LeishMANIAdb
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Putative cytochrome P450 reductase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative cytochrome P450 reductase
Gene product:
cytochrome P450 reductase, putative
Species:
Leishmania major
UniProt:
E9AF79_LEIMA
TriTrypDb:
LmjF.35.2560 , LMJLV39_350032300 , LMJSD75_350031800
Length:
831

Annotations

LeishMANIAdb annotations

Homologous to other eukaryotic CYP450 reductases.. For some reason, these proteins duplicated in Kinetoplastids. Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 16
NetGPI no yes: 0, no: 16
Cellular components
Term Name Level Count
GO:0005829 cytosol 2 3
GO:0110165 cellular anatomical entity 1 5
GO:0016020 membrane 2 2

Expansion

Sequence features

E9AF79
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF79

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 17
GO:0003824 catalytic activity 1 17
GO:0003958 NADPH-hemoprotein reductase activity 5 6
GO:0005488 binding 1 17
GO:0010181 FMN binding 4 17
GO:0016491 oxidoreductase activity 2 17
GO:0016651 oxidoreductase activity, acting on NAD(P)H 3 6
GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor 4 6
GO:0032553 ribonucleotide binding 3 17
GO:0036094 small molecule binding 2 17
GO:0043167 ion binding 2 17
GO:0043168 anion binding 3 17
GO:0050660 flavin adenine dinucleotide binding 4 3
GO:0097159 organic cyclic compound binding 2 17
GO:0097367 carbohydrate derivative binding 2 17
GO:1901265 nucleoside phosphate binding 3 17
GO:1901363 heterocyclic compound binding 2 17

