Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

E9AF77_LEIMA

TriTrypDb:

LmjF.35.2540 , LMJLV39_350032100 , LMJSD75_350031600

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AF77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF77

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	180	182	PF00675	0.747
CLV_NRD_NRD_1	185	187	PF00675	0.675
CLV_PCSK_KEX2_1	180	182	PF00082	0.747
CLV_PCSK_SKI1_1	100	104	PF00082	0.737
CLV_PCSK_SKI1_1	38	42	PF00082	0.618
DEG_APCC_DBOX_1	86	94	PF00400	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.769
DOC_MAPK_gen_1	131	139	PF00069	0.718
DOC_MAPK_gen_1	62	70	PF00069	0.444
DOC_MAPK_MEF2A_6	141	149	PF00069	0.530
DOC_USP7_MATH_1	63	67	PF00917	0.504
DOC_WW_Pin1_4	180	185	PF00397	0.536
DOC_WW_Pin1_4	206	211	PF00397	0.476
DOC_WW_Pin1_4	25	30	PF00397	0.530
LIG_14-3-3_CanoR_1	100	108	PF00244	0.235
LIG_14-3-3_CanoR_1	62	71	PF00244	0.444
LIG_14-3-3_CanoR_1	85	91	PF00244	0.595
LIG_Actin_WH2_2	116	133	PF00022	0.432
LIG_BRCT_BRCA1_1	189	193	PF00533	0.435
LIG_FHA_1	101	107	PF00498	0.375
LIG_FHA_1	138	144	PF00498	0.613
LIG_LIR_Gen_1	103	113	PF02991	0.530
LIG_LIR_Gen_1	122	130	PF02991	0.355
LIG_LIR_Gen_1	13	22	PF02991	0.374
LIG_LIR_Gen_1	165	176	PF02991	0.510
LIG_LIR_Gen_1	190	201	PF02991	0.530
LIG_LIR_LC3C_4	6	9	PF02991	0.580
LIG_LIR_Nem_3	103	108	PF02991	0.530
LIG_LIR_Nem_3	13	17	PF02991	0.374
LIG_LIR_Nem_3	165	171	PF02991	0.512
LIG_LIR_Nem_3	190	196	PF02991	0.530
LIG_MLH1_MIPbox_1	189	193	PF16413	0.435
LIG_NRBOX	203	209	PF00104	0.421
LIG_SH2_CRK	14	18	PF00017	0.530
LIG_SH2_CRK	168	172	PF00017	0.510
LIG_SH2_CRK	49	53	PF00017	0.589
LIG_SH2_GRB2like	168	171	PF00017	0.511
LIG_SH2_NCK_1	49	53	PF00017	0.589
LIG_SH2_STAP1	14	18	PF00017	0.530
LIG_SH2_STAT5	105	108	PF00017	0.369
LIG_SH2_STAT5	11	14	PF00017	0.530
LIG_SH2_STAT5	176	179	PF00017	0.533
LIG_SH3_3	142	148	PF00018	0.465
LIG_SH3_3	23	29	PF00018	0.530
LIG_SUMO_SIM_anti_2	115	122	PF11976	0.413
LIG_SUMO_SIM_anti_2	66	75	PF11976	0.445
LIG_SUMO_SIM_par_1	203	209	PF11976	0.377
LIG_UBA3_1	123	131	PF00899	0.564
MOD_CDC14_SPxK_1	183	186	PF00782	0.412
MOD_CDK_SPxK_1	180	186	PF00069	0.422
MOD_CDK_SPxxK_3	180	187	PF00069	0.533
MOD_CDK_SPxxK_3	206	213	PF00069	0.452
MOD_CK1_1	25	31	PF00069	0.400
MOD_CK1_1	64	70	PF00069	0.593
MOD_CK1_1	74	80	PF00069	0.452
MOD_CK1_1	96	102	PF00069	0.542
MOD_CK2_1	31	37	PF00069	0.577
MOD_GlcNHglycan	189	192	PF01048	0.636
MOD_GlcNHglycan	74	77	PF01048	0.648
MOD_GSK3_1	115	122	PF00069	0.290
MOD_GSK3_1	187	194	PF00069	0.377
MOD_GSK3_1	57	64	PF00069	0.489
MOD_GSK3_1	70	77	PF00069	0.503
MOD_GSK3_1	96	103	PF00069	0.532
MOD_NEK2_1	10	15	PF00069	0.530
MOD_NEK2_1	119	124	PF00069	0.530
MOD_NEK2_1	192	197	PF00069	0.530
MOD_NEK2_1	22	27	PF00069	0.452
MOD_NEK2_1	71	76	PF00069	0.591
MOD_PKA_2	61	67	PF00069	0.443
MOD_PKA_2	86	92	PF00069	0.588
MOD_Plk_4	115	121	PF00069	0.382
MOD_Plk_4	22	28	PF00069	0.356
MOD_Plk_4	52	58	PF00069	0.431
MOD_ProDKin_1	180	186	PF00069	0.533
MOD_ProDKin_1	206	212	PF00069	0.476
MOD_ProDKin_1	25	31	PF00069	0.530
TRG_DiLeu_BaEn_2	36	42	PF01217	0.420
TRG_ENDOCYTIC_2	105	108	PF00928	0.530
TRG_ENDOCYTIC_2	14	17	PF00928	0.530
TRG_ENDOCYTIC_2	168	171	PF00928	0.566
TRG_ER_diArg_1	84	87	PF00400	0.464

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7Z5	Leishmania donovani	91%	100%
A4HMS5	Leishmania braziliensis	65%	100%
A4IBG3	Leishmania infantum	91%	100%
E9B6D3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%