177	180	PF01048	0.708
MOD_GlcNHglycan	282	285	PF01048	0.659
MOD_GlcNHglycan	314	317	PF01048	0.502
MOD_GlcNHglycan	96	99	PF01048	0.596
MOD_GSK3_1	188	195	PF00069	0.670
MOD_GSK3_1	238	245	PF00069	0.528
MOD_GSK3_1	247	254	PF00069	0.528
MOD_GSK3_1	258	265	PF00069	0.365
MOD_GSK3_1	278	285	PF00069	0.376
MOD_GSK3_1	31	38	PF00069	0.666
MOD_GSK3_1	312	319	PF00069	0.552
MOD_GSK3_1	46	53	PF00069	0.602
MOD_GSK3_1	56	63	PF00069	0.681
MOD_GSK3_1	68	75	PF00069	0.593
MOD_N-GLC_1	251	256	PF02516	0.552
MOD_NEK2_1	247	252	PF00069	0.554
MOD_NEK2_2	316	321	PF00069	0.480
MOD_PIKK_1	69	75	PF00454	0.618
MOD_PKA_1	110	116	PF00069	0.680
MOD_PKA_1	35	41	PF00069	0.679
MOD_PKA_2	109	115	PF00069	0.766
MOD_PKA_2	192	198	PF00069	0.761
MOD_PKA_2	312	318	PF00069	0.494
MOD_PKA_2	35	41	PF00069	0.679
MOD_PKB_1	108	116	PF00069	0.676
MOD_PKB_1	129	137	PF00069	0.660
MOD_PKB_1	146	154	PF00069	0.572
MOD_PKB_1	210	218	PF00069	0.549
MOD_Plk_1	242	248	PF00069	0.542
MOD_Plk_1	262	268	PF00069	0.276
MOD_Plk_1	316	322	PF00069	0.475
MOD_Plk_1	69	75	PF00069	0.588
MOD_Plk_4	200	206	PF00069	0.738
MOD_Plk_4	242	248	PF00069	0.524
MOD_Plk_4	262	268	PF00069	0.305
MOD_Plk_4	285	291	PF00069	0.593
MOD_Plk_4	316	322	PF00069	0.535
MOD_ProDKin_1	111	117	PF00069	0.661
MOD_ProDKin_1	132	138	PF00069	0.643
MOD_ProDKin_1	183	189	PF00069	0.672
MOD_ProDKin_1	224	230	PF00069	0.697
MOD_ProDKin_1	282	288	PF00069	0.633
MOD_ProDKin_1	41	47	PF00069	0.771
MOD_ProDKin_1	82	88	PF00069	0.678
MOD_ProDKin_1	96	102	PF00069	0.631
MOD_SUMO_for_1	1	4	PF00179	0.666
TRG_ER_diArg_1	105	108	PF00400	0.699
TRG_ER_diArg_1	129	132	PF00400	0.686
TRG_ER_diArg_1	210	212	PF00400	0.747
TRG_ER_diArg_1	271	273	PF00400	0.539
TRG_ER_diArg_1	8	11	PF00400	0.647
TRG_NLS_MonoCore_2	102	107	PF00514	0.602
TRG_NLS_MonoExtC_3	269	275	PF00514	0.526
TRG_NLS_MonoExtC_3	34	39	PF00514	0.664
TRG_NLS_MonoExtN_4	100	107	PF00514	0.616
TRG_NLS_MonoExtN_4	33	39	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.539
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IF70	Leishmania donovani	89%	100%
A4HMT0	Leishmania braziliensis	62%	100%
A4IBC8	Leishmania infantum	88%	100%
E9B6D9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%