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 66 70 PF00656 0.762
CLV_NRD_NRD_1 150 152 PF00675 0.427
CLV_NRD_NRD_1 194 196 PF00675 0.312
CLV_NRD_NRD_1 661 663 PF00675 0.277
CLV_NRD_NRD_1 667 669 PF00675 0.297
CLV_NRD_NRD_1 686 688 PF00675 0.305
CLV_NRD_NRD_1 724 726 PF00675 0.355
CLV_NRD_NRD_1 818 820 PF00675 0.337
CLV_PCSK_KEX2_1 127 129 PF00082 0.392
CLV_PCSK_KEX2_1 194 196 PF00082 0.312
CLV_PCSK_KEX2_1 4 6 PF00082 0.589
CLV_PCSK_KEX2_1 641 643 PF00082 0.274
CLV_PCSK_KEX2_1 686 688 PF00082 0.339
CLV_PCSK_KEX2_1 724 726 PF00082 0.355
CLV_PCSK_KEX2_1 753 755 PF00082 0.292
CLV_PCSK_KEX2_1 818 820 PF00082 0.340
CLV_PCSK_PC1ET2_1 127 129 PF00082 0.385
CLV_PCSK_PC1ET2_1 4 6 PF00082 0.547
CLV_PCSK_PC1ET2_1 641 643 PF00082 0.274
CLV_PCSK_PC1ET2_1 753 755 PF00082 0.292
CLV_PCSK_PC7_1 637 643 PF00082 0.291
CLV_PCSK_SKI1_1 144 148 PF00082 0.529
CLV_PCSK_SKI1_1 194 198 PF00082 0.338
CLV_PCSK_SKI1_1 243 247 PF00082 0.304
CLV_PCSK_SKI1_1 283 287 PF00082 0.376
CLV_PCSK_SKI1_1 355 359 PF00082 0.396
CLV_PCSK_SKI1_1 360 364 PF00082 0.404
CLV_PCSK_SKI1_1 39 43 PF00082 0.523
CLV_PCSK_SKI1_1 451 455 PF00082 0.233
CLV_PCSK_SKI1_1 476 480 PF00082 0.286
CLV_PCSK_SKI1_1 490 494 PF00082 0.210
CLV_PCSK_SKI1_1 505 509 PF00082 0.211
CLV_PCSK_SKI1_1 602 606 PF00082 0.305
CLV_PCSK_SKI1_1 642 646 PF00082 0.312
CLV_PCSK_SKI1_1 754 758 PF00082 0.402
CLV_PCSK_SKI1_1 825 829 PF00082 0.279
CLV_Separin_Metazoa 526 530 PF03568 0.485
DEG_APCC_DBOX_1 160 168 PF00400 0.585
DEG_APCC_DBOX_1 475 483 PF00400 0.445
DEG_APCC_DBOX_1 485 493 PF00400 0.415
DEG_SPOP_SBC_1 321 325 PF00917 0.668
DEG_SPOP_SBC_1 370 374 PF00917 0.640
DOC_CKS1_1 463 468 PF01111 0.497
DOC_CYCLIN_yCln2_LP_2 132 138 PF00134 0.619
DOC_CYCLIN_yCln2_LP_2 463 469 PF00134 0.464
DOC_MAPK_gen_1 253 260 PF00069 0.430
DOC_MAPK_gen_1 502 510 PF00069 0.428
DOC_MAPK_gen_1 641 647 PF00069 0.578
DOC_MAPK_MEF2A_6 161 169 PF00069 0.500
DOC_MAPK_MEF2A_6 301 310 PF00069 0.639
DOC_MAPK_MEF2A_6 486 493 PF00069 0.409
DOC_MAPK_MEF2A_6 596 603 PF00069 0.512
DOC_PP1_RVXF_1 260 266 PF00149 0.512
DOC_PP1_SILK_1 476 481 PF00149 0.399
DOC_PP2B_LxvP_1 407 410 PF13499 0.399
DOC_PP2B_LxvP_1 456 459 PF13499 0.471
DOC_PP2B_LxvP_1 528 531 PF13499 0.430
DOC_PP4_FxxP_1 382 385 PF00568 0.737
DOC_PP4_FxxP_1 632 635 PF00568 0.487
DOC_USP7_MATH_1 139 143 PF00917 0.589
DOC_USP7_MATH_1 202 206 PF00917 0.571
DOC_USP7_MATH_1 212 216 PF00917 0.376
DOC_USP7_MATH_1 322 326 PF00917 0.744
DOC_USP7_MATH_1 340 344 PF00917 0.764
DOC_USP7_MATH_1 353 357 PF00917 0.632
DOC_USP7_MATH_1 362 366 PF00917 0.758
DOC_USP7_MATH_1 369 373 PF00917 0.693
DOC_USP7_MATH_1 410 414 PF00917 0.533
DOC_USP7_MATH_1 503 507 PF00917 0.417
DOC_USP7_MATH_1 539 543 PF00917 0.533
DOC_USP7_MATH_1 723 727 PF00917 0.643
DOC_USP7_UBL2_3 148 152 PF12436 0.646
DOC_WW_Pin1_4 150 155 PF00397 0.733
DOC_WW_Pin1_4 156 161 PF00397 0.677
DOC_WW_Pin1_4 360 365 PF00397 0.626
DOC_WW_Pin1_4 405 410 PF00397 0.496
DOC_WW_Pin1_4 462 467 PF00397 0.464
DOC_WW_Pin1_4 58 63 PF00397 0.761
LIG_14-3-3_CanoR_1 194 202 PF00244 0.430
LIG_14-3-3_CanoR_1 243 252 PF00244 0.502
LIG_14-3-3_CanoR_1 502 511 PF00244 0.461
LIG_14-3-3_CanoR_1 590 597 PF00244 0.512
LIG_14-3-3_CanoR_1 628 633 PF00244 0.490
LIG_14-3-3_CanoR_1 724 734 PF00244 0.658
