CS domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF76_LEIMA

TriTrypDb:

LmjF.35.2530 , LMJLV39_350032000 , LMJSD75_350031500

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.485
CLV_C14_Caspase3-7	79	83	PF00656	0.718
CLV_NRD_NRD_1	120	122	PF00675	0.724
CLV_NRD_NRD_1	253	255	PF00675	0.497
CLV_NRD_NRD_1	296	298	PF00675	0.594
CLV_NRD_NRD_1	299	301	PF00675	0.614
CLV_NRD_NRD_1	314	316	PF00675	0.459
CLV_NRD_NRD_1	327	329	PF00675	0.405
CLV_NRD_NRD_1	331	333	PF00675	0.379
CLV_PCSK_FUR_1	297	301	PF00082	0.540
CLV_PCSK_KEX2_1	120	122	PF00082	0.655
CLV_PCSK_KEX2_1	253	255	PF00082	0.522
CLV_PCSK_KEX2_1	298	300	PF00082	0.554
CLV_PCSK_KEX2_1	326	328	PF00082	0.437
CLV_PCSK_KEX2_1	333	335	PF00082	0.454
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.554
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.510
CLV_PCSK_SKI1_1	175	179	PF00082	0.515
DEG_APCC_DBOX_1	252	260	PF00400	0.468
DEG_SCF_TRCP1_1	14	19	PF00400	0.652
DEG_SPOP_SBC_1	185	189	PF00917	0.467
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.519
DOC_MAPK_FxFP_2	231	234	PF00069	0.400
DOC_MAPK_gen_1	253	263	PF00069	0.386
DOC_MAPK_MEF2A_6	253	260	PF00069	0.380
DOC_MAPK_MEF2A_6	265	272	PF00069	0.385
DOC_MAPK_NFAT4_5	253	261	PF00069	0.512
DOC_PP4_FxxP_1	166	169	PF00568	0.394
DOC_PP4_FxxP_1	231	234	PF00568	0.400
DOC_PP4_FxxP_1	264	267	PF00568	0.494
DOC_USP7_MATH_1	190	194	PF00917	0.575
DOC_USP7_MATH_1	218	222	PF00917	0.564
DOC_USP7_MATH_1	64	68	PF00917	0.642
DOC_WW_Pin1_4	210	215	PF00397	0.582
DOC_WW_Pin1_4	301	306	PF00397	0.600
DOC_WW_Pin1_4	66	71	PF00397	0.600
LIG_14-3-3_CanoR_1	127	137	PF00244	0.433
LIG_14-3-3_CanoR_1	186	195	PF00244	0.544
LIG_14-3-3_CanoR_1	278	288	PF00244	0.448
LIG_14-3-3_CanoR_1	49	53	PF00244	0.531
LIG_APCC_ABBA_1	261	266	PF00400	0.439
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_deltaCOP1_diTrp_1	243	250	PF00928	0.500
LIG_FHA_1	159	165	PF00498	0.384
LIG_FHA_1	186	192	PF00498	0.606
LIG_FHA_1	201	207	PF00498	0.448
LIG_FHA_1	282	288	PF00498	0.434
LIG_FHA_1	289	295	PF00498	0.450
LIG_FHA_2	129	135	PF00498	0.595
LIG_FHA_2	154	160	PF00498	0.575
LIG_FHA_2	187	193	PF00498	0.502
LIG_FHA_2	19	25	PF00498	0.593
LIG_FHA_2	291	297	PF00498	0.398
LIG_FHA_2	40	46	PF00498	0.606
LIG_LIR_Apic_2	163	169	PF02991	0.384
LIG_LIR_Gen_1	136	143	PF02991	0.570
LIG_LIR_Gen_1	7	14	PF02991	0.510
LIG_LIR_Nem_3	136	142	PF02991	0.497
LIG_LIR_Nem_3	178	183	PF02991	0.574
LIG_LIR_Nem_3	7	12	PF02991	0.532
LIG_Pex14_1	246	250	PF04695	0.493
LIG_Pex14_1	276	280	PF04695	0.351
LIG_Pex14_2	166	170	PF04695	0.516
LIG_Pex14_2	314	318	PF04695	0.493
LIG_SH2_STAP1	139	143	PF00017	0.566
LIG_SUMO_SIM_anti_2	201	206	PF11976	0.414
