Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF81_LEIMA

TriTrypDb:

LmjF.35.2580 , LMJLV39_350032500 , LMJSD75_350032000

Length:

191

Annotations

LeishMANIAdb annotations

Might be an organellar (mitochondrial) protein with transit signal. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9AF81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF81

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	10	12	PF00675	0.715
CLV_NRD_NRD_1	35	37	PF00675	0.821
CLV_PCSK_KEX2_1	10	12	PF00082	0.715
CLV_PCSK_KEX2_1	35	37	PF00082	0.821
CLV_PCSK_SKI1_1	176	180	PF00082	0.491
CLV_PCSK_SKI1_1	98	102	PF00082	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.517
DOC_CYCLIN_yCln2_LP_2	20	26	PF00134	0.474
DOC_PP1_RVXF_1	157	164	PF00149	0.654
DOC_PP1_RVXF_1	95	102	PF00149	0.411
DOC_PP2B_LxvP_1	20	23	PF13499	0.469
DOC_PP2B_LxvP_1	31	34	PF13499	0.431
DOC_USP7_MATH_1	180	184	PF00917	0.615
DOC_USP7_MATH_1	45	49	PF00917	0.586
DOC_USP7_MATH_1	56	60	PF00917	0.484
DOC_WW_Pin1_4	25	30	PF00397	0.566
DOC_WW_Pin1_4	51	56	PF00397	0.530
LIG_14-3-3_CanoR_1	10	17	PF00244	0.540
LIG_14-3-3_CterR_2	189	191	PF00244	0.634
LIG_BIR_III_2	131	135	PF00653	0.697
LIG_FHA_1	91	97	PF00498	0.480
LIG_FHA_2	165	171	PF00498	0.653
LIG_LIR_LC3C_4	28	33	PF02991	0.482
LIG_SH2_STAT5	154	157	PF00017	0.658
LIG_SH3_3	133	139	PF00018	0.717
LIG_SH3_3	52	58	PF00018	0.525
LIG_TRAF2_1	167	170	PF00917	0.658
MOD_CDC14_SPxK_1	54	57	PF00782	0.520
MOD_CDK_SPxK_1	51	57	PF00069	0.516
MOD_CK1_1	25	31	PF00069	0.481
MOD_CK1_1	90	96	PF00069	0.446
MOD_CK2_1	164	170	PF00069	0.729
MOD_GlcNHglycan	12	15	PF01048	0.671
MOD_GlcNHglycan	47	50	PF01048	0.776
MOD_GlcNHglycan	58	61	PF01048	0.699
MOD_GlcNHglycan	6	9	PF01048	0.690
MOD_GSK3_1	45	52	PF00069	0.516
MOD_NEK2_1	4	9	PF00069	0.481
MOD_PIKK_1	148	154	PF00454	0.691
MOD_PIKK_1	180	186	PF00454	0.637
MOD_PIKK_1	61	67	PF00454	0.555
MOD_PKA_1	10	16	PF00069	0.504
MOD_PKA_2	10	16	PF00069	0.508
MOD_Plk_1	36	42	PF00069	0.588
MOD_Plk_2-3	164	170	PF00069	0.651
MOD_ProDKin_1	25	31	PF00069	0.567
MOD_ProDKin_1	51	57	PF00069	0.532
MOD_SUMO_rev_2	69	75	PF00179	0.402
TRG_ER_diArg_1	34	36	PF00400	0.617
TRG_ER_diArg_1	9	11	PF00400	0.515
TRG_NLS_MonoCore_2	121	126	PF00514	0.662
TRG_NLS_MonoExtC_3	121	127	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	159	164	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IMC4	Leishmania donovani	94%	100%
A4IBG7	Leishmania infantum	94%	100%
E9AIW4	Leishmania braziliensis	66%	100%
E9B6D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%