LIG_14-3-3_CanoR_1 754 760 PF00244 0.461
LIG_Actin_WH2_2 465 482 PF00022 0.505
LIG_Actin_WH2_2 813 830 PF00022 0.518
LIG_APCC_ABBA_1 183 188 PF00400 0.471
LIG_BRCT_BRCA1_1 378 382 PF00533 0.676
LIG_CtBP_PxDLS_1 445 449 PF00389 0.512
LIG_EVH1_1 380 384 PF00568 0.713
LIG_FHA_1 16 22 PF00498 0.326
LIG_FHA_1 196 202 PF00498 0.520
LIG_FHA_1 246 252 PF00498 0.471
LIG_FHA_1 322 328 PF00498 0.628
LIG_FHA_1 603 609 PF00498 0.521
LIG_FHA_1 629 635 PF00498 0.496
LIG_FHA_1 676 682 PF00498 0.545
LIG_FHA_1 734 740 PF00498 0.538
LIG_FHA_1 755 761 PF00498 0.478
LIG_FHA_2 151 157 PF00498 0.763
LIG_FHA_2 170 176 PF00498 0.419
LIG_FHA_2 463 469 PF00498 0.481
LIG_FHA_2 551 557 PF00498 0.428
LIG_FHA_2 593 599 PF00498 0.445
LIG_FHA_2 738 744 PF00498 0.495
LIG_FHA_2 98 104 PF00498 0.522
LIG_GBD_Chelix_1 600 608 PF00786 0.312
LIG_HCF-1_HBM_1 823 826 PF13415 0.560
LIG_LIR_Apic_2 379 385 PF02991 0.735
LIG_LIR_Apic_2 630 635 PF02991 0.498
LIG_LIR_Gen_1 114 124 PF02991 0.549
LIG_LIR_Gen_1 179 189 PF02991 0.512
LIG_LIR_Gen_1 522 532 PF02991 0.510
LIG_LIR_Gen_1 621 632 PF02991 0.478
LIG_LIR_Gen_1 765 775 PF02991 0.589
LIG_LIR_Nem_3 179 185 PF02991 0.512
LIG_LIR_Nem_3 220 226 PF02991 0.439
LIG_LIR_Nem_3 235 241 PF02991 0.451
LIG_LIR_Nem_3 307 313 PF02991 0.598
LIG_LIR_Nem_3 522 527 PF02991 0.498
LIG_LIR_Nem_3 621 627 PF02991 0.547
LIG_LIR_Nem_3 728 734 PF02991 0.514
LIG_LIR_Nem_3 765 771 PF02991 0.506
LIG_NRBOX 797 803 PF00104 0.485
LIG_Pex14_2 182 186 PF04695 0.445
LIG_PTB_Apo_2 222 229 PF02174 0.512
LIG_PTB_Phospho_1 222 228 PF10480 0.512
LIG_SH2_GRB2like 124 127 PF00017 0.548
LIG_SH2_NCK_1 584 588 PF00017 0.444
LIG_SH2_PTP2 166 169 PF00017 0.512
LIG_SH2_PTP2 496 499 PF00017 0.488
LIG_SH2_PTP2 6 9 PF00017 0.363
LIG_SH2_PTP2 626 629 PF00017 0.567
LIG_SH2_SRC 122 125 PF00017 0.533
LIG_SH2_STAP1 40 44 PF00017 0.579
LIG_SH2_STAT3 270 273 PF00017 0.383
LIG_SH2_STAT3 40 43 PF00017 0.674
LIG_SH2_STAT5 122 125 PF00017 0.585
LIG_SH2_STAT5 166 169 PF00017 0.512
LIG_SH2_STAT5 241 244 PF00017 0.460
LIG_SH2_STAT5 496 499 PF00017 0.445
LIG_SH2_STAT5 514 517 PF00017 0.445
LIG_SH2_STAT5 557 560 PF00017 0.439
LIG_SH2_STAT5 6 9 PF00017 0.420
LIG_SH2_STAT5 612 615 PF00017 0.486
LIG_SH2_STAT5 626 629 PF00017 0.501
LIG_SH2_STAT5 691 694 PF00017 0.498
LIG_SH2_STAT5 755 758 PF00017 0.509
LIG_SH2_STAT5 826 829 PF00017 0.492
LIG_SH3_3 157 163 PF00018 0.564
LIG_SH3_3 300 306 PF00018 0.579
LIG_SH3_3 378 384 PF00018 0.673
LIG_SH3_3 439 445 PF00018 0.467
LIG_SH3_4 305 312 PF00018 0.634
LIG_Sin3_3 10 17 PF02671 0.219
LIG_SUMO_SIM_anti_2 18 25 PF11976 0.301
LIG_SUMO_SIM_anti_2 595 601 PF11976 0.479
LIG_SUMO_SIM_par_1 284 290 PF11976 0.494
LIG_SUMO_SIM_par_1 385 390 PF11976 0.673
LIG_SUMO_SIM_par_1 464 471 PF11976 0.407
LIG_TRAF2_1 153 156 PF00917 0.629
LIG_TRAF2_1 217 220 PF00917 0.479
LIG_TRAF2_1 287 290 PF00917 0.560
LIG_TRAF2_1 531 534 PF00917 0.494
LIG_TYR_ITIM 164 169 PF00017 0.518
LIG_TYR_ITIM 766 771 PF00017 0.470
LIG_UBA3_1 132 137 PF00899 0.568
LIG_UBA3_1 285 291 PF00899 0.503
LIG_WRC_WIRS_1 629 634 PF05994 0.553
LIG_WW_3 408 412 PF00397 0.399
MOD_CDC14_SPxK_1 408 411 PF00782 0.486
MOD_CDK_SPK_2 156 161 PF00069 0.584
MOD_CDK_SPxK_1 405 411 PF00069 0.486
MOD_CK1_1 140 146 PF00069 0.715