LIG_SUMO_SIM_par_1	158	165	PF11976	0.509
LIG_TRAF2_1	321	324	PF00917	0.453
LIG_TRAF2_1	77	80	PF00917	0.525
LIG_TYR_ITIM	137	142	PF00017	0.573
MOD_CDK_SPxxK_3	301	308	PF00069	0.615
MOD_CK1_1	107	113	PF00069	0.741
MOD_CK1_1	15	21	PF00069	0.585
MOD_CK1_1	213	219	PF00069	0.431
MOD_CK1_1	48	54	PF00069	0.480
MOD_CK2_1	153	159	PF00069	0.506
MOD_CK2_1	16	22	PF00069	0.626
MOD_CK2_1	173	179	PF00069	0.520
MOD_CK2_1	186	192	PF00069	0.579
MOD_CK2_1	39	45	PF00069	0.635
MOD_Cter_Amidation	118	121	PF01082	0.653
MOD_GlcNHglycan	14	17	PF01048	0.622
MOD_GlcNHglycan	18	21	PF01048	0.623
MOD_GlcNHglycan	215	218	PF01048	0.637
MOD_GlcNHglycan	220	223	PF01048	0.608
MOD_GlcNHglycan	66	69	PF01048	0.690
MOD_GSK3_1	104	111	PF00069	0.644
MOD_GSK3_1	12	19	PF00069	0.673
MOD_GSK3_1	158	165	PF00069	0.481
MOD_GSK3_1	169	176	PF00069	0.415
MOD_GSK3_1	186	193	PF00069	0.571
MOD_GSK3_1	209	216	PF00069	0.621
MOD_GSK3_1	279	286	PF00069	0.383
MOD_GSK3_1	78	85	PF00069	0.673
MOD_N-GLC_1	107	112	PF02516	0.665
MOD_N-GLC_1	82	87	PF02516	0.653
MOD_NEK2_1	12	17	PF00069	0.651
MOD_NEK2_1	138	143	PF00069	0.497
MOD_NEK2_1	200	205	PF00069	0.442
MOD_NEK2_1	270	275	PF00069	0.481
MOD_PIKK_1	153	159	PF00454	0.398
MOD_PIKK_1	288	294	PF00454	0.547
MOD_PK_1	173	179	PF00069	0.512
MOD_PKA_2	185	191	PF00069	0.512
MOD_PKA_2	48	54	PF00069	0.556
MOD_Plk_1	158	164	PF00069	0.434
MOD_Plk_1	200	206	PF00069	0.428
MOD_Plk_1	282	288	PF00069	0.426
MOD_Plk_1	94	100	PF00069	0.506
MOD_Plk_2-3	290	296	PF00069	0.434
MOD_Plk_4	162	168	PF00069	0.377
MOD_Plk_4	270	276	PF00069	0.424
MOD_Plk_4	283	289	PF00069	0.469
MOD_ProDKin_1	210	216	PF00069	0.583
MOD_ProDKin_1	301	307	PF00069	0.592
MOD_ProDKin_1	66	72	PF00069	0.602
MOD_SUMO_for_1	93	96	PF00179	0.640
TRG_DiLeu_BaEn_1	201	206	PF01217	0.414
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.382
TRG_ENDOCYTIC_2	139	142	PF00928	0.449
TRG_ER_diArg_1	252	254	PF00400	0.494
TRG_ER_diArg_1	297	300	PF00400	0.543
TRG_ER_diArg_1	325	328	PF00400	0.484
TRG_ER_diLys_1	333	338	PF00400	0.386
TRG_NLS_Bipartite_1	315	337	PF00514	0.359
TRG_NLS_MonoExtC_3	332	338	PF00514	0.484
TRG_NLS_MonoExtN_4	332	337	PF00514	0.537
TRG_Pf-PMV_PEXEL_1	257	262	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	334	338	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE56	Leptomonas seymouri	50%	100%
A0A0S4KNN3	Bodo saltans	32%	100%
A0A1X0P6G0	Trypanosomatidae	39%	100%
A0A3R7NBC1	Trypanosoma rangeli	42%	100%
A0A3S7X9A9	Leishmania donovani	89%	100%
A4HMS4	Leishmania braziliensis	73%	99%
A4IBG2	Leishmania infantum	90%	100%
C9ZZA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9B6D2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BJ90	Trypanosoma cruzi	39%	100%