RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania major

UniProt:

E9AF75_LEIMA

TriTrypDb:

LmjF.35.2520 , LMJLV39_350031900 , LMJSD75_350031400

Length:

396

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.370
CLV_C14_Caspase3-7	278	282	PF00656	0.594
CLV_NRD_NRD_1	130	132	PF00675	0.494
CLV_NRD_NRD_1	159	161	PF00675	0.551
CLV_NRD_NRD_1	213	215	PF00675	0.622
CLV_NRD_NRD_1	230	232	PF00675	0.471
CLV_NRD_NRD_1	262	264	PF00675	0.693
CLV_NRD_NRD_1	364	366	PF00675	0.468
CLV_NRD_NRD_1	90	92	PF00675	0.257
CLV_PCSK_KEX2_1	130	132	PF00082	0.491
CLV_PCSK_KEX2_1	213	215	PF00082	0.658
CLV_PCSK_KEX2_1	235	237	PF00082	0.495
CLV_PCSK_KEX2_1	364	366	PF00082	0.468
CLV_PCSK_KEX2_1	62	64	PF00082	0.426
CLV_PCSK_KEX2_1	90	92	PF00082	0.345
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.565
CLV_PCSK_PC1ET2_1	62	64	PF00082	0.409
CLV_PCSK_PC7_1	231	237	PF00082	0.512
CLV_PCSK_PC7_1	360	366	PF00082	0.451
CLV_PCSK_SKI1_1	146	150	PF00082	0.447
CLV_PCSK_SKI1_1	213	217	PF00082	0.538
CLV_PCSK_SKI1_1	232	236	PF00082	0.364
CLV_PCSK_SKI1_1	62	66	PF00082	0.400
CLV_PCSK_SKI1_1	85	89	PF00082	0.267
DEG_APCC_DBOX_1	363	371	PF00400	0.498
DEG_SPOP_SBC_1	166	170	PF00917	0.620
DOC_MAPK_gen_1	90	98	PF00069	0.516
DOC_MAPK_MEF2A_6	90	98	PF00069	0.451
DOC_MAPK_RevD_3	75	91	PF00069	0.468
DOC_PP4_FxxP_1	300	303	PF00568	0.494
DOC_USP7_MATH_1	166	170	PF00917	0.678
DOC_USP7_MATH_1	172	176	PF00917	0.632
DOC_USP7_MATH_1	181	185	PF00917	0.368
DOC_USP7_MATH_1	204	208	PF00917	0.501
DOC_USP7_MATH_1	245	249	PF00917	0.648
DOC_USP7_MATH_1	275	279	PF00917	0.593
DOC_USP7_MATH_1	318	322	PF00917	0.716
DOC_USP7_MATH_1	379	383	PF00917	0.488
DOC_WW_Pin1_4	267	272	PF00397	0.594
LIG_14-3-3_CanoR_1	115	123	PF00244	0.407
LIG_14-3-3_CanoR_1	23	29	PF00244	0.474
LIG_14-3-3_CanoR_1	246	253	PF00244	0.665
LIG_14-3-3_CanoR_1	56	61	PF00244	0.499
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BIR_III_4	326	330	PF00653	0.577
LIG_BRCT_BRCA1_1	16	20	PF00533	0.380
LIG_CaM_IQ_9	77	93	PF13499	0.454
LIG_deltaCOP1_diTrp_1	152	159	PF00928	0.512
LIG_FHA_1	104	110	PF00498	0.482
LIG_FHA_2	166	172	PF00498	0.732
LIG_FHA_2	214	220	PF00498	0.514
LIG_FHA_2	3	9	PF00498	0.525
LIG_LIR_Gen_1	117	125	PF02991	0.516
LIG_LIR_Gen_1	152	163	PF02991	0.448
LIG_LIR_Gen_1	356	363	PF02991	0.366
LIG_LIR_Nem_3	117	123	PF02991	0.408
LIG_LIR_Nem_3	152	158	PF02991	0.410
LIG_LIR_Nem_3	27	31	PF02991	0.411
LIG_LIR_Nem_3	356	361	PF02991	0.390
LIG_LIR_Nem_3	59	64	PF02991	0.438
LIG_PCNA_yPIPBox_3	74	88	PF02747	0.545
LIG_PTB_Apo_2	98	105	PF02174	0.440
LIG_SH2_CRK	61	65	PF00017	0.491
LIG_SH2_PTP2	93	96	PF00017	0.317
LIG_SH2_STAT5	108	111	PF00017	0.499
LIG_SH2_STAT5	31	34	PF00017	0.500
LIG_SH2_STAT5	93	96	PF00017	0.393
LIG_SH3_3	160	166	PF00018	0.573
LIG_SH3_3	182	188	PF00018	0.557
LIG_SH3_3	332	338	PF00018	0.569
LIG_SH3_3	375	381	PF00018	0.473
LIG_SH3_3	43	49	PF00018	0.511
LIG_Sin3_3	249	256	PF02671	0.470
LIG_TRAF2_1	125	128	PF00917	0.522
LIG_WRC_WIRS_1	25	30	PF05994	0.467
MOD_CK1_1	167	173	PF00069	0.655
MOD_CK1_1	2	8	PF00069	0.646
MOD_CK2_1	165	171	PF00069	0.716
MOD_GlcNHglycan	116	119	PF01048	0.468
MOD_GlcNHglycan	174	177	PF01048	0.667
MOD_GlcNHglycan	247	250	PF01048	0.698
MOD_GlcNHglycan	254	257	PF01048	0.717
MOD_GlcNHglycan	320	323	PF01048	0.765
MOD_GlcNHglycan	339	342	PF01048	0.378
MOD_GlcNHglycan	388	391	PF01048	0.404
MOD_GlcNHglycan	45	49	PF01048	0.423
MOD_GSK3_1	167	174	PF00069	0.744
MOD_GSK3_1	177	184	PF00069	0.725
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	14	19	PF00069	0.381
MOD_NEK2_1	252	257	PF00069	0.634
MOD_NEK2_2	275	280	PF00069	0.633
MOD_PIKK_1	194	200	PF00454	0.562
MOD_PIKK_1	54	60	PF00454	0.510
MOD_PK_1	236	242	PF00069	0.662
MOD_PKA_1	213	219	PF00069	0.462
MOD_PKA_2	114	120	PF00069	0.388
MOD_PKA_2	213	219	PF00069	0.521
MOD_PKA_2	245	251	PF00069	0.661
MOD_PKA_2	262	268	PF00069	0.512
MOD_Plk_4	56	62	PF00069	0.513
MOD_ProDKin_1	267	273	PF00069	0.591
MOD_SUMO_rev_2	239	245	PF00179	0.686
MOD_SUMO_rev_2	278	285	PF00179	0.585
TRG_ENDOCYTIC_2	358	361	PF00928	0.449
TRG_ENDOCYTIC_2	61	64	PF00928	0.491
TRG_ENDOCYTIC_2	93	96	PF00928	0.388
TRG_ER_diArg_1	104	107	PF00400	0.445
TRG_ER_diArg_1	212	214	PF00400	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8I6	Leptomonas seymouri	45%	72%
A0A1X0P5K1	Trypanosomatidae	34%	89%
A0A3Q8IGA8	Leishmania donovani	84%	100%
A0A3S5IR12	Trypanosoma rangeli	33%	92%
A4IBG1	Leishmania infantum	84%	100%
C9ZZA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	75%
E9AIW3	Leishmania braziliensis	69%	100%
E9B6D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5B3S2	Trypanosoma cruzi	34%	91%