MOD_CK1_1 150 156 PF00069 0.747
MOD_CK1_1 206 212 PF00069 0.584
MOD_CK1_1 215 221 PF00069 0.532
MOD_CK1_1 413 419 PF00069 0.482
MOD_CK1_1 585 591 PF00069 0.445
MOD_CK1_1 592 598 PF00069 0.445
MOD_CK1_1 61 67 PF00069 0.713
MOD_CK1_1 737 743 PF00069 0.543
MOD_CK2_1 150 156 PF00069 0.769
MOD_CK2_1 169 175 PF00069 0.430
MOD_CK2_1 213 219 PF00069 0.461
MOD_CK2_1 462 468 PF00069 0.522
MOD_CK2_1 592 598 PF00069 0.445
MOD_GlcNHglycan 139 142 PF01048 0.444
MOD_GlcNHglycan 18 21 PF01048 0.364
MOD_GlcNHglycan 190 193 PF01048 0.300
MOD_GlcNHglycan 205 208 PF01048 0.295
MOD_GlcNHglycan 215 218 PF01048 0.280
MOD_GlcNHglycan 243 246 PF01048 0.230
MOD_GlcNHglycan 342 345 PF01048 0.471
MOD_GlcNHglycan 365 368 PF01048 0.562
MOD_GlcNHglycan 373 376 PF01048 0.530
MOD_GlcNHglycan 505 508 PF01048 0.214
MOD_GlcNHglycan 58 61 PF01048 0.533
MOD_GlcNHglycan 63 66 PF01048 0.555
MOD_GlcNHglycan 783 786 PF01048 0.277
MOD_GlcNHglycan 86 89 PF01048 0.316
MOD_GSK3_1 202 209 PF00069 0.585
MOD_GSK3_1 241 248 PF00069 0.517
MOD_GSK3_1 312 319 PF00069 0.640
MOD_GSK3_1 336 343 PF00069 0.772
MOD_GSK3_1 358 365 PF00069 0.652
MOD_GSK3_1 410 417 PF00069 0.479
MOD_GSK3_1 585 592 PF00069 0.434
MOD_GSK3_1 61 68 PF00069 0.708
MOD_GSK3_1 723 730 PF00069 0.660
MOD_GSK3_1 733 740 PF00069 0.548
MOD_GSK3_1 781 788 PF00069 0.483
MOD_N-GLC_1 353 358 PF02516 0.380
MOD_NEK2_1 15 20 PF00069 0.338
MOD_NEK2_1 233 238 PF00069 0.445
MOD_NEK2_1 294 299 PF00069 0.647
MOD_NEK2_1 312 317 PF00069 0.669
MOD_NEK2_1 358 363 PF00069 0.636
MOD_NEK2_1 608 613 PF00069 0.521
MOD_NEK2_1 770 775 PF00069 0.503
MOD_NEK2_1 97 102 PF00069 0.517
MOD_PIKK_1 402 408 PF00454 0.499
MOD_PIKK_1 576 582 PF00454 0.430
MOD_PK_1 454 460 PF00069 0.430
MOD_PK_1 582 588 PF00069 0.445
MOD_PKA_1 147 153 PF00069 0.589
MOD_PKA_1 194 200 PF00069 0.430
MOD_PKA_1 686 692 PF00069 0.510
MOD_PKA_2 194 200 PF00069 0.430
MOD_PKA_2 410 416 PF00069 0.478
MOD_PKA_2 589 595 PF00069 0.512
MOD_PKA_2 627 633 PF00069 0.507
MOD_PKA_2 686 692 PF00069 0.484
MOD_PKA_2 723 729 PF00069 0.668
MOD_Plk_1 234 240 PF00069 0.456
MOD_Plk_1 353 359 PF00069 0.584
MOD_Plk_1 785 791 PF00069 0.520
MOD_Plk_4 247 253 PF00069 0.517
MOD_Plk_4 389 395 PF00069 0.574
MOD_Plk_4 414 420 PF00069 0.446
MOD_Plk_4 608 614 PF00069 0.487
MOD_Plk_4 675 681 PF00069 0.575
MOD_Plk_4 734 740 PF00069 0.490
MOD_Plk_4 755 761 PF00069 0.620
MOD_Plk_4 785 791 PF00069 0.536
MOD_ProDKin_1 150 156 PF00069 0.729
MOD_ProDKin_1 360 366 PF00069 0.624
MOD_ProDKin_1 405 411 PF00069 0.496
MOD_ProDKin_1 462 468 PF00069 0.464
MOD_ProDKin_1 58 64 PF00069 0.761
MOD_SUMO_for_1 146 149 PF00179 0.709
MOD_SUMO_for_1 304 307 PF00179 0.616
MOD_SUMO_for_1 693 696 PF00179 0.495
TRG_DiLeu_BaEn_2 687 693 PF01217 0.489
TRG_DiLeu_BaEn_4 289 295 PF01217 0.531
TRG_ENDOCYTIC_2 166 169 PF00928 0.494
TRG_ENDOCYTIC_2 227 230 PF00928 0.447
TRG_ENDOCYTIC_2 496 499 PF00928 0.445
TRG_ENDOCYTIC_2 583 586 PF00928 0.471
TRG_ENDOCYTIC_2 6 9 PF00928 0.384
TRG_ENDOCYTIC_2 626 629 PF00928 0.567
TRG_ENDOCYTIC_2 768 771 PF00928 0.553
TRG_ER_diArg_1 193 195 PF00400 0.512
TRG_ER_diArg_1 817 819 PF00400 0.538
TRG_NLS_MonoExtN_4 547 553 PF00514 0.511
TRG_Pf-PMV_PEXEL_1 602 606 PF00026 0.245
TRG_Pf-PMV_PEXEL_1 818 823 PF00026 0.333
TRG_Pf-PMV_PEXEL_1 825 829 PF00026 0.297

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P7X2 Leptomonas seymouri 29% 100%
A0A0N1IBR8 Leptomonas seymouri 67% 100%
A0A1X0P5U2 Trypanosomatidae 41% 100%
A0A2U1KZS6 Artemisia annua 25% 100%
A0A3Q8II21 Leishmania donovani 96% 100%
A0A3R7K908 Trypanosoma rangeli 43% 100%
A0A3S7X1H9 Leishmania donovani 30% 100%
A2AI05 Mus musculus 24% 100%
A4HGH1 Leishmania braziliensis 29% 100%
A4HMS7 Leishmania braziliensis 84% 100%
A4I3K3 Leishmania infantum 30% 100%
A4IBG5 Leishmania infantum 96% 100%
C9ZZA0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
D0A835 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
E9AZU3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B557 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
E9B6D5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
O61608 Anopheles stephensi 24% 67%
P04175 Sus scrofa 23% 100%
P29477 Mus musculus 23% 73%
P35228 Homo sapiens 23% 72%
P37116 Vigna radiata var. radiata 23% 100%
Q05001 Catharanthus roseus 26% 100%
Q17574 Caenorhabditis elegans 20% 100%
Q1JPJ0 Bos taurus 25% 100%
Q3SYT8 Bos taurus 23% 100%
Q4JIJ2 Bos taurus 25% 100%
Q4Q8E2 Leishmania major 31% 100%
Q6NRG5 Xenopus laevis 23% 100%
Q6PFP6 Danio rerio 23% 100%
Q7VQH2 Blochmannia floridanus 20% 100%
Q7X7K8 Oryza sativa subsp. japonica 25% 100%
Q9UBK8 Homo sapiens 23% 100%
Q9UHB4 Homo sapiens 25% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS