LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
E9AF83_LEIMA
TriTrypDb:
LmjF.35.2600 , LMJLV39_350032700 *
Length:
159

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF83
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF83

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.510
CLV_C14_Caspase3-7 67 71 PF00656 0.533
CLV_NRD_NRD_1 14 16 PF00675 0.658
CLV_NRD_NRD_1 45 47 PF00675 0.506
CLV_PCSK_FUR_1 42 46 PF00082 0.480
CLV_PCSK_KEX2_1 14 16 PF00082 0.658
CLV_PCSK_KEX2_1 44 46 PF00082 0.491
CLV_PCSK_PC7_1 40 46 PF00082 0.469
DEG_APCC_DBOX_1 100 108 PF00400 0.552
DOC_CYCLIN_yCln2_LP_2 90 93 PF00134 0.616
DOC_MAPK_gen_1 2 11 PF00069 0.447
DOC_PP1_RVXF_1 130 137 PF00149 0.758
DOC_PP1_RVXF_1 38 44 PF00149 0.453
DOC_PP2B_LxvP_1 155 158 PF13499 0.548
DOC_PP2B_LxvP_1 90 93 PF13499 0.616
DOC_PP4_FxxP_1 136 139 PF00568 0.617
LIG_Actin_WH2_2 119 137 PF00022 0.569
LIG_Actin_WH2_2 54 71 PF00022 0.523
LIG_FHA_1 125 131 PF00498 0.464
LIG_SH3_3 136 142 PF00018 0.538
LIG_SH3_3 18 24 PF00018 0.547
MOD_Cter_Amidation 12 15 PF01082 0.507
MOD_N-GLC_2 33 35 PF02516 0.472
MOD_NEK2_1 110 115 PF00069 0.439
TRG_DiLeu_BaEn_1 86 91 PF01217 0.544
TRG_ER_diArg_1 1 4 PF00400 0.578
TRG_ER_diArg_1 39 42 PF00400 0.444
TRG_ER_diArg_1 43 46 PF00400 0.469
TRG_NES_CRM1_1 109 124 PF08389 0.522
TRG_Pf-PMV_PEXEL_1 45 50 PF00026 0.508

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IVA6 Leishmania donovani 80% 100%
A4IBG9 Leishmania infantum 80% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS