GCP_N_terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

E9AF73_LEIMA

TriTrypDb:

LmjF.35.2500 , LMJLV39_350031700 , LMJSD75_350031200

Length:

555

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AF73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AF73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	454	458	PF00656	0.795
CLV_NRD_NRD_1	100	102	PF00675	0.640
CLV_NRD_NRD_1	212	214	PF00675	0.670
CLV_NRD_NRD_1	434	436	PF00675	0.721
CLV_PCSK_KEX2_1	100	102	PF00082	0.768
CLV_PCSK_KEX2_1	214	216	PF00082	0.649
CLV_PCSK_KEX2_1	434	436	PF00082	0.686
CLV_PCSK_KEX2_1	444	446	PF00082	0.749
CLV_PCSK_KEX2_1	471	473	PF00082	0.579
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.703
CLV_PCSK_PC1ET2_1	444	446	PF00082	0.795
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.561
CLV_PCSK_SKI1_1	129	133	PF00082	0.603
CLV_Separin_Metazoa	263	267	PF03568	0.431
DEG_APCC_DBOX_1	366	374	PF00400	0.533
DOC_CKS1_1	49	54	PF01111	0.664
DOC_CYCLIN_yCln2_LP_2	311	317	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	43	46	PF00134	0.723
DOC_MAPK_gen_1	100	108	PF00069	0.603
DOC_MAPK_gen_1	434	442	PF00069	0.593
DOC_PP2B_LxvP_1	43	46	PF13499	0.594
DOC_PP4_FxxP_1	288	291	PF00568	0.628
DOC_USP7_MATH_1	131	135	PF00917	0.549
DOC_USP7_MATH_1	157	161	PF00917	0.487
DOC_USP7_MATH_1	182	186	PF00917	0.751
DOC_USP7_MATH_1	196	200	PF00917	0.684
DOC_USP7_MATH_1	302	306	PF00917	0.651
DOC_USP7_MATH_1	357	361	PF00917	0.584
DOC_USP7_MATH_1	453	457	PF00917	0.756
DOC_USP7_MATH_1	531	535	PF00917	0.619
DOC_USP7_MATH_1	541	545	PF00917	0.688
DOC_USP7_MATH_1	67	71	PF00917	0.662
DOC_USP7_MATH_1	87	91	PF00917	0.397
DOC_WW_Pin1_4	200	205	PF00397	0.785
DOC_WW_Pin1_4	228	233	PF00397	0.657
DOC_WW_Pin1_4	296	301	PF00397	0.566
DOC_WW_Pin1_4	350	355	PF00397	0.427
DOC_WW_Pin1_4	392	397	PF00397	0.582
DOC_WW_Pin1_4	48	53	PF00397	0.606
LIG_14-3-3_CanoR_1	274	280	PF00244	0.559
LIG_14-3-3_CanoR_1	282	292	PF00244	0.594
LIG_14-3-3_CanoR_1	29	34	PF00244	0.594
LIG_14-3-3_CanoR_1	337	347	PF00244	0.455
LIG_APCC_ABBA_1	37	42	PF00400	0.517
LIG_BRCT_BRCA1_1	159	163	PF00533	0.457
LIG_BRCT_BRCA1_1	198	202	PF00533	0.669
LIG_BRCT_BRCA1_1	246	250	PF00533	0.555
LIG_CSL_BTD_1	227	230	PF09270	0.631
LIG_deltaCOP1_diTrp_1	226	235	PF00928	0.621
LIG_eIF4E_1	38	44	PF01652	0.518
LIG_EVH1_1	44	48	PF00568	0.586
LIG_FHA_1	107	113	PF00498	0.609
LIG_FHA_1	14	20	PF00498	0.525
LIG_FHA_1	284	290	PF00498	0.639
LIG_FHA_1	292	298	PF00498	0.635
LIG_FHA_1	475	481	PF00498	0.464
LIG_FHA_1	49	55	PF00498	0.572
LIG_FHA_1	538	544	PF00498	0.750
LIG_FHA_1	75	81	PF00498	0.659
LIG_FHA_1	87	93	PF00498	0.581
LIG_FHA_2	123	129	PF00498	0.687
LIG_FHA_2	235	241	PF00498	0.549
LIG_FHA_2	265	271	PF00498	0.610
LIG_FHA_2	29	35	PF00498	0.557
LIG_FHA_2	404	410	PF00498	0.534
LIG_FHA_2	447	453	PF00498	0.537
LIG_FHA_2	94	100	PF00498	0.586
LIG_LIR_Apic_2	270	275	PF02991	0.565
LIG_LIR_Apic_2	286	291	PF02991	0.522
LIG_LIR_Apic_2	30	36	PF02991	0.533
LIG_LIR_Gen_1	160	168	PF02991	0.446
LIG_LIR_Gen_1	247	258	PF02991	0.459
LIG_LIR_Nem_3	160	166	PF02991	0.453
LIG_LIR_Nem_3	247	253	PF02991	0.468
LIG_LIR_Nem_3	330	336	PF02991	0.615
LIG_LIR_Nem_3	341	347	PF02991	0.498
LIG_MYND_1	41	45	PF01753	0.543
LIG_PCNA_PIPBox_1	516	525	PF02747	0.459
LIG_Pex14_1	479	483	PF04695	0.393
LIG_SH2_CRK	345	349	PF00017	0.456
LIG_SH2_NCK_1	424	428	PF00017	0.487
LIG_SH2_SRC	33	36	PF00017	0.503
LIG_SH2_SRC	424	427	PF00017	0.477
LIG_SH2_STAP1	345	349	PF00017	0.456
LIG_SH2_STAP1	424	428	PF00017	0.599
LIG_SH2_STAP1	476	480	PF00017	0.503
LIG_SH2_STAT5	332	335	PF00017	0.548
LIG_SH2_STAT5	376	379	PF00017	0.504
LIG_SH2_STAT5	38	41	PF00017	0.513
LIG_SH2_STAT5	404	407	PF00017	0.525
LIG_SH2_STAT5	476	479	PF00017	0.507
LIG_SH3_3	224	230	PF00018	0.591
LIG_SH3_3	286	292	PF00018	0.691
LIG_SH3_3	294	300	PF00018	0.654
LIG_SH3_3	416	422	PF00018	0.496
LIG_SH3_3	42	48	PF00018	0.537
LIG_SH3_3	430	436	PF00018	0.703
LIG_SH3_3	49	55	PF00018	0.547
LIG_Sin3_3	344	351	PF02671	0.338
LIG_SUMO_SIM_anti_2	507	514	PF11976	0.509
LIG_SUMO_SIM_par_1	104	110	PF11976	0.631
LIG_SUMO_SIM_par_1	507	514	PF11976	0.509
LIG_TRAF2_1	151	154	PF00917	0.611
LIG_TRAF2_1	192	195	PF00917	0.536
LIG_WW_1	35	38	PF00397	0.508
LIG_WW_2	52	55	PF00397	0.662
MOD_CK1_1	244	250	PF00069	0.551
MOD_CK1_1	28	34	PF00069	0.708
MOD_CK1_1	326	332	PF00069	0.619
MOD_CK1_1	350	356	PF00069	0.456
MOD_CK1_1	534	540	PF00069	0.597
MOD_CK1_1	542	548	PF00069	0.578
MOD_CK2_1	122	128	PF00069	0.556
MOD_CK2_1	148	154	PF00069	0.567
MOD_CK2_1	182	188	PF00069	0.638
MOD_CK2_1	189	195	PF00069	0.716
MOD_CK2_1	234	240	PF00069	0.641
MOD_CK2_1	264	270	PF00069	0.672
MOD_CK2_1	28	34	PF00069	0.559
MOD_CK2_1	403	409	PF00069	0.534
MOD_CK2_1	446	452	PF00069	0.784
MOD_CK2_1	93	99	PF00069	0.585
MOD_Cter_Amidation	442	445	PF01082	0.639
MOD_GlcNHglycan	133	136	PF01048	0.493
MOD_GlcNHglycan	198	201	PF01048	0.740
MOD_GlcNHglycan	245	249	PF01048	0.592
MOD_GlcNHglycan	349	352	PF01048	0.498
MOD_GlcNHglycan	355	358	PF01048	0.658
MOD_GlcNHglycan	380	383	PF01048	0.463
MOD_GlcNHglycan	523	526	PF01048	0.658
MOD_GlcNHglycan	89	92	PF01048	0.598
MOD_GSK3_1	196	203	PF00069	0.731
MOD_GSK3_1	209	216	PF00069	0.746
MOD_GSK3_1	25	32	PF00069	0.687
MOD_GSK3_1	291	298	PF00069	0.605
MOD_GSK3_1	320	327	PF00069	0.664
MOD_GSK3_1	353	360	PF00069	0.552
MOD_GSK3_1	537	544	PF00069	0.687
MOD_N-GLC_1	295	300	PF02516	0.518
MOD_NEK2_1	122	127	PF00069	0.524
MOD_NEK2_1	25	30	PF00069	0.610
MOD_NEK2_1	264	269	PF00069	0.520
MOD_NEK2_1	324	329	PF00069	0.452
MOD_PIKK_1	543	549	PF00454	0.688
MOD_PIKK_1	74	80	PF00454	0.584
MOD_PKA_1	213	219	PF00069	0.690
MOD_PKA_2	28	34	PF00069	0.595
MOD_PKA_2	378	384	PF00069	0.486
MOD_Plk_1	122	128	PF00069	0.580
MOD_Plk_1	371	377	PF00069	0.472
MOD_Plk_1	534	540	PF00069	0.701
MOD_Plk_1	74	80	PF00069	0.519
MOD_Plk_2-3	446	452	PF00069	0.642
MOD_Plk_4	107	113	PF00069	0.490
MOD_Plk_4	122	128	PF00069	0.455
MOD_Plk_4	372	378	PF00069	0.528
MOD_Plk_4	474	480	PF00069	0.468
MOD_ProDKin_1	200	206	PF00069	0.788
MOD_ProDKin_1	228	234	PF00069	0.653
MOD_ProDKin_1	296	302	PF00069	0.560
MOD_ProDKin_1	350	356	PF00069	0.443
MOD_ProDKin_1	392	398	PF00069	0.580
MOD_ProDKin_1	48	54	PF00069	0.607
MOD_SUMO_for_1	548	551	PF00179	0.586
MOD_SUMO_rev_2	185	192	PF00179	0.631
TRG_DiLeu_BaEn_3	153	159	PF01217	0.579
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.600
TRG_ENDOCYTIC_2	345	348	PF00928	0.457
TRG_ER_diArg_1	100	102	PF00400	0.640
TRG_ER_diArg_1	433	435	PF00400	0.584
TRG_NLS_MonoExtC_3	212	217	PF00514	0.755
TRG_NLS_MonoExtN_4	210	217	PF00514	0.754
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG0	Leptomonas seymouri	61%	100%
A0A1X0P5K7	Trypanosomatidae	33%	100%
A0A3Q8IJ29	Leishmania donovani	93%	100%
A0A3R7KY71	Trypanosoma rangeli	36%	100%
A4HMS3	Leishmania braziliensis	80%	100%
A4IBF9	Leishmania infantum	94%	100%
C9ZZA5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B6C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5DK90	Trypanosoma cruzi	35%